Mechanisms of eosinophil recruitment and activation.

abstract：:Asthma affects 5% to 10% of the population of the United States. In asthmatics, oxidative stress occurs not only as a result of inflammation but also from environmental exposure to air pollution. The specific localization of antioxidants in the lung and the adaptive changes during asthma underscore the importance of o...

journal_title：Current allergy and asthma reports

authors： Bowler RP

更新日期：2004-03-01 00:00:00

abstract：:Traditionally, symptoms are important patient-oriented outcomes in asthma treatment, and assessment of symptoms is an essential component of assessing asthma control. However, variable airways obstruction, airways hyperresponsiveness and chronic inflammation are key components of the asthma syndrome, and correlations ...

journal_title：Current allergy and asthma reports

authors： Nuijsink M,De Jongste JC,Pijnenburg MW

更新日期：2013-10-01 00:00:00

abstract：:Nonspecific lipid transfer proteins (LTPs) are important allergens in fruits, vegetables, nuts, pollen, and latex. Despite their wide distribution throughout the plant kingdom, their clinical relevance is largely confined to the Mediterranean area. As they can sensitize via the gastrointestinal tract, LPTs are conside...

journal_title：Current allergy and asthma reports

authors： Egger M,Hauser M,Mari A,Ferreira F,Gadermaier G

更新日期：2010-09-01 00:00:00

abstract：PURPOSE OF REVIEW:There has been an explosion in the number of published systematic reviews on chronic rhinosinusitis in the last decade. RECENT FINDINGS:While the aim of these reviews in facilitating evidence-based practice is laudable, poor quality reviews may contain significant bias that can mislead a non-discerni...

journal_title：Current allergy and asthma reports

authors： Walker A,Hopkins C

更新日期：2018-02-16 00:00:00

abstract：:Otitis media is currently the most common diagnosis made by clinicians, which has a major impact on managed care. The emergence of resistant bacterial pathogens has caused controversy over the use of antibiotics when acute otitis media (AOM) is diagnosed. All infants with AOM and all older children with severe AOM sho...

journal_title：Current allergy and asthma reports

authors： Gungor A,Bluestone CD

更新日期：2001-07-01 00:00:00

abstract：:Eosinophilic chronic rhinosinusitis (ECRS) encompasses a wide variety of etiologies. To date, a unifying pathophysiologic mechanism remains elusive. Eosinophilia is frequently, but not exclusively, caused by immunoglobulin (Ig)E-mediated hypersensitivity and is dominated by the associated cytokine milieu of Th2 inflam...

journal_title：Current allergy and asthma reports

authors： Sok JC,Ferguson BJ

更新日期：2006-05-01 00:00:00

abstract：:The role of fungi in chronic rhinosinusitis (CRS) is not clear. Fungi can be detected in the nose and paranasal sinuses of virtually all CRS patients; however, they also appear to be present in healthy controls. Various theories attempt to explain the mechanisms by which fungi can exert an effect on sinus mucosa in su...

journal_title：Current allergy and asthma reports

authors： Ebbens FA,Georgalas C,Fokkens WJ

更新日期：2009-03-01 00:00:00

abstract：:Multiple sclerosis (MS) is the most common cause of chronic neurologic disability in young people. Genetic susceptibility and unidentified environmental triggers appear to be necessary in order to result in disease. MS is an extraordinarily complex trait with evidence of heterogeneity at clinical, pathologic, and ther...

journal_title：Current allergy and asthma reports

authors： Heard RN

更新日期：2007-07-01 00:00:00

abstract：:The cutaneous microbiome has been investigated broadly in recent years and some traditional perspectives are beginning to change. A diverse microbiome exists on human skin and has a potential to influence pathogenic microbes and modulate the course of skin disorders, e.g. atopic dermatitis. In addition to the known dy...

journal_title：Current allergy and asthma reports

authors： Fyhrquist N,Salava A,Auvinen P,Lauerma A

更新日期：2016-05-01 00:00:00

abstract：:Health-related quality of life (HRQL) has become an emerging focus of interest in food allergy. Food allergy is a disease characterized by low mortality and symptoms which only occur during an allergic reaction. However, food-allergic patients continuously need to be alert when eating in order to prevent potentially s...

