Abstract:
:Cyclic adenosine monophosphate (cAMP) signaling is critical for regulating metabolic homeostasis in mammals. In particular, transcriptional regulation by cAMP response element-binding protein (CREB) and its coactivator, CREB-regulated transcription coactivator (CRTC), is essential for controlling the expression of critical enzymes in the metabolic process, leading to more chronic changes in metabolic flux. Among the CRTC isoforms, CRTC2 is predominantly expressed in peripheral tissues and has been shown to be associated with various metabolic pathways in tissue-specific manners. While initial reports showed the physiological role of CRTC2 in regulating gluconeogenesis in the liver, recent studies have further delineated the role of this transcriptional coactivator in the regulation of glucose and lipid metabolism in various tissues, including the liver, pancreatic islets, endocrine tissues of the small intestines, and adipose tissues. In this review, we discuss recent studies that have utilized knockout mouse models to delineate the role of CRTC2 in the regulation of metabolic homeostasis.
journal_name
Diabetes Metab Jjournal_title
Diabetes & metabolism journalauthors
Han HS,Kwon Y,Koo SHdoi
10.4093/dmj.2019.0200subject
Has Abstractpub_date
2020-08-01 00:00:00pages
498-508issue
4eissn
2233-6079issn
2233-6087pii
44.e5journal_volume
44pub_type
杂志文章,评审abstract:BACKGROUND:Diabetes self-management education and reinforcement are important for effective management of the disease. We investigated the effectiveness of interactive small-group education on glycemic, blood pressure, and lipid levels. METHODS:For this study, 207 type 2 diabetes patients with suboptimal glycemic cont...
journal_title:Diabetes & metabolism journal
pub_type: 杂志文章
doi:10.4093/dmj.2011.35.6.580
更新日期:2011-12-01 00:00:00
abstract:BACKGROUND:We investigated whether patients' perceived glycemic control and self-reported diabetes self-care correlated with their actual glycemic control. METHODS:A survey was administered among patients with diabetes mellitus at an outpatient clinic with structured self-report questionnaires regarding perceived glyc...
journal_title:Diabetes & metabolism journal
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journal_title:Diabetes & metabolism journal
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更新日期:2016-02-01 00:00:00
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journal_title:Diabetes & metabolism journal
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更新日期:2016-04-01 00:00:00
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journal_title:Diabetes & metabolism journal
pub_type: 杂志文章,已发布勘误
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更新日期:2011-12-01 00:00:00
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journal_title:Diabetes & metabolism journal
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journal_title:Diabetes & metabolism journal
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更新日期:2014-08-01 00:00:00
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journal_title:Diabetes & metabolism journal
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更新日期:2013-08-01 00:00:00
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journal_title:Diabetes & metabolism journal
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更新日期:2012-04-01 00:00:00
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journal_title:Diabetes & metabolism journal
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journal_title:Diabetes & metabolism journal
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更新日期:2020-02-01 00:00:00
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更新日期:2011-04-01 00:00:00
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journal_title:Diabetes & metabolism journal
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journal_title:Diabetes & metabolism journal
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更新日期:2019-02-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2019-02-01 00:00:00