Statin Discontinuation after Achieving a Target Low Density Lipoprotein Cholesterol Level in Type 2 Diabetic Patients without Cardiovascular Disease: A Randomized Controlled Study.

abstract：BACKGROUND:We evaluated decreases in glycosylated hemoglobin (HbA1c) achieved by reducing carbohydrate from various sources in type 2 diabetes mellitus patients. METHODS:We followed up 138 male and 107 female outpatients on a moderate low-carbohydrate diet without diabetic medication for 6 months. Changes in carbohydr...

journal_title：Diabetes & metabolism journal

authors： Haimoto H,Watanabe S,Maeda K,Murase T,Wakai K

更新日期：2020-07-21 00:00:00

abstract：:Serotonin (5-hydroxytryptamine [5-HT]) is a monoamine that has various functions in both neuronal and non-neuronal systems. In the central nervous system, 5-HT regulates mood and feeding behaviors as a neurotransmitter. Thus, there have been many trials aimed at increasing the activity of 5-HT in the central nervous s...

journal_title：Diabetes & metabolism journal

authors： Oh CM,Park S,Kim H

更新日期：2016-04-01 00:00:00

abstract：BACKGROUND:Chronic exposure to elevated levels of free fatty acids contributes to pancreatic β-cell dysfunction. Although it is well known that metformin induces cellular energy depletion and a concomitant activation of AMP-activated protein kinase (AMPK) through inhibition of the respiratory chain, previous studies ha...

journal_title：Diabetes & metabolism journal

authors： Kim HI,Lee JS,Kwak BK,Hwang WM,Kim MJ,Kim YB,Chung SS,Park KS

更新日期：2019-12-01 00:00:00

abstract：BACKGROUND:A latent cytomegalovirus (CMV) cause chronic inflammation through undesirable inflation of cell-mediated immune response. CMV immunoglobulin G has been associated with cardiovascular disease and type 1 diabetes mellitus. We evaluated impact of CMV diseases on new-onset type 2 diabetes mellitus (T2DM). METHO...

journal_title：Diabetes & metabolism journal

authors： Yoo SG,Han KD,Lee KH,La Y,Kwon DE,Han SH

更新日期：2019-12-01 00:00:00

abstract：:Mitochondrial dysfunction is a hallmark of metabolic diseases such as obesity, type 2 diabetes mellitus, neurodegenerative diseases, and cancers. Dysfunction occurs in part because of altered regulation of the mitochondrial pyruvate dehydrogenase complex (PDC), which acts as a central metabolic node that mediates pyru...

journal_title：Diabetes & metabolism journal

authors： Park S,Jeon JH,Min BK,Ha CM,Thoudam T,Park BY,Lee IK

更新日期：2018-08-01 00:00:00

abstract：:In cases of chronic hyperglycemia, advanced glycation end-products (AGEs) are actively produced and accumulated in the circulating blood and various tissues. AGEs also accelerate the expression of receptors for AGEs, and they play an important role in the development of diabetic vascular complications through various ...

journal_title：Diabetes & metabolism journal

authors： Rhee SY,Kim YS

更新日期：2018-06-01 00:00:00

abstract：:This report presents the status of diabetic neuropathy (DN) in Korea as determined using a National Health Insurance ServiceNational Sample Cohort (NHIS-NSC). Annual prevalences of DN were estimated by age and gender using descriptive statistics. Pharmacological treatments for DN were also analyzed. The annual prevale...

journal_title：Diabetes & metabolism journal

authors： Moon SS,Kim CH,Kang SM,Kim ES,Oh TJ,Yun JS,Cho HC,Kim DJ,Park TS

更新日期：2021-01-01 00:00:00

abstract：:Several polymers were used to delivery genes to diabetic animals. Polyaminobutyl glycolic acid was utilized to deliver IL-10 plasmid DNA to prevent autoimmune insulitis of non-obese diabetic (NOD) mouse. Polyethylene glycol grafted polylysine was combined with antisense glutamic acid decarboxylase (GAD) MRNA to repres...

journal_title：Diabetes & metabolism journal

authors： Kim SW

更新日期：2011-08-01 00:00:00

abstract：BACKGROUND:Some patients admitted to hospitals for glycemic control experience hypoglycemia despite regular meals and despite adhering to standard blood glucose control protocols. Different factors can have a negative impact on blood glucose control and prognosis after discharge. This study investigated risk factors fo...

journal_title：Diabetes & metabolism journal

authors： Lee J,Kim TM,Kim H,Lee SH,Cho JH,Lee H,Yim HW,Yoon KH,Kim HS

更新日期：2020-08-01 00:00:00

abstract：BACKGROUND:To explore the efficacy and safety of switching from once-daily basal insulin therapy to once-daily pre-meal injection insulin degludec/insulin aspart (IDegAsp) with respect to the glycemic control of participants with type 2 diabetes mellitus (T2DM). METHODS:In this multicenter, open-label, prospective, ra...

journal_title：Diabetes & metabolism journal

authors： Cho KY,Nakamura A,Oba-Yamamoto C,Tsuchida K,Yanagiya S,Manda N,Kurihara Y,Aoki S,Atsumi T,Miyoshi H

