Abstract：
INTRODUCTION:Several factors influence the severity of Plasmodium falciparum; here, we investigate the impact of alpha+-thalassaemia genotype on P. falciparum parasitemia and prevalence of severe anaemia amongst microcytic children from Kumasi, Ghana. METHODS:Seven hundred and thirty-two children (≤10 years) with P. falciparum were categorised into normocytic and microcytic (mean cell volume ≤76 fL). Microcytic individuals were genotyped for the -α(3.7) deletional thalassaemia mutation and parasite densities determined. RESULTS:Amongst microcytic patients both parasite densities and prevalence of severe malaria parasitemia (≥100 000/μL) were significantly lower (P < 0.001) in the presence of an alpha+-thalassaemia genotype compared with non-alpha+-thalassaemia genotype. There was no evidence that alpha+-thalassaemia protected against severe anaemia. The protection conferred by alpha-thalassaemia genotype against severe P. falciparum parasitemia did not change with increasing age. CONCLUSION:The severity of P. falciparum parasitemia was significantly lower in both the homozygous and heterozygous alpha+-thalassaemia groups compared with microcytic individuals with non-alpha+-thalassaemia genotype. The protective effect, from severe malaria, of the alpha+-thalassaemia allele does not alter with age.
journal_name
Int J Lab Hematoljournal_title
International journal of laboratory hematologyauthors
Opoku-Okrah C,Gordge M,Kweku Nakua E,Abgenyega T,Parry M,Robertson C,Smith CLdoi
10.1111/ijlh.12122subject
Has Abstractpub_date
2014-02-01 00:00:00pages
62-70issue
1eissn
1751-5521issn
1751-553Xjournal_volume
36pub_type
杂志文章abstract：INTRODUCTION:Paroxysmal nocturnal hemoglobinuria (PNH) is a hemolytic, clonal and acquired disorder of the hematopoietic stem cell with a deficiency of all glycophosphatidyl-inositol (GPI) linked proteins. The aim of this retrospective study was to analyse haematological and biochemical data from 152 patients referred ...
journal_title：International journal of laboratory hematology
pub_type： 杂志文章
doi：10.1111/ijlh.12156
更新日期：2014-04-01 00:00:00
abstract：INTRODUCTION:The STA R Max® 2 is a new coagulation analyser developed by Diagnostica Stago, able to perform clotting, chromogenic and immuno-turbidimetric tests. A pre-analytical module build into the cap-piercing needle performs the sample integrity verification (sample tube filling and measurement of haemolysis, icte...
journal_title：International journal of laboratory hematology
pub_type： 杂志文章
doi：10.1111/ijlh.13100
更新日期：2019-12-01 00:00:00
abstract：:Chronic active Epstein-Barr virus infection of T- and NK-cell type, systemic form, is a rare entity within the spectrum of EBV-driven T- and NK-cell lymphoproliferative disorders. Established diagnostic criteria and a characteristic clinical course help to differentiate it from other closely related EBV-positive neopl...
journal_title：International journal of laboratory hematology
pub_type： 杂志文章,评审
doi：10.1111/ijlh.13199
更新日期：2020-06-01 00:00:00
abstract：:The majority, if not all, of human cell types secrete extracellular vesicles (EVs) into their environment, at least partly as a means of intercellular communication. These secreted vesicles can be detected in most bodily fluids including blood, urine, and saliva. The number of secreted vesicles and their composition i...
journal_title：International journal of laboratory hematology
pub_type： 杂志文章,评审
doi：10.1111/ijlh.12247
更新日期：2014-06-01 00:00:00
abstract：INTRODUCTION:Frequent PT (INR) testing may represent a problem for patients on warfarin treatment, and capillary or small-volume tubes may be more appropriate for such patients. A demand for small-volume tubes also comes from pediatric wards. Yet, while various small-volume tubes are available, they have not been prope...
journal_title：International journal of laboratory hematology
pub_type： 杂志文章
doi：10.1111/ijlh.12387
更新日期：2015-10-01 00:00:00
abstract：:Myelodysplastic syndrome (MDS) with hypocellular bone marrow (BM) is often difficult to distinguish from aplastic anemia (AA). Furthermore, the diagnosis of MDS with low blast counts and normal karyotype may be problematic. These issues highlight the need for a reliable marker for the diagnosis of MDS. This study was ...
journal_title：International journal of laboratory hematology
pub_type： 杂志文章
doi：10.1111/j.1751-553X.2008.01056.x
更新日期：2009-06-01 00:00:00
abstract：:Significant advances have been made in our understanding of the structural basis for altered cell function in various inherited red cell membrane disorders with reduced red cell survival and resulting hemolytic anemia. The current review summarizes these advances as they relate to defining the molecular and structural...
