Abstract:
BACKGROUND:Chronic exposure to elevated levels of free fatty acids contributes to pancreatic β-cell dysfunction. Although it is well known that metformin induces cellular energy depletion and a concomitant activation of AMP-activated protein kinase (AMPK) through inhibition of the respiratory chain, previous studies have shown inconsistent results with regard to the action of metformin on pancreatic β-cells. We therefore examined the effects of metformin on pancreatic β-cells under lipotoxic stress. METHODS:NIT-1 cells and mouse islets were exposed to palmitate and treated with 0.05 and 0.5 mM metformin. Cell viability, glucose-stimulated insulin secretion, cellular adenosine triphosphate, reactive oxygen species (ROS) levels and Rho kinase (ROCK) activities were measured. The phosphorylation of AMPK was evaluated by Western blot analysis and mRNA levels of endoplasmic reticulum (ER) stress markers and NADPH oxidase (NOX) were measured by real-time quantitative polymerase chain reaction analysis. RESULTS:We found that metformin has protective effects on palmitate-induced β-cell dysfunction. Metformin at a concentration of 0.05 mM inhibits NOX and suppresses the palmitate-induced elevation of ER stress markers and ROS levels in a AMPK-independent manner, whereas 0.5 mM metformin inhibits ROCK activity and activates AMPK. CONCLUSION:This study suggests that the action of metformin on β-cell lipotoxicity was implemented by different molecular pathways depending on its concentration. Metformin at a usual therapeutic dose is supposed to alleviate lipotoxic β-cell dysfunction through inhibition of oxidative stress and ER stress.
journal_name
Diabetes Metab Jjournal_title
Diabetes & metabolism journalauthors
Kim HI,Lee JS,Kwak BK,Hwang WM,Kim MJ,Kim YB,Chung SS,Park KSdoi
10.4093/dmj.2018.0179subject
Has Abstractpub_date
2019-12-01 00:00:00pages
854-866issue
6eissn
2233-6079issn
2233-6087pii
43.e41journal_volume
43pub_type
杂志文章abstract:BACKGROUND:The aim of this study was to investigate the influences of visceral adiposity on cardiovascular autonomic neuropathy (CAN) in patients with type 2 diabetes mellitus. METHODS:Two hundred eleven patients with type 2 diabetes participated in this study. Anthropometric and metabolic parameters were measured, an...
journal_title:Diabetes & metabolism journal
pub_type: 杂志文章
doi:10.4093/dmj.2012.36.4.285
更新日期:2012-08-01 00:00:00
abstract::Obesity and diabetes has become a major epidemic across the globe. Controlling obesity has been a challenge since this would require either increased physical activity or reduced caloric intake; both are difficult to enforce. There has been renewed interest in exploiting pathways such as uncoupling protein 1 (UCP1)-me...
journal_title:Diabetes & metabolism journal
pub_type: 杂志文章,评审
doi:10.4093/dmj.2017.41.5.327
更新日期:2017-10-01 00:00:00
abstract::Mitochondrial dysfunction is a hallmark of metabolic diseases such as obesity, type 2 diabetes mellitus, neurodegenerative diseases, and cancers. Dysfunction occurs in part because of altered regulation of the mitochondrial pyruvate dehydrogenase complex (PDC), which acts as a central metabolic node that mediates pyru...
journal_title:Diabetes & metabolism journal
pub_type: 杂志文章,评审
doi:10.4093/dmj.2018.0101
更新日期:2018-08-01 00:00:00
abstract:BACKGROUND:Diabetes mellitus is a chronic disease and one of the main causes of mortality in developing countries. The main objective of treating all chronic diseases, of course, is to improve well-being and attain a satisfactory quality of life (QOL). The major goal of this study is comparison of attitude toward QOL i...
