Addition of Ipragliflozin to Metformin Treatment in Korean Patients with Type 2 Diabetes Mellitus: Subgroup Analysis of a Phase 3 Trial.


BACKGROUND:This is a subgroup analysis of Korean patients from a phase 3 clinical trial investigating the efficacy and safety of ipragliflozin in patients with type 2 diabetes mellitus inadequately controlled with metformin. METHODS:This multicenter, placebo-controlled, double-blind, parallel-group study was carried out between November 2011 and January 2013. Patients entered a 2-week placebo pretreatment period, followed by a 24-week treatment period with either ipragliflozin (50 mg/day) or placebo, while continuing metformin. Efficacy outcomes (glycosylated hemoglobin [HbA1c], fasting plasma glucose [FPG], and body weight) and safety outcomes (treatment-emergent adverse events [TEAEs]) were measured and compared between the two treatment groups for patients enrolled in all 18 study sites in Korea. RESULTS:Eighty-two Korean patients received ipragliflozin (n=43) or placebo (n=39) during the study period. Mean changes in HbA1c levels from baseline to the end of treatment were -0.97% in the ipragliflozin group and -0.31% in the placebo group, with an adjusted between-group difference of -0.60% (P<0.001). Compared to placebo, FPG and body weight also decreased significantly (both P<0.001) from baseline after treatment in the ipragliflozin group, with between-group differences of -21.4 mg/dL and -1.53 kg, respectively. Decreased weight was the most common TEAE in the ipragliflozin group (7.0%); there were no reports of genital and urinary tract infection. CONCLUSION:Ipragliflozin treatment in addition to metformin led to significant improvement in glycemic outcomes and reduction in body weight in Korean patients with type 2 diabetes mellitus, compared with metformin treatment alone; the safety profile was comparable in both groups.


Diabetes Metab J


Min KW,Ku BJ,Lee JH,Kim MS,Ahn KJ,Lee MK,Kokubo S,Yoshida S,Cho HJ,Cha BS




Has Abstract


2017-04-01 00:00:00














  • Subjective Assessment of Diabetes Self-Care Correlates with Perceived Glycemic Control but not with Actual Glycemic Control.

    abstract:BACKGROUND:We investigated whether patients' perceived glycemic control and self-reported diabetes self-care correlated with their actual glycemic control. METHODS:A survey was administered among patients with diabetes mellitus at an outpatient clinic with structured self-report questionnaires regarding perceived glyc...

    journal_title:Diabetes & metabolism journal

    pub_type: 杂志文章


    authors: Ohn JH,Lee JH,Hong ES,Koo BK,Kim SW,Yi KH,Moon MK

    更新日期:2015-02-01 00:00:00

  • Glycemic Effects of Rebaudioside A and Erythritol in People with Glucose Intolerance.

    abstract:BACKGROUND:Rebaudioside A and erythritol are nonnutritive sweeteners. There have been several studies of their glycemic effects, but the outcomes remain controversial. The purpose of this study was to evaluate the glycemic effects of rebaudioside A and erythritol as a sweetener in people with glucose intolerance. METH...

    journal_title:Diabetes & metabolism journal

    pub_type: 杂志文章


    authors: Shin DH,Lee JH,Kang MS,Kim TH,Jeong SJ,Kim CH,Kim SS,Kim IJ

    更新日期:2016-08-01 00:00:00

  • Role of the Pyruvate Dehydrogenase Complex in Metabolic Remodeling: Differential Pyruvate Dehydrogenase Complex Functions in Metabolism.

    abstract::Mitochondrial dysfunction is a hallmark of metabolic diseases such as obesity, type 2 diabetes mellitus, neurodegenerative diseases, and cancers. Dysfunction occurs in part because of altered regulation of the mitochondrial pyruvate dehydrogenase complex (PDC), which acts as a central metabolic node that mediates pyru...

    journal_title:Diabetes & metabolism journal

    pub_type: 杂志文章,评审


    authors: Park S,Jeon JH,Min BK,Ha CM,Thoudam T,Park BY,Lee IK

    更新日期:2018-08-01 00:00:00

  • The Preventive Effects of 8 Weeks of Resistance Training on Glucose Tolerance and Muscle Fiber Type Composition in Zucker Rats.

