FGF21 as a Stress Hormone: The Roles of FGF21 in Stress Adaptation and the Treatment of Metabolic Diseases.

Abstract:

:Fibroblast growth factor 21 (FGF21) is an endocrine hormone that is primarily expressed in the liver and exerts beneficial effects on obesity and related metabolic diseases. In addition to its remarkable pharmacologic actions, the physiological roles of FGF21 include the maintenance of energy homeostasis in the body in conditions of metabolic or environmental stress. The expression of FGF21 is induced in multiple organs in response to diverse physiological or pathological stressors, such as starvation, nutrient excess, autophagy deficiency, mitochondrial stress, exercise, and cold exposure. Thus, the FGF21 induction caused by stress plays an important role in adaptive response to these stimuli. Here, we highlight our current understanding of the functional importance of the induction of FGF21 by diverse stressors as a feedback mechanism that prevents excessive stress.

journal_name

Diabetes Metab J

authors

Kim KH,Lee MS

doi

10.4093/dmj.2014.38.4.245

subject

Has Abstract

pub_date

2014-08-01 00:00:00

pages

245-51

issue

4

eissn

2233-6079

issn

2233-6087

journal_volume

38

pub_type

杂志文章,评审
  • Role of Intestinal Microbiota in Metabolism of Voglibose In Vitro and In Vivo.

    abstract:BACKGROUND:Voglibose, an α-glucosidase inhibitor, inhibits breakdown of complex carbohydrates into simple sugar units in intestine. Studies showed that voglibose metabolism in the liver might be negligible due to its poor intestinal absorption. Numerous microorganisms live in intestine and have several roles in metabol...

    journal_title:Diabetes & metabolism journal

    pub_type: 杂志文章

    doi:10.4093/dmj.2019.0147

    authors: Nepal MR,Kang MJ,Kim GH,Cha DH,Kim JH,Jeong TC

    更新日期:2020-12-01 00:00:00

  • Role of the Pyruvate Dehydrogenase Complex in Metabolic Remodeling: Differential Pyruvate Dehydrogenase Complex Functions in Metabolism.

    abstract::Mitochondrial dysfunction is a hallmark of metabolic diseases such as obesity, type 2 diabetes mellitus, neurodegenerative diseases, and cancers. Dysfunction occurs in part because of altered regulation of the mitochondrial pyruvate dehydrogenase complex (PDC), which acts as a central metabolic node that mediates pyru...

    journal_title:Diabetes & metabolism journal

    pub_type: 杂志文章,评审

    doi:10.4093/dmj.2018.0101

    authors: Park S,Jeon JH,Min BK,Ha CM,Thoudam T,Park BY,Lee IK

    更新日期:2018-08-01 00:00:00

  • Status of Diabetic Neuropathy in Korea: A National Health Insurance Service-National Sample Cohort Analysis (2006 to 2015).

    abstract::This report presents the status of diabetic neuropathy (DN) in Korea as determined using a National Health Insurance ServiceNational Sample Cohort (NHIS-NSC). Annual prevalences of DN were estimated by age and gender using descriptive statistics. Pharmacological treatments for DN were also analyzed. The annual prevale...

    journal_title:Diabetes & metabolism journal

    pub_type: 杂志文章

    doi:10.4093/dmj.2020.0120

    authors: Moon SS,Kim CH,Kang SM,Kim ES,Oh TJ,Yun JS,Cho HC,Kim DJ,Park TS

    更新日期:2021-01-01 00:00:00

  • Subjective Assessment of Diabetes Self-Care Correlates with Perceived Glycemic Control but not with Actual Glycemic Control.

    abstract:BACKGROUND:We investigated whether patients' perceived glycemic control and self-reported diabetes self-care correlated with their actual glycemic control. METHODS:A survey was administered among patients with diabetes mellitus at an outpatient clinic with structured self-report questionnaires regarding perceived glyc...

    journal_title:Diabetes & metabolism journal

    pub_type: 杂志文章

    doi:10.4093/dmj.2015.39.1.31

    authors: Ohn JH,Lee JH,Hong ES,Koo BK,Kim SW,Yi KH,Moon MK

    更新日期:2015-02-01 00:00:00

  • Impact of Cytomegalovirus Disease on New-Onset Type 2 Diabetes Mellitus: Population-Based Matched Case-Control Cohort Study.

    abstract:BACKGROUND:A latent cytomegalovirus (CMV) cause chronic inflammation through undesirable inflation of cell-mediated immune response. CMV immunoglobulin G has been associated with cardiovascular disease and type 1 diabetes mellitus. We evaluated impact of CMV diseases on new-onset type 2 diabetes mellitus (T2DM). METHO...

