Abstract:
:Adipose tissue, which was once viewed as a simple organ for storage of triglycerides, is now considered an important endocrine organ. Abnormal adipose tissue mass is associated with defects in endocrine and metabolic functions which are the underlying causes of the metabolic syndrome. Many adipokines, hormones secreted by adipose tissue, regulate cells from the immune system. Interestingly, most of these adipokines are proinflammatory mediators, which increase dramatically in the obese state and are believed to be involved in the pathogenesis of insulin resistance. Drugs that target peroxisome proliferator-activated receptor-γ have been shown to possess anti-inflammatory effects in animal models of diabetes. These findings, and the link between inflammation and the metabolic syndrome, will be reviewed here.
journal_name
Diabetes Metab Jjournal_title
Diabetes & metabolism journalauthors
Corzo C,Griffin PRdoi
10.4093/dmj.2013.37.6.395subject
Has Abstractpub_date
2013-12-01 00:00:00pages
395-403issue
6eissn
2233-6079issn
2233-6087journal_volume
37pub_type
杂志文章abstract:BACKGROUND:Diabetes self-management education and reinforcement are important for effective management of the disease. We investigated the effectiveness of interactive small-group education on glycemic, blood pressure, and lipid levels. METHODS:For this study, 207 type 2 diabetes patients with suboptimal glycemic cont...
journal_title:Diabetes & metabolism journal
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更新日期:2011-12-01 00:00:00
abstract:BACKGROUND:The aim of this study was to investigate the influences of visceral adiposity on cardiovascular autonomic neuropathy (CAN) in patients with type 2 diabetes mellitus. METHODS:Two hundred eleven patients with type 2 diabetes participated in this study. Anthropometric and metabolic parameters were measured, an...
journal_title:Diabetes & metabolism journal
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pub_type: 杂志文章,评审
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更新日期:2019-02-01 00:00:00
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journal_title:Diabetes & metabolism journal
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doi:10.4093/dmj.2012.36.5.357
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abstract:BACKGROUND:Despite the confluence of multiple cardiovascular risk factors, subclinical atherosclerotic damage and cardiovascular events remain extremely rare in adults with Down syndrome (DS). We aim to determine the prevalence of obesity and metabolic disorders in an adult cohort with DS and to compare our findings wi...
journal_title:Diabetes & metabolism journal
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更新日期:2014-12-01 00:00:00
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journal_title:Diabetes & metabolism journal
pub_type: 杂志文章
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journal_title:Diabetes & metabolism journal
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journal_title:Diabetes & metabolism journal
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更新日期:2013-06-01 00:00:00
abstract:BACKGROUND:Non-alcoholic fatty liver disease (NAFLD) is increasingly recognized as a major cause of liver-related morbidity and mortality. The underlying mechanisms of disease progression remain poorly understood, and primary therapy of NAFLD is not yet established. We investigated the effects of dietary oleate on the ...
journal_title:Diabetes & metabolism journal
pub_type: 杂志文章
doi:10.4093/dmj.2011.35.5.489
更新日期:2011-10-01 00:00:00
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journal_title:Diabetes & metabolism journal
pub_type: 杂志文章
doi:10.4093/dmj.2018.0179
更新日期:2019-12-01 00:00:00
abstract::Several polymers were used to delivery genes to diabetic animals. Polyaminobutyl glycolic acid was utilized to deliver IL-10 plasmid DNA to prevent autoimmune insulitis of non-obese diabetic (NOD) mouse. Polyethylene glycol grafted polylysine was combined with antisense glutamic acid decarboxylase (GAD) MRNA to repres...
journal_title:Diabetes & metabolism journal
pub_type: 杂志文章
doi:10.4093/dmj.2011.35.4.317
更新日期:2011-08-01 00:00:00
abstract::Fibroblast growth factor 21 (FGF21) is an endocrine hormone that is primarily expressed in the liver and exerts beneficial effects on obesity and related metabolic diseases. In addition to its remarkable pharmacologic actions, the physiological roles of FGF21 include the maintenance of energy homeostasis in the body i...
journal_title:Diabetes & metabolism journal
pub_type: 杂志文章,评审
doi:10.4093/dmj.2014.38.4.245
更新日期:2014-08-01 00:00:00
abstract:BACKGROUND:Some patients with type 2 diabetes mellitus (T2DM) do not develop diabetic kidney disease (DKD) despite the presence of advanced diabetic retinopathy (DR). We aimed to investigate the presence of DKD and its risk factors in patients with T2DM and advanced DR. METHODS:We conducted a cross-sectional study in ...
journal_title:Diabetes & metabolism journal
pub_type: 杂志文章
doi:10.4093/dmj.2016.40.6.473
更新日期:2016-12-01 00:00:00
abstract:BACKGROUND:Rebaudioside A and erythritol are nonnutritive sweeteners. There have been several studies of their glycemic effects, but the outcomes remain controversial. The purpose of this study was to evaluate the glycemic effects of rebaudioside A and erythritol as a sweetener in people with glucose intolerance. METH...
journal_title:Diabetes & metabolism journal
pub_type: 杂志文章
doi:10.4093/dmj.2016.40.4.283
更新日期:2016-08-01 00:00:00
abstract::As the number of individuals with non-alcoholic fatty liver disease (NAFLD) has increased, the influence of NAFLD on other metabolic diseases has been highlighted. Accumulating epidemiologic evidence indicates that NAFLD not only affects the liver but also increases the risk of extra-hepatic diseases such as type 2 di...
journal_title:Diabetes & metabolism journal
pub_type: 杂志文章,评审
doi:10.4093/dmj.2017.41.6.430
更新日期:2017-12-01 00:00:00
abstract::There are many studies on the prevalence, clinical characteristics, and economic burden of diabetes across the past four decades in Korea. Nonetheless, there is a dearth of nationwide study regarding diabetes encompassing all age group. Eight years ago, the Committee on the Epidemiology of Diabetes Mellitus of Korean ...
