Consequences of a mutation in the UNC119 gene for T cell function in idiopathic CD4 lymphopenia.

abstract：:Chronic rhinosinusitis (CRS) is a heterogeneous inflammatory condition with a multifactorial basis. Infectious triggers of CRS have been proposed, but demonstration remains elusive. Evolving research suggests that abnormal host mucosal immune responses, rather than specific pathogens themselves, may underlie the chron...

journal_title：Current allergy and asthma reports

authors： Lane AP

更新日期：2009-05-01 00:00:00

abstract：:Pain and itch sensations are induced by depolarization of distinct populations of unmyelinated type C, and possibly other, neurons. Both sets of neurons and sensations serve critical protective mechanisms that maintain the integrity and patency of the upper airways. When noxious or pruritic stimuli are applied on the ...

journal_title：Current allergy and asthma reports

authors： Tai CF,Baraniuk JN

更新日期：2003-05-01 00:00:00

abstract：:Expanding knowledge about an interaction of the bacterial colonization with pathogenic and non-pathogenic bacteria and the human immune system leads to speculation on potential effects on health and disease. Recent advances in sequencing technologies and new bioinformatic possibilities now allow investigating the micr...

journal_title：Current allergy and asthma reports

authors： Bendiks M,Kopp MV

更新日期：2013-10-01 00:00:00

abstract：:Adverse reactions to contrast material are a concern because iodinated contrast materials are commonly used drugs. The risk for adverse reaction is 4% to 12% with ionic contrast materials and 1% to 3% with nonionic contrast materials. The risk for severe adverse reaction is 0.16% with ionic contrast materials and 0.03...

journal_title：Current allergy and asthma reports

authors： Cochran ST

更新日期：2005-01-01 00:00:00

abstract：PURPOSE OF REVIESW:Local respiratory allergy (LRA) is an eosinophilic phenotype of chronic airway disease. Three entities have been described within the LRA spectrum: local allergic rhinitis (LAR) and local allergic asthma (LAA) in non-atopic patients, and dual allergic rhinitis (DAR) in atopic patients (coexistence of...

journal_title：Current allergy and asthma reports

authors： Eguiluz-Gracia I,Ariza A,Testera-Montes A,Rondón C,Campo P

更新日期：2020-05-19 00:00:00

abstract：:Viral rhinitis is a common, morbid, and costly malady, often complicated by otitis media, sinusitis, and asthma. Current therapies are relatively ineffective and aimed at reducing symptoms rather than moderating underlying mechanisms. Nasal elevations of proinflammatory cytokines track symptom expression during viral ...

journal_title：Current allergy and asthma reports

authors： Gentile DA,Skoner DP

更新日期：2001-05-01 00:00:00

abstract：:The cutaneous microbiome has been investigated broadly in recent years and some traditional perspectives are beginning to change. A diverse microbiome exists on human skin and has a potential to influence pathogenic microbes and modulate the course of skin disorders, e.g. atopic dermatitis. In addition to the known dy...

journal_title：Current allergy and asthma reports

authors： Fyhrquist N,Salava A,Auvinen P,Lauerma A

更新日期：2016-05-01 00:00:00

abstract：:Traditionally, symptoms are important patient-oriented outcomes in asthma treatment, and assessment of symptoms is an essential component of assessing asthma control. However, variable airways obstruction, airways hyperresponsiveness and chronic inflammation are key components of the asthma syndrome, and correlations ...

journal_title：Current allergy and asthma reports

authors： Nuijsink M,De Jongste JC,Pijnenburg MW

更新日期：2013-10-01 00:00:00

abstract：PURPOSE OF REVIEW:The objective of this article is to provide an updated review of the economic burden of chronic rhinosinusitis (CRS) and discuss how both medical and surgical interventions impact direct and indirect costs related to CRS. By understanding the economics of CRS, clinicians may improve the patient-center...

journal_title：Current allergy and asthma reports

authors： Rudmik L

更新日期：2017-04-01 00:00:00

abstract：:Glucocorticoid insensitivity presents a profound management problem in patients with asthma because conventional therapies are not effective. Glucocorticoids, acting through the glucocorticoid receptor (GR), are able to selectively repress inflammatory gene expression by utilizing several distinct mechanisms targeting...