journal_title:Diabetes & metabolism journal
pub_type: 杂志文章
doi:10.4093/dmj.2011.35.4.397
更新日期:2011-08-01 00:00:00
abstract:BACKGROUND:The aim of this study is to investigate the cardio-metabolic parameters and surrogate markers of insulin resistance in a discordant group of type 2 diabetes (T2DM) subjects who satisfy the Adults Treatment Panel (ATP) III criteria, but not the International Diabetes Federation (IDF) criteria, for metabolic s...
journal_title:Diabetes & metabolism journal
pub_type: 杂志文章
doi:10.4093/dmj.2012.36.5.357
更新日期:2012-10-01 00:00:00
abstract::As the number of individuals with non-alcoholic fatty liver disease (NAFLD) has increased, the influence of NAFLD on other metabolic diseases has been highlighted. Accumulating epidemiologic evidence indicates that NAFLD not only affects the liver but also increases the risk of extra-hepatic diseases such as type 2 di...
journal_title:Diabetes & metabolism journal
pub_type: 杂志文章,评审
doi:10.4093/dmj.2017.41.6.430
更新日期:2017-12-01 00:00:00
abstract::Care of the elderly population with diabetes may not be restricted to the management of hyperglycemia, associated risk factors, and specific diabetic complications. An integrated approach should also include the assessment and management of gerontological problems. Both diabetes mellitus and aging interact toward the ...
journal_title:Diabetes & metabolism journal
pub_type: 杂志文章,评审
doi:10.4093/dmj.2017.41.3.155
更新日期:2017-06-01 00:00:00
abstract:BACKGROUND:This study investigated the rate of relapse of dyslipidemia and the factors which could predict relapse following a short-term statin discontinuation after achieving a target low density lipoprotein cholesterol (LDL-C) level in type 2 diabetic patients without cardiovascular disease (CVD). METHODS:Ninety-ni...
journal_title:Diabetes & metabolism journal
pub_type: 杂志文章
doi:10.4093/dmj.2014.38.1.64
更新日期:2014-02-01 00:00:00
abstract:BACKGROUND:Food exchange lists are one of the main methods of nutritional education. However, Korean food exchange lists have not been revised since 1994. Therefore, we surveyed the opinions of diabetes educators and patients with diabetes regarding the need for revision of the current food exchange lists. METHODS:For...
journal_title:Diabetes & metabolism journal
pub_type: 杂志文章
doi:10.4093/dmj.2011.35.2.173
更新日期:2011-04-01 00:00:00
abstract:BACKGROUND:The objective of this systematic review and meta-analysis was to determine the effects of omega-3 supplementation on adipocytokine levels in adult prediabetic and diabetic individuals. METHODS:We searched PubMed, Medline, EMBASE, Scopus, Web of Science, Google Scholar, Cochrane Trial Register, World Health ...
journal_title:Diabetes & metabolism journal
pub_type: 杂志文章,评审
doi:10.4093/dmj.2018.42.2.101
更新日期:2018-04-01 00:00:00
abstract:BACKGROUND:Voglibose, an α-glucosidase inhibitor, inhibits breakdown of complex carbohydrates into simple sugar units in intestine. Studies showed that voglibose metabolism in the liver might be negligible due to its poor intestinal absorption. Numerous microorganisms live in intestine and have several roles in metabol...
journal_title:Diabetes & metabolism journal
pub_type: 杂志文章
doi:10.4093/dmj.2019.0147
更新日期:2020-12-01 00:00:00
abstract::There are many studies on the prevalence, clinical characteristics, and economic burden of diabetes across the past four decades in Korea. Nonetheless, there is a dearth of nationwide study regarding diabetes encompassing all age group. Eight years ago, the Committee on the Epidemiology of Diabetes Mellitus of Korean ...
journal_title:Diabetes & metabolism journal
pub_type: 杂志文章
doi:10.4093/dmj.2013.37.4.233
更新日期:2013-08-01 00:00:00
abstract:BACKGROUND:We investigated whether patients' perceived glycemic control and self-reported diabetes self-care correlated with their actual glycemic control. METHODS:A survey was administered among patients with diabetes mellitus at an outpatient clinic with structured self-report questionnaires regarding perceived glyc...