journal_title：International journal of laboratory hematology
pub_type： 杂志文章,评审
doi：10.1111/ijlh.12657
更新日期：2017-05-01 00:00:00
abstract：:Multiple myeloma (MM) is a malignant plasma cell disorder that involves multiple genetic abnormalities. Chimeric transcription factors, created by gene fusion as a result of chromosomal translocations, have been implicated in the pathogenesis of the disease. Here, we report the conventional cytogenetic analysis of a M...
journal_title：International journal of laboratory hematology
pub_type： 杂志文章
doi：10.1111/j.1751-553X.2006.00837.x
更新日期：2007-06-01 00:00:00
abstract：BACKGROUND:Argatroban is licensed for patients with heparin-induced thrombocytopenia and monitoring is conventionally by activated partial thromboplastin time (APTT) ratio with a target of 1.5-3.0 and not exceeding 100 s. The APTT may be influenced by coagulopathies, lupus anticoagulant and raised FVIII levels. Variabl...
journal_title：International journal of laboratory hematology
pub_type： 杂志文章
doi：10.1111/ijlh.12414
更新日期：2015-12-01 00:00:00
abstract：:Three major types of rearrangements are involved in acute myeloid leukemias (AML): t(8;21)(q22;q22), inv(16)(p13q22), and 11q23/MLL abnormalities. Their precise identification becomes essential for diagnosis, prognosis, and therapeutic choices. Resulting fusion transcripts (FT) are also powerful markers for monitoring...
journal_title：International journal of laboratory hematology
pub_type： 杂志文章
doi：10.1111/j.1751-553X.2009.01201.x
更新日期：2010-08-01 00:00:00
abstract：:Bone marrow aspiration and biopsy can be a painful procedure. Sedation techniques may make this investigation more acceptable to patients, but have the potential to cause life-threatening complications, as well as requiring additional staff and equipment for safe administration. We assessed the use of Entonox, a 50 : ...
journal_title：International journal of laboratory hematology
pub_type： 临床试验,杂志文章
doi：10.1111/j.1751-553X.2007.00905.x
更新日期：2008-02-01 00:00:00
abstract：INTRODUCTION:Venous blood (VB) sampling for complete blood count (CBC) via venipuncture is the basic method for the daily evaluation of hematological patients. However, several issues during this process, such as venipuncture difficulty and repetitive attempts, may cause pain, phlebitis, hematomas, inadequate sampling,...
journal_title：International journal of laboratory hematology
pub_type： 杂志文章
doi：10.1111/ijlh.13237
更新日期：2020-10-01 00:00:00
abstract：INTRODUCTION:In the cytogenetically normal population of AML (CN-AML), FLT3-ITD-positive and wild-type NPM1 is correlated with a worse outcome, and FLT3-ITD-negative with NPM1-mut is correlated with a better outcome. This leaves a large subpopulation of CN-AML patients without NPM1 or FLT3-ITD mutations with heterogene...
journal_title：International journal of laboratory hematology
pub_type： 杂志文章
doi：10.1111/ijlh.12649
更新日期：2017-08-01 00:00:00
abstract：INTRODUCTION:Mean platelet volume (MPV) and platelet (PLT) count are the two major parameters that reflect the functions and activities of PLTs. The associations of MPV and PLT count with the occurrence and prognosis of stroke have not been fully clarified. This study aimed to investigate the association of MPV and PLT...
journal_title：International journal of laboratory hematology
pub_type： 临床试验,杂志文章
doi：10.1111/ijlh.12474
更新日期：2016-06-01 00:00:00
abstract：INTRODUCTION:We developed and validated reflex testing rules for the microscopic examination (ME) of body fluids (BFs) on the Sysmex XN-550 (Sysmex Corporation) instrument. METHODS:We assessed the detection limits, precision, linearity, and carryover. To develop the reflex testing rules (derivation arm), we tested 515...
journal_title：International journal of laboratory hematology
pub_type： 杂志文章
doi：10.1111/ijlh.12774
更新日期：2018-06-01 00:00:00
abstract：INTRODUCTION:Direct oral anticoagulants (DOAC) are commonly prescribed and measuring drug levels may be useful in a number of contexts. However, data on DOAC level measurement and their clinical utility in real-world studies are limited. METHODS:We carried out a 2-year retrospective cohort study of DOAC levels measure...
journal_title：International journal of laboratory hematology
pub_type： 杂志文章
doi：10.1111/ijlh.12944
更新日期：2019-04-01 00:00:00
abstract：:Eosinophilia is typically secondary, that is, reactive, in nature and is associated with a wide variety of neoplastic and non-neoplastic disorders. Clonal eosinophilia is also seen in a wide variety of hematopoietic neoplasms, and sub-classification can be diagnostically challenging. A proper evaluation of persistent ...