journal_title：Current allergy and asthma reports

authors： van der Velde JL,Dubois AE,Flokstra-de Blok BM

更新日期：2013-12-01 00:00:00

abstract：PURPOSE OF REVIEW:The purpose of this review is to describe the process of administering a telemedicine program including reviewing telemedicine guidelines; discussing licensing, credentialing, and privileging of providers; outlining scheduling and recruitment of patients; and measuring outcomes of a telemedicine progr...

journal_title：Current allergy and asthma reports

authors： Taylor L,Capling H,Portnoy JM

更新日期：2018-09-15 00:00:00

abstract：:The best possible allergen immunotherapy clinical outcomes require the provision of high quality and safe allergen immunotherapy extract preparations. Evolving national guidelines and regulatory bodies have devoted special attention to the safe compounding of sterile products, including allergen extracts. It is incumb...

journal_title：Current allergy and asthma reports

authors： Nelson MR,Petersen MM,Wolverton WO,Mikita CP

更新日期：2013-08-01 00:00:00

abstract：:Otitis media (OM) imposes significant morbidity on the pediatric age group and a large financial burden on the general population. Because standard medical treatments are not highly efficacious in resolving the accompanying middle ear (ME) inflammation, a goal of current research is OM prevention. Past studies show th...

journal_title：Current allergy and asthma reports

authors： Doyle WJ,Alper CM

更新日期：2003-07-01 00:00:00

abstract：:Many fungi are capable of causing IgE-mediated hypersensitivity in humans. However, the most predominant fungi implicated in allergy belong to the genera Aspergillus, Alternaria, Cladosporium, and Penicillium. Pure and relevant allergens are essential for diagnosis as well as for understanding the immunopathogenesis o...

journal_title：Current allergy and asthma reports

authors： Kurup VP

更新日期：2003-09-01 00:00:00

abstract：:The dynamic expression of various phenotypic markers during B cell development not only defines the particular stage in ontogeny but also provides the necessary growth, differentiation, maturation and survival signals. When a B cell at any given stage becomes cancerous, these cell surface molecules, intracellular sign...

journal_title：Current allergy and asthma reports

authors： Baskar S,Muthusamy N

更新日期：2013-02-01 00:00:00

abstract：:Exposure to airborne pollen, fungal allergens, and dust mite allergens is associated with the development of allergic rhinitis. Biologic function of allergens is considered to be a key determinant for allergenicity, and many clinically important allergens have been shown to possess enzymatic activity. It is proposed t...

journal_title：Current allergy and asthma reports

authors： Sehgal N,Custovic A,Woodcock A

更新日期：2005-05-01 00:00:00

abstract：:IgG4 is the least abundant subclass of IgG in normal human serum, but elevated IgG4 levels are triggered in response to a chronic antigenic stimulus and inflammation. Since the immune system is exposed to tumor-associated antigens over a relatively long period of time, and tumors notoriously promote inflammation, it i...

journal_title：Current allergy and asthma reports

authors： Crescioli S,Correa I,Karagiannis P,Davies AM,Sutton BJ,Nestle FO,Karagiannis SN

更新日期：2016-01-01 00:00:00

abstract：:Omalizumab is a recently developed monoclonal anti-IgE antibody. Clinical trials have demonstrated its efficacy in patients with moderate-to-severe and severe or poorly controlled allergic asthma, in patients with seasonal and perennial allergic disease, and in subjects with concomitant asthma and allergic rhinitis. P...

journal_title：Current allergy and asthma reports

authors： Sandström T

更新日期：2005-03-01 00:00:00

abstract：:Common variable immunodeficiency (CVID) is the most prevalent symptomatic primary immune deficiency. With widespread use of immunoglobulin replacement therapy, non-infectious complications, such as autoimmunity, chronic intestinal inflammation, and lung disease, have replaced infections as the major cause of morbidity...

journal_title：Current allergy and asthma reports

authors： Maglione PJ,Cols M,Cunningham-Rundles C

更新日期：2017-10-05 00:00:00

abstract：:The role of distinct CD4(+) T-cell populations in regulating the nature and strength of immune responses is well documented and in the past has principally focused on the cross-regulation of T-helper type 1 (Th1) and Th2 cells, which secrete interferon-gamma and interleukin-4, respectively. However, the identification...

