2016 WHO Classification update-What's new in lymphoid neoplasms.


:In the 8 years since the publication of the 4th edition of the WHO Classification of Hematopoietic and Lymphoid Tumours in 2008, there has been rapid accumulation of knowledge in the molecular genetics, biology, clinical behavior of many hematologic malignancies. Concepts and models have advanced to the point at which updates were deemed necessary prior to the formal WHO process of publication of a 5th edition as part of the WHO "blue book" series. This overview will focus on lymphoid tumors and highlight important changes and updates to these neoplasms.


Int J Lab Hematol


Hsi ED




Has Abstract


2017-05-01 00:00:00








39 Suppl 1


  • Performance evaluation of the Sysmex(®) XP-300 in an oncology setting: evaluation and comparison of hematological parameters with the Sysmex(®) XN-3000.

    abstract:INTRODUCTION:The Sysmex XP-300(®) (XP-300) is a new, fully automated hematology analyzer, designed to generate complete blood counts (CBC) with 3-part differential. In our study, the XP-300 was evaluated as a point-of-care (POC) analyzer in an oncology setting. In which blood samples from patients with different pathol...

    journal_title:International journal of laboratory hematology

    pub_type: 杂志文章,随机对照试验


    authors: van Dievoet MA,Louagie H,Ghys T

    更新日期:2016-10-01 00:00:00

  • Evaluation of small-volume tubes for venous and capillary PT (INR) samples.

    abstract:INTRODUCTION:Frequent PT (INR) testing may represent a problem for patients on warfarin treatment, and capillary or small-volume tubes may be more appropriate for such patients. A demand for small-volume tubes also comes from pediatric wards. Yet, while various small-volume tubes are available, they have not been prope...

    journal_title:International journal of laboratory hematology

    pub_type: 杂志文章


    authors: Onelöv L,Basmaji R,Svensson A,Nilsson M,Antovic JP

    更新日期:2015-10-01 00:00:00

  • Hemostasis critical values among Iranian clinical laboratories "National Survey of 157 Clinical Laboratories".

    abstract:BACKGROUND:Immediate reporting of critical values or test results significantly outside the normal range has a growing role in the management of patients, especially in life-threatening conditions. Due to the lack of international consensus, diverse approaches are used for determination of thresholds, reporting, docume...

    journal_title:International journal of laboratory hematology

    pub_type: 杂志文章


    authors: Dorgalaleh A,Shiravand Y,Dabbagh A,Tabibian S,Hosseini MS,Mansouri Tourghabeh H,Rashidpanah J,Narouei F,Shams M,Gholami MS,Saneei Moghaddam E,Shahreki H

    更新日期:2019-12-01 00:00:00

  • A study of disseminated intravascular coagulation in acute leukemia reveals markedly elevated D-dimer levels are a sensitive indicator of acute promyelocytic leukemia.

    abstract:INTRODUCTION:While the presence of disseminated intravascular coagulation (DIC) has been implicated in worse clinical outcome in acute leukemia, the relationship between different subtypes of acute leukemia and the clinicopathologic features of DIC has not been systematically well studied. METHODS:In this study, we re...

    journal_title:International journal of laboratory hematology

    pub_type: 杂志文章


    authors: Shahmarvand N,Oak JS,Cascio MJ,Alcasid M,Goodman E,Medeiros BC,Arber DA,Zehnder JL,Ohgami RS

    更新日期:2017-08-01 00:00:00

  • Entonox as a sedative for bone marrow aspiration and biopsy.

    abstract::Bone marrow aspiration and biopsy can be a painful procedure. Sedation techniques may make this investigation more acceptable to patients, but have the potential to cause life-threatening complications, as well as requiring additional staff and equipment for safe administration. We assessed the use of Entonox, a 50 : ...

    journal_title:International journal of laboratory hematology

    pub_type: 临床试验,杂志文章


    authors: Gudgin EJ,Besser MW,Craig JI

    更新日期:2008-02-01 00:00:00

  • Usefulness of automated fragmented red blood cell percentage in the diagnosis of paediatric haemolytic uraemic syndrome.

