Th9 Cells in Allergic Disease.

abstract：:Mouse allergen has long been recognized as an important cause of occupational allergy and asthma, but only recently has it been implicated in asthma and allergic diseases in community settings. Recent studies have established that mouse allergen is detectable in most US homes, with strikingly high levels in some inner...

journal_title：Current allergy and asthma reports

authors： Matsui EC

更新日期：2009-09-01 00:00:00

abstract：:Although eustachian tube dysfunction and bacterial infection have been shown to cause otitis media with effusion (OME), other etiologies are possible. One of the most common medical conditions in children is obesity, which can have effects throughout the body. Little is known, however, about the relationship between o...

journal_title：Current allergy and asthma reports

authors： Lee SK,Yeo SG

更新日期：2009-11-01 00:00:00

abstract：PURPOSE OF REVIEW:This review is focused on the existing evidence for circadian control of innate and adaptive immune responses to provide a framework for evaluating the contributions of diurnal rhythms to control of infections and pathogenesis of disease. RECENT FINDINGS:Circadian rhythms driven by cell-autonomous bi...

journal_title：Current allergy and asthma reports

authors： Waggoner SN

更新日期：2020-01-10 00:00:00

abstract：:IgG4 is the least abundant subclass of IgG in normal human serum, but elevated IgG4 levels are triggered in response to a chronic antigenic stimulus and inflammation. Since the immune system is exposed to tumor-associated antigens over a relatively long period of time, and tumors notoriously promote inflammation, it i...

journal_title：Current allergy and asthma reports

authors： Crescioli S,Correa I,Karagiannis P,Davies AM,Sutton BJ,Nestle FO,Karagiannis SN

更新日期：2016-01-01 00:00:00

abstract：:Weeds represent a heterogeneous group of plants, usually defined by no commercial or aesthetic value. Important allergenic weeds belong to the plant families Asteraceae, Amaranthaceae, Urticaceae, Euphorbiaceae, and Plantaginaceae. Major allergens from ragweed, mugwort, feverfew, pellitory, goosefoot, Russian thistle,...

journal_title：Current allergy and asthma reports

authors： Gadermaier G,Dedic A,Obermeyer G,Frank S,Himly M,Ferreira F

更新日期：2004-09-01 00:00:00

abstract：PURPOSE OF REVIEW:To describe inherited and acquired genetic variants and clinical entities associated with increased basal serum tryptase (BST), distinguish these levels from those which acutely rise due to mast cell activation, and finally to characterize the association between chronically elevated basal serum trypt...

journal_title：Current allergy and asthma reports

authors： Khoury P,Lyons JJ

更新日期：2019-11-27 00:00:00

abstract：:The role of the eosinophil in the pathophysiology of allergy and asthma has been the focus of intense interest during the last two decades. While the presence of eosinophils in humans with allergy and asthma is well established, the precise role of this cell in humans and in animal models is less clear. However, recen...

journal_title：Current allergy and asthma reports

authors： Adamko D,Lacy P,Moqbel R

更新日期：2002-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Antibiotics are commonly used to treat wheezy lower respiratory tract illnesses in preschoolers, although these infections have been traditionally thought to be predominantly of viral origin. Our purpose is to review recent research pertaining to the role of antibiotics in lower respiratory tract illn...

journal_title：Current allergy and asthma reports

authors： Kwong CG,Bacharier LB

更新日期：2017-05-01 00:00:00

abstract：:Glucocorticoid insensitivity presents a profound management problem in patients with asthma because conventional therapies are not effective. Glucocorticoids, acting through the glucocorticoid receptor (GR), are able to selectively repress inflammatory gene expression by utilizing several distinct mechanisms targeting...

journal_title：Current allergy and asthma reports

authors： Adcock IM,Ford PA,Bhavsar P,Ahmad T,Chung KF

更新日期：2008-04-01 00:00:00

abstract：:Over the past four decades, many patients have been reported to have deficiencies of one or more subclasses of immunoglobulin G (IgG), despite normal total IgG serum concentrations. However, except for those with extremely low or absent IgG2 concentrations and an inability to produce antibodies to polysaccharide antig...