    journal_title:Diabetes & metabolism journal

    pub_type: 杂志文章

    doi:10.4093/dmj.2018.0167

    authors: Yoo SG,Han KD,Lee KH,La Y,Kwon DE,Han SH

    更新日期:2019-12-01 00:00:00

  • Targeting the Peroxisome Proliferator-Activated Receptor-γ to Counter the Inflammatory Milieu in Obesity.

    abstract::Adipose tissue, which was once viewed as a simple organ for storage of triglycerides, is now considered an important endocrine organ. Abnormal adipose tissue mass is associated with defects in endocrine and metabolic functions which are the underlying causes of the metabolic syndrome. Many adipokines, hormones secrete...

    journal_title:Diabetes & metabolism journal

    pub_type: 杂志文章

    doi:10.4093/dmj.2013.37.6.395

    authors: Corzo C,Griffin PR

    更新日期:2013-12-01 00:00:00

  • Effect on Glycemic, Blood Pressure, and Lipid Control according to Education Types.

    abstract:BACKGROUND:Diabetes self-management education and reinforcement are important for effective management of the disease. We investigated the effectiveness of interactive small-group education on glycemic, blood pressure, and lipid levels. METHODS:For this study, 207 type 2 diabetes patients with suboptimal glycemic cont...

    journal_title:Diabetes & metabolism journal

    pub_type: 杂志文章

    doi:10.4093/dmj.2011.35.6.580

    authors: Choi MJ,Yoo SH,Kim KR,Bae YM,Ahn SH,Kim SS,Min SA,Choi JS,Lee SE,Moon YJ,Rhee EJ,Park CY,Lee WY,Oh KW,Park SW,Kim SW

    更新日期:2011-12-01 00:00:00

  • Serotonin as a New Therapeutic Target for Diabetes Mellitus and Obesity.

    abstract::Serotonin (5-hydroxytryptamine [5-HT]) is a monoamine that has various functions in both neuronal and non-neuronal systems. In the central nervous system, 5-HT regulates mood and feeding behaviors as a neurotransmitter. Thus, there have been many trials aimed at increasing the activity of 5-HT in the central nervous s...

    journal_title:Diabetes & metabolism journal

    pub_type: 杂志文章,评审

    doi:10.4093/dmj.2016.40.2.89

    authors: Oh CM,Park S,Kim H

    更新日期:2016-04-01 00:00:00

  • The role of pyruvate dehydrogenase kinase in diabetes and obesity.

    abstract::The pyruvate dehydrogenase complex (PDC) is an emerging target for the treatment of metabolic syndrome. To maintain a steady-state concentration of adenosine triphosphate during the feed-fast cycle, cells require efficient utilization of fatty acid and glucose, which is controlled by the PDC. The PDC converts pyruvate...

    journal_title:Diabetes & metabolism journal

    pub_type: 杂志文章,评审

    doi:10.4093/dmj.2014.38.3.181

    authors: Lee IK

    更新日期:2014-06-01 00:00:00

  • Switching to Once-Daily Insulin Degludec/Insulin Aspart from Basal Insulin Improves Postprandial Glycemia in Patients with Type 2 Diabetes Mellitus: Randomized Controlled Trial.

    abstract:BACKGROUND:To explore the efficacy and safety of switching from once-daily basal insulin therapy to once-daily pre-meal injection insulin degludec/insulin aspart (IDegAsp) with respect to the glycemic control of participants with type 2 diabetes mellitus (T2DM). METHODS:In this multicenter, open-label, prospective, ra...

    journal_title:Diabetes & metabolism journal

    pub_type: 杂志文章

    doi:10.4093/dmj.2019.0093

    authors: Cho KY,Nakamura A,Oba-Yamamoto C,Tsuchida K,Yanagiya S,Manda N,Kurihara Y,Aoki S,Atsumi T,Miyoshi H

    更新日期:2020-08-01 00:00:00

  • Sodium-Glucose Cotransporter-2 Inhibitor for Renal Function Preservation in Patients with Type 2 Diabetes Mellitus: A Korean Diabetes Association and Korean Society of Nephrology Consensus Statement.

    abstract::Diabetes is a leading cause of end-stage renal disease. Therefore, prevention of renal dysfunction is an important treatment goal in the management of diabetes. The data of landmark cardiovascular outcome trials of sodium-glucose cotransporter-2 (SGLT2) inhibitor showed profound reno-protective effects. The Korean Dia...

    journal_title:Diabetes & metabolism journal

    pub_type: 杂志文章,评审

    doi:10.4093/dmj.2020.0172

    authors: Oh TJ,Moon JY,Hur KY,Ko SH,Kim HJ,Kim T,Lee DW,Moon MK,Committee of Clinical Practice Guideline, Korean Diabetes Association.,Committee of the Cooperative Studies, Korean Society of Nephrology.