journal_title:Diabetes & metabolism journal
pub_type: 杂志文章
doi:10.4093/dmj.2015.39.1.31
更新日期:2015-02-01 00:00:00
abstract:BACKGROUND:The second derivative of the finger photoplethysmogram (SDPTG) is an indicator of arterial stiffness. The present study was conducted to clarify the factor structure of indices of the SDPTG in combination with components of the metabolic syndrome (MetS), to elucidate the significance of the SDPTG among vario...
journal_title:Diabetes & metabolism journal
pub_type: 杂志文章
doi:10.4093/dmj.2013.37.1.40
更新日期:2013-02-01 00:00:00
abstract:BACKGROUND:Rebaudioside A and erythritol are nonnutritive sweeteners. There have been several studies of their glycemic effects, but the outcomes remain controversial. The purpose of this study was to evaluate the glycemic effects of rebaudioside A and erythritol as a sweetener in people with glucose intolerance. METH...
journal_title:Diabetes & metabolism journal
pub_type: 杂志文章
doi:10.4093/dmj.2016.40.4.283
更新日期:2016-08-01 00:00:00
abstract:BACKGROUND:To investigate the clinical results of sitagliptin (SITA) and the characteristics of the treatment failure group or of low responders to SITA. METHODS:A retrospective study of type 2 diabetic patients reviewed 99 cases, including 12 treatment failure cases, who stopped SITA because of worsening patients' co...
journal_title:Diabetes & metabolism journal
pub_type: 杂志文章
doi:10.4093/dmj.2011.35.3.290
更新日期:2011-06-01 00:00:00
abstract::Latent autoimmune diabetes in adults (LADA) is a heterogeneous disease characterized by a less intensive autoimmune process and a broad clinical phenotype compared to classical type 1 diabetes mellitus (T1DM), sharing features with both type 2 diabetes mellitus (T2DM) and T1DM. Since patients affected by LADA are init...
journal_title:Diabetes & metabolism journal
pub_type: 杂志文章,评审
doi:10.4093/dmj.2018.0190
更新日期:2018-12-01 00:00:00
abstract::This corrects the article on p. 218 in vol. 39, PMID: 26124992. ...
journal_title:Diabetes & metabolism journal
pub_type: 已发布勘误
doi:10.4093/dmj.2016.40.1.87
更新日期:2016-02-01 00:00:00
abstract:BACKGROUND:Some patients admitted to hospitals for glycemic control experience hypoglycemia despite regular meals and despite adhering to standard blood glucose control protocols. Different factors can have a negative impact on blood glucose control and prognosis after discharge. This study investigated risk factors fo...
journal_title:Diabetes & metabolism journal
pub_type: 杂志文章
doi:10.4093/dmj.2019.0064
更新日期:2020-08-01 00:00:00
abstract:BACKGROUND:This study aimed to design a simple surrogate marker (i.e., predictor) of the minimal model glucose effectiveness (SG), namely calculated SG (CSG), from a short insulin-modified intravenous glucose tolerance test (IM-IVGTT), and then to apply it to study women with previous gestational diabetes mellitus (pGD...
journal_title:Diabetes & metabolism journal
pub_type: 杂志文章
doi:10.4093/dmj.2019.0016
更新日期:2020-04-01 00:00:00
abstract:BACKGROUND:Type 2 diabetes mellitus (T2DM) is associated with an increased risk for dementia. The effects of hypoglycemia on dementia are controversial. Thus, we evaluated whether hypoglycemia increases the risk for dementia in senior patients with T2DM. METHODS:We used the Korean National Health Insurance Service Sen...
journal_title:Diabetes & metabolism journal
pub_type: 杂志文章
doi:10.4093/dmj.2018.0260
更新日期:2020-02-01 00:00:00
abstract:BACKGROUND:Despite the confluence of multiple cardiovascular risk factors, subclinical atherosclerotic damage and cardiovascular events remain extremely rare in adults with Down syndrome (DS). We aim to determine the prevalence of obesity and metabolic disorders in an adult cohort with DS and to compare our findings wi...