    abstract:BACKGROUND:We investigated the therapeutic effects of resistance training on Zucker rats before and after the onset of diabetes to understand the importance of the timing of exercise intervention. We assessed whether 8 weeks of resistance training ameliorated impaired glucose tolerance and altered muscle fiber type com...

    journal_title:Diabetes & metabolism journal

    pub_type: 杂志文章


    authors: Kim JY,Choi MJ,So B,Kim HJ,Seong JK,Song W

    更新日期:2015-10-01 00:00:00

  • Nonalcoholic Fatty Liver Disease in Diabetes. Part I: Epidemiology and Diagnosis.

    abstract::Nonalcoholic fatty liver disease (NAFLD) and diabetes are common metabolic disorders whose prevalence rates are expected to rise worldwide, corresponding to aging and increasingly obese populations. Compared to the general population (around 25%), 50% to 70% of people with diabetes have NAFLD, and NAFLD severity (incl...

    journal_title:Diabetes & metabolism journal

    pub_type: 杂志文章,评审


    authors: Lee YH,Cho Y,Lee BW,Park CY,Lee DH,Cha BS,Rhee EJ

    更新日期:2019-02-01 00:00:00


    abstract::[This corrects the article on p. 504 in vol. 35, PMID: 22111042.]. ...

    journal_title:Diabetes & metabolism journal

    pub_type: 杂志文章,已发布勘误



    更新日期:2011-12-01 00:00:00

  • Skeletal Muscle Thermogenesis and Its Role in Whole Body Energy Metabolism.

    abstract::Obesity and diabetes has become a major epidemic across the globe. Controlling obesity has been a challenge since this would require either increased physical activity or reduced caloric intake; both are difficult to enforce. There has been renewed interest in exploiting pathways such as uncoupling protein 1 (UCP1)-me...

    journal_title:Diabetes & metabolism journal

    pub_type: 杂志文章,评审


    authors: Periasamy M,Herrera JL,Reis FCG

    更新日期:2017-10-01 00:00:00

  • Diabetic cardiomyopathy and its prevention by nrf2: current status.

    abstract::Diabetic cardiomyopathy (DCM), as one of the major cardiac complications in diabetic patients, is known to related with oxidative stress that is due to a severe imbalance between reactive oxygen species (ROS) and/or reactive nitrogen species (RNS) generation and their clearance by antioxidant defense systems. Transcri...

    journal_title:Diabetes & metabolism journal

    pub_type: 杂志文章,评审


    authors: Chen J,Zhang Z,Cai L

    更新日期:2014-10-01 00:00:00

  • Serotonin as a New Therapeutic Target for Diabetes Mellitus and Obesity.

    abstract::Serotonin (5-hydroxytryptamine [5-HT]) is a monoamine that has various functions in both neuronal and non-neuronal systems. In the central nervous system, 5-HT regulates mood and feeding behaviors as a neurotransmitter. Thus, there have been many trials aimed at increasing the activity of 5-HT in the central nervous s...

    journal_title:Diabetes & metabolism journal

    pub_type: 杂志文章,评审


    authors: Oh CM,Park S,Kim H

    更新日期:2016-04-01 00:00:00

  • Reducing Carbohydrate from Individual Sources Has Differential Effects on Glycosylated Hemoglobin in Type 2 Diabetes Mellitus Patients on Moderate Low-Carbohydrate Diets.

    abstract:BACKGROUND:We evaluated decreases in glycosylated hemoglobin (HbA1c) achieved by reducing carbohydrate from various sources in type 2 diabetes mellitus patients. METHODS:We followed up 138 male and 107 female outpatients on a moderate low-carbohydrate diet without diabetic medication for 6 months. Changes in carbohydr...

    journal_title:Diabetes & metabolism journal

    pub_type: 杂志文章


    authors: Haimoto H,Watanabe S,Maeda K,Murase T,Wakai K

    更新日期:2020-07-21 00:00:00

  • Intensive individualized reinforcement education is important for the prevention of hypoglycemia in patients with type 2 diabetes.