journal_title:Diabetes & metabolism journal
pub_type: 杂志文章
doi:10.4093/dmj.2013.37.4.233
更新日期:2013-08-01 00:00:00
abstract:BACKGROUND:The second derivative of the finger photoplethysmogram (SDPTG) is an indicator of arterial stiffness. The present study was conducted to clarify the factor structure of indices of the SDPTG in combination with components of the metabolic syndrome (MetS), to elucidate the significance of the SDPTG among vario...
journal_title:Diabetes & metabolism journal
pub_type: 杂志文章
doi:10.4093/dmj.2013.37.1.40
更新日期:2013-02-01 00:00:00
abstract::Diabetic cardiomyopathy (DCM), as one of the major cardiac complications in diabetic patients, is known to related with oxidative stress that is due to a severe imbalance between reactive oxygen species (ROS) and/or reactive nitrogen species (RNS) generation and their clearance by antioxidant defense systems. Transcri...
journal_title:Diabetes & metabolism journal
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doi:10.4093/dmj.2014.38.5.337
更新日期:2014-10-01 00:00:00
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journal_title:Diabetes & metabolism journal
pub_type: 杂志文章,评审
doi:10.4093/dmj.2016.40.2.89
更新日期:2016-04-01 00:00:00
abstract:BACKGROUND:Latent autoimmune diabetes in adults (LADA) refers to a specific type of diabetes characterized by adult onset, presence of islet auto-antibodies, insulin independence at the time of diagnosis, and rapid decline in β-cell function. The prevalence of LADA among patients with type 2 diabetes varies from 2% to ...
journal_title:Diabetes & metabolism journal
pub_type: 杂志文章
doi:10.4093/dmj.2012.36.2.136
更新日期:2012-04-01 00:00:00
abstract::Despite overall reductions in heart disease prevalence, the risk of developing heart failure has remained 2-fold greater among people with diabetes. Growing evidence has supported that fluctuations in glucose level and uptake contribute to cardiovascular disease (CVD) by modifying proteins, DNA, and gene expression. I...
journal_title:Diabetes & metabolism journal
pub_type: 杂志文章,评审
doi:10.4093/dmj.2017.41.1.1
更新日期:2017-02-01 00:00:00
abstract:BACKGROUND:A 64-slice multidetector computed tomography (MDCT) is well known to be a useful noninvasive form of angiography for the general population, but not for certain patients with diabetes. The aim of this study was to investigate the diagnostic accuracy and usefulness of 64-slice MDCT coronary angiography for de...
journal_title:Diabetes & metabolism journal
pub_type: 杂志文章
doi:10.4093/dmj.2013.37.1.54
更新日期:2013-02-01 00:00:00
abstract::Over the past decade, growing evidence has established the gut microbiota as one of the most important determinants of metabolic disorders such as obesity and type 2 diabetes. Indeed, obesogenic diet can drastically alter bacterial populations (i.e., dysbiosis) leading to activation of pro-inflammatory mechanisms and ...
journal_title:Diabetes & metabolism journal
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doi:10.4093/dmj.2015.39.4.291
更新日期:2015-08-01 00:00:00
abstract:BACKGROUND:A latent cytomegalovirus (CMV) cause chronic inflammation through undesirable inflation of cell-mediated immune response. CMV immunoglobulin G has been associated with cardiovascular disease and type 1 diabetes mellitus. We evaluated impact of CMV diseases on new-onset type 2 diabetes mellitus (T2DM). METHO...
journal_title:Diabetes & metabolism journal
pub_type: 杂志文章
doi:10.4093/dmj.2018.0167
更新日期:2019-12-01 00:00:00
abstract:BACKGROUND:Type 2 diabetes mellitus (T2DM) is associated with an increased risk for dementia. The effects of hypoglycemia on dementia are controversial. Thus, we evaluated whether hypoglycemia increases the risk for dementia in senior patients with T2DM. METHODS:We used the Korean National Health Insurance Service Sen...
journal_title:Diabetes & metabolism journal
pub_type: 杂志文章
doi:10.4093/dmj.2018.0260
更新日期:2020-02-01 00:00:00
abstract::This report presents the status of diabetic neuropathy (DN) in Korea as determined using a National Health Insurance ServiceNational Sample Cohort (NHIS-NSC). Annual prevalences of DN were estimated by age and gender using descriptive statistics. Pharmacological treatments for DN were also analyzed. The annual prevale...
journal_title:Diabetes & metabolism journal
pub_type: 杂志文章
doi:10.4093/dmj.2020.0120
更新日期:2021-01-01 00:00:00
abstract::Diabetes is a leading cause of end-stage renal disease. Therefore, prevention of renal dysfunction is an important treatment goal in the management of diabetes. The data of landmark cardiovascular outcome trials of sodium-glucose cotransporter-2 (SGLT2) inhibitor showed profound reno-protective effects. The Korean Dia...
journal_title:Diabetes & metabolism journal
pub_type: 杂志文章,评审
doi:10.4093/dmj.2020.0172
更新日期:2020-08-01 00:00:00
abstract:BACKGROUND:The objective of this systematic review and meta-analysis was to determine the effects of omega-3 supplementation on adipocytokine levels in adult prediabetic and diabetic individuals. METHODS:We searched PubMed, Medline, EMBASE, Scopus, Web of Science, Google Scholar, Cochrane Trial Register, World Health ...
journal_title:Diabetes & metabolism journal
pub_type: 杂志文章,评审
doi:10.4093/dmj.2018.42.2.101
更新日期:2018-04-01 00:00:00