    更新日期:2020-08-01 00:00:00

  • Latent Autoimmune Diabetes in Adults: A Review on Clinical Implications and Management.

    abstract::Latent autoimmune diabetes in adults (LADA) is a heterogeneous disease characterized by a less intensive autoimmune process and a broad clinical phenotype compared to classical type 1 diabetes mellitus (T1DM), sharing features with both type 2 diabetes mellitus (T2DM) and T1DM. Since patients affected by LADA are init...

    journal_title:Diabetes & metabolism journal

    pub_type: 杂志文章,评审

    doi:10.4093/dmj.2018.0190

    authors: Pieralice S,Pozzilli P

    更新日期:2018-12-01 00:00:00

  • Glucose Effectiveness from Short Insulin-Modified IVGTT and Its Application to the Study of Women with Previous Gestational Diabetes Mellitus.

    abstract:BACKGROUND:This study aimed to design a simple surrogate marker (i.e., predictor) of the minimal model glucose effectiveness (SG), namely calculated SG (CSG), from a short insulin-modified intravenous glucose tolerance test (IM-IVGTT), and then to apply it to study women with previous gestational diabetes mellitus (pGD...

    journal_title:Diabetes & metabolism journal

    pub_type: 杂志文章

    doi:10.4093/dmj.2019.0016

    authors: Morettini M,Castriota C,Göbl C,Kautzky-Willer A,Pacini G,Burattini L,Tura A

    更新日期:2020-04-01 00:00:00

  • Comparison of the efficacy of glimepiride, metformin, and rosiglitazone monotherapy in korean drug-naïve type 2 diabetic patients: the practical evidence of antidiabetic monotherapy study.

    abstract:BACKGROUND:Although many anti-diabetic drugs have been used to control hyperglycemia for decades, the efficacy of commonly-used oral glucose-lowering agents in Korean type 2 diabetic patients has yet to be clearly demonstrated. METHODS:We evaluated the efficacy of glimepiride, metformin, and rosiglitazone as initial t...

    journal_title:Diabetes & metabolism journal

    pub_type: 杂志文章

    doi:10.4093/dmj.2011.35.1.26

    authors: Yoon KH,Shin JA,Kwon HS,Lee SH,Min KW,Ahn YB,Yoo SJ,Ahn KJ,Park SW,Lee KW,Sung YA,Park TS,Kim MS,Kim YK,Nam MS,Kim HS,Park IeB,Park JS,Woo JT,Son HY

    更新日期:2011-02-01 00:00:00

  • Role of HbA1c in the Screening of Diabetes Mellitus in a Korean Rural Community.

    abstract:BACKGROUND:Recently, the measurement of glycated hemoglobin (HbA1c) was recommended as an alternative to fasting plasma glucose or oral glucose tolerance tests for diagnosing diabetes mellitus (DM). In this study, we analyzed HbA1c levels for diabetes mellitus screening in a Korean rural population. METHODS:We analyze...

    journal_title:Diabetes & metabolism journal

    pub_type: 杂志文章

    doi:10.4093/dmj.2012.36.1.37

    authors: Kim JH,Kim GW,Lee MY,Shin JY,Shin YG,Koh SB,Chung CH

    更新日期:2012-02-01 00:00:00

  • The Association between Z-Score of Log-Transformed A Body Shape Index and Cardiovascular Disease in Korea.

    abstract:BACKGROUND:In order to overcome the limitations of body mass index (BMI) and waist circumference (WC), the z-score of the log-transformed A Body Shape Index (LBSIZ) has recently been introduced. In this study, we analyzed the relationship between the LBSIZ and cardiovascular disease (CVD) in a Korean representative sam...

    journal_title:Diabetes & metabolism journal

    pub_type: 杂志文章

    doi:10.4093/dmj.2018.0169

    authors: Chung W,Park JH,Chung HS,Yu JM,Moon S,Kim DS

    更新日期:2019-10-01 00:00:00

  • Statin Discontinuation after Achieving a Target Low Density Lipoprotein Cholesterol Level in Type 2 Diabetic Patients without Cardiovascular Disease: A Randomized Controlled Study.

    abstract:BACKGROUND:This study investigated the rate of relapse of dyslipidemia and the factors which could predict relapse following a short-term statin discontinuation after achieving a target low density lipoprotein cholesterol (LDL-C) level in type 2 diabetic patients without cardiovascular disease (CVD). METHODS:Ninety-ni...