更新日期：2020-08-01 00:00:00

abstract：BACKGROUND:This study aimed to design a simple surrogate marker (i.e., predictor) of the minimal model glucose effectiveness (SG), namely calculated SG (CSG), from a short insulin-modified intravenous glucose tolerance test (IM-IVGTT), and then to apply it to study women with previous gestational diabetes mellitus (pGD...

journal_title：Diabetes & metabolism journal

authors： Morettini M,Castriota C,Göbl C,Kautzky-Willer A,Pacini G,Burattini L,Tura A

更新日期：2020-04-01 00:00:00

abstract：BACKGROUND:Diabetes mellitus is a chronic disease and one of the main causes of mortality in developing countries. The main objective of treating all chronic diseases, of course, is to improve well-being and attain a satisfactory quality of life (QOL). The major goal of this study is comparison of attitude toward QOL i...

journal_title：Diabetes & metabolism journal

authors： Hashemi Hefz Abad F,Shabany Hamedan M

更新日期：2011-08-01 00:00:00

abstract：:Despite overall reductions in heart disease prevalence, the risk of developing heart failure has remained 2-fold greater among people with diabetes. Growing evidence has supported that fluctuations in glucose level and uptake contribute to cardiovascular disease (CVD) by modifying proteins, DNA, and gene expression. I...

journal_title：Diabetes & metabolism journal

authors： Brahma MK,Pepin ME,Wende AR

更新日期：2017-02-01 00:00:00

abstract：BACKGROUND:This is a subgroup analysis of Korean patients from a phase 3 clinical trial investigating the efficacy and safety of ipragliflozin in patients with type 2 diabetes mellitus inadequately controlled with metformin. METHODS:This multicenter, placebo-controlled, double-blind, parallel-group study was carried o...

journal_title：Diabetes & metabolism journal

authors： Min KW,Ku BJ,Lee JH,Kim MS,Ahn KJ,Lee MK,Kokubo S,Yoshida S,Cho HJ,Cha BS

更新日期：2017-04-01 00:00:00

abstract：BACKGROUND:The prevalence and incidence of type 1 diabetes mellitus (T1DM) in all age groups and the prevalence of metabolic syndrome in patients with T1DM in Korea were estimated. METHODS:The incidence and prevalence of T1DM between 2007 and 2013 were calculated using the Korean National Health Insurance Service (NHI...

journal_title：Diabetes & metabolism journal

authors： Lee YB,Han K,Kim B,Jin SM,Lee SE,Jun JE,Ahn J,Kim G,Kim JH

更新日期：2019-02-01 00:00:00

abstract：BACKGROUND:In order to overcome the limitations of body mass index (BMI) and waist circumference (WC), the z-score of the log-transformed A Body Shape Index (LBSIZ) has recently been introduced. In this study, we analyzed the relationship between the LBSIZ and cardiovascular disease (CVD) in a Korean representative sam...

journal_title：Diabetes & metabolism journal

authors： Chung W,Park JH,Chung HS,Yu JM,Moon S,Kim DS

更新日期：2019-10-01 00:00:00

abstract：BACKGROUND:We investigated whether patients' perceived glycemic control and self-reported diabetes self-care correlated with their actual glycemic control. METHODS:A survey was administered among patients with diabetes mellitus at an outpatient clinic with structured self-report questionnaires regarding perceived glyc...

journal_title：Diabetes & metabolism journal

authors： Ohn JH,Lee JH,Hong ES,Koo BK,Kim SW,Yi KH,Moon MK

更新日期：2015-02-01 00:00:00

abstract：BACKGROUND:Women with one abnormal value (OAV) in a 100 g oral glucose tolerance test (OGTT) during pregnancy are reported to have an increased risk of adverse pregnancy outcomes. However, there is limited data about whether women with OAV will progress to gestational diabetes mellitus (GDM) when the OGTT is repeated. ...

journal_title：Diabetes & metabolism journal

authors： Kang S,Kim MH,Kim MY,Hong JS,Kwak SH,Choi SH,Lim S,Park KS,Jang HC

更新日期：2019-10-01 00:00:00

abstract：BACKGROUND:Voglibose, an α-glucosidase inhibitor, inhibits breakdown of complex carbohydrates into simple sugar units in intestine. Studies showed that voglibose metabolism in the liver might be negligible due to its poor intestinal absorption. Numerous microorganisms live in intestine and have several roles in metabol...

journal_title：Diabetes & metabolism journal

authors： Nepal MR,Kang MJ,Kim GH,Cha DH,Kim JH,Jeong TC

更新日期：2020-12-01 00:00:00

abstract：:Obesity and diabetes has become a major epidemic across the globe. Controlling obesity has been a challenge since this would require either increased physical activity or reduced caloric intake; both are difficult to enforce. There has been renewed interest in exploiting pathways such as uncoupling protein 1 (UCP1)-me...