journal_title:Diabetes & metabolism journal
pub_type: 杂志文章
doi:10.4093/dmj.2014.38.6.464
更新日期:2014-12-01 00:00:00
abstract:BACKGROUND:Women with one abnormal value (OAV) in a 100 g oral glucose tolerance test (OGTT) during pregnancy are reported to have an increased risk of adverse pregnancy outcomes. However, there is limited data about whether women with OAV will progress to gestational diabetes mellitus (GDM) when the OGTT is repeated. ...
journal_title:Diabetes & metabolism journal
pub_type: 杂志文章
doi:10.4093/dmj.2018.0159
更新日期:2019-10-01 00:00:00
abstract:BACKGROUND:Diabetes self-management education and reinforcement are important for effective management of the disease. We investigated the effectiveness of interactive small-group education on glycemic, blood pressure, and lipid levels. METHODS:For this study, 207 type 2 diabetes patients with suboptimal glycemic cont...
journal_title:Diabetes & metabolism journal
pub_type: 杂志文章
doi:10.4093/dmj.2011.35.6.580
更新日期:2011-12-01 00:00:00
abstract::Nonalcoholic fatty liver disease (NAFLD) and diabetes are common metabolic disorders whose prevalence rates are expected to rise worldwide, corresponding to aging and increasingly obese populations. Compared to the general population (around 25%), 50% to 70% of people with diabetes have NAFLD, and NAFLD severity (incl...
journal_title:Diabetes & metabolism journal
pub_type: 杂志文章,评审
doi:10.4093/dmj.2019.0011
更新日期:2019-02-01 00:00:00
abstract::Genome wide association analyses have revealed large numbers of common variants influencing predisposition to type 2 diabetes and related phenotypes. These studies have predominantly featured European populations, but are now being extended to samples from a wider range of ethnic groups. The transethnic analysis of as...
journal_title:Diabetes & metabolism journal
pub_type: 杂志文章
doi:10.4093/dmj.2011.35.2.91
更新日期:2011-04-01 00:00:00
abstract::This corrects the article on p. 3 in vol. 42, PMID: 29504302. ...
journal_title:Diabetes & metabolism journal
pub_type: 杂志文章,已发布勘误
doi:10.4093/dmj.2018.42.2.177
更新日期:2018-04-01 00:00:00
abstract::Although glucose-lowering treatment shows some risk lowering effects in cardiovascular diseases, risks of macrovascular and microvascular complications have still remained, and development of new therapeutic strategies is needed. Recent data have shown that peroxisome proliferator activated receptor-α (PPAR-α) plays a...
journal_title:Diabetes & metabolism journal
pub_type: 杂志文章,评审
doi:10.4093/dmj.2013.37.5.326
更新日期:2013-10-01 00:00:00
abstract::A growing body of evidence suggests that hyperglycemia-induced oxidative stress plays an important role in diabetic complications, especially β-cell dysfunction and failure. Under physiological conditions, reactive oxygen species serve as second messengers that facilitate signal transduction and gene expression in pan...
journal_title:Diabetes & metabolism journal
pub_type: 杂志文章
doi:10.4093/dmj.2013.37.2.106
更新日期:2013-04-01 00:00:00
abstract::Several polymers were used to delivery genes to diabetic animals. Polyaminobutyl glycolic acid was utilized to deliver IL-10 plasmid DNA to prevent autoimmune insulitis of non-obese diabetic (NOD) mouse. Polyethylene glycol grafted polylysine was combined with antisense glutamic acid decarboxylase (GAD) MRNA to repres...
journal_title:Diabetes & metabolism journal
pub_type: 杂志文章
doi:10.4093/dmj.2011.35.4.317
更新日期:2011-08-01 00:00:00