Statin Discontinuation after Achieving a Target Low Density Lipoprotein Cholesterol Level in Type 2 Diabetic Patients without Cardiovascular Disease: A Randomized Controlled Study.


BACKGROUND:This study investigated the rate of relapse of dyslipidemia and the factors which could predict relapse following a short-term statin discontinuation after achieving a target low density lipoprotein cholesterol (LDL-C) level in type 2 diabetic patients without cardiovascular disease (CVD). METHODS:Ninety-nine subjects on rosuvastatin treatment and whose LDL-C level was lower than 100 mg/dL were randomly assigned to discontinue or maintain statin treatment at a 2:1 ratio. The subjects were followed-up after 10 weeks. A relapse of dyslipidemia was defined as a reascent of LDL-C level to greater than 100 mg/dL. RESULTS:The statin discontinuation group had a significant rate of relapse compared to the maintenance group (79% vs. 3%, respectively). Pretreatment and baseline lipid levels, their ratios, and hemoglobin A1c level were significantly different between the relapse and nonrelapse groups. The pretreatment and baseline lipid profiles and their ratios were independently associated with relapse. The pretreatment LDL-C level was the most useful parameter for predicting a relapse, with a cutoff of 123 mg/dL. During the follow-up period, no CVD event was noted. CONCLUSION:The relapse rate of dyslipidemia was high when statins were discontinued in type 2 diabetic patients without CVD. Statin discontinuation should be considered carefully based on the pretreatment lipid profiles of patients.


Diabetes Metab J


Lee SH,Kwon HS,Park YM,Ko SH,Choi YH,Yoon KH,Ahn YB




Has Abstract


2014-02-01 00:00:00












  • The Relationship between Thyroid Function and Different Obesity Phenotypes in Korean Euthyroid Adults.

    abstract:BACKGROUND:Thyroid disease and metabolic syndrome are both associated with cardiovascular disease. The aim of this study was to investigate the correlation between thyroid hormones and obesity sub-phenotypes using nationwide data from Korea, a country known to be iodine replete. METHODS:This study was based on data ob...

    journal_title:Diabetes & metabolism journal

    pub_type: 杂志文章


    authors: Kim JM,Kim BH,Lee H,Kim EH,Kim M,Kim JH,Jeon YK,Kim SS,Kim IJ,Kim YK

    更新日期:2019-12-01 00:00:00

  • A systematic review of oxidative stress and safety of antioxidants in diabetes: focus on islets and their defense.

    abstract::A growing body of evidence suggests that hyperglycemia-induced oxidative stress plays an important role in diabetic complications, especially β-cell dysfunction and failure. Under physiological conditions, reactive oxygen species serve as second messengers that facilitate signal transduction and gene expression in pan...

    journal_title:Diabetes & metabolism journal

    pub_type: 杂志文章


    authors: Karunakaran U,Park KG

    更新日期:2013-04-01 00:00:00

  • The Role of Advanced Glycation End Products in Diabetic Vascular Complications.

    abstract::In cases of chronic hyperglycemia, advanced glycation end-products (AGEs) are actively produced and accumulated in the circulating blood and various tissues. AGEs also accelerate the expression of receptors for AGEs, and they play an important role in the development of diabetic vascular complications through various ...

    journal_title:Diabetes & metabolism journal

    pub_type: 杂志文章,评审


    authors: Rhee SY,Kim YS

    更新日期:2018-06-01 00:00:00

  • Switching to Once-Daily Insulin Degludec/Insulin Aspart from Basal Insulin Improves Postprandial Glycemia in Patients with Type 2 Diabetes Mellitus: Randomized Controlled Trial.

    abstract:BACKGROUND:To explore the efficacy and safety of switching from once-daily basal insulin therapy to once-daily pre-meal injection insulin degludec/insulin aspart (IDegAsp) with respect to the glycemic control of participants with type 2 diabetes mellitus (T2DM). METHODS:In this multicenter, open-label, prospective, ra...

    journal_title:Diabetes & metabolism journal

    pub_type: 杂志文章


    authors: Cho KY,Nakamura A,Oba-Yamamoto C,Tsuchida K,Yanagiya S,Manda N,Kurihara Y,Aoki S,Atsumi T,Miyoshi H

    更新日期:2020-08-01 00:00:00

  • Corrigendum: Increasing Prevalence of Type 2 Diabetes in a Rural Bangladeshi Population: A Population Based Study for 10 Years.

