Abstract:
:Eosinophilic chronic rhinosinusitis (ECRS) encompasses a wide variety of etiologies. To date, a unifying pathophysiologic mechanism remains elusive. Eosinophilia is frequently, but not exclusively, caused by immunoglobulin (Ig)E-mediated hypersensitivity and is dominated by the associated cytokine milieu of Th2 inflammation. The provisional subcategories of ECRS include superantigen-induced eosinophilic chronic rhinosinusitis, allergic fungal sinusitis, nonallergic fungal eosinophilic chronic rhinosinusitis, and aspirin-exacerbated eosinophilic chronic rhinosinusitis. Within each subcategory, recent findings supporting distinct mechanisms that promote eosinophilic infiltration are presented, and, therefore, targeted therapeutic interventions with specific antibacterial, antifungal, or immune modulation may be indicated.
journal_name
Curr Allergy Asthma Repjournal_title
Current allergy and asthma reportsauthors
Sok JC,Ferguson BJdoi
10.1007/s11882-006-0036-1keywords:
subject
Has Abstractpub_date
2006-05-01 00:00:00pages
203-14issue
3eissn
1529-7322issn
1534-6315journal_volume
6pub_type
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