Sodium-Glucose Cotransporter-2 Inhibitor for Renal Function Preservation in Patients with Type 2 Diabetes Mellitus: A Korean Diabetes Association and Korean Society of Nephrology Consensus Statement.

abstract：:Although glucose-lowering treatment shows some risk lowering effects in cardiovascular diseases, risks of macrovascular and microvascular complications have still remained, and development of new therapeutic strategies is needed. Recent data have shown that peroxisome proliferator activated receptor-α (PPAR-α) plays a...

journal_title：Diabetes & metabolism journal

authors： Seok H,Cha BS

更新日期：2013-10-01 00:00:00

abstract：:In cases of chronic hyperglycemia, advanced glycation end-products (AGEs) are actively produced and accumulated in the circulating blood and various tissues. AGEs also accelerate the expression of receptors for AGEs, and they play an important role in the development of diabetic vascular complications through various ...

journal_title：Diabetes & metabolism journal

authors： Rhee SY,Kim YS

更新日期：2018-06-01 00:00:00

abstract：:Nonalcoholic fatty liver disease (NAFLD) and diabetes are common metabolic disorders whose prevalence rates are expected to rise worldwide, corresponding to aging and increasingly obese populations. Compared to the general population (around 25%), 50% to 70% of people with diabetes have NAFLD, and NAFLD severity (incl...

journal_title：Diabetes & metabolism journal

authors： Lee YH,Cho Y,Lee BW,Park CY,Lee DH,Cha BS,Rhee EJ

更新日期：2019-02-01 00:00:00

abstract：:There are many studies on the prevalence, clinical characteristics, and economic burden of diabetes across the past four decades in Korea. Nonetheless, there is a dearth of nationwide study regarding diabetes encompassing all age group. Eight years ago, the Committee on the Epidemiology of Diabetes Mellitus of Korean ...

journal_title：Diabetes & metabolism journal

authors： Task Force Team for Basic Statistical Study of Korean Diabetes Mellitus of Korean Diabetes Association.,Park IeB,Kim J,Kim DJ,Chung CH,Oh JY,Park SW,Lee J,Choi KM,Min KW,Park JH,Son HS,Ahn CW,Kim H,Lee S,Lee IB,Choi I,B

更新日期：2013-08-01 00:00:00

abstract：BACKGROUND:Despite the confluence of multiple cardiovascular risk factors, subclinical atherosclerotic damage and cardiovascular events remain extremely rare in adults with Down syndrome (DS). We aim to determine the prevalence of obesity and metabolic disorders in an adult cohort with DS and to compare our findings wi...

journal_title：Diabetes & metabolism journal

authors： Real de Asua D,Parra P,Costa R,Moldenhauer F,Suarez C

更新日期：2014-12-01 00:00:00

abstract：:My professional journey to understand the glucose homeostasis began in the 1990s, starting from cloning of the promoter region of glucose transporter type 2 (GLUT2) gene that led us to establish research foundation of my group. When I was a graduate student, I simply thought that hyperglycemia, a typical clinical mani...

journal_title：Diabetes & metabolism journal

authors： Ahn YH

更新日期：2018-12-01 00:00:00

abstract：BACKGROUND:To investigate the clinical results of sitagliptin (SITA) and the characteristics of the treatment failure group or of low responders to SITA. METHODS:A retrospective study of type 2 diabetic patients reviewed 99 cases, including 12 treatment failure cases, who stopped SITA because of worsening patients' co...

journal_title：Diabetes & metabolism journal

authors： Kim WJ,Park CY,Jeong EH,Seo JY,Seol JS,Park SE,Rhee EJ,Lee WY,Oh KW,Park SW,Kim SW

更新日期：2011-06-01 00:00:00

abstract：BACKGROUND:Recently, the measurement of glycated hemoglobin (HbA1c) was recommended as an alternative to fasting plasma glucose or oral glucose tolerance tests for diagnosing diabetes mellitus (DM). In this study, we analyzed HbA1c levels for diabetes mellitus screening in a Korean rural population. METHODS:We analyze...

journal_title：Diabetes & metabolism journal

authors： Kim JH,Kim GW,Lee MY,Shin JY,Shin YG,Koh SB,Chung CH

更新日期：2012-02-01 00:00:00

abstract：BACKGROUND:The aim of this study is to investigate the cardio-metabolic parameters and surrogate markers of insulin resistance in a discordant group of type 2 diabetes (T2DM) subjects who satisfy the Adults Treatment Panel (ATP) III criteria, but not the International Diabetes Federation (IDF) criteria, for metabolic s...

journal_title：Diabetes & metabolism journal

authors： Lee SR,Han Y,Kim JW,Park JY,Kim JM,Suh S,Park MK,Lee HJ,Kim DK

更新日期：2012-10-01 00:00:00

abstract：BACKGROUND:Chronic exposure to elevated levels of free fatty acids contributes to pancreatic β-cell dysfunction. Although it is well known that metformin induces cellular energy depletion and a concomitant activation of AMP-activated protein kinase (AMPK) through inhibition of the respiratory chain, previous studies ha...