    abstract:BACKGROUND:We investigated whether an intensive individualized reinforcement education program could influence the prevention of hypoglycemic events in patients with type 2 diabetes. METHODS:From March 2013 to September 2013, patients aged 35 to 75 years with type 2 diabetes who had not previously participated in diab...

    journal_title:Diabetes & metabolism journal

    pub_type: 杂志文章


    authors: Yong YM,Shin KM,Lee KM,Cho JY,Ko SH,Yoon MH,Kim TW,Jeong JH,Park YM,Ko SH,Ahn YB

    更新日期:2015-04-01 00:00:00

  • The importance of global studies of the genetics of type 2 diabetes.

    abstract::Genome wide association analyses have revealed large numbers of common variants influencing predisposition to type 2 diabetes and related phenotypes. These studies have predominantly featured European populations, but are now being extended to samples from a wider range of ethnic groups. The transethnic analysis of as...

    journal_title:Diabetes & metabolism journal

    pub_type: 杂志文章


    authors: McCarthy MI

    更新日期:2011-04-01 00:00:00

  • A Journey to Understand Glucose Homeostasis: Starting from Rat Glucose Transporter Type 2 Promoter Cloning to Hyperglycemia.

    abstract::My professional journey to understand the glucose homeostasis began in the 1990s, starting from cloning of the promoter region of glucose transporter type 2 (GLUT2) gene that led us to establish research foundation of my group. When I was a graduate student, I simply thought that hyperglycemia, a typical clinical mani...

    journal_title:Diabetes & metabolism journal

    pub_type: 杂志文章,评审


    authors: Ahn YH

    更新日期:2018-12-01 00:00:00

  • A survey of diabetic educators and patients for the revision of korean food exchange lists.

    abstract:BACKGROUND:Food exchange lists are one of the main methods of nutritional education. However, Korean food exchange lists have not been revised since 1994. Therefore, we surveyed the opinions of diabetes educators and patients with diabetes regarding the need for revision of the current food exchange lists. METHODS:For...

    journal_title:Diabetes & metabolism journal

    pub_type: 杂志文章


    authors: Cho JW,Kweon MR,Park YM,Woo MH,Yoo HS,Lim JH,Koo BK,Kim CH,Kim HJ,Park JS,Shin CH,Won KC,Lim S,Jang HC

    更新日期:2011-04-01 00:00:00

  • Polymeric gene delivery for diabetic treatment.

    abstract::Several polymers were used to delivery genes to diabetic animals. Polyaminobutyl glycolic acid was utilized to deliver IL-10 plasmid DNA to prevent autoimmune insulitis of non-obese diabetic (NOD) mouse. Polyethylene glycol grafted polylysine was combined with antisense glutamic acid decarboxylase (GAD) MRNA to repres...

    journal_title:Diabetes & metabolism journal

    pub_type: 杂志文章


    authors: Kim SW

    更新日期:2011-08-01 00:00:00

  • Corrigendum: Prevalence of Depression and Glucose Abnormality in an Urbanizing Rural Population of Bangladesh.

    abstract::This corrects the article on p. 218 in vol. 39, PMID: 26124992. ...

    journal_title:Diabetes & metabolism journal

    pub_type: 已发布勘误


    authors: Natasha K,Hussain A,Azad Khan AK,Bhowmik B

    更新日期:2016-02-01 00:00:00

  • Refocusing Peroxisome Proliferator Activated Receptor-α: A New Insight for Therapeutic Roles in Diabetes.

    abstract::Although glucose-lowering treatment shows some risk lowering effects in cardiovascular diseases, risks of macrovascular and microvascular complications have still remained, and development of new therapeutic strategies is needed. Recent data have shown that peroxisome proliferator activated receptor-α (PPAR-α) plays a...

    journal_title:Diabetes & metabolism journal

    pub_type: 杂志文章,评审


    authors: Seok H,Cha BS

    更新日期:2013-10-01 00:00:00

  • A cross-sectional study of the phenotypes of obesity and insulin resistance in adults with down syndrome.

