Abstract:
:Fibroblast growth factor 21 (FGF21) is an endocrine hormone that is primarily expressed in the liver and exerts beneficial effects on obesity and related metabolic diseases. In addition to its remarkable pharmacologic actions, the physiological roles of FGF21 include the maintenance of energy homeostasis in the body in conditions of metabolic or environmental stress. The expression of FGF21 is induced in multiple organs in response to diverse physiological or pathological stressors, such as starvation, nutrient excess, autophagy deficiency, mitochondrial stress, exercise, and cold exposure. Thus, the FGF21 induction caused by stress plays an important role in adaptive response to these stimuli. Here, we highlight our current understanding of the functional importance of the induction of FGF21 by diverse stressors as a feedback mechanism that prevents excessive stress.
journal_name
Diabetes Metab Jjournal_title
Diabetes & metabolism journalauthors
Kim KH,Lee MSdoi
10.4093/dmj.2014.38.4.245subject
Has Abstractpub_date
2014-08-01 00:00:00pages
245-51issue
4eissn
2233-6079issn
2233-6087journal_volume
38pub_type
杂志文章,评审abstract:BACKGROUND:Voglibose, an α-glucosidase inhibitor, inhibits breakdown of complex carbohydrates into simple sugar units in intestine. Studies showed that voglibose metabolism in the liver might be negligible due to its poor intestinal absorption. Numerous microorganisms live in intestine and have several roles in metabol...
journal_title:Diabetes & metabolism journal
pub_type: 杂志文章
doi:10.4093/dmj.2019.0147
更新日期:2020-12-01 00:00:00
abstract::Mitochondrial dysfunction is a hallmark of metabolic diseases such as obesity, type 2 diabetes mellitus, neurodegenerative diseases, and cancers. Dysfunction occurs in part because of altered regulation of the mitochondrial pyruvate dehydrogenase complex (PDC), which acts as a central metabolic node that mediates pyru...
journal_title:Diabetes & metabolism journal
pub_type: 杂志文章,评审
doi:10.4093/dmj.2018.0101
更新日期:2018-08-01 00:00:00
abstract::This report presents the status of diabetic neuropathy (DN) in Korea as determined using a National Health Insurance ServiceNational Sample Cohort (NHIS-NSC). Annual prevalences of DN were estimated by age and gender using descriptive statistics. Pharmacological treatments for DN were also analyzed. The annual prevale...
journal_title:Diabetes & metabolism journal
pub_type: 杂志文章
doi:10.4093/dmj.2020.0120
更新日期:2021-01-01 00:00:00
abstract:BACKGROUND:We investigated whether patients' perceived glycemic control and self-reported diabetes self-care correlated with their actual glycemic control. METHODS:A survey was administered among patients with diabetes mellitus at an outpatient clinic with structured self-report questionnaires regarding perceived glyc...
journal_title:Diabetes & metabolism journal
pub_type: 杂志文章
doi:10.4093/dmj.2015.39.1.31
更新日期:2015-02-01 00:00:00
abstract:BACKGROUND:A latent cytomegalovirus (CMV) cause chronic inflammation through undesirable inflation of cell-mediated immune response. CMV immunoglobulin G has been associated with cardiovascular disease and type 1 diabetes mellitus. We evaluated impact of CMV diseases on new-onset type 2 diabetes mellitus (T2DM). METHO...
journal_title:Diabetes & metabolism journal
pub_type: 杂志文章
doi:10.4093/dmj.2018.0167
更新日期:2019-12-01 00:00:00
abstract::Adipose tissue, which was once viewed as a simple organ for storage of triglycerides, is now considered an important endocrine organ. Abnormal adipose tissue mass is associated with defects in endocrine and metabolic functions which are the underlying causes of the metabolic syndrome. Many adipokines, hormones secrete...
journal_title:Diabetes & metabolism journal
pub_type: 杂志文章
doi:10.4093/dmj.2013.37.6.395
更新日期:2013-12-01 00:00:00
abstract:BACKGROUND:Diabetes self-management education and reinforcement are important for effective management of the disease. We investigated the effectiveness of interactive small-group education on glycemic, blood pressure, and lipid levels. METHODS:For this study, 207 type 2 diabetes patients with suboptimal glycemic cont...
journal_title:Diabetes & metabolism journal
pub_type: 杂志文章
doi:10.4093/dmj.2011.35.6.580
更新日期:2011-12-01 00:00:00
abstract::Serotonin (5-hydroxytryptamine [5-HT]) is a monoamine that has various functions in both neuronal and non-neuronal systems. In the central nervous system, 5-HT regulates mood and feeding behaviors as a neurotransmitter. Thus, there have been many trials aimed at increasing the activity of 5-HT in the central nervous s...