    abstract:INTRODUCTION:Presence of schistocytes in peripheral blood smear supporting haemolysis is important for diagnosis and decision-making in paediatric haemolytic uraemic syndrome (HUS). High observer dependency and requirement of expertise for peripheral smear evaluation propels us to think of other modalities to overcome ...

    journal_title:International journal of laboratory hematology

    pub_type: 杂志文章


    authors: Govindarajan S,Bhatia P,Dawman L,Tiewsoh K

    更新日期:2021-02-01 00:00:00

  • Evaluation of the HemoCue WBC DIFF in leukopenic patient samples.

    abstract:BACKGROUND:White blood cell (WBC) counts are used to monitor bone marrow function and to screen for infections. The HemoCue WBC DIFF Point-Of-Care (POC) instrument classifies WBCs through cell image recognition. To evaluate its suitability for monitoring cancer patients, we examined its performance in samples from pati...

    journal_title:International journal of laboratory hematology

    pub_type: 杂志文章


    authors: Kur DK,Agersnap N,Holländer NH,Pedersen OBV,Friis-Hansen L

    更新日期:2020-06-01 00:00:00

  • ICSH recommendations for the measurement of haemoglobin F.

    abstract::Measurement of the Haemoglobin F in red cell haemolysates is important in the diagnosis of δβ thalassaemia, hereditary persistence of fetal haemoglobin (HPFH) and in the diagnosis and management of sickle cell disease. The distribution of Hb F in red cells is useful in the diagnosis of HPFH and in the assessment of fe...

    journal_title:International journal of laboratory hematology

    pub_type: 杂志文章,实务指引


    authors: Stephens AD,Angastiniotis M,Baysal E,Chan V,Davis B,Fucharoen S,Giordano PC,Hoyer JD,Mosca A,Wild B,International Council for The Standardisation of Haematology (ICSH).

    更新日期:2012-02-01 00:00:00

  • Evaluation of the leukocyte differential on a new automated flow cytometry hematology analyzer.

    abstract:INTRODUCTION:The Hematoflow (Beckman Coulter, USA) is a new automated hematology analyzer, which provides a 16-part white blood cell count (WBC) differential. METHODS:We evaluated the differential WBC count performance of the Hematoflow. 101 blood samples from patients were selected for comparison analysis. RESULTS:T...

    journal_title:International journal of laboratory hematology

    pub_type: 杂志文章


    authors: Kim JE,Kim BR,Woo KS,Han JY

    更新日期:2012-10-01 00:00:00

  • Morphologic identification of atypical chronic lymphocytic leukemia by digital microscopy.

    abstract:INTRODUCTION:Atypical chronic lymphocytic leukemia (aCLL) is a morphologic variant found in approximately 25% of patients with chronic lymphocytic leukemia (CLL). Although aCLL has a more aggressive course compared to typical CLL (tCLL), it is not usually reported. This retrospective study used digital microscopy to mo...

    journal_title:International journal of laboratory hematology

    pub_type: 杂志文章


    authors: Marionneaux S,Maslak P,Keohane EM

    更新日期:2014-08-01 00:00:00

  • Upregulation of long noncoding RNA Lnc-IRF2-3 and Lnc-ZNF667-AS1 is associated with poor survival in B-chronic lymphocytic leukemia.

    abstract:BACKGROUND:Lnc-IRF2-3 and Lnc-ZNF667-AS1 were recently studied as a positive biomarker for many tumor cells. However, experimental studies found that they are associated with worse outcomes in B-CLL. METHODS:A prospective case study was conducted on 135 B-CLL patients that were compared to thirty healthy controls. The...

    journal_title:International journal of laboratory hematology

    pub_type: 杂志文章


    authors: El-Khazragy N,Esmaiel MA,Mohamed MM,Hassan NS

    更新日期:2020-06-01 00:00:00

  • DOAC plasma levels measured by chromogenic anti-Xa assays and HPLC-UV in apixaban- and rivaroxaban-treated patients from the START-Register.