journal_title：Current allergy and asthma reports

authors： McGuirk P,Higgins SC,Mills KH

更新日期：2010-01-01 00:00:00

abstract：:The nasal provocation test (NPT) could be more extensively used in the diagnosis of allergic rhinitis by practicing physicians. However, the procedure has not been standardized, and has mainly been utilized for scientific purposes in the US. This review illustrates a wide variety of techniques and approaches to dosing...

journal_title：Current allergy and asthma reports

authors： Litvyakova LI,Baraniuk JN

更新日期：2002-05-01 00:00:00

abstract：:The physical urticarias are a heterogeneous subgroup of chronic urticarias in which wheals can be reproducibly induced by different specific physical stimuli such as cold, heat, pressure, vibration, or sunlight. Physical urticarias comprise up to 25 % of chronic urticarias and occur more frequently in young adults. Sy...

journal_title：Current allergy and asthma reports

authors： Abajian M,Młynek A,Maurer M

更新日期：2012-08-01 00:00:00

abstract：:The present review aims to identify and summarize epidemiologic investigations published during 2011 on the environmental risk factors for asthma. Potentially eligible papers were identified by a MEDLINE search. In total, 1,130 items were retrieved. Based on a broad definition of environment, the following topics were...

journal_title：Current allergy and asthma reports

authors： Antó JM

更新日期：2012-06-01 00:00:00

abstract：PURPOSE OF REVIEW:This review aims to update the information available on the prevalence, clinical picture, diagnostic methods, and treatment of urticarias induced by external physical stimuli. RECENT FINDINGS:Physical urticarias are present in up to 5% of the general population, and in 10 to 50% of patients with chro...

journal_title：Current allergy and asthma reports

authors： Sánchez-Borges M,González-Aveledo L,Caballero-Fonseca F,Capriles-Hulett A

更新日期：2017-08-01 00:00:00

abstract：:Chronic rhinosinusitis (CRS) is one of the most common chronic disease conditions in the United States. Currently, diagnosis is based initially on clinical symptomatology and signs, but the final diagnosis of CRS should be confirmed by objective measures. CT of the paranasal sinuses is the most commonly obtained test ...

journal_title：Current allergy and asthma reports

authors： Bhattacharyya N

更新日期：2010-05-01 00:00:00

abstract：:The incidence, morbidity, and mortality of asthma have been increasing at an alarming rate, making asthma the most common chronic illness of childhood. An asthma disease management program was developed to improve the care and management of patients with asthma--a comprehensive health care delivery model that was desi...

journal_title：Current allergy and asthma reports

authors： Miller K,Ward-Smith P,Cox K,Jones EM,Portnoy JM

更新日期：2003-11-01 00:00:00

abstract：:Chronic rhinosinusitis (CRS) is an inflammatory disorder affecting the nose and paranasal sinuses. Although bacteria have long been implicated as pathogens in most forms of CRS, fungi may be responsible for some forms. Several recent studies demonstrated that, under optimal conditions, fungi can be identified in the n...

journal_title：Current allergy and asthma reports

authors： Ebbens FA,Fokkens WJ

更新日期：2008-04-01 00:00:00

abstract：:The nasal mucosa is a complex tissue that interacts with its environment and effects local and systemic changes. Receptors in the nose receive signals from stimuli, and respond locally through afferent, nociceptive, type C neurons to elicit nasonasal reflex responses mediated via cholinergic neurons. This efferent lim...

journal_title：Current allergy and asthma reports

authors： Baraniuk JN,Kim D

更新日期：2007-05-01 00:00:00

abstract：:Respiratory viruses appear to play a central role in asthma pathogenesis. In addition to a major role in triggering asthma exacerbations, viral infections early in life may play a role in disease development. Although defensins were initially identified as antimicrobial peptides, recent studies have demonstrated that ...

journal_title：Current allergy and asthma reports

authors： Proud D

更新日期：2006-02-01 00:00:00

abstract：:DiGeorge syndrome is characterized by conotruncal cardiac defects, hypocalcemia, and a hypoplastic thymus. Many, but not all, patients have a heterozygous deletion of chromosome 22q11.2. In its most severe form, it represents a devastating syndrome with high mortality. Patients with severe immunodeficiency are candida...

journal_title：Current allergy and asthma reports

authors： Sullivan KE

更新日期：2001-09-01 00:00:00