journal_title：Diabetes & metabolism journal

authors： Periasamy M,Herrera JL,Reis FCG

更新日期：2017-10-01 00:00:00

abstract：BACKGROUND:Although many anti-diabetic drugs have been used to control hyperglycemia for decades, the efficacy of commonly-used oral glucose-lowering agents in Korean type 2 diabetic patients has yet to be clearly demonstrated. METHODS:We evaluated the efficacy of glimepiride, metformin, and rosiglitazone as initial t...

journal_title：Diabetes & metabolism journal

authors： Yoon KH,Shin JA,Kwon HS,Lee SH,Min KW,Ahn YB,Yoo SJ,Ahn KJ,Park SW,Lee KW,Sung YA,Park TS,Kim MS,Kim YK,Nam MS,Kim HS,Park IeB,Park JS,Woo JT,Son HY

更新日期：2011-02-01 00:00:00

abstract：:Cyclic adenosine monophosphate (cAMP) signaling is critical for regulating metabolic homeostasis in mammals. In particular, transcriptional regulation by cAMP response element-binding protein (CREB) and its coactivator, CREB-regulated transcription coactivator (CRTC), is essential for controlling the expression of cri...

journal_title：Diabetes & metabolism journal

authors： Han HS,Kwon Y,Koo SH

更新日期：2020-08-01 00:00:00

abstract：:Care of the elderly population with diabetes may not be restricted to the management of hyperglycemia, associated risk factors, and specific diabetic complications. An integrated approach should also include the assessment and management of gerontological problems. Both diabetes mellitus and aging interact toward the ...

journal_title：Diabetes & metabolism journal

authors： Yoo HJ

更新日期：2017-06-01 00:00:00

abstract：:As the number of individuals with non-alcoholic fatty liver disease (NAFLD) has increased, the influence of NAFLD on other metabolic diseases has been highlighted. Accumulating epidemiologic evidence indicates that NAFLD not only affects the liver but also increases the risk of extra-hepatic diseases such as type 2 di...

journal_title：Diabetes & metabolism journal

authors： Han E,Lee YH

更新日期：2017-12-01 00:00:00

abstract：BACKGROUND:The prevalence of novel type 1 diabetes mellitus (T1DM) antibodies targeting eukaryote translation elongation factor 1 alpha 1 autoantibody (EEF1A1-AAb) and ubiquitin-conjugating enzyme 2L3 autoantibody (UBE2L3-AAb) has been shown to be negatively correlated with age in T1DM subjects. Therefore, we aimed to ...

journal_title：Diabetes & metabolism journal

authors： Kim EG,Kwak SH,Hwang D,Yi EC,Park KS,Koo BK,Kim KM

更新日期：2016-04-01 00:00:00

abstract：:A growing body of evidence suggests that hyperglycemia-induced oxidative stress plays an important role in diabetic complications, especially β-cell dysfunction and failure. Under physiological conditions, reactive oxygen species serve as second messengers that facilitate signal transduction and gene expression in pan...

journal_title：Diabetes & metabolism journal

authors： Karunakaran U,Park KG

更新日期：2013-04-01 00:00:00

abstract：:Although glucose-lowering treatment shows some risk lowering effects in cardiovascular diseases, risks of macrovascular and microvascular complications have still remained, and development of new therapeutic strategies is needed. Recent data have shown that peroxisome proliferator activated receptor-α (PPAR-α) plays a...

journal_title：Diabetes & metabolism journal

authors： Seok H,Cha BS

更新日期：2013-10-01 00:00:00

abstract：:Diabetic cardiomyopathy (DCM), as one of the major cardiac complications in diabetic patients, is known to related with oxidative stress that is due to a severe imbalance between reactive oxygen species (ROS) and/or reactive nitrogen species (RNS) generation and their clearance by antioxidant defense systems. Transcri...

journal_title：Diabetes & metabolism journal

authors： Chen J,Zhang Z,Cai L

更新日期：2014-10-01 00:00:00

abstract：:There are many studies on the prevalence, clinical characteristics, and economic burden of diabetes across the past four decades in Korea. Nonetheless, there is a dearth of nationwide study regarding diabetes encompassing all age group. Eight years ago, the Committee on the Epidemiology of Diabetes Mellitus of Korean ...

journal_title：Diabetes & metabolism journal

authors： Task Force Team for Basic Statistical Study of Korean Diabetes Mellitus of Korean Diabetes Association.,Park IeB,Kim J,Kim DJ,Chung CH,Oh JY,Park SW,Lee J,Choi KM,Min KW,Park JH,Son HS,Ahn CW,Kim H,Lee S,Lee IB,Choi I,B

更新日期：2013-08-01 00:00:00

abstract：BACKGROUND:Non-alcoholic fatty liver disease (NAFLD) is increasingly recognized as a major cause of liver-related morbidity and mortality. The underlying mechanisms of disease progression remain poorly understood, and primary therapy of NAFLD is not yet established. We investigated the effects of dietary oleate on the ...

journal_title：Diabetes & metabolism journal

authors： Lee JY,Moon JH,Park JS,Lee BW,Kang ES,Ahn CW,Lee HC,Cha BS

更新日期：2011-10-01 00:00:00