Abstract:
BACKGROUND:This study investigated the rate of relapse of dyslipidemia and the factors which could predict relapse following a short-term statin discontinuation after achieving a target low density lipoprotein cholesterol (LDL-C) level in type 2 diabetic patients without cardiovascular disease (CVD). METHODS:Ninety-nine subjects on rosuvastatin treatment and whose LDL-C level was lower than 100 mg/dL were randomly assigned to discontinue or maintain statin treatment at a 2:1 ratio. The subjects were followed-up after 10 weeks. A relapse of dyslipidemia was defined as a reascent of LDL-C level to greater than 100 mg/dL. RESULTS:The statin discontinuation group had a significant rate of relapse compared to the maintenance group (79% vs. 3%, respectively). Pretreatment and baseline lipid levels, their ratios, and hemoglobin A1c level were significantly different between the relapse and nonrelapse groups. The pretreatment and baseline lipid profiles and their ratios were independently associated with relapse. The pretreatment LDL-C level was the most useful parameter for predicting a relapse, with a cutoff of 123 mg/dL. During the follow-up period, no CVD event was noted. CONCLUSION:The relapse rate of dyslipidemia was high when statins were discontinued in type 2 diabetic patients without CVD. Statin discontinuation should be considered carefully based on the pretreatment lipid profiles of patients.
journal_name
Diabetes Metab Jjournal_title
Diabetes & metabolism journalauthors
Lee SH,Kwon HS,Park YM,Ko SH,Choi YH,Yoon KH,Ahn YBdoi
10.4093/dmj.2014.38.1.64subject
Has Abstractpub_date
2014-02-01 00:00:00pages
64-73issue
1eissn
2233-6079issn
2233-6087journal_volume
38pub_type
杂志文章abstract:BACKGROUND:Some patients with type 2 diabetes mellitus (T2DM) do not develop diabetic kidney disease (DKD) despite the presence of advanced diabetic retinopathy (DR). We aimed to investigate the presence of DKD and its risk factors in patients with T2DM and advanced DR. METHODS:We conducted a cross-sectional study in ...
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abstract:BACKGROUND:Voglibose, an α-glucosidase inhibitor, inhibits breakdown of complex carbohydrates into simple sugar units in intestine. Studies showed that voglibose metabolism in the liver might be negligible due to its poor intestinal absorption. Numerous microorganisms live in intestine and have several roles in metabol...
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abstract::Care of the elderly population with diabetes may not be restricted to the management of hyperglycemia, associated risk factors, and specific diabetic complications. An integrated approach should also include the assessment and management of gerontological problems. Both diabetes mellitus and aging interact toward the ...
journal_title:Diabetes & metabolism journal
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更新日期:2017-06-01 00:00:00
abstract:BACKGROUND:The prevalence of novel type 1 diabetes mellitus (T1DM) antibodies targeting eukaryote translation elongation factor 1 alpha 1 autoantibody (EEF1A1-AAb) and ubiquitin-conjugating enzyme 2L3 autoantibody (UBE2L3-AAb) has been shown to be negatively correlated with age in T1DM subjects. Therefore, we aimed to ...
journal_title:Diabetes & metabolism journal
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abstract::This corrects the article on p. 218 in vol. 39, PMID: 26124992. ...
journal_title:Diabetes & metabolism journal
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abstract::Mitochondrial dysfunction is a hallmark of metabolic diseases such as obesity, type 2 diabetes mellitus, neurodegenerative diseases, and cancers. Dysfunction occurs in part because of altered regulation of the mitochondrial pyruvate dehydrogenase complex (PDC), which acts as a central metabolic node that mediates pyru...
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abstract::Although glucose-lowering treatment shows some risk lowering effects in cardiovascular diseases, risks of macrovascular and microvascular complications have still remained, and development of new therapeutic strategies is needed. Recent data have shown that peroxisome proliferator activated receptor-α (PPAR-α) plays a...
journal_title:Diabetes & metabolism journal
pub_type: 杂志文章,评审
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更新日期:2013-10-01 00:00:00
abstract:BACKGROUND:To investigate the clinical results of sitagliptin (SITA) and the characteristics of the treatment failure group or of low responders to SITA. METHODS:A retrospective study of type 2 diabetic patients reviewed 99 cases, including 12 treatment failure cases, who stopped SITA because of worsening patients' co...