journal_title：International journal of laboratory hematology
pub_type： 杂志文章,评审
doi：10.1111/ijlh.12955
更新日期：2019-04-01 00:00:00
abstract：INTRODUCTION:Thrombotic thrombocytopenic purpura (TTP) is a rare life-threatening thrombotic microangiopathy (TMA) characterized by the severe deficiency of ADAMTS13 activity (<10%). Rapid ADAMTS13 testing is crucial for early diagnosis and optimal management of TTP patients and other TMAs. The objective of this study ...
journal_title：International journal of laboratory hematology
pub_type： 杂志文章
doi：10.1111/ijlh.13414
更新日期：2020-12-02 00:00:00
abstract：BACKGROUND:Hematological patients, receiving intensive chemotherapy (predominantly acute leukemia patients), have repeated postchemotherapy periods with severe bone marrow suppression. As a result, these patients require regular monitoring of the complete blood counts (CBC) for optimal patient care. To reduce the strai...
journal_title：International journal of laboratory hematology
pub_type： 杂志文章
doi：10.1111/ijlh.13330
更新日期：2021-02-01 00:00:00
abstract：INTRODUCTION:Iron deficiency (ID) is a major cause of morbidity in pregnancy. Antenatal clinics use a hemoglobin to screen for ID, which delays the diagnosis of subclinical ID. The aim of this study was to investigate the clinical utility of the percentage of microcytic red cells (%Micro-R), percentage of hypochromic r...
journal_title：International journal of laboratory hematology
pub_type： 临床试验,杂志文章
doi：10.1111/ijlh.12904
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journal_title：International journal of laboratory hematology
pub_type： 杂志文章
doi：10.1111/ijlh.13395
更新日期：2020-11-15 00:00:00
abstract：:Congenital protein C deficiency significantly increases the risk of venous thromboembolism, a serious and potentially lethal condition. Protein C levels can be determined by chromogenic, clotting and antigenic assays, each type of assay has differences in specificity and sensitivity to protein C deficiency. In princip...
journal_title：International journal of laboratory hematology
pub_type： 杂志文章
doi：10.1111/j.1751-553X.2007.00972.x
更新日期：2008-10-01 00:00:00
abstract：:Direct international normalized ratio (INR) determination using certified INR plasmas was shown to improve precision and accuracy. We evaluated the utility of a multicalibrator in determining INR. INR values were measured in 493 blood samples from patients subjected to anticoagulation therapy (320) and control subject...
journal_title：International journal of laboratory hematology
pub_type： 杂志文章
doi：10.1111/j.1751-553X.2009.01195.x
更新日期：2010-08-01 00:00:00
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journal_title：International journal of laboratory hematology
pub_type： 杂志文章
doi：10.1111/j.1751-553X.2012.01421.x
更新日期：2012-10-01 00:00:00
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journal_title：International journal of laboratory hematology
pub_type： 杂志文章
doi：10.1111/ijlh.12030
更新日期：2013-08-01 00:00:00
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journal_title：International journal of laboratory hematology
pub_type： 杂志文章
doi：10.1111/ijlh.13109
更新日期：2019-12-01 00:00:00
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journal_title：International journal of laboratory hematology
pub_type： 杂志文章
doi：10.1111/j.1751-553X.2012.01450.x
更新日期：2012-12-01 00:00:00
abstract：INTRODUCTION:Gene expression profiling (GEP) risk models in multiple myeloma are based on 3'-end microarrays. We hypothesized that GEP risk signatures could retain prognostic power despite being translated and applied to whole-transcript microarray data. METHODS:We studied CD138-positive bone marrow plasma cells in a ...
journal_title：International journal of laboratory hematology
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1111/ijlh.12486
更新日期：2016-06-01 00:00:00
abstract：:Modern photo-optical coagulometers collect optical data in the form of reaction curves and offer a possibility to determine clotting times at different points of clot formation by using different evaluation modes. The objectives of this study were to determine the possible impact of an evaluation mode on activated par...
journal_title：International journal of laboratory hematology
pub_type： 杂志文章
doi：10.1111/j.1751-553X.2008.01111.x
更新日期：2010-02-01 00:00:00
abstract：:Acute myeloid leukemia (AML) is a complex disease, for which our understanding of the role of genetic and epigenetic changes has undergone significant advancements. Newer diagnostic and prognostic classifications have increasingly incorporated such information, and novel therapies have been developed to target specifi...
journal_title：International journal of laboratory hematology
pub_type： 杂志文章,评审
doi：10.1111/ijlh.12367
更新日期：2015-05-01 00:00:00