journal_title：Current allergy and asthma reports

authors： Adcock IM,Ford PA,Bhavsar P,Ahmad T,Chung KF

更新日期：2008-04-01 00:00:00

abstract：:Perioperative anaphylaxis is a unique condition as a result of the additive cardiovascular effects of anesthetics on the cardiovascular disturbances of anaphylaxis. It occurs mainly in adulthood, primarily follows anesthetic induction, and for the most part, is an IgE-mediated pathomechanism. Neuromuscular blocking ag...

journal_title：Current allergy and asthma reports

authors： Dewachter P,Mouton-Faivre C,Hepner DL

更新日期：2015-05-01 00:00:00

abstract：PURPOSE OF REVIEW:This study aimed to review important hidden causes of anaphylaxis in ingestants, non-ingestants, and uncommon settings. RECENT FINDINGS:Multiple new and elusive causes of anaphylaxis have been described over the past 35 years. Further research is required to identify the epidemiology, pathophysiology...

journal_title：Current allergy and asthma reports

authors： Nanagas VC,Baldwin JL,Karamched KR

更新日期：2017-07-01 00:00:00

abstract：:Respiratory viruses appear to play a central role in asthma pathogenesis. In addition to a major role in triggering asthma exacerbations, viral infections early in life may play a role in disease development. Although defensins were initially identified as antimicrobial peptides, recent studies have demonstrated that ...

journal_title：Current allergy and asthma reports

authors： Proud D

更新日期：2006-02-01 00:00:00

abstract：:Weeds represent a heterogeneous group of plants, usually defined by no commercial or aesthetic value. Important allergenic weeds belong to the plant families Asteraceae, Amaranthaceae, Urticaceae, Euphorbiaceae, and Plantaginaceae. Major allergens from ragweed, mugwort, feverfew, pellitory, goosefoot, Russian thistle,...

journal_title：Current allergy and asthma reports

authors： Gadermaier G,Dedic A,Obermeyer G,Frank S,Himly M,Ferreira F

更新日期：2004-09-01 00:00:00

abstract：:Specific allergen immunotherapy (SIT) is the only disease-modifying treatment for allergic rhinitis and asthma. Subcutaneous immunotherapy (SCIT) is the only method with a US Food and Drug Administration (FDA)-approved formulation, but safety concerns limit administration to medical facilities. Sublingual immunotherap...

journal_title：Current allergy and asthma reports

authors： Cox L

更新日期：2007-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Food allergy is increasing in prevalence, and management focuses on strict avoidance of known allergens and appropriately treating reactions. Any reaction has the potential to result in anaphylaxis, which can be fatal. Children spend a significant amount of time in the childcare or school setting, and...

journal_title：Current allergy and asthma reports

authors： Hui JW,Copeland M,Lanser BJ

更新日期：2020-06-06 00:00:00

abstract：:Asthma and chronic obstructive pulmonary disease (COPD) have traditionally been viewed as distinct clinical entities. Recently, however, much attention has been focused on patients with overlapping features of both asthma and COPD: those with asthma COPD overlap syndrome (ACOS). Although no universal definition criter...

journal_title：Current allergy and asthma reports

authors： Bujarski S,Parulekar AD,Sharafkhaneh A,Hanania NA

更新日期：2015-03-01 00:00:00

abstract：:Over the past few decades, significant scientific progress has influenced clinical allergy practice. The biological standardization of extracts was followed by the massive identification and characterization of new allergens and their progressive use as diagnostic tools including allergen micro arrays that facilitate ...

journal_title：Current allergy and asthma reports

authors： Barber D,Díaz-Perales A,Villalba M,Chivato T

更新日期：2015-02-01 00:00:00

abstract：PURPOSE OF REVIEW:There has been an explosion in the number of published systematic reviews on chronic rhinosinusitis in the last decade. RECENT FINDINGS:While the aim of these reviews in facilitating evidence-based practice is laudable, poor quality reviews may contain significant bias that can mislead a non-discerni...

journal_title：Current allergy and asthma reports

authors： Walker A,Hopkins C

更新日期：2018-02-16 00:00:00

abstract：:Major progress has been made during the past few years in developing a better understanding of the genetic basis of asthma, which has led to the identification of several chromosomal regions and loci showing linkage to and association with asthma and asthma-related phenotypes. Recent positional cloning approaches have...