    abstract:INTRODUCTION:To measure direct factor Xa inhibitor (apixaban, edoxaban, rivaroxaban) concentrations, dedicated chromogenic anti-Xa assays are recommended as suitable methods to provide rapid drug quantification. Moreover, the high-performance liquid chromatography with ultraviolet detection (HPLC-UV) is reported as a r...

    journal_title:International journal of laboratory hematology

    pub_type: 杂志文章


    authors: Cini M,Legnani C,Padrini R,Cosmi B,Dellanoce C,De Rosa G,Marcucci R,Pengo V,Poli D,Testa S,Palareti G

    更新日期:2020-04-01 00:00:00

  • Evaluation of a new venom-based clotting assay of protein C.

    abstract::Congenital protein C deficiency significantly increases the risk of venous thromboembolism, a serious and potentially lethal condition. Protein C levels can be determined by chromogenic, clotting and antigenic assays, each type of assay has differences in specificity and sensitivity to protein C deficiency. In princip...

    journal_title:International journal of laboratory hematology

    pub_type: 杂志文章


    authors: Cooper PC,Cooper SM,Goodfellow KJ,Hickey KP,Kitchen S,Makris M

    更新日期:2008-10-01 00:00:00

  • Abnormal scattergrams and cell population data generated by fully automated hematological analyzers: New tools for screening malaria infection?

    abstract:INTRODUCTION:Malaria is a life-threatening infectious disease, which has been for long confined to specific endemic areas. Nevertheless, the recent increase in immigration flows from endemic regions and imported cases has reemphasized many diagnostic challenges in Western countries, thus paving the way to introduce rap...

    journal_title:International journal of laboratory hematology

    pub_type: 杂志文章


    authors: Buoro S,Manenti B,Seghezzi M,Moioli V,Bagorria M,Callegaro A,Ottomano C,Lippi G

    更新日期:2018-06-01 00:00:00

  • Flow cytometry data analysis: Recent tools and algorithms.

    abstract::Flow cytometry (FCM) allows scientists to rapidly quantify up to 50 parameters for millions of cells per sample. The bottleneck in the application of the technology is data analysis, and the high number of parameters measured by the current generation of instruments requires the use of advanced computational algorithm...

    journal_title:International journal of laboratory hematology

    pub_type: 杂志文章,评审


    authors: Montante S,Brinkman RR

    更新日期:2019-05-01 00:00:00

  • CD34, RAB20, PU.1 and GFI1 mRNA expression in myelodysplastic syndrome.

    abstract::Myelodysplastic syndrome (MDS) with hypocellular bone marrow (BM) is often difficult to distinguish from aplastic anemia (AA). Furthermore, the diagnosis of MDS with low blast counts and normal karyotype may be problematic. These issues highlight the need for a reliable marker for the diagnosis of MDS. This study was ...

    journal_title:International journal of laboratory hematology

    pub_type: 杂志文章


    authors: Huh HJ,Chae SL,Lee M,Hong KS,Mun YC,Seong CM,Chung WS,Huh JW

    更新日期:2009-06-01 00:00:00

  • How I investigate Eosinophilia.

    abstract::Eosinophilia is typically secondary, that is, reactive, in nature and is associated with a wide variety of neoplastic and non-neoplastic disorders. Clonal eosinophilia is also seen in a wide variety of hematopoietic neoplasms, and sub-classification can be diagnostically challenging. A proper evaluation of persistent ...

    journal_title:International journal of laboratory hematology

    pub_type: 杂志文章,评审


    authors: Larsen RL,Savage NM

    更新日期:2019-04-01 00:00:00

  • The hematology laboratory's response to the COVID-19 pandemic: A scoping review.

    abstract::The ongoing COVID-19 pandemic has had a profound worldwide impact on the laboratory hematology community. Nevertheless, the pace of COVID-19 hematology-related research has continued to accelerate and has established the role of laboratory hematology data for many purposes including disease prognosis and outcome. The ...

