B Cell Disorders in Children: Part II.

abstract：:Eosinophilic gastrointestinal disease (EGID) can be classified as eosinophilic esophagitis (EoE) when the eosinophilia is limited to the esophagus or as eosinophilic gastritis (EG) if it is limited to the gastric tract, eosinophilic colitis (EC) if it is limited to the colon, and eosinophilic gastroenteritis (EGE) if ...

journal_title：Current allergy and asthma reports

authors： Cianferoni A,Spergel JM

更新日期：2015-09-01 00:00:00

abstract：:Monogenic autoinflammatory diseases encompass a distinct and growing clinical entity of multisystem inflammatory diseases with known genetic defects in the innate immune system. The diseases present clinically with episodes of seemingly unprovoked inflammation (fever, rashes, and elevation of acute phase reactants). U...

journal_title：Current allergy and asthma reports

authors： Glaser RL,Goldbach-Mansky R

更新日期：2008-07-01 00:00:00

abstract：PURPOSE OF REVIEW:There has been an explosion in the number of published systematic reviews on chronic rhinosinusitis in the last decade. RECENT FINDINGS:While the aim of these reviews in facilitating evidence-based practice is laudable, poor quality reviews may contain significant bias that can mislead a non-discerni...

journal_title：Current allergy and asthma reports

authors： Walker A,Hopkins C

更新日期：2018-02-16 00:00:00

abstract：PURPOSE OF REVIEW:Agriculture remains a major economic sector globally, and workers experience high rates of chronic inflammatory lung and musculoskeletal diseases. Whereas obstructive pulmonary diseases are known risk factors for bone loss, the underlying relationship between lung inflammation and bone health is not w...

journal_title：Current allergy and asthma reports

authors： Carrington JM,Poole JA

更新日期：2018-02-22 00:00:00

abstract：PURPOSE OF REVIEW:The prevalence of food allergy is increasing. At the current time, there are no approved treatments for food allergy. Major limitations of immunotherapy are long treatment periods (months or years), frequent clinic visits, high costs, increased risk of adverse events during treatment, and lack of dura...

journal_title：Current allergy and asthma reports

authors： Long A,Borro M,Sampath V,Chinthrajah RS

更新日期：2020-01-16 00:00:00

abstract：:Genome-wide screens for asthma and atopy susceptibility loci have been completed in six population samples. Despite the extensive clinical heterogeneity associated with these phenotypes, 20 chromosomal regions show evidence of linkage (P < 0.01) in three or more population samples. Thus, this survey suggests that at l...

journal_title：Current allergy and asthma reports

authors： Ober C

更新日期：2001-03-01 00:00:00

abstract：:Nasal polyposis is the end result of a variety of pathologic processes. The aims of treatment are to relieve nasal blockage, restore olfaction, and improve sinus drainage. Treating any accompanying rhinitis is also an aim, which requires that medical treatment be given to all patients with an inflammatory problem. Mos...

journal_title：Current allergy and asthma reports

authors： Scadding GK

更新日期：2002-11-01 00:00:00

abstract：PURPOSE OF REVIEW:The purpose of this review is to provide an overview of diagnostic testing in primary immunodeficiency and immune dysregulatory disorders (PIDDs), particularly focusing on flow cytometry and genetic techniques, utilizing specific examples of PIDDs. RECENT FINDINGS:Flow cytometry remains a vital tool ...

journal_title：Current allergy and asthma reports

authors： Richardson AM,Moyer AM,Hasadsri L,Abraham RS

更新日期：2018-02-22 00:00:00

abstract：:Subcutaneous allergen immunotherapy (SCIT) is beneficial for the treatment of allergic rhinitis, asthma, and in preventing stinging insect anaphylaxis, but is not without risks. Four retrospective surveillance surveys and one on-going national prospective study have attempted to characterize the incidence and risk fac...

journal_title：Current allergy and asthma reports

authors： Kannan JA,Epstein TG

更新日期：2013-08-01 00:00:00

abstract：:IgG4 is the least abundant subclass of IgG in normal human serum, but elevated IgG4 levels are triggered in response to a chronic antigenic stimulus and inflammation. Since the immune system is exposed to tumor-associated antigens over a relatively long period of time, and tumors notoriously promote inflammation, it i...