journal_title:Diabetes & metabolism journal
pub_type: 杂志文章,评审
doi:10.4093/dmj.2016.40.2.89
更新日期:2016-04-01 00:00:00
abstract::The pyruvate dehydrogenase complex (PDC) is an emerging target for the treatment of metabolic syndrome. To maintain a steady-state concentration of adenosine triphosphate during the feed-fast cycle, cells require efficient utilization of fatty acid and glucose, which is controlled by the PDC. The PDC converts pyruvate...
journal_title:Diabetes & metabolism journal
pub_type: 杂志文章,评审
doi:10.4093/dmj.2014.38.3.181
更新日期:2014-06-01 00:00:00
abstract:BACKGROUND:To explore the efficacy and safety of switching from once-daily basal insulin therapy to once-daily pre-meal injection insulin degludec/insulin aspart (IDegAsp) with respect to the glycemic control of participants with type 2 diabetes mellitus (T2DM). METHODS:In this multicenter, open-label, prospective, ra...
journal_title:Diabetes & metabolism journal
pub_type: 杂志文章
doi:10.4093/dmj.2019.0093
更新日期:2020-08-01 00:00:00
abstract::Diabetes is a leading cause of end-stage renal disease. Therefore, prevention of renal dysfunction is an important treatment goal in the management of diabetes. The data of landmark cardiovascular outcome trials of sodium-glucose cotransporter-2 (SGLT2) inhibitor showed profound reno-protective effects. The Korean Dia...
journal_title:Diabetes & metabolism journal
pub_type: 杂志文章,评审
doi:10.4093/dmj.2020.0172
更新日期:2020-08-01 00:00:00
abstract::Latent autoimmune diabetes in adults (LADA) is a heterogeneous disease characterized by a less intensive autoimmune process and a broad clinical phenotype compared to classical type 1 diabetes mellitus (T1DM), sharing features with both type 2 diabetes mellitus (T2DM) and T1DM. Since patients affected by LADA are init...
journal_title:Diabetes & metabolism journal
pub_type: 杂志文章,评审
doi:10.4093/dmj.2018.0190
更新日期:2018-12-01 00:00:00
abstract:BACKGROUND:This study aimed to design a simple surrogate marker (i.e., predictor) of the minimal model glucose effectiveness (SG), namely calculated SG (CSG), from a short insulin-modified intravenous glucose tolerance test (IM-IVGTT), and then to apply it to study women with previous gestational diabetes mellitus (pGD...
journal_title:Diabetes & metabolism journal
pub_type: 杂志文章
doi:10.4093/dmj.2019.0016
更新日期:2020-04-01 00:00:00
abstract:BACKGROUND:Although many anti-diabetic drugs have been used to control hyperglycemia for decades, the efficacy of commonly-used oral glucose-lowering agents in Korean type 2 diabetic patients has yet to be clearly demonstrated. METHODS:We evaluated the efficacy of glimepiride, metformin, and rosiglitazone as initial t...
journal_title:Diabetes & metabolism journal
pub_type: 杂志文章
doi:10.4093/dmj.2011.35.1.26
更新日期:2011-02-01 00:00:00
abstract:BACKGROUND:Recently, the measurement of glycated hemoglobin (HbA1c) was recommended as an alternative to fasting plasma glucose or oral glucose tolerance tests for diagnosing diabetes mellitus (DM). In this study, we analyzed HbA1c levels for diabetes mellitus screening in a Korean rural population. METHODS:We analyze...
journal_title:Diabetes & metabolism journal
pub_type: 杂志文章
doi:10.4093/dmj.2012.36.1.37
更新日期:2012-02-01 00:00:00
abstract:BACKGROUND:In order to overcome the limitations of body mass index (BMI) and waist circumference (WC), the z-score of the log-transformed A Body Shape Index (LBSIZ) has recently been introduced. In this study, we analyzed the relationship between the LBSIZ and cardiovascular disease (CVD) in a Korean representative sam...
journal_title:Diabetes & metabolism journal
pub_type: 杂志文章
doi:10.4093/dmj.2018.0169
更新日期:2019-10-01 00:00:00
abstract:BACKGROUND:This study investigated the rate of relapse of dyslipidemia and the factors which could predict relapse following a short-term statin discontinuation after achieving a target low density lipoprotein cholesterol (LDL-C) level in type 2 diabetic patients without cardiovascular disease (CVD). METHODS:Ninety-ni...
journal_title:Diabetes & metabolism journal
pub_type: 杂志文章
doi:10.4093/dmj.2014.38.1.64
更新日期:2014-02-01 00:00:00
abstract:BACKGROUND:Food exchange lists are one of the main methods of nutritional education. However, Korean food exchange lists have not been revised since 1994. Therefore, we surveyed the opinions of diabetes educators and patients with diabetes regarding the need for revision of the current food exchange lists. METHODS:For...
journal_title:Diabetes & metabolism journal
pub_type: 杂志文章
doi:10.4093/dmj.2011.35.2.173
更新日期:2011-04-01 00:00:00
abstract:BACKGROUND:The second derivative of the finger photoplethysmogram (SDPTG) is an indicator of arterial stiffness. The present study was conducted to clarify the factor structure of indices of the SDPTG in combination with components of the metabolic syndrome (MetS), to elucidate the significance of the SDPTG among vario...