journal_title：Diabetes & metabolism journal

authors： Kim HI,Lee JS,Kwak BK,Hwang WM,Kim MJ,Kim YB,Chung SS,Park KS

更新日期：2019-12-01 00:00:00

abstract：:This corrects the article on p. 3 in vol. 42, PMID: 29504302. ...

journal_title：Diabetes & metabolism journal

authors： Iqbal A,Novodvorsky P,Heller SR

更新日期：2018-04-01 00:00:00

abstract：BACKGROUND:We investigated whether patients' perceived glycemic control and self-reported diabetes self-care correlated with their actual glycemic control. METHODS:A survey was administered among patients with diabetes mellitus at an outpatient clinic with structured self-report questionnaires regarding perceived glyc...

journal_title：Diabetes & metabolism journal

authors： Ohn JH,Lee JH,Hong ES,Koo BK,Kim SW,Yi KH,Moon MK

更新日期：2015-02-01 00:00:00

abstract：:As the number of individuals with non-alcoholic fatty liver disease (NAFLD) has increased, the influence of NAFLD on other metabolic diseases has been highlighted. Accumulating epidemiologic evidence indicates that NAFLD not only affects the liver but also increases the risk of extra-hepatic diseases such as type 2 di...

journal_title：Diabetes & metabolism journal

authors： Han E,Lee YH

更新日期：2017-12-01 00:00:00

abstract：BACKGROUND:Voglibose, an α-glucosidase inhibitor, inhibits breakdown of complex carbohydrates into simple sugar units in intestine. Studies showed that voglibose metabolism in the liver might be negligible due to its poor intestinal absorption. Numerous microorganisms live in intestine and have several roles in metabol...

journal_title：Diabetes & metabolism journal

authors： Nepal MR,Kang MJ,Kim GH,Cha DH,Kim JH,Jeong TC

更新日期：2020-12-01 00:00:00

abstract：BACKGROUND:Some patients with type 2 diabetes mellitus (T2DM) do not develop diabetic kidney disease (DKD) despite the presence of advanced diabetic retinopathy (DR). We aimed to investigate the presence of DKD and its risk factors in patients with T2DM and advanced DR. METHODS:We conducted a cross-sectional study in ...

journal_title：Diabetes & metabolism journal

authors： Yun KJ,Kim HJ,Kim MK,Kwon HS,Baek KH,Roh YJ,Song KH

更新日期：2016-12-01 00:00:00

abstract：:Latent autoimmune diabetes in adults (LADA) is a heterogeneous disease characterized by a less intensive autoimmune process and a broad clinical phenotype compared to classical type 1 diabetes mellitus (T1DM), sharing features with both type 2 diabetes mellitus (T2DM) and T1DM. Since patients affected by LADA are init...

journal_title：Diabetes & metabolism journal

authors： Pieralice S,Pozzilli P

更新日期：2018-12-01 00:00:00

abstract：:Non-alcoholic fatty liver disease (NAFLD) is one of the most common causes of chronic liver disease in adults and children worldwide. NAFLD has become a severe health issue and it can progress towards a more severe form of the disease, the non-alcoholic steatohepatitis (NASH). A combination of environmental factors, h...

journal_title：Diabetes & metabolism journal

authors： Povero D,Feldstein AE

更新日期：2016-02-01 00:00:00

abstract：BACKGROUND:Type 2 diabetes mellitus (T2DM) is associated with an increased risk for dementia. The effects of hypoglycemia on dementia are controversial. Thus, we evaluated whether hypoglycemia increases the risk for dementia in senior patients with T2DM. METHODS:We used the Korean National Health Insurance Service Sen...

journal_title：Diabetes & metabolism journal

authors： Kim YG,Park DG,Moon SY,Jeon JY,Kim HJ,Kim DJ,Lee KW,Han SJ

更新日期：2020-02-01 00:00:00

abstract：BACKGROUND:Women with one abnormal value (OAV) in a 100 g oral glucose tolerance test (OGTT) during pregnancy are reported to have an increased risk of adverse pregnancy outcomes. However, there is limited data about whether women with OAV will progress to gestational diabetes mellitus (GDM) when the OGTT is repeated. ...

journal_title：Diabetes & metabolism journal

authors： Kang S,Kim MH,Kim MY,Hong JS,Kwak SH,Choi SH,Lim S,Park KS,Jang HC

更新日期：2019-10-01 00:00:00

abstract：BACKGROUND:This is a subgroup analysis of Korean patients from a phase 3 clinical trial investigating the efficacy and safety of ipragliflozin in patients with type 2 diabetes mellitus inadequately controlled with metformin. METHODS:This multicenter, placebo-controlled, double-blind, parallel-group study was carried o...