journal_title：Current allergy and asthma reports

authors： Park HS,Kim SH,Park CS

更新日期：2006-03-01 00:00:00

abstract：PURPOSE OF REVIEW:The adaptive immune response orchestrated by type 2 T helper (Th2) lymphocytes, strictly cooperates with the innate response of group 2 innate lymphoid cells (ILC2), in the protection from helminths infection, as well as in the pathogenesis of allergic disease. The aim of this review is to explore the...

journal_title：Current allergy and asthma reports

authors： Cosmi L,Liotta F,Maggi L,Annunziato F

更新日期：2017-09-11 00:00:00

abstract：PURPOSE OF REVIEW:Agriculture remains a major economic sector globally, and workers experience high rates of chronic inflammatory lung and musculoskeletal diseases. Whereas obstructive pulmonary diseases are known risk factors for bone loss, the underlying relationship between lung inflammation and bone health is not w...

journal_title：Current allergy and asthma reports

authors： Carrington JM,Poole JA

更新日期：2018-02-22 00:00:00

abstract：:The gut-associated lymphoid tissue is the specialized arm of the immune system responsible for distinguishing innocuous dietary nutrients, self-proteins, and gut flora from pathogens. Oral tolerance is the active immunologic response to innocuous ingested antigens that leads to a systemic tolerance for that antigen. T...

journal_title：Current allergy and asthma reports

authors： Stanley S

更新日期：2002-01-01 00:00:00

abstract：:Genome-wide screens for asthma and atopy susceptibility loci have been completed in six population samples. Despite the extensive clinical heterogeneity associated with these phenotypes, 20 chromosomal regions show evidence of linkage (P < 0.01) in three or more population samples. Thus, this survey suggests that at l...

journal_title：Current allergy and asthma reports

authors： Ober C

更新日期：2001-03-01 00:00:00

abstract：PURPOSE OF REVIEW:This paper offers a comprehensive review of interactive mobile allergy and asthma smartphone applications available within the USA in 2018, with an emphasis on interactive asthma apps. RECENT FINDINGS:Primary care and specialty clinicians interested in introducing digital health apps into their pract...

journal_title：Current allergy and asthma reports

authors： Kagen S,Garland A

更新日期：2019-02-02 00:00:00

abstract：PURPOSE OF REVIEW:Chronic rhinosinusitis (CRS) is a multidimensional inflammatory disorder of the nose and paranasal sinuses. We reviewed the recent literature to identify improved methods to assess, control, and manage these difficult to control patients. RECENT FINDINGS:The role of endotyping in CRS has offered a be...

journal_title：Current allergy and asthma reports

authors： Sivasubramaniam R,Harvey RJ

更新日期：2017-09-01 00:00:00

abstract：:Urticaria can present acutely and be self-limiting or become chronic and persist for weeks, months, or years. In either case, the condition may have a significant impact on the patient's quality of life. Two major consensus groups, the EAACI/WAO and the AAAAI/ACAAI Joint Task Force, have written guidelines on the diag...

journal_title：Current allergy and asthma reports

authors： Fine LM,Bernstein JA

更新日期：2015-06-01 00:00:00

abstract：:Aspirin-exacerbated respiratory disease (AERD) is an acquired disease characterized by chronic eosinophilic airway inflammation with underlying dysregulation of arachidonic acid metabolism. The purpose of this paper is to review the latest developments in our understanding of the underlying pathophysiology including t...

journal_title：Current allergy and asthma reports

authors： Woessner KM

更新日期：2017-01-01 00:00:00

abstract：:Mouse allergen has long been recognized as an important cause of occupational allergy and asthma, but only recently has it been implicated in asthma and allergic diseases in community settings. Recent studies have established that mouse allergen is detectable in most US homes, with strikingly high levels in some inner...

journal_title：Current allergy and asthma reports

authors： Matsui EC

更新日期：2009-09-01 00:00:00

abstract：:Recognition of asthma as a heterogeneous disease revealed different potential molecular targets and urged the development of targeted, customized treatment modalities. Evidence was provided for different inflammatory subsets of asthma and more recently, further refined to T helper (Th)2-high and Th2-low subphenotypes ...

journal_title：Current allergy and asthma reports

authors： Diamant Z,Tufvesson E,Bjermer L

更新日期：2013-10-01 00:00:00