    journal_title:International journal of laboratory hematology

    pub_type: 杂志文章,评审


    authors: Bell R,Zini G,d'Onofrio G,Rogers HJ,Lee YS,Frater JL

    更新日期:2020-11-12 00:00:00

  • Accuracy of serum transferrin receptor levels in the diagnosis of iron deficiency among hospital patients in a population with a high prevalence of thalassaemia trait.

    abstract::The diagnosis of iron deficiency in hospital patients can be difficult in the presence of inflammation. A raised serum transferrin receptor (sTfR) level is useful as a marker of iron deficiency as it is unaffected by inflammation. However, diseases that cause an increase in erythropoietic activity can also result in a...

    journal_title:International journal of laboratory hematology

    pub_type: 杂志文章


    authors: Ong KH,Tan HL,Tam LP,Hawkins RC,Kuperan P

    更新日期:2008-12-01 00:00:00

  • The mutual control of iron and erythropoiesis.

    abstract:BACKGROUND:Iron is essential for hemoglobin synthesis during terminal erythropoiesis. To supply adequate iron the carrier transferrin is required together with transferrin receptor endosomal cycle and normal mitochondrial iron utilization. Iron and iron protein deficiencies result in different types of anemia. Iron-def...

    journal_title:International journal of laboratory hematology

    pub_type: 杂志文章,评审


    authors: Camaschella C,Pagani A,Nai A,Silvestri L

    更新日期:2016-05-01 00:00:00

  • The diagnostic and clinical impact of genetics and epigenetics in acute myeloid leukemia.

    abstract::Acute myeloid leukemia (AML) is a complex disease, for which our understanding of the role of genetic and epigenetic changes has undergone significant advancements. Newer diagnostic and prognostic classifications have increasingly incorporated such information, and novel therapies have been developed to target specifi...

    journal_title:International journal of laboratory hematology

    pub_type: 杂志文章,评审


    authors: Ohgami RS,Arber DA

    更新日期:2015-05-01 00:00:00

  • Expression analysis of BECN1 in acute myeloid leukemia: association with distinct cytogenetic and molecular abnormalities.

    abstract:INTRODUCTION:In acute myeloid leukemia (AML), it has been shown that AML-derived cells often remain sensitive to autophagy-inducing stimuli, leading to the idea that harnessing the autophagy can be pertinent to AML cytotoxic therapy. Despite this promising notion, to date, there is no comprehensive study addressing aut...

    journal_title:International journal of laboratory hematology

    pub_type: 杂志文章


    authors: Zare-Abdollahi D,Safari S,Movafagh A,Ghadiani M,Tabarraee M,Riazi-Isfahani S,Gorji S,Keyvan L,Gachkar L

    更新日期:2016-04-01 00:00:00

  • Real-world assay variability between laboratories in monitoring of recombinant factor IX Fc fusion protein activity in plasma samples.

    abstract:INTRODUCTION:Monitoring of factor IX (FIX) replacement therapy in haemophilia B relies on accurate coagulation assays. However, considerable interlaboratory variability has been reported for one-stage clotting (OSC) assays. This study aimed to evaluate the real-world, interlaboratory variability of routine FIX activity...

    journal_title:International journal of laboratory hematology

    pub_type: 杂志文章,多中心研究


    authors: Sommer JM,Sadeghi-Khomami A,Barnowski C,Wikén M,Willemze AJ

    更新日期:2020-06-01 00:00:00

  • A level-headed approach to measuring direct oral anticoagulants: A 2-year retrospective analysis of DOAC levels from a tertiary UK centre.

    abstract:INTRODUCTION:Direct oral anticoagulants (DOAC) are commonly prescribed and measuring drug levels may be useful in a number of contexts. However, data on DOAC level measurement and their clinical utility in real-world studies are limited. METHODS:We carried out a 2-year retrospective cohort study of DOAC levels measure...