    abstract:BACKGROUND:Despite the confluence of multiple cardiovascular risk factors, subclinical atherosclerotic damage and cardiovascular events remain extremely rare in adults with Down syndrome (DS). We aim to determine the prevalence of obesity and metabolic disorders in an adult cohort with DS and to compare our findings wi...

    journal_title:Diabetes & metabolism journal

    pub_type: 杂志文章


    authors: Real de Asua D,Parra P,Costa R,Moldenhauer F,Suarez C

    更新日期:2014-12-01 00:00:00

  • Progression to Gestational Diabetes Mellitus in Pregnant Women with One Abnormal Value in Repeated Oral Glucose Tolerance Tests.

    abstract:BACKGROUND:Women with one abnormal value (OAV) in a 100 g oral glucose tolerance test (OGTT) during pregnancy are reported to have an increased risk of adverse pregnancy outcomes. However, there is limited data about whether women with OAV will progress to gestational diabetes mellitus (GDM) when the OGTT is repeated. ...

    journal_title:Diabetes & metabolism journal

    pub_type: 杂志文章


    authors: Kang S,Kim MH,Kim MY,Hong JS,Kwak SH,Choi SH,Lim S,Park KS,Jang HC

    更新日期:2019-10-01 00:00:00

  • Comprehensive Approach for Managing the Older Person with Diabetes Mellitus.

    abstract::Care of the elderly population with diabetes may not be restricted to the management of hyperglycemia, associated risk factors, and specific diabetic complications. An integrated approach should also include the assessment and management of gerontological problems. Both diabetes mellitus and aging interact toward the ...

    journal_title:Diabetes & metabolism journal

    pub_type: 杂志文章,评审


    authors: Yoo HJ

    更新日期:2017-06-01 00:00:00

  • Targeting the Peroxisome Proliferator-Activated Receptor-γ to Counter the Inflammatory Milieu in Obesity.

    abstract::Adipose tissue, which was once viewed as a simple organ for storage of triglycerides, is now considered an important endocrine organ. Abnormal adipose tissue mass is associated with defects in endocrine and metabolic functions which are the underlying causes of the metabolic syndrome. Many adipokines, hormones secrete...

    journal_title:Diabetes & metabolism journal

    pub_type: 杂志文章


    authors: Corzo C,Griffin PR

    更新日期:2013-12-01 00:00:00

  • The Relationship between Thyroid Function and Different Obesity Phenotypes in Korean Euthyroid Adults.

    abstract:BACKGROUND:Thyroid disease and metabolic syndrome are both associated with cardiovascular disease. The aim of this study was to investigate the correlation between thyroid hormones and obesity sub-phenotypes using nationwide data from Korea, a country known to be iodine replete. METHODS:This study was based on data ob...

    journal_title:Diabetes & metabolism journal

    pub_type: 杂志文章


    authors: Kim JM,Kim BH,Lee H,Kim EH,Kim M,Kim JH,Jeon YK,Kim SS,Kim IJ,Kim YK

    更新日期:2019-12-01 00:00:00

  • Role of CRTC2 in Metabolic Homeostasis: Key Regulator of Whole-Body Energy Metabolism?

    abstract::Cyclic adenosine monophosphate (cAMP) signaling is critical for regulating metabolic homeostasis in mammals. In particular, transcriptional regulation by cAMP response element-binding protein (CREB) and its coactivator, CREB-regulated transcription coactivator (CRTC), is essential for controlling the expression of cri...

    journal_title:Diabetes & metabolism journal

    pub_type: 杂志文章,评审


    authors: Han HS,Kwon Y,Koo SH

    更新日期:2020-08-01 00:00:00

  • Trends in the Incidence, Prevalence, and Mortality of End-Stage Kidney Disease in South Korea.

    abstract::Knowledge of the epidemiologic characteristics of end-stage kidney disease (ESKD) patients is essential. The trends in the prevalence, incidence, and mortality rates of ESKD were analyzed retrospectively using the Korean National Health Insurance ServiceNational Sample Cohort database between 2006 and 2015. From 2006 ...