journal_title：Current allergy and asthma reports

authors： Buckley RH

更新日期：2002-09-01 00:00:00

abstract：:The gut-associated lymphoid tissue is the specialized arm of the immune system responsible for distinguishing innocuous dietary nutrients, self-proteins, and gut flora from pathogens. Oral tolerance is the active immunologic response to innocuous ingested antigens that leads to a systemic tolerance for that antigen. T...

journal_title：Current allergy and asthma reports

authors： Stanley S

更新日期：2002-01-01 00:00:00

abstract：:Common variable immunodeficiency (CVID) is the most prevalent symptomatic primary immune deficiency. With widespread use of immunoglobulin replacement therapy, non-infectious complications, such as autoimmunity, chronic intestinal inflammation, and lung disease, have replaced infections as the major cause of morbidity...

journal_title：Current allergy and asthma reports

authors： Maglione PJ,Cols M,Cunningham-Rundles C

更新日期：2017-10-05 00:00:00

abstract：:Concerns about cross-allergenicity between sulfonamide antibiotics and nonantibiotic sulfonamide-containing drugs continue to complicate pharmacotherapy. Several elegant investigations have demonstrated unequivocal lack of interaction between the sulfonamide group and either cellular or humoral immunity. The immunolog...

journal_title：Current allergy and asthma reports

authors： Brackett CC

更新日期：2007-04-01 00:00:00

abstract：:The dynamic expression of various phenotypic markers during B cell development not only defines the particular stage in ontogeny but also provides the necessary growth, differentiation, maturation and survival signals. When a B cell at any given stage becomes cancerous, these cell surface molecules, intracellular sign...

journal_title：Current allergy and asthma reports

authors： Baskar S,Muthusamy N

更新日期：2013-02-01 00:00:00

abstract：:The activation of a T cell through T cell receptor (TCR) is fundamental to adaptive immune responses. The lymphocyte specific kinase (LCK) plays a central role in the initiation of signaling from the TCR. TCR activates LCK through the adaptor protein uncoordinated 119 (UNC119). A mutation of human UNC119 impairs LCK a...

journal_title：Current allergy and asthma reports

authors： Gorska MM,Alam R

更新日期：2012-10-01 00:00:00

abstract：:Chronic rhinosinusitis (CRS) is one of the most common chronic disease conditions in the United States. Currently, diagnosis is based initially on clinical symptomatology and signs, but the final diagnosis of CRS should be confirmed by objective measures. CT of the paranasal sinuses is the most commonly obtained test ...

journal_title：Current allergy and asthma reports

authors： Bhattacharyya N

更新日期：2010-05-01 00:00:00

abstract：:Chronic rhinosinusitis (CRS) is a heterogeneous inflammatory condition with a multifactorial basis. Infectious triggers of CRS have been proposed, but demonstration remains elusive. Evolving research suggests that abnormal host mucosal immune responses, rather than specific pathogens themselves, may underlie the chron...

journal_title：Current allergy and asthma reports

authors： Lane AP

更新日期：2009-05-01 00:00:00

abstract：:The cutaneous microbiome has been investigated broadly in recent years and some traditional perspectives are beginning to change. A diverse microbiome exists on human skin and has a potential to influence pathogenic microbes and modulate the course of skin disorders, e.g. atopic dermatitis. In addition to the known dy...

journal_title：Current allergy and asthma reports

authors： Fyhrquist N,Salava A,Auvinen P,Lauerma A

更新日期：2016-05-01 00:00:00

abstract：:Asthma is an increasingly prevalent disease, particularly in industrialized countries. With modern treatment, many patients can expect good asthma control; however, a significant minority continue to have excessive symptoms. Bronchial thermoplasty is a novel approach to treating asthma in which the hypertrophied airwa...

journal_title：Current allergy and asthma reports

authors： Martin N,Pavord ID

更新日期：2009-01-01 00:00:00

abstract：:Eosinophilic chronic rhinosinusitis (ECRS) encompasses a wide variety of etiologies. To date, a unifying pathophysiologic mechanism remains elusive. Eosinophilia is frequently, but not exclusively, caused by immunoglobulin (Ig)E-mediated hypersensitivity and is dominated by the associated cytokine milieu of Th2 inflam...

