Retrospective analysis on the efficacy, safety and treatment failure group of sitagliptin for mean 10-month duration.

abstract：:In cases of chronic hyperglycemia, advanced glycation end-products (AGEs) are actively produced and accumulated in the circulating blood and various tissues. AGEs also accelerate the expression of receptors for AGEs, and they play an important role in the development of diabetic vascular complications through various ...

journal_title：Diabetes & metabolism journal

authors： Rhee SY,Kim YS

更新日期：2018-06-01 00:00:00

abstract：:Obesity and diabetes has become a major epidemic across the globe. Controlling obesity has been a challenge since this would require either increased physical activity or reduced caloric intake; both are difficult to enforce. There has been renewed interest in exploiting pathways such as uncoupling protein 1 (UCP1)-me...

journal_title：Diabetes & metabolism journal

authors： Periasamy M,Herrera JL,Reis FCG

更新日期：2017-10-01 00:00:00

abstract：BACKGROUND:Non-alcoholic fatty liver disease (NAFLD) is increasingly recognized as a major cause of liver-related morbidity and mortality. The underlying mechanisms of disease progression remain poorly understood, and primary therapy of NAFLD is not yet established. We investigated the effects of dietary oleate on the ...

journal_title：Diabetes & metabolism journal

authors： Lee JY,Moon JH,Park JS,Lee BW,Kang ES,Ahn CW,Lee HC,Cha BS

更新日期：2011-10-01 00:00:00

abstract：BACKGROUND:Chronic exposure to elevated levels of free fatty acids contributes to pancreatic β-cell dysfunction. Although it is well known that metformin induces cellular energy depletion and a concomitant activation of AMP-activated protein kinase (AMPK) through inhibition of the respiratory chain, previous studies ha...

journal_title：Diabetes & metabolism journal

authors： Kim HI,Lee JS,Kwak BK,Hwang WM,Kim MJ,Kim YB,Chung SS,Park KS

更新日期：2019-12-01 00:00:00

abstract：:Diabetic cardiomyopathy (DCM), as one of the major cardiac complications in diabetic patients, is known to related with oxidative stress that is due to a severe imbalance between reactive oxygen species (ROS) and/or reactive nitrogen species (RNS) generation and their clearance by antioxidant defense systems. Transcri...

journal_title：Diabetes & metabolism journal

authors： Chen J,Zhang Z,Cai L

更新日期：2014-10-01 00:00:00

abstract：:Several polymers were used to delivery genes to diabetic animals. Polyaminobutyl glycolic acid was utilized to deliver IL-10 plasmid DNA to prevent autoimmune insulitis of non-obese diabetic (NOD) mouse. Polyethylene glycol grafted polylysine was combined with antisense glutamic acid decarboxylase (GAD) MRNA to repres...

journal_title：Diabetes & metabolism journal

authors： Kim SW

更新日期：2011-08-01 00:00:00

abstract：:The pyruvate dehydrogenase complex (PDC) is an emerging target for the treatment of metabolic syndrome. To maintain a steady-state concentration of adenosine triphosphate during the feed-fast cycle, cells require efficient utilization of fatty acid and glucose, which is controlled by the PDC. The PDC converts pyruvate...

journal_title：Diabetes & metabolism journal

authors： Lee IK

更新日期：2014-06-01 00:00:00

abstract：:Serotonin (5-hydroxytryptamine [5-HT]) is a monoamine that has various functions in both neuronal and non-neuronal systems. In the central nervous system, 5-HT regulates mood and feeding behaviors as a neurotransmitter. Thus, there have been many trials aimed at increasing the activity of 5-HT in the central nervous s...

journal_title：Diabetes & metabolism journal

authors： Oh CM,Park S,Kim H

更新日期：2016-04-01 00:00:00

abstract：:[This corrects the article on p. 504 in vol. 35, PMID: 22111042.]. ...

journal_title：Diabetes & metabolism journal

authors：

更新日期：2011-12-01 00:00:00

abstract：BACKGROUND:A latent cytomegalovirus (CMV) cause chronic inflammation through undesirable inflation of cell-mediated immune response. CMV immunoglobulin G has been associated with cardiovascular disease and type 1 diabetes mellitus. We evaluated impact of CMV diseases on new-onset type 2 diabetes mellitus (T2DM). METHO...

journal_title：Diabetes & metabolism journal

authors： Yoo SG,Han KD,Lee KH,La Y,Kwon DE,Han SH

更新日期：2019-12-01 00:00:00

abstract：:Care of the elderly population with diabetes may not be restricted to the management of hyperglycemia, associated risk factors, and specific diabetic complications. An integrated approach should also include the assessment and management of gerontological problems. Both diabetes mellitus and aging interact toward the ...