    abstract::[This corrects the article on p. 46 in vol. 37, PMID: 23439676.]. ...

    journal_title:Diabetes & metabolism journal

    pub_type: 已发布勘误


    authors: Bhowmik B,Afsana F,My Diep L,Binte Munir S,Wright E,Mahmood S,Khan AK,Hussain A

    更新日期:2015-06-01 00:00:00

  • The role of pyruvate dehydrogenase kinase in diabetes and obesity.

    abstract::The pyruvate dehydrogenase complex (PDC) is an emerging target for the treatment of metabolic syndrome. To maintain a steady-state concentration of adenosine triphosphate during the feed-fast cycle, cells require efficient utilization of fatty acid and glucose, which is controlled by the PDC. The PDC converts pyruvate...

    journal_title:Diabetes & metabolism journal

    pub_type: 杂志文章,评审


    authors: Lee IK

    更新日期:2014-06-01 00:00:00

  • Differences in Clinical Outcomes between Patients with and without Hypoglycemia during Hospitalization: A Retrospective Study Using Real-World Evidence.

    abstract:BACKGROUND:Some patients admitted to hospitals for glycemic control experience hypoglycemia despite regular meals and despite adhering to standard blood glucose control protocols. Different factors can have a negative impact on blood glucose control and prognosis after discharge. This study investigated risk factors fo...

    journal_title:Diabetes & metabolism journal

    pub_type: 杂志文章


    authors: Lee J,Kim TM,Kim H,Lee SH,Cho JH,Lee H,Yim HW,Yoon KH,Kim HS

    更新日期:2020-08-01 00:00:00

  • Diabetic cardiomyopathy and its prevention by nrf2: current status.

    abstract::Diabetic cardiomyopathy (DCM), as one of the major cardiac complications in diabetic patients, is known to related with oxidative stress that is due to a severe imbalance between reactive oxygen species (ROS) and/or reactive nitrogen species (RNS) generation and their clearance by antioxidant defense systems. Transcri...

    journal_title:Diabetes & metabolism journal

    pub_type: 杂志文章,评审


    authors: Chen J,Zhang Z,Cai L

    更新日期:2014-10-01 00:00:00

  • Polymeric gene delivery for diabetic treatment.

    abstract::Several polymers were used to delivery genes to diabetic animals. Polyaminobutyl glycolic acid was utilized to deliver IL-10 plasmid DNA to prevent autoimmune insulitis of non-obese diabetic (NOD) mouse. Polyethylene glycol grafted polylysine was combined with antisense glutamic acid decarboxylase (GAD) MRNA to repres...

    journal_title:Diabetes & metabolism journal

    pub_type: 杂志文章


    authors: Kim SW

    更新日期:2011-08-01 00:00:00

  • Retrospective analysis on the efficacy, safety and treatment failure group of sitagliptin for mean 10-month duration.

    abstract:BACKGROUND:To investigate the clinical results of sitagliptin (SITA) and the characteristics of the treatment failure group or of low responders to SITA. METHODS:A retrospective study of type 2 diabetic patients reviewed 99 cases, including 12 treatment failure cases, who stopped SITA because of worsening patients' co...

    journal_title:Diabetes & metabolism journal

    pub_type: 杂志文章


    authors: Kim WJ,Park CY,Jeong EH,Seo JY,Seol JS,Park SE,Rhee EJ,Lee WY,Oh KW,Park SW,Kim SW

    更新日期:2011-06-01 00:00:00

  • Risk Factors for the Development and Progression of Diabetic Kidney Disease in Patients with Type 2 Diabetes Mellitus and Advanced Diabetic Retinopathy.

    abstract:BACKGROUND:Some patients with type 2 diabetes mellitus (T2DM) do not develop diabetic kidney disease (DKD) despite the presence of advanced diabetic retinopathy (DR). We aimed to investigate the presence of DKD and its risk factors in patients with T2DM and advanced DR. METHODS:We conducted a cross-sectional study in ...

    journal_title:Diabetes & metabolism journal

    pub_type: 杂志文章


    authors: Yun KJ,Kim HJ,Kim MK,Kwon HS,Baek KH,Roh YJ,Song KH

    更新日期:2016-12-01 00:00:00

  • Comparison of the efficacy of glimepiride, metformin, and rosiglitazone monotherapy in korean drug-naïve type 2 diabetic patients: the practical evidence of antidiabetic monotherapy study.

