Abstract：
INTRODUCTION:Laboratory investigations for bleeding disorders are warranted when an individual has a personal and/or family history of bleeding, and/or laboratory findings that suggest the possibility of an inherited or acquired bleeding disorder. METHODS:This review summarizes author's experience with ordering and reporting on diagnostic investigations for common and rare bleeding disorders, with consideration of recent articles on diagnosing bleeding disorders. An updated strategy is presented for investigating common and rare, congenital and acquired bleeding disorders. RESULTS:An investigation of a suspected bleeding disorder requires a practical strategy that considers the clinical problem to be investigated, the pretest probability of true-positive and false-positive findings, the investigations can be performed locally or in a reference laboratory and limit the number of blood samples required to establish a diagnosis. It is often advantageous to simultaneously test for von Willebrand disease and platelet function disorders, and for coagulation defects, including fibrinogen disorders. An investigation for rarer bleeding disorders, including those affecting factor XIII, α2 antiplasmin, and plasminogen activator inhibitor-1, is appropriate when faced with a severe congenital or acquired bleeding problem that cannot be explained by the initial diagnostic investigations. CONCLUSION:An organized strategy for investigating bleeding disorders that consider important issues, confirms abnormal findings, encourages proper interpretation of the results, and provides a helpful framework for assessing both common and rare causes of bleeding.
journal_name
Int J Lab Hematoljournal_title
International journal of laboratory hematologyauthors
Hayward CPMdoi
10.1111/ijlh.12822subject
Has Abstractpub_date
2018-05-01 00:00:00pages
6-14eissn
1751-5521issn
1751-553Xjournal_volume
40 Suppl 1pub_type
杂志文章,评审abstract：:Advances in lab-on-a-chip technologies enabled programmable, reconfigurable, and scalable manipulation of a variety of laboratory procedures. Samples, reagents, and fluids can be precisely controlled; buffer temperature, pH, and concentration control systems as well as a variety of detection systems can be integrated ...
journal_title：International journal of laboratory hematology
pub_type： 杂志文章,评审
doi：10.1111/ijlh.12054
更新日期：2013-10-01 00:00:00
abstract：:Bone marrow aspiration and biopsy can be a painful procedure. Sedation techniques may make this investigation more acceptable to patients, but have the potential to cause life-threatening complications, as well as requiring additional staff and equipment for safe administration. We assessed the use of Entonox, a 50 : ...
journal_title：International journal of laboratory hematology
pub_type： 临床试验,杂志文章
doi：10.1111/j.1751-553X.2007.00905.x
更新日期：2008-02-01 00:00:00
abstract：:The majority, if not all, of human cell types secrete extracellular vesicles (EVs) into their environment, at least partly as a means of intercellular communication. These secreted vesicles can be detected in most bodily fluids including blood, urine, and saliva. The number of secreted vesicles and their composition i...
journal_title：International journal of laboratory hematology
pub_type： 杂志文章,评审
doi：10.1111/ijlh.12247
更新日期：2014-06-01 00:00:00
abstract：INTRODUCTION:With the progression of blood analysis technology, hematology analyzers become more complex and diverse. How to choose a superb instrument is a challenge for the laboratories. In the essay, we studied whether the newest BC-6000 hematology analyzer meets the needs of a clinical hematology laboratory. METHO...
journal_title：International journal of laboratory hematology
pub_type： 杂志文章
doi：10.1111/ijlh.13075
更新日期：2019-10-01 00:00:00
abstract：INTRODUCTION:While the presence of disseminated intravascular coagulation (DIC) has been implicated in worse clinical outcome in acute leukemia, the relationship between different subtypes of acute leukemia and the clinicopathologic features of DIC has not been systematically well studied. METHODS:In this study, we re...
journal_title：International journal of laboratory hematology
pub_type： 杂志文章
doi：10.1111/ijlh.12636
更新日期：2017-08-01 00:00:00
abstract：:Promoter hypermethylation plays an important role in the inactivation of cancer-related genes. This abnormality occurs early in leukemogenesis and seems to be associated with poor prognosis in myelodsplastic syndrome (MDS). The identification of more inactivated tumor suppressor genes contributing to the development o...
journal_title：International journal of laboratory hematology
pub_type： 杂志文章
doi：10.1111/j.1751-553X.2008.01131.x
更新日期：2010-02-01 00:00:00
abstract：INTRODUCTION:Malaria is a life-threatening infectious disease, which has been for long confined to specific endemic areas. Nevertheless, the recent increase in immigration flows from endemic regions and imported cases has reemphasized many diagnostic challenges in Western countries, thus paving the way to introduce rap...
journal_title：International journal of laboratory hematology
pub_type： 杂志文章
doi：10.1111/ijlh.12790
更新日期：2018-06-01 00:00:00
abstract：:Significant advances have been made in our understanding of the structural basis for altered cell function in various inherited red cell membrane disorders with reduced red cell survival and resulting hemolytic anemia. The current review summarizes these advances as they relate to defining the molecular and structural...
journal_title：International journal of laboratory hematology
pub_type： 杂志文章,评审
doi：10.1111/ijlh.12657
更新日期：2017-05-01 00:00:00
abstract：:Platelets play a central role in physiological hemostasis and also in pathological thrombosis. It is well established that congenital or acquired abnormalities of platelet function are associated with a heightened risk of bleeding of variable severity and excessive hemorrhage after surgery or trauma. Several kinds of ...
