Abstract:
:The pyruvate dehydrogenase complex (PDC) is an emerging target for the treatment of metabolic syndrome. To maintain a steady-state concentration of adenosine triphosphate during the feed-fast cycle, cells require efficient utilization of fatty acid and glucose, which is controlled by the PDC. The PDC converts pyruvate, coenzyme A (CoA), and oxidized nicotinamide adenine dinucleotide (NAD(+)) into acetyl-CoA, reduced form of nicotinamide adenine dinucleotide (NADH), and carbon dioxide. The activity of the PDC is up- and down-regulated by pyruvate dehydrogenase kinase and pyruvate dehydrogenase phosphatase, respectively. In addition, pyruvate is a key intermediate of glucose oxidation and an important precursor for the synthesis of glucose, glycerol, fatty acids, and nonessential amino acids.
journal_name
Diabetes Metab Jjournal_title
Diabetes & metabolism journalauthors
Lee IKdoi
10.4093/dmj.2014.38.3.181subject
Has Abstractpub_date
2014-06-01 00:00:00pages
181-6issue
3eissn
2233-6079issn
2233-6087journal_volume
38pub_type
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