journal_title：Diabetes & metabolism journal

authors： Min KW,Ku BJ,Lee JH,Kim MS,Ahn KJ,Lee MK,Kokubo S,Yoshida S,Cho HJ,Cha BS

更新日期：2017-04-01 00:00:00

abstract：BACKGROUND:We evaluated decreases in glycosylated hemoglobin (HbA1c) achieved by reducing carbohydrate from various sources in type 2 diabetes mellitus patients. METHODS:We followed up 138 male and 107 female outpatients on a moderate low-carbohydrate diet without diabetic medication for 6 months. Changes in carbohydr...

journal_title：Diabetes & metabolism journal

authors： Haimoto H,Watanabe S,Maeda K,Murase T,Wakai K

更新日期：2020-07-21 00:00:00

abstract：:Serotonin (5-hydroxytryptamine [5-HT]) is a monoamine that has various functions in both neuronal and non-neuronal systems. In the central nervous system, 5-HT regulates mood and feeding behaviors as a neurotransmitter. Thus, there have been many trials aimed at increasing the activity of 5-HT in the central nervous s...

journal_title：Diabetes & metabolism journal

authors： Oh CM,Park S,Kim H

更新日期：2016-04-01 00:00:00

abstract：BACKGROUND:Diabetes mellitus is a chronic disease and one of the main causes of mortality in developing countries. The main objective of treating all chronic diseases, of course, is to improve well-being and attain a satisfactory quality of life (QOL). The major goal of this study is comparison of attitude toward QOL i...

journal_title：Diabetes & metabolism journal

authors： Hashemi Hefz Abad F,Shabany Hamedan M

更新日期：2011-08-01 00:00:00

abstract：:Fibroblast growth factor 21 (FGF21) is an endocrine hormone that is primarily expressed in the liver and exerts beneficial effects on obesity and related metabolic diseases. In addition to its remarkable pharmacologic actions, the physiological roles of FGF21 include the maintenance of energy homeostasis in the body i...

journal_title：Diabetes & metabolism journal

authors： Kim KH,Lee MS

更新日期：2014-08-01 00:00:00

abstract：:Obesity and diabetes has become a major epidemic across the globe. Controlling obesity has been a challenge since this would require either increased physical activity or reduced caloric intake; both are difficult to enforce. There has been renewed interest in exploiting pathways such as uncoupling protein 1 (UCP1)-me...

journal_title：Diabetes & metabolism journal

authors： Periasamy M,Herrera JL,Reis FCG

更新日期：2017-10-01 00:00:00

abstract：BACKGROUND:Some patients admitted to hospitals for glycemic control experience hypoglycemia despite regular meals and despite adhering to standard blood glucose control protocols. Different factors can have a negative impact on blood glucose control and prognosis after discharge. This study investigated risk factors fo...

journal_title：Diabetes & metabolism journal

authors： Lee J,Kim TM,Kim H,Lee SH,Cho JH,Lee H,Yim HW,Yoon KH,Kim HS

更新日期：2020-08-01 00:00:00

abstract：BACKGROUND:We investigated the therapeutic effects of resistance training on Zucker rats before and after the onset of diabetes to understand the importance of the timing of exercise intervention. We assessed whether 8 weeks of resistance training ameliorated impaired glucose tolerance and altered muscle fiber type com...

journal_title：Diabetes & metabolism journal

authors： Kim JY,Choi MJ,So B,Kim HJ,Seong JK,Song W

更新日期：2015-10-01 00:00:00

abstract：:Diabetic cardiomyopathy (DCM), as one of the major cardiac complications in diabetic patients, is known to related with oxidative stress that is due to a severe imbalance between reactive oxygen species (ROS) and/or reactive nitrogen species (RNS) generation and their clearance by antioxidant defense systems. Transcri...

journal_title：Diabetes & metabolism journal

authors： Chen J,Zhang Z,Cai L

更新日期：2014-10-01 00:00:00

abstract：:The pyruvate dehydrogenase complex (PDC) is an emerging target for the treatment of metabolic syndrome. To maintain a steady-state concentration of adenosine triphosphate during the feed-fast cycle, cells require efficient utilization of fatty acid and glucose, which is controlled by the PDC. The PDC converts pyruvate...

journal_title：Diabetes & metabolism journal

authors： Lee IK

更新日期：2014-06-01 00:00:00

abstract：BACKGROUND:The aim of this study was an in vitro investigation of the effect of high glucose concentration on adipogenesis, as prolonged hyperglycemia alters adipocyte differentiation. METHODS:3T3-L1 preadipocytes differentiated in the presence of varying concentrations of glucose (25, 45, 65, 85, and 105 mM) were ass...

journal_title：Diabetes & metabolism journal

authors： Shilpa K,Dinesh T,Lakshmi BS

更新日期：2013-06-01 00:00:00