journal_title:Diabetes & metabolism journal
pub_type: 杂志文章
doi:10.4093/dmj.2013.37.1.40
更新日期:2013-02-01 00:00:00
abstract:BACKGROUND:Thyroid disease and metabolic syndrome are both associated with cardiovascular disease. The aim of this study was to investigate the correlation between thyroid hormones and obesity sub-phenotypes using nationwide data from Korea, a country known to be iodine replete. METHODS:This study was based on data ob...
journal_title:Diabetes & metabolism journal
pub_type: 杂志文章
doi:10.4093/dmj.2018.0130
更新日期:2019-12-01 00:00:00
abstract:BACKGROUND:Chronic exposure to elevated levels of free fatty acids contributes to pancreatic β-cell dysfunction. Although it is well known that metformin induces cellular energy depletion and a concomitant activation of AMP-activated protein kinase (AMPK) through inhibition of the respiratory chain, previous studies ha...
journal_title:Diabetes & metabolism journal
pub_type: 杂志文章
doi:10.4093/dmj.2018.0179
更新日期:2019-12-01 00:00:00
abstract::Although glucose-lowering treatment shows some risk lowering effects in cardiovascular diseases, risks of macrovascular and microvascular complications have still remained, and development of new therapeutic strategies is needed. Recent data have shown that peroxisome proliferator activated receptor-α (PPAR-α) plays a...
journal_title:Diabetes & metabolism journal
pub_type: 杂志文章,评审
doi:10.4093/dmj.2013.37.5.326
更新日期:2013-10-01 00:00:00
abstract:BACKGROUND:Rebaudioside A and erythritol are nonnutritive sweeteners. There have been several studies of their glycemic effects, but the outcomes remain controversial. The purpose of this study was to evaluate the glycemic effects of rebaudioside A and erythritol as a sweetener in people with glucose intolerance. METH...
journal_title:Diabetes & metabolism journal
pub_type: 杂志文章
doi:10.4093/dmj.2016.40.4.283
更新日期:2016-08-01 00:00:00
abstract::Over the past decade, growing evidence has established the gut microbiota as one of the most important determinants of metabolic disorders such as obesity and type 2 diabetes. Indeed, obesogenic diet can drastically alter bacterial populations (i.e., dysbiosis) leading to activation of pro-inflammatory mechanisms and ...
journal_title:Diabetes & metabolism journal
pub_type: 杂志文章,评审
doi:10.4093/dmj.2015.39.4.291
更新日期:2015-08-01 00:00:00
abstract::This corrects the article on p. 218 in vol. 39, PMID: 26124992. ...
journal_title:Diabetes & metabolism journal
pub_type: 已发布勘误
doi:10.4093/dmj.2016.40.1.87
更新日期:2016-02-01 00:00:00
abstract:BACKGROUND:Women with one abnormal value (OAV) in a 100 g oral glucose tolerance test (OGTT) during pregnancy are reported to have an increased risk of adverse pregnancy outcomes. However, there is limited data about whether women with OAV will progress to gestational diabetes mellitus (GDM) when the OGTT is repeated. ...
journal_title:Diabetes & metabolism journal
pub_type: 杂志文章
doi:10.4093/dmj.2018.0159
更新日期:2019-10-01 00:00:00
abstract:BACKGROUND:Diabetes mellitus is a chronic disease and one of the main causes of mortality in developing countries. The main objective of treating all chronic diseases, of course, is to improve well-being and attain a satisfactory quality of life (QOL). The major goal of this study is comparison of attitude toward QOL i...
journal_title:Diabetes & metabolism journal
pub_type: 杂志文章
doi:10.4093/dmj.2011.35.4.397
更新日期:2011-08-01 00:00:00
abstract::[This corrects the article on p. 46 in vol. 37, PMID: 23439676.]. ...
journal_title:Diabetes & metabolism journal
pub_type: 已发布勘误
doi:10.4093/dmj.2015.39.3.272
更新日期:2015-06-01 00:00:00
abstract:BACKGROUND:Latent autoimmune diabetes in adults (LADA) refers to a specific type of diabetes characterized by adult onset, presence of islet auto-antibodies, insulin independence at the time of diagnosis, and rapid decline in β-cell function. The prevalence of LADA among patients with type 2 diabetes varies from 2% to ...
journal_title:Diabetes & metabolism journal
pub_type: 杂志文章
doi:10.4093/dmj.2012.36.2.136
更新日期:2012-04-01 00:00:00
abstract::This corrects the article on p. 3 in vol. 42, PMID: 29504302. ...
journal_title:Diabetes & metabolism journal
pub_type: 杂志文章,已发布勘误
doi:10.4093/dmj.2018.42.2.177
更新日期:2018-04-01 00:00:00