    journal_title:Diabetes & metabolism journal

    pub_type: 杂志文章

    doi:10.4093/dmj.2014.38.1.64

    authors: Lee SH,Kwon HS,Park YM,Ko SH,Choi YH,Yoon KH,Ahn YB

    更新日期:2014-02-01 00:00:00

  • A survey of diabetic educators and patients for the revision of korean food exchange lists.

    abstract:BACKGROUND:Food exchange lists are one of the main methods of nutritional education. However, Korean food exchange lists have not been revised since 1994. Therefore, we surveyed the opinions of diabetes educators and patients with diabetes regarding the need for revision of the current food exchange lists. METHODS:For...

    journal_title:Diabetes & metabolism journal

    pub_type: 杂志文章

    doi:10.4093/dmj.2011.35.2.173

    authors: Cho JW,Kweon MR,Park YM,Woo MH,Yoo HS,Lim JH,Koo BK,Kim CH,Kim HJ,Park JS,Shin CH,Won KC,Lim S,Jang HC

    更新日期:2011-04-01 00:00:00

  • Factor structure of indices of the second derivative of the finger photoplethysmogram with metabolic components and other cardiovascular risk indicators.

    abstract:BACKGROUND:The second derivative of the finger photoplethysmogram (SDPTG) is an indicator of arterial stiffness. The present study was conducted to clarify the factor structure of indices of the SDPTG in combination with components of the metabolic syndrome (MetS), to elucidate the significance of the SDPTG among vario...

    journal_title:Diabetes & metabolism journal

    pub_type: 杂志文章

    doi:10.4093/dmj.2013.37.1.40

    authors: Kawada T,Otsuka T

    更新日期:2013-02-01 00:00:00

  • The Relationship between Thyroid Function and Different Obesity Phenotypes in Korean Euthyroid Adults.

    abstract:BACKGROUND:Thyroid disease and metabolic syndrome are both associated with cardiovascular disease. The aim of this study was to investigate the correlation between thyroid hormones and obesity sub-phenotypes using nationwide data from Korea, a country known to be iodine replete. METHODS:This study was based on data ob...

    journal_title:Diabetes & metabolism journal

    pub_type: 杂志文章

    doi:10.4093/dmj.2018.0130

    authors: Kim JM,Kim BH,Lee H,Kim EH,Kim M,Kim JH,Jeon YK,Kim SS,Kim IJ,Kim YK

    更新日期:2019-12-01 00:00:00

  • Metformin Ameliorates Lipotoxic β-Cell Dysfunction through a Concentration-Dependent Dual Mechanism of Action.

    abstract:BACKGROUND:Chronic exposure to elevated levels of free fatty acids contributes to pancreatic β-cell dysfunction. Although it is well known that metformin induces cellular energy depletion and a concomitant activation of AMP-activated protein kinase (AMPK) through inhibition of the respiratory chain, previous studies ha...

    journal_title:Diabetes & metabolism journal

    pub_type: 杂志文章

    doi:10.4093/dmj.2018.0179

    authors: Kim HI,Lee JS,Kwak BK,Hwang WM,Kim MJ,Kim YB,Chung SS,Park KS

    更新日期:2019-12-01 00:00:00

  • Refocusing Peroxisome Proliferator Activated Receptor-α: A New Insight for Therapeutic Roles in Diabetes.

    abstract::Although glucose-lowering treatment shows some risk lowering effects in cardiovascular diseases, risks of macrovascular and microvascular complications have still remained, and development of new therapeutic strategies is needed. Recent data have shown that peroxisome proliferator activated receptor-α (PPAR-α) plays a...

    journal_title:Diabetes & metabolism journal

    pub_type: 杂志文章,评审

    doi:10.4093/dmj.2013.37.5.326

    authors: Seok H,Cha BS

    更新日期:2013-10-01 00:00:00

  • Glycemic Effects of Rebaudioside A and Erythritol in People with Glucose Intolerance.

    abstract:BACKGROUND:Rebaudioside A and erythritol are nonnutritive sweeteners. There have been several studies of their glycemic effects, but the outcomes remain controversial. The purpose of this study was to evaluate the glycemic effects of rebaudioside A and erythritol as a sweetener in people with glucose intolerance. METH...

    journal_title:Diabetes & metabolism journal

    pub_type: 杂志文章

    doi:10.4093/dmj.2016.40.4.283

    authors: Shin DH,Lee JH,Kang MS,Kim TH,Jeong SJ,Kim CH,Kim SS,Kim IJ

    更新日期:2016-08-01 00:00:00

  • Probiotics as Complementary Treatment for Metabolic Disorders.