journal_title:Diabetes & metabolism journal
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abstract:BACKGROUND:Non-alcoholic fatty liver disease (NAFLD) is increasingly recognized as a major cause of liver-related morbidity and mortality. The underlying mechanisms of disease progression remain poorly understood, and primary therapy of NAFLD is not yet established. We investigated the effects of dietary oleate on the ...
journal_title:Diabetes & metabolism journal
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更新日期:2011-10-01 00:00:00
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journal_title:Diabetes & metabolism journal
pub_type: 杂志文章,评审
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abstract:BACKGROUND:A 64-slice multidetector computed tomography (MDCT) is well known to be a useful noninvasive form of angiography for the general population, but not for certain patients with diabetes. The aim of this study was to investigate the diagnostic accuracy and usefulness of 64-slice MDCT coronary angiography for de...
journal_title:Diabetes & metabolism journal
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更新日期:2013-02-01 00:00:00
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journal_title:Diabetes & metabolism journal
pub_type: 杂志文章
doi:10.4093/dmj.2015.39.5.424
更新日期:2015-10-01 00:00:00
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journal_title:Diabetes & metabolism journal
pub_type: 已发布勘误
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更新日期:2015-06-01 00:00:00
abstract::Cyclic adenosine monophosphate (cAMP) signaling is critical for regulating metabolic homeostasis in mammals. In particular, transcriptional regulation by cAMP response element-binding protein (CREB) and its coactivator, CREB-regulated transcription coactivator (CRTC), is essential for controlling the expression of cri...
journal_title:Diabetes & metabolism journal
pub_type: 杂志文章,评审
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更新日期:2020-08-01 00:00:00
abstract:BACKGROUND:To explore the efficacy and safety of switching from once-daily basal insulin therapy to once-daily pre-meal injection insulin degludec/insulin aspart (IDegAsp) with respect to the glycemic control of participants with type 2 diabetes mellitus (T2DM). METHODS:In this multicenter, open-label, prospective, ra...
journal_title:Diabetes & metabolism journal
pub_type: 杂志文章
doi:10.4093/dmj.2019.0093
更新日期:2020-08-01 00:00:00
abstract::This report presents the status of diabetic neuropathy (DN) in Korea as determined using a National Health Insurance ServiceNational Sample Cohort (NHIS-NSC). Annual prevalences of DN were estimated by age and gender using descriptive statistics. Pharmacological treatments for DN were also analyzed. The annual prevale...
journal_title:Diabetes & metabolism journal
pub_type: 杂志文章
doi:10.4093/dmj.2020.0120
更新日期:2021-01-01 00:00:00
abstract:BACKGROUND:Diabetes self-management education and reinforcement are important for effective management of the disease. We investigated the effectiveness of interactive small-group education on glycemic, blood pressure, and lipid levels. METHODS:For this study, 207 type 2 diabetes patients with suboptimal glycemic cont...
journal_title:Diabetes & metabolism journal
pub_type: 杂志文章
doi:10.4093/dmj.2011.35.6.580
更新日期:2011-12-01 00:00:00
abstract:BACKGROUND:Food exchange lists are one of the main methods of nutritional education. However, Korean food exchange lists have not been revised since 1994. Therefore, we surveyed the opinions of diabetes educators and patients with diabetes regarding the need for revision of the current food exchange lists. METHODS:For...
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pub_type: 杂志文章
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更新日期:2011-04-01 00:00:00
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pub_type: 杂志文章
doi:10.4093/dmj.2015.39.1.31
更新日期:2015-02-01 00:00:00
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doi:10.4093/dmj.2014.38.4.245
更新日期:2014-08-01 00:00:00
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更新日期:2020-08-01 00:00:00
abstract::Nonalcoholic fatty liver disease (NAFLD) and diabetes are common metabolic disorders whose prevalence rates are expected to rise worldwide, corresponding to aging and increasingly obese populations. Compared to the general population (around 25%), 50% to 70% of people with diabetes have NAFLD, and NAFLD severity (incl...
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更新日期:2019-02-01 00:00:00
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journal_title:Diabetes & metabolism journal
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更新日期:2020-04-01 00:00:00
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journal_title:Diabetes & metabolism journal
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更新日期:2016-04-01 00:00:00
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journal_title:Diabetes & metabolism journal
pub_type: 杂志文章
doi:10.4093/dmj.2013.37.6.395
更新日期:2013-12-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2018-04-01 00:00:00
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更新日期:2017-12-01 00:00:00
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journal_title:Diabetes & metabolism journal
pub_type: 杂志文章
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更新日期:2019-10-01 00:00:00