journal_title：Current allergy and asthma reports

authors： Crescioli S,Correa I,Karagiannis P,Davies AM,Sutton BJ,Nestle FO,Karagiannis SN

更新日期：2016-01-01 00:00:00

abstract：:The pathology of atopic dermatitis is orchestrated on the cellular level by several different cell types in the characteristic skin lesions. In such lesions, histamine as a mediator of many biological functions is also present in high concentrations. Most of the cells involved in the inflammatory responses express the...

journal_title：Current allergy and asthma reports

authors： Mommert S,Gschwandtner M,Gutzmer R,Werfel T

更新日期：2011-02-01 00:00:00

abstract：:Cyclooxygenase (COX) enzymes catalyze the rate-limiting steps in prostaglandin synthesis. Prostaglandins have an important role in several physiological processes such as maintenance of gastrointestinal integrity and pathological processes such as inflammation and neoplasia. Several mechanisms have been proposed for t...

journal_title：Current allergy and asthma reports

authors： Guilemany JM,Roca-Ferrer J,Mullol J

更新日期：2008-05-01 00:00:00

abstract：:Differences in asthma prevalence have been described across different populations, suggesting that genetic ancestry can play an important role in this disease. In fact, several studies have demonstrated an association between African ancestry with increased asthma susceptibility and severity, higher immunoglobulin E l...

journal_title：Current allergy and asthma reports

authors： Hernandez-Pacheco N,Flores C,Oh SS,Burchard EG,Pino-Yanes M

更新日期：2016-07-01 00:00:00

abstract：:Atopic dermatitis (AD) is a complex disease that manifests immunologic abnormalities in the skin. The immunologic changes of AD are characterized by a T helper cell type 2 (Th2)-dominated immune response in its acute phase and a Th1/Th2 mixed immune response in its chronic phase. Although the clinical presentation and...

journal_title：Current allergy and asthma reports

authors： Zheng T,Zhu Z

更新日期：2005-07-01 00:00:00

abstract：:Although fungi are pervasive in many environments, few cause disease in humans. Of these, Aspergillus fumigatus is particularly well suited to be a pathogen of the human lung. Its physical and biological characteristics combine to provide an organism that can cause tremendous morbidity and high mortality if left unche...

journal_title：Current allergy and asthma reports

authors： Ghosh S,Hoselton SA,Schuh JM

更新日期：2015-10-01 00:00:00

abstract：:Experimental autoimmune encephalomyelitis (EAE) is widely depicted as the prototypical CD4+ Th1-mediated autoimmune disease. Microglia and perivascular macrophages are believed to act as antigen-presenting cells during the effector phase of EAE. In this article, recent data that challenge these conceptions are reviewe...

journal_title：Current allergy and asthma reports

authors： Segal BM

更新日期：2003-01-01 00:00:00

abstract：:Given the increased recognition of pediatric allergic contact dermatitis and lack of patch testing consensus in children, we present a minimum basic 20-allergen North American pediatric series, for screening children ages 6-12 with suspected contact allergy. ...

journal_title：Current allergy and asthma reports

authors： Jacob SE,Admani S,Herro EM

更新日期：2014-06-01 00:00:00

abstract：:Glucocorticoid insensitivity presents a profound management problem in patients with asthma because conventional therapies are not effective. Glucocorticoids, acting through the glucocorticoid receptor (GR), are able to selectively repress inflammatory gene expression by utilizing several distinct mechanisms targeting...

journal_title：Current allergy and asthma reports

authors： Adcock IM,Ford PA,Bhavsar P,Ahmad T,Chung KF

更新日期：2008-04-01 00:00:00

abstract：:The dynamic expression of various phenotypic markers during B cell development not only defines the particular stage in ontogeny but also provides the necessary growth, differentiation, maturation and survival signals. When a B cell at any given stage becomes cancerous, these cell surface molecules, intracellular sign...

journal_title：Current allergy and asthma reports

authors： Baskar S,Muthusamy N

更新日期：2013-02-01 00:00:00

abstract：:Primary immunodeficiencies (PIDs) are a group of genetically heterogeneous disorders that present with very similar symptoms, complicating definitive diagnosis. More than 240 genes have hitherto been associated with PIDs, of which more than 30 have been identified in the last 3 years. Next generation sequencing (NGS) ...