    abstract::Over the past decade, growing evidence has established the gut microbiota as one of the most important determinants of metabolic disorders such as obesity and type 2 diabetes. Indeed, obesogenic diet can drastically alter bacterial populations (i.e., dysbiosis) leading to activation of pro-inflammatory mechanisms and ...

    journal_title:Diabetes & metabolism journal

    pub_type: 杂志文章,评审

    doi:10.4093/dmj.2015.39.4.291

    authors: Le Barz M,Anhê FF,Varin TV,Desjardins Y,Levy E,Roy D,Urdaci MC,Marette A

    更新日期:2015-08-01 00:00:00

  • Corrigendum: Prevalence of Depression and Glucose Abnormality in an Urbanizing Rural Population of Bangladesh.

    abstract::This corrects the article on p. 218 in vol. 39, PMID: 26124992. ...

    journal_title:Diabetes & metabolism journal

    pub_type: 已发布勘误

    doi:10.4093/dmj.2016.40.1.87

    authors: Natasha K,Hussain A,Azad Khan AK,Bhowmik B

    更新日期:2016-02-01 00:00:00

  • Progression to Gestational Diabetes Mellitus in Pregnant Women with One Abnormal Value in Repeated Oral Glucose Tolerance Tests.

    abstract:BACKGROUND:Women with one abnormal value (OAV) in a 100 g oral glucose tolerance test (OGTT) during pregnancy are reported to have an increased risk of adverse pregnancy outcomes. However, there is limited data about whether women with OAV will progress to gestational diabetes mellitus (GDM) when the OGTT is repeated. ...

    journal_title:Diabetes & metabolism journal

    pub_type: 杂志文章

    doi:10.4093/dmj.2018.0159

    authors: Kang S,Kim MH,Kim MY,Hong JS,Kwak SH,Choi SH,Lim S,Park KS,Jang HC

    更新日期:2019-10-01 00:00:00

  • Comparison of Attitudes Regarding Quality of Life between Insulin-Treated Subjects with Diabetes Mellitus and Healthy Populations.

    abstract:BACKGROUND:Diabetes mellitus is a chronic disease and one of the main causes of mortality in developing countries. The main objective of treating all chronic diseases, of course, is to improve well-being and attain a satisfactory quality of life (QOL). The major goal of this study is comparison of attitude toward QOL i...

    journal_title:Diabetes & metabolism journal

    pub_type: 杂志文章

    doi:10.4093/dmj.2011.35.4.397

    authors: Hashemi Hefz Abad F,Shabany Hamedan M

    更新日期:2011-08-01 00:00:00

  • Corrigendum: Increasing Prevalence of Type 2 Diabetes in a Rural Bangladeshi Population: A Population Based Study for 10 Years.

    abstract::[This corrects the article on p. 46 in vol. 37, PMID: 23439676.]. ...

    journal_title:Diabetes & metabolism journal

    pub_type: 已发布勘误

    doi:10.4093/dmj.2015.39.3.272

    authors: Bhowmik B,Afsana F,My Diep L,Binte Munir S,Wright E,Mahmood S,Khan AK,Hussain A

    更新日期:2015-06-01 00:00:00

  • Prevalence and clinical characteristics of recently diagnosed type 2 diabetes patients with positive anti-glutamic Acid decarboxylase antibody.

    abstract:BACKGROUND:Latent autoimmune diabetes in adults (LADA) refers to a specific type of diabetes characterized by adult onset, presence of islet auto-antibodies, insulin independence at the time of diagnosis, and rapid decline in β-cell function. The prevalence of LADA among patients with type 2 diabetes varies from 2% to ...

    journal_title:Diabetes & metabolism journal

    pub_type: 杂志文章

    doi:10.4093/dmj.2012.36.2.136

    authors: Hwangbo Y,Kim JT,Kim EK,Khang AR,Oh TJ,Jang HC,Park KS,Kim SY,Lee HK,Cho YM

    更新日期:2012-04-01 00:00:00

  • Corrigendum: Table and Text Correction. Recent Updates on Type 1 Diabetes Mellitus Management for Clinicians.

    abstract::This corrects the article on p. 3 in vol. 42, PMID: 29504302. ...

    journal_title:Diabetes & metabolism journal

    pub_type: 杂志文章,已发布勘误

    doi:10.4093/dmj.2018.42.2.177

    authors: Iqbal A,Novodvorsky P,Heller SR

    更新日期:2018-04-01 00:00:00