    journal_title:Diabetes & metabolism journal

    pub_type: 杂志文章


    authors: Lee MJ,Ha KH,Kim DJ,Park I

    更新日期:2020-12-01 00:00:00

  • Effect on Glycemic, Blood Pressure, and Lipid Control according to Education Types.

    abstract:BACKGROUND:Diabetes self-management education and reinforcement are important for effective management of the disease. We investigated the effectiveness of interactive small-group education on glycemic, blood pressure, and lipid levels. METHODS:For this study, 207 type 2 diabetes patients with suboptimal glycemic cont...

    journal_title:Diabetes & metabolism journal

    pub_type: 杂志文章


    authors: Choi MJ,Yoo SH,Kim KR,Bae YM,Ahn SH,Kim SS,Min SA,Choi JS,Lee SE,Moon YJ,Rhee EJ,Park CY,Lee WY,Oh KW,Park SW,Kim SW

    更新日期:2011-12-01 00:00:00

  • Diagnostic Accuracy of 64-Slice MDCT Coronary Angiography for the Assessment of Coronary Artery Disease in Korean Patients with Type 2 Diabetes.

    abstract:BACKGROUND:A 64-slice multidetector computed tomography (MDCT) is well known to be a useful noninvasive form of angiography for the general population, but not for certain patients with diabetes. The aim of this study was to investigate the diagnostic accuracy and usefulness of 64-slice MDCT coronary angiography for de...

    journal_title:Diabetes & metabolism journal

    pub_type: 杂志文章


    authors: Moon JS,Yoon JS,Won KC,Cho IH,Lee HW

    更新日期:2013-02-01 00:00:00

  • Differences in Clinical Outcomes between Patients with and without Hypoglycemia during Hospitalization: A Retrospective Study Using Real-World Evidence.

    abstract:BACKGROUND:Some patients admitted to hospitals for glycemic control experience hypoglycemia despite regular meals and despite adhering to standard blood glucose control protocols. Different factors can have a negative impact on blood glucose control and prognosis after discharge. This study investigated risk factors fo...

    journal_title:Diabetes & metabolism journal

    pub_type: 杂志文章


    authors: Lee J,Kim TM,Kim H,Lee SH,Cho JH,Lee H,Yim HW,Yoon KH,Kim HS

    更新日期:2020-08-01 00:00:00

  • Novel Molecular Mechanisms in the Development of Non-Alcoholic Steatohepatitis.

    abstract::Non-alcoholic fatty liver disease (NAFLD) is one of the most common causes of chronic liver disease in adults and children worldwide. NAFLD has become a severe health issue and it can progress towards a more severe form of the disease, the non-alcoholic steatohepatitis (NASH). A combination of environmental factors, h...

    journal_title:Diabetes & metabolism journal

    pub_type: 杂志文章,评审


    authors: Povero D,Feldstein AE

    更新日期:2016-02-01 00:00:00

  • The role of pyruvate dehydrogenase kinase in diabetes and obesity.

    abstract::The pyruvate dehydrogenase complex (PDC) is an emerging target for the treatment of metabolic syndrome. To maintain a steady-state concentration of adenosine triphosphate during the feed-fast cycle, cells require efficient utilization of fatty acid and glucose, which is controlled by the PDC. The PDC converts pyruvate...

    journal_title:Diabetes & metabolism journal

    pub_type: 杂志文章,评审


    authors: Lee IK

    更新日期:2014-06-01 00:00:00

  • Comparison of Attitudes Regarding Quality of Life between Insulin-Treated Subjects with Diabetes Mellitus and Healthy Populations.

    abstract:BACKGROUND:Diabetes mellitus is a chronic disease and one of the main causes of mortality in developing countries. The main objective of treating all chronic diseases, of course, is to improve well-being and attain a satisfactory quality of life (QOL). The major goal of this study is comparison of attitude toward QOL i...

    journal_title:Diabetes & metabolism journal

    pub_type: 杂志文章


    authors: Hashemi Hefz Abad F,Shabany Hamedan M

    更新日期:2011-08-01 00:00:00