    abstract:BACKGROUND:Although many anti-diabetic drugs have been used to control hyperglycemia for decades, the efficacy of commonly-used oral glucose-lowering agents in Korean type 2 diabetic patients has yet to be clearly demonstrated. METHODS:We evaluated the efficacy of glimepiride, metformin, and rosiglitazone as initial t...

    journal_title:Diabetes & metabolism journal

    pub_type: 杂志文章


    authors: Yoon KH,Shin JA,Kwon HS,Lee SH,Min KW,Ahn YB,Yoo SJ,Ahn KJ,Park SW,Lee KW,Sung YA,Park TS,Kim MS,Kim YK,Nam MS,Kim HS,Park IeB,Park JS,Woo JT,Son HY

    更新日期:2011-02-01 00:00:00

  • The Preventive Effects of 8 Weeks of Resistance Training on Glucose Tolerance and Muscle Fiber Type Composition in Zucker Rats.

    abstract:BACKGROUND:We investigated the therapeutic effects of resistance training on Zucker rats before and after the onset of diabetes to understand the importance of the timing of exercise intervention. We assessed whether 8 weeks of resistance training ameliorated impaired glucose tolerance and altered muscle fiber type com...

    journal_title:Diabetes & metabolism journal

    pub_type: 杂志文章


    authors: Kim JY,Choi MJ,So B,Kim HJ,Seong JK,Song W

    更新日期:2015-10-01 00:00:00

  • A survey of diabetic educators and patients for the revision of korean food exchange lists.

    abstract:BACKGROUND:Food exchange lists are one of the main methods of nutritional education. However, Korean food exchange lists have not been revised since 1994. Therefore, we surveyed the opinions of diabetes educators and patients with diabetes regarding the need for revision of the current food exchange lists. METHODS:For...

    journal_title:Diabetes & metabolism journal

    pub_type: 杂志文章


    authors: Cho JW,Kweon MR,Park YM,Woo MH,Yoo HS,Lim JH,Koo BK,Kim CH,Kim HJ,Park JS,Shin CH,Won KC,Lim S,Jang HC

    更新日期:2011-04-01 00:00:00

  • Diagnostic Accuracy of 64-Slice MDCT Coronary Angiography for the Assessment of Coronary Artery Disease in Korean Patients with Type 2 Diabetes.

    abstract:BACKGROUND:A 64-slice multidetector computed tomography (MDCT) is well known to be a useful noninvasive form of angiography for the general population, but not for certain patients with diabetes. The aim of this study was to investigate the diagnostic accuracy and usefulness of 64-slice MDCT coronary angiography for de...

    journal_title:Diabetes & metabolism journal

    pub_type: 杂志文章


    authors: Moon JS,Yoon JS,Won KC,Cho IH,Lee HW

    更新日期:2013-02-01 00:00:00

  • Hypoglycemia and Dementia Risk in Older Patients with Type 2 Diabetes Mellitus: A Propensity-Score Matched Analysis of a Population-Based Cohort Study.

    abstract:BACKGROUND:Type 2 diabetes mellitus (T2DM) is associated with an increased risk for dementia. The effects of hypoglycemia on dementia are controversial. Thus, we evaluated whether hypoglycemia increases the risk for dementia in senior patients with T2DM. METHODS:We used the Korean National Health Insurance Service Sen...

    journal_title:Diabetes & metabolism journal

    pub_type: 杂志文章


    authors: Kim YG,Park DG,Moon SY,Jeon JY,Kim HJ,Kim DJ,Lee KW,Han SJ

    更新日期:2020-02-01 00:00:00

  • Progression to Gestational Diabetes Mellitus in Pregnant Women with One Abnormal Value in Repeated Oral Glucose Tolerance Tests.

    abstract:BACKGROUND:Women with one abnormal value (OAV) in a 100 g oral glucose tolerance test (OGTT) during pregnancy are reported to have an increased risk of adverse pregnancy outcomes. However, there is limited data about whether women with OAV will progress to gestational diabetes mellitus (GDM) when the OGTT is repeated. ...