    journal_title:International journal of laboratory hematology

    pub_type: 杂志文章


    authors: Denny NDR,Keighley L,Siganporia Z,Thachil J,Nash MJ

    更新日期:2019-04-01 00:00:00

  • Guidance for storing blood samples in laboratories performing complete blood count with differential.

    abstract:INTRODUCTION:The complete blood count (CBC) with differential leukocyte count (DIFF) is an important part of clinical laboratory analyses and provides crucial data for clinicians. Delivery time after blood collection and conditions of storage is known to affect the reliability of results of some hematologic parameters....

    journal_title:International journal of laboratory hematology

    pub_type: 杂志文章


    authors: Cornet E,Behier C,Troussard X

    更新日期:2012-12-01 00:00:00

  • Optimal wavelength for the clot waveform analysis: Determination of the best resolution with minimal interference of the reagents.

    abstract:INTRODUCTION:Clot waveform analysis (CWA), a new methodology to assess coagulation process, can be usefully applied in various clinical settings. However, its clinical use is limited mainly because of the absence of standardization. No consensus exists regarding the wavelengths at which CWA has to be performed what is ...

    journal_title:International journal of laboratory hematology

    pub_type: 杂志文章


    authors: Evrard J,Siriez R,Morimont L,Thémans P,Laloy J,Bouvy C,Gheldof D,Mullier F,Dogné JM,Douxfils J

    更新日期:2019-06-01 00:00:00

  • Three novel alternative splicing mutations in BCR-ABL1 detected in CML patients with resistance to kinase inhibitors.

    abstract:INTRODUCTION:Multiple types of mutations in the BCR-ABL1 kinase domain have been reported. We previously reported a common alternatively spliced BCR-ABL mRNA with a 35-nucleotide insertion (35INS). We report three novel alternative splicing mutants expressed as the dominant transcripts in patient with chronic myelogeno...

    journal_title:International journal of laboratory hematology

    pub_type: 杂志文章


    authors: Ma W,Giles F,Zhang X,Wang X,Zhang Z,Lee TS,Yeh CH,Albitar M

    更新日期:2011-06-01 00:00:00

  • Methylation of DAPK1 promoter: frequent but not an adverse prognostic factor in myelodysplastic syndrome.

    abstract::Promoter hypermethylation plays an important role in the inactivation of cancer-related genes. This abnormality occurs early in leukemogenesis and seems to be associated with poor prognosis in myelodsplastic syndrome (MDS). The identification of more inactivated tumor suppressor genes contributing to the development o...

    journal_title:International journal of laboratory hematology

    pub_type: 杂志文章


    authors: Qian J,Yao DM,Lin J,Wang YL,Han LX,Xu WR,Wu CY

    更新日期:2010-02-01 00:00:00

  • Clinical and hematological characteristics of 88 patients with COVID-19.

    abstract:INTRODUCTION:To retrospectively analyze epidemiological, clinical and hematological characteristics of COVID-19 patients. METHODS:The demographic, symptoms, and physiological parameters of 88 patients were collected and analyzed. The performance of complete blood count (CBC) indexes for monitoring and predicting the s...

    journal_title:International journal of laboratory hematology

    pub_type: 杂志文章


    authors: Zhang H,Cao X,Kong M,Mao X,Huang L,He P,Pan S,Li J,Lu Z

    更新日期:2020-12-01 00:00:00

  • Case report of HbC/beta(0)-thalassemia from India.

    abstract::This 22-year-old women presented to the ante-natal clinic of this hospital for prenatal screening for beta-thalassemia. Cation exchange high performance liquid chromatography (HPLC) using 'Beta Thalassemia Short Program' on Bio-Rad 'Variant' system revealed HbC value of 81.6%. The CBC showed microcytic hypochromic ane...

    journal_title:International journal of laboratory hematology

    pub_type: 杂志文章


    authors: Kumar S,Rana M,Handoo A,Saxena R,Verma IC,Bhargava M,Sood SK

    更新日期:2007-10-01 00:00:00