journal_title：Current allergy and asthma reports

authors： Raje N,Soden S,Swanson D,Ciaccio CE,Kingsmore SF,Dinwiddie DL

更新日期：2014-10-01 00:00:00

abstract：:The nasal mucosa is a complex tissue that interacts with its environment and effects local and systemic changes. Receptors in the nose receive signals from stimuli, and respond locally through afferent, nociceptive, type C neurons to elicit nasonasal reflex responses mediated via cholinergic neurons. This efferent lim...

journal_title：Current allergy and asthma reports

authors： Baraniuk JN,Kim D

更新日期：2007-05-01 00:00:00

abstract：:Recent advances in our understanding of mast cell biology and disease resulted in identification of important differences in expression of mast cell surface antigens in normal and neoplastic mast cells. Most notably, detection of aberrant expression of CD25 and CD2 on the surface of neoplastic mast cells but not on th...

journal_title：Current allergy and asthma reports

authors： Akin C,Valent P,Escribano L

更新日期：2006-07-01 00:00:00

abstract：:Urticaria can present acutely and be self-limiting or become chronic and persist for weeks, months, or years. In either case, the condition may have a significant impact on the patient's quality of life. Two major consensus groups, the EAACI/WAO and the AAAAI/ACAAI Joint Task Force, have written guidelines on the diag...

journal_title：Current allergy and asthma reports

authors： Fine LM,Bernstein JA

更新日期：2015-06-01 00:00:00

abstract：:Vaccines have had a tremendous impact on public health by reducing morbidity and mortality from a variety of virulent pathogens. However, unintended side effects continue to pose a potential risk that may outweigh the vaccine's protective attributes. In this review, we discuss recent articles and controversies pertain...

journal_title：Current allergy and asthma reports

authors： Song BJ,Katial RK

更新日期：2004-11-01 00:00:00

abstract：:Asthma is an increasingly prevalent disease, particularly in industrialized countries. With modern treatment, many patients can expect good asthma control; however, a significant minority continue to have excessive symptoms. Bronchial thermoplasty is a novel approach to treating asthma in which the hypertrophied airwa...

journal_title：Current allergy and asthma reports

authors： Martin N,Pavord ID

更新日期：2009-01-01 00:00:00

abstract：PURPOSE OF REVIEW:This review is focused on the existing evidence for circadian control of innate and adaptive immune responses to provide a framework for evaluating the contributions of diurnal rhythms to control of infections and pathogenesis of disease. RECENT FINDINGS:Circadian rhythms driven by cell-autonomous bi...

journal_title：Current allergy and asthma reports

authors： Waggoner SN

更新日期：2020-01-10 00:00:00

abstract：:Multiple sclerosis (MS) is the most common cause of chronic neurologic disability in young people. Genetic susceptibility and unidentified environmental triggers appear to be necessary in order to result in disease. MS is an extraordinarily complex trait with evidence of heterogeneity at clinical, pathologic, and ther...

journal_title：Current allergy and asthma reports

authors： Heard RN

更新日期：2007-07-01 00:00:00

abstract：:Exposure to airborne pollen, fungal allergens, and dust mite allergens is associated with the development of allergic rhinitis. Biologic function of allergens is considered to be a key determinant for allergenicity, and many clinically important allergens have been shown to possess enzymatic activity. It is proposed t...

journal_title：Current allergy and asthma reports

authors： Sehgal N,Custovic A,Woodcock A

更新日期：2005-05-01 00:00:00

abstract：:The role of the eosinophil in the pathophysiology of allergy and asthma has been the focus of intense interest during the last two decades. While the presence of eosinophils in humans with allergy and asthma is well established, the precise role of this cell in humans and in animal models is less clear. However, recen...

journal_title：Current allergy and asthma reports

authors： Adamko D,Lacy P,Moqbel R

更新日期：2002-03-01 00:00:00

abstract：PURPOSE OF REVIEW:This review aims to provide an update of recent advances in the epidemiology, clinical features and diagnosis, and management of food-induced anaphylaxis (FIA). RECENT FINDINGS:Food allergy prevalence and FIA rates continue to rise, but FIA fatalities are stable. Basophil and mast cell activation tes...

journal_title：Current allergy and asthma reports

authors： Parrish CP,Kim H

更新日期：2018-06-14 00:00:00