    journal_title:Diabetes & metabolism journal

    pub_type: 杂志文章


    authors: Kang S,Kim MH,Kim MY,Hong JS,Kwak SH,Choi SH,Lim S,Park KS,Jang HC

    更新日期:2019-10-01 00:00:00

  • Corrigendum: Prevalence of Depression and Glucose Abnormality in an Urbanizing Rural Population of Bangladesh.

    abstract::This corrects the article on p. 218 in vol. 39, PMID: 26124992. ...

    journal_title:Diabetes & metabolism journal

    pub_type: 已发布勘误


    authors: Natasha K,Hussain A,Azad Khan AK,Bhowmik B

    更新日期:2016-02-01 00:00:00

  • High Proportion of Adult Cases and Prevalence of Metabolic Syndrome in Type 1 Diabetes Mellitus Population in Korea: A Nationwide Study.

    abstract:BACKGROUND:The prevalence and incidence of type 1 diabetes mellitus (T1DM) in all age groups and the prevalence of metabolic syndrome in patients with T1DM in Korea were estimated. METHODS:The incidence and prevalence of T1DM between 2007 and 2013 were calculated using the Korean National Health Insurance Service (NHI...

    journal_title:Diabetes & metabolism journal

    pub_type: 杂志文章


    authors: Lee YB,Han K,Kim B,Jin SM,Lee SE,Jun JE,Ahn J,Kim G,Kim JH

    更新日期:2019-02-01 00:00:00

  • Glucose Effectiveness from Short Insulin-Modified IVGTT and Its Application to the Study of Women with Previous Gestational Diabetes Mellitus.

    abstract:BACKGROUND:This study aimed to design a simple surrogate marker (i.e., predictor) of the minimal model glucose effectiveness (SG), namely calculated SG (CSG), from a short insulin-modified intravenous glucose tolerance test (IM-IVGTT), and then to apply it to study women with previous gestational diabetes mellitus (pGD...

    journal_title:Diabetes & metabolism journal

    pub_type: 杂志文章


    authors: Morettini M,Castriota C,Göbl C,Kautzky-Willer A,Pacini G,Burattini L,Tura A

    更新日期:2020-04-01 00:00:00

  • A cross-sectional study of the phenotypes of obesity and insulin resistance in adults with down syndrome.

    abstract:BACKGROUND:Despite the confluence of multiple cardiovascular risk factors, subclinical atherosclerotic damage and cardiovascular events remain extremely rare in adults with Down syndrome (DS). We aim to determine the prevalence of obesity and metabolic disorders in an adult cohort with DS and to compare our findings wi...

    journal_title:Diabetes & metabolism journal

    pub_type: 杂志文章


    authors: Real de Asua D,Parra P,Costa R,Moldenhauer F,Suarez C

    更新日期:2014-12-01 00:00:00

  • Effects of Omega-3 Supplementation on Adipocytokines in Prediabetes and Type 2 Diabetes Mellitus: Systematic Review and Meta-Analysis of Randomized Controlled Trials.

    abstract:BACKGROUND:The objective of this systematic review and meta-analysis was to determine the effects of omega-3 supplementation on adipocytokine levels in adult prediabetic and diabetic individuals. METHODS:We searched PubMed, Medline, EMBASE, Scopus, Web of Science, Google Scholar, Cochrane Trial Register, World Health ...

    journal_title:Diabetes & metabolism journal

    pub_type: 杂志文章,评审


    authors: Becic T,Studenik C

    更新日期:2018-04-01 00:00:00

  • Status of Diabetic Neuropathy in Korea: A National Health Insurance Service-National Sample Cohort Analysis (2006 to 2015).

    abstract::This report presents the status of diabetic neuropathy (DN) in Korea as determined using a National Health Insurance ServiceNational Sample Cohort (NHIS-NSC). Annual prevalences of DN were estimated by age and gender using descriptive statistics. Pharmacological treatments for DN were also analyzed. The annual prevale...

    journal_title:Diabetes & metabolism journal

    pub_type: 杂志文章


    authors: Moon SS,Kim CH,Kang SM,Kim ES,Oh TJ,Yun JS,Cho HC,Kim DJ,Park TS

    更新日期:2021-01-01 00:00:00

  • Influence of visceral adiposity on cardiovascular autonomic neuropathy in patients with type 2 diabetes mellitus.