journal_title：Diabetes & metabolism journal

authors： Yoo HJ

更新日期：2017-06-01 00:00:00

abstract：BACKGROUND:Type 2 diabetes mellitus (T2DM) is associated with an increased risk for dementia. The effects of hypoglycemia on dementia are controversial. Thus, we evaluated whether hypoglycemia increases the risk for dementia in senior patients with T2DM. METHODS:We used the Korean National Health Insurance Service Sen...

journal_title：Diabetes & metabolism journal

authors： Kim YG,Park DG,Moon SY,Jeon JY,Kim HJ,Kim DJ,Lee KW,Han SJ

更新日期：2020-02-01 00:00:00

abstract：BACKGROUND:We evaluated decreases in glycosylated hemoglobin (HbA1c) achieved by reducing carbohydrate from various sources in type 2 diabetes mellitus patients. METHODS:We followed up 138 male and 107 female outpatients on a moderate low-carbohydrate diet without diabetic medication for 6 months. Changes in carbohydr...

journal_title：Diabetes & metabolism journal

authors： Haimoto H,Watanabe S,Maeda K,Murase T,Wakai K

更新日期：2020-07-21 00:00:00

abstract：:This corrects the article on p. 3 in vol. 42, PMID: 29504302. ...

journal_title：Diabetes & metabolism journal

authors： Iqbal A,Novodvorsky P,Heller SR

更新日期：2018-04-01 00:00:00

abstract：BACKGROUND:The prevalence and incidence of type 1 diabetes mellitus (T1DM) in all age groups and the prevalence of metabolic syndrome in patients with T1DM in Korea were estimated. METHODS:The incidence and prevalence of T1DM between 2007 and 2013 were calculated using the Korean National Health Insurance Service (NHI...

journal_title：Diabetes & metabolism journal

authors： Lee YB,Han K,Kim B,Jin SM,Lee SE,Jun JE,Ahn J,Kim G,Kim JH

更新日期：2019-02-01 00:00:00

abstract：BACKGROUND:This is a subgroup analysis of Korean patients from a phase 3 clinical trial investigating the efficacy and safety of ipragliflozin in patients with type 2 diabetes mellitus inadequately controlled with metformin. METHODS:This multicenter, placebo-controlled, double-blind, parallel-group study was carried o...

journal_title：Diabetes & metabolism journal

authors： Min KW,Ku BJ,Lee JH,Kim MS,Ahn KJ,Lee MK,Kokubo S,Yoshida S,Cho HJ,Cha BS

更新日期：2017-04-01 00:00:00

abstract：BACKGROUND:This study aimed to design a simple surrogate marker (i.e., predictor) of the minimal model glucose effectiveness (SG), namely calculated SG (CSG), from a short insulin-modified intravenous glucose tolerance test (IM-IVGTT), and then to apply it to study women with previous gestational diabetes mellitus (pGD...

journal_title：Diabetes & metabolism journal

authors： Morettini M,Castriota C,Göbl C,Kautzky-Willer A,Pacini G,Burattini L,Tura A

更新日期：2020-04-01 00:00:00

abstract：:This corrects the article on p. 218 in vol. 39, PMID: 26124992. ...

journal_title：Diabetes & metabolism journal

authors： Natasha K,Hussain A,Azad Khan AK,Bhowmik B

更新日期：2016-02-01 00:00:00

abstract：BACKGROUND:The aim of this study was to investigate the influences of visceral adiposity on cardiovascular autonomic neuropathy (CAN) in patients with type 2 diabetes mellitus. METHODS:Two hundred eleven patients with type 2 diabetes participated in this study. Anthropometric and metabolic parameters were measured, an...

journal_title：Diabetes & metabolism journal

authors： Jang EH,Kim NY,Park YM,Kim MK,Baek KH,Song KH,Lee KW,Kwon HS

更新日期：2012-08-01 00:00:00

abstract：:Diabetes is a leading cause of end-stage renal disease. Therefore, prevention of renal dysfunction is an important treatment goal in the management of diabetes. The data of landmark cardiovascular outcome trials of sodium-glucose cotransporter-2 (SGLT2) inhibitor showed profound reno-protective effects. The Korean Dia...

journal_title：Diabetes & metabolism journal

authors： Oh TJ,Moon JY,Hur KY,Ko SH,Kim HJ,Kim T,Lee DW,Moon MK,Committee of Clinical Practice Guideline, Korean Diabetes Association.,Committee of the Cooperative Studies, Korean Society of Nephrology.

