Role of HbA1c in the Screening of Diabetes Mellitus in a Korean Rural Community.

Abstract:

BACKGROUND:Recently, the measurement of glycated hemoglobin (HbA1c) was recommended as an alternative to fasting plasma glucose or oral glucose tolerance tests for diagnosing diabetes mellitus (DM). In this study, we analyzed HbA1c levels for diabetes mellitus screening in a Korean rural population. METHODS:We analyzed data from 10,111 subjects from a Korean Rural Genomic Cohort study and generated a receiver operating characteristic curve to determine an appropriate HbA1c cutoff value for diabetes. RESULTS:The mean age of the subjects was 56.3±8.1 years. Fasting plasma glucose and 2-hour plasma glucose after 75 g oral glucose tolerance tests were 97.5±25.6 and 138.3±67.1 mg/dL, respectively. The mean HbA1c level of the subjects was 5.7±0.9%. There were 8,809 non-DM patients (87.1%) and 1,302 DM patients (12.9%). A positive relationship between HbA1c and plasma glucose levels and between HbA1c and 2-hour plasma glucose levels after oral glucose tolerance tests was found in a scatter plot of the data. Using Youden's index, the proper cutoff level of HbA1c for diabetes mellitus screening was 5.95% (sensitivity, 77%; specificity, 89.4%). CONCLUSION:Our results suggest that the optimal HbA1c level for DM screening is 5.95%.

journal_name

Diabetes Metab J

authors

Kim JH,Kim GW,Lee MY,Shin JY,Shin YG,Koh SB,Chung CH

doi

10.4093/dmj.2012.36.1.37

subject

Has Abstract

pub_date

2012-02-01 00:00:00

pages

37-42

issue

1

eissn

2233-6079

issn

2233-6087

journal_volume

36

pub_type

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