    abstract:BACKGROUND:The aim of this study was to investigate the influences of visceral adiposity on cardiovascular autonomic neuropathy (CAN) in patients with type 2 diabetes mellitus. METHODS:Two hundred eleven patients with type 2 diabetes participated in this study. Anthropometric and metabolic parameters were measured, an...

    journal_title:Diabetes & metabolism journal

    pub_type: 杂志文章


    authors: Jang EH,Kim NY,Park YM,Kim MK,Baek KH,Song KH,Lee KW,Kwon HS

    更新日期:2012-08-01 00:00:00

  • Comparison of Attitudes Regarding Quality of Life between Insulin-Treated Subjects with Diabetes Mellitus and Healthy Populations.

    abstract:BACKGROUND:Diabetes mellitus is a chronic disease and one of the main causes of mortality in developing countries. The main objective of treating all chronic diseases, of course, is to improve well-being and attain a satisfactory quality of life (QOL). The major goal of this study is comparison of attitude toward QOL i...

    journal_title:Diabetes & metabolism journal

    pub_type: 杂志文章


    authors: Hashemi Hefz Abad F,Shabany Hamedan M

    更新日期:2011-08-01 00:00:00

  • Non-Alcoholic Fatty Liver Disease: The Emerging Burden in Cardiometabolic and Renal Diseases.

    abstract::As the number of individuals with non-alcoholic fatty liver disease (NAFLD) has increased, the influence of NAFLD on other metabolic diseases has been highlighted. Accumulating epidemiologic evidence indicates that NAFLD not only affects the liver but also increases the risk of extra-hepatic diseases such as type 2 di...

    journal_title:Diabetes & metabolism journal

    pub_type: 杂志文章,评审


    authors: Han E,Lee YH

    更新日期:2017-12-01 00:00:00

  • Role of the Pyruvate Dehydrogenase Complex in Metabolic Remodeling: Differential Pyruvate Dehydrogenase Complex Functions in Metabolism.

    abstract::Mitochondrial dysfunction is a hallmark of metabolic diseases such as obesity, type 2 diabetes mellitus, neurodegenerative diseases, and cancers. Dysfunction occurs in part because of altered regulation of the mitochondrial pyruvate dehydrogenase complex (PDC), which acts as a central metabolic node that mediates pyru...

    journal_title:Diabetes & metabolism journal

    pub_type: 杂志文章,评审


    authors: Park S,Jeon JH,Min BK,Ha CM,Thoudam T,Park BY,Lee IK

    更新日期:2018-08-01 00:00:00

  • My Sweetheart Is Broken: Role of Glucose in Diabetic Cardiomyopathy.

    abstract::Despite overall reductions in heart disease prevalence, the risk of developing heart failure has remained 2-fold greater among people with diabetes. Growing evidence has supported that fluctuations in glucose level and uptake contribute to cardiovascular disease (CVD) by modifying proteins, DNA, and gene expression. I...

    journal_title:Diabetes & metabolism journal

    pub_type: 杂志文章,评审


    authors: Brahma MK,Pepin ME,Wende AR

    更新日期:2017-02-01 00:00:00

  • Role of HbA1c in the Screening of Diabetes Mellitus in a Korean Rural Community.

    abstract:BACKGROUND:Recently, the measurement of glycated hemoglobin (HbA1c) was recommended as an alternative to fasting plasma glucose or oral glucose tolerance tests for diagnosing diabetes mellitus (DM). In this study, we analyzed HbA1c levels for diabetes mellitus screening in a Korean rural population. METHODS:We analyze...

    journal_title:Diabetes & metabolism journal

    pub_type: 杂志文章


    authors: Kim JH,Kim GW,Lee MY,Shin JY,Shin YG,Koh SB,Chung CH

    更新日期:2012-02-01 00:00:00

  • Intensive individualized reinforcement education is important for the prevention of hypoglycemia in patients with type 2 diabetes.

    abstract:BACKGROUND:We investigated whether an intensive individualized reinforcement education program could influence the prevention of hypoglycemic events in patients with type 2 diabetes. METHODS:From March 2013 to September 2013, patients aged 35 to 75 years with type 2 diabetes who had not previously participated in diab...

    journal_title:Diabetes & metabolism journal

    pub_type: 杂志文章


    authors: Yong YM,Shin KM,Lee KM,Cho JY,Ko SH,Yoon MH,Kim TW,Jeong JH,Park YM,Ko SH,Ahn YB

    更新日期:2015-04-01 00:00:00