journal_title：Current allergy and asthma reports

authors： Sok JC,Ferguson BJ

更新日期：2006-05-01 00:00:00

abstract：:Diagnosing food allergies can be challenging to the practitioner. Our armamentarium includes standardized skin prick testing, radioallergoimmunosorbent (RAST) testing, and food challenges. These methods have certainly been helpful in the IgE-mediated disorders, including urticaria and anaphylaxis. However, diagnosing ...

journal_title：Current allergy and asthma reports

authors： Spergel JM,Brown-Whitehorn T

更新日期：2005-01-01 00:00:00

abstract：:Otitis media is one of the most common childhood infections leading to doctor's visits and a leading cause of antibiotic prescriptions in children. Twin and family studies have confirmed that the predisposition of developing a bacterial middle ear infection is genetically determined. Several case-control studies have ...

journal_title：Current allergy and asthma reports

authors： Hafrén L,Kentala E,Einarsdottir E,Kere J,Mattila PS

更新日期：2012-12-01 00:00:00

abstract：:Otitis media is currently the most common diagnosis made by clinicians, which has a major impact on managed care. The emergence of resistant bacterial pathogens has caused controversy over the use of antibiotics when acute otitis media (AOM) is diagnosed. All infants with AOM and all older children with severe AOM sho...

journal_title：Current allergy and asthma reports

authors： Gungor A,Bluestone CD

更新日期：2001-07-01 00:00:00

abstract：:The nasal mucosa is a complex tissue that interacts with its environment and effects local and systemic changes. Receptors in the nose receive signals from stimuli, and respond locally through afferent, nociceptive, type C neurons to elicit nasonasal reflex responses mediated via cholinergic neurons. This efferent lim...

journal_title：Current allergy and asthma reports

authors： Baraniuk JN,Kim D

更新日期：2007-05-01 00:00:00

abstract：:Recognition of asthma as a heterogeneous disease revealed different potential molecular targets and urged the development of targeted, customized treatment modalities. Evidence was provided for different inflammatory subsets of asthma and more recently, further refined to T helper (Th)2-high and Th2-low subphenotypes ...

journal_title：Current allergy and asthma reports

authors： Diamant Z,Tufvesson E,Bjermer L

更新日期：2013-10-01 00:00:00

abstract：:In this review, we examine the critical periods of immune development and how these might be modified to prevent food allergy. The relevant dietary intervention studies, roles of microorganisms and their products, and other strategies are critically analyzed. Additionally, we highlight the potential importance of diff...

journal_title：Current allergy and asthma reports

authors： Khakoo A,Lack G

更新日期：2004-01-01 00:00:00

abstract：:Allergic eye disease is associated with IgE-mediated conjunctival inflammation leading to signs of immediate hypersensitivity, including redness, itching, and tearing. Pathologic studies using conjunctival mast cells demonstrate that these cells, when sensitized with IgE antibody and exposed to environmental allergens...

journal_title：Current allergy and asthma reports

authors： Stahl JL,Cook EB,Barney NP,Graziano FM

更新日期：2002-07-01 00:00:00

abstract：:Research evidence supports a causative relationship between indoor allergen exposure and the development of asthma. Epidemiologic studies demonstrate that exposure to indoor allergens, particularly house-dust mites and cockroaches and, to a lesser extent, animal allergens and mold, is a risk factor for the development...

journal_title：Current allergy and asthma reports

authors： Arshad SH

更新日期：2003-03-01 00:00:00

abstract：:Given the increased recognition of pediatric allergic contact dermatitis and lack of patch testing consensus in children, we present a minimum basic 20-allergen North American pediatric series, for screening children ages 6-12 with suspected contact allergy. ...

journal_title：Current allergy and asthma reports

authors： Jacob SE,Admani S,Herro EM

更新日期：2014-06-01 00:00:00

abstract：:Experimental autoimmune encephalomyelitis (EAE) is widely depicted as the prototypical CD4+ Th1-mediated autoimmune disease. Microglia and perivascular macrophages are believed to act as antigen-presenting cells during the effector phase of EAE. In this article, recent data that challenge these conceptions are reviewe...

journal_title：Current allergy and asthma reports

authors： Segal BM

更新日期：2003-01-01 00:00:00