journal_title：International journal of laboratory hematology
pub_type： 杂志文章
doi：10.1111/ijlh.12539
更新日期：2016-05-01 00:00:00
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journal_title：International journal of laboratory hematology
pub_type： 杂志文章
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更新日期：2021-02-01 00:00:00
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journal_title：International journal of laboratory hematology
pub_type： 杂志文章
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更新日期：2020-04-01 00:00:00
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journal_title：International journal of laboratory hematology
pub_type： 杂志文章
doi：10.1111/j.1751-553X.2011.01384.x
更新日期：2012-06-01 00:00:00
abstract：INTRODUCTION:New generation osmotic gradient ektacytometry has become a powerful procedure for measuring red blood cell deformability and therefore for the diagnosis of red blood cell membrane disorders. In this study, we aim to provide further support to the usefulness of osmotic gradient ektacytometry for the differe...
journal_title：International journal of laboratory hematology
pub_type： 临床试验,杂志文章
doi：10.1111/ijlh.12746
更新日期：2018-02-01 00:00:00
abstract：:The foundation of laboratory hematologic diagnosis is the complete blood count and review of the peripheral smear. In patients with anemia, the peripheral smear permits interpretation of diagnostically significant red blood cell (RBC) findings. These include assessment of RBC shape, size, color, inclusions, and arrang...
journal_title：International journal of laboratory hematology
pub_type： 杂志文章,评审
doi：10.1111/ijlh.12082
更新日期：2013-06-01 00:00:00
abstract：INTRODUCTION:Beta globin deletion/duplication analysis may serve as a useful adjunct to sequence analysis. Our purpose was to develop a robust assay for beta globin deletion/duplication analysis and determine its role in evaluating patients with beta thalassemia. METHODS:A single tube semi-quantitative fluorescent PCR...
journal_title：International journal of laboratory hematology
pub_type： 杂志文章
doi：10.1111/j.1751-553X.2010.01287.x
更新日期：2011-06-01 00:00:00
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journal_title：International journal of laboratory hematology
pub_type： 杂志文章,评审
doi：10.1111/ijlh.12505
更新日期：2016-05-01 00:00:00
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journal_title：International journal of laboratory hematology
pub_type： 杂志文章,评审
doi：10.1111/ijlh.13016
更新日期：2019-05-01 00:00:00
abstract：INTRODUCTION:The study aims to evaluate the diagnostic utility of thyrogastric immune features in the identification of intrinsic factor antibody negative (IFA -ve) pernicious anaemia (PA) patients. METHODS:Clinico-pathological features of 'intrinsic factor antibody positive (IFA +ve) PA' and 'IFA -ve presumed PA' Chi...
journal_title：International journal of laboratory hematology
pub_type： 杂志文章
doi：10.1111/j.1751-553X.2010.01295.x
更新日期：2011-08-01 00:00:00
abstract：INTRODUCTION:Thrombotic complications are a main concern in patients with myeloproliferative neoplasms. Recently, a gain-of-function mutation of the gene encoding the JAK2 tyrosine kinase that results in a valine-to-phenylalanine substitution at position 617 (V617F) has been described. Since the description of the JAK2...
journal_title：International journal of laboratory hematology
pub_type： 杂志文章,评审
doi：10.1111/j.1751-553X.2010.01275.x
更新日期：2011-04-01 00:00:00
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journal_title：International journal of laboratory hematology
pub_type： 杂志文章,评审
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更新日期：2010-12-01 00:00:00
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journal_title：International journal of laboratory hematology
pub_type： 杂志文章
doi：10.1111/j.1751-553X.2007.00934.x
更新日期：2007-12-01 00:00:00
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journal_title：International journal of laboratory hematology
pub_type： 杂志文章
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journal_title：International journal of laboratory hematology
pub_type： 杂志文章
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更新日期：2018-04-01 00:00:00
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journal_title：International journal of laboratory hematology
pub_type： 杂志文章
doi：10.1111/j.1751-553X.2012.01432.x
更新日期：2012-10-01 00:00:00
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journal_title：International journal of laboratory hematology
pub_type： 杂志文章
doi：10.1111/j.1751-553X.2009.01201.x
更新日期：2010-08-01 00:00:00
abstract：INTRODUCTION:It has been recently suggested that microparticles (MP) play a role in the pathogenesis of thrombotic complications. This study aimed to assess the contribution of procoagulant activity expressed by circulating MP in thrombotic events in MPN patients. METHODS:Seventy-four MPN patients were enrolled in a t...
journal_title：International journal of laboratory hematology
pub_type： 杂志文章
doi：10.1111/ijlh.12676
更新日期：2017-10-01 00:00:00
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journal_title：International journal of laboratory hematology
pub_type： 杂志文章
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更新日期：2013-12-01 00:00:00
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journal_title：International journal of laboratory hematology
pub_type： 杂志文章
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更新日期：2021-02-01 00:00:00
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journal_title：International journal of laboratory hematology
pub_type： 杂志文章
doi：10.1111/ijlh.13167
更新日期：2020-06-01 00:00:00
abstract：:Modern photo-optical coagulometers collect optical data in the form of reaction curves and offer a possibility to determine clotting times at different points of clot formation by using different evaluation modes. The objectives of this study were to determine the possible impact of an evaluation mode on activated par...
journal_title：International journal of laboratory hematology
pub_type： 杂志文章
doi：10.1111/j.1751-553X.2008.01111.x
更新日期：2010-02-01 00:00:00