更新日期：2020-08-01 00:00:00

abstract：BACKGROUND:Although many anti-diabetic drugs have been used to control hyperglycemia for decades, the efficacy of commonly-used oral glucose-lowering agents in Korean type 2 diabetic patients has yet to be clearly demonstrated. METHODS:We evaluated the efficacy of glimepiride, metformin, and rosiglitazone as initial t...

journal_title：Diabetes & metabolism journal

authors： Yoon KH,Shin JA,Kwon HS,Lee SH,Min KW,Ahn YB,Yoo SJ,Ahn KJ,Park SW,Lee KW,Sung YA,Park TS,Kim MS,Kim YK,Nam MS,Kim HS,Park IeB,Park JS,Woo JT,Son HY

更新日期：2011-02-01 00:00:00

abstract：:Fibroblast growth factor 21 (FGF21) is an endocrine hormone that is primarily expressed in the liver and exerts beneficial effects on obesity and related metabolic diseases. In addition to its remarkable pharmacologic actions, the physiological roles of FGF21 include the maintenance of energy homeostasis in the body i...

journal_title：Diabetes & metabolism journal

authors： Kim KH,Lee MS

更新日期：2014-08-01 00:00:00

abstract：:Non-alcoholic fatty liver disease (NAFLD) is one of the most common causes of chronic liver disease in adults and children worldwide. NAFLD has become a severe health issue and it can progress towards a more severe form of the disease, the non-alcoholic steatohepatitis (NASH). A combination of environmental factors, h...

journal_title：Diabetes & metabolism journal

authors： Povero D,Feldstein AE

更新日期：2016-02-01 00:00:00

abstract：:Nonalcoholic fatty liver disease (NAFLD) and diabetes are common metabolic disorders whose prevalence rates are expected to rise worldwide, corresponding to aging and increasingly obese populations. Compared to the general population (around 25%), 50% to 70% of people with diabetes have NAFLD, and NAFLD severity (incl...

journal_title：Diabetes & metabolism journal

authors： Lee YH,Cho Y,Lee BW,Park CY,Lee DH,Cha BS,Rhee EJ

更新日期：2019-02-01 00:00:00

abstract：BACKGROUND:In order to overcome the limitations of body mass index (BMI) and waist circumference (WC), the z-score of the log-transformed A Body Shape Index (LBSIZ) has recently been introduced. In this study, we analyzed the relationship between the LBSIZ and cardiovascular disease (CVD) in a Korean representative sam...

journal_title：Diabetes & metabolism journal

authors： Chung W,Park JH,Chung HS,Yu JM,Moon S,Kim DS

更新日期：2019-10-01 00:00:00

abstract：BACKGROUND:This study investigated the rate of relapse of dyslipidemia and the factors which could predict relapse following a short-term statin discontinuation after achieving a target low density lipoprotein cholesterol (LDL-C) level in type 2 diabetic patients without cardiovascular disease (CVD). METHODS:Ninety-ni...

journal_title：Diabetes & metabolism journal

authors： Lee SH,Kwon HS,Park YM,Ko SH,Choi YH,Yoon KH,Ahn YB

更新日期：2014-02-01 00:00:00

abstract：BACKGROUND:Women with one abnormal value (OAV) in a 100 g oral glucose tolerance test (OGTT) during pregnancy are reported to have an increased risk of adverse pregnancy outcomes. However, there is limited data about whether women with OAV will progress to gestational diabetes mellitus (GDM) when the OGTT is repeated. ...

journal_title：Diabetes & metabolism journal

authors： Kang S,Kim MH,Kim MY,Hong JS,Kwak SH,Choi SH,Lim S,Park KS,Jang HC

更新日期：2019-10-01 00:00:00

abstract：BACKGROUND:Latent autoimmune diabetes in adults (LADA) refers to a specific type of diabetes characterized by adult onset, presence of islet auto-antibodies, insulin independence at the time of diagnosis, and rapid decline in β-cell function. The prevalence of LADA among patients with type 2 diabetes varies from 2% to ...

journal_title：Diabetes & metabolism journal

authors： Hwangbo Y,Kim JT,Kim EK,Khang AR,Oh TJ,Jang HC,Park KS,Kim SY,Lee HK,Cho YM

更新日期：2012-04-01 00:00:00

abstract：BACKGROUND:Diabetes mellitus is a chronic disease and one of the main causes of mortality in developing countries. The main objective of treating all chronic diseases, of course, is to improve well-being and attain a satisfactory quality of life (QOL). The major goal of this study is comparison of attitude toward QOL i...

journal_title：Diabetes & metabolism journal

authors： Hashemi Hefz Abad F,Shabany Hamedan M

更新日期：2011-08-01 00:00:00

abstract：:Knowledge of the epidemiologic characteristics of end-stage kidney disease (ESKD) patients is essential. The trends in the prevalence, incidence, and mortality rates of ESKD were analyzed retrospectively using the Korean National Health Insurance ServiceNational Sample Cohort database between 2006 and 2015. From 2006 ...

journal_title：Diabetes & metabolism journal

authors： Lee MJ,Ha KH,Kim DJ,Park I

更新日期：2020-12-01 00:00:00