Abstract：
:Specific allergen immunotherapy (SIT) is the only disease-modifying treatment for allergic rhinitis and asthma. Subcutaneous immunotherapy (SCIT) is the only method with a US Food and Drug Administration (FDA)-approved formulation, but safety concerns limit administration to medical facilities. Sublingual immunotherapy (SLIT), under investigation in the United States, appears to have a more favorable safety profile, which may expand its use to populations generally not treated with SIT (eg, young children). This paper reviews SLIT studies that were specifically limited to the pediatric population. Most demonstrated evidence of clinical efficacy, but approximately 29% failed to demonstrate efficacy in symptom and medication scores in the first treatment year. Efficacy was seen in a broad range of allergen doses, but optimal dose range has not been established. SLIT appeared to be well tolerated in children as young as 2 years, but serious adverse reactions, including anaphylaxis, were reported. SLIT is a promising immunotherapy that may expand the population receiving SIT because of the convenience of home administration due to its favorable safety profile. However, questions remain unanswered, including optimal therapeutic dose.
journal_name
Curr Allergy Asthma Repjournal_title
Current allergy and asthma reportsauthors
Cox Ldoi
10.1007/s11882-007-0063-6subject
Has Abstractpub_date
2007-11-01 00:00:00pages
410-20issue
6eissn
1529-7322issn
1534-6315journal_volume
7pub_type
杂志文章,评审abstract：:Nasal polyposis is the end result of a variety of pathologic processes. The aims of treatment are to relieve nasal blockage, restore olfaction, and improve sinus drainage. Treating any accompanying rhinitis is also an aim, which requires that medical treatment be given to all patients with an inflammatory problem. Mos...
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journal_title：Current allergy and asthma reports
pub_type： 杂志文章,评审
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journal_title：Current allergy and asthma reports
pub_type： 杂志文章,评审
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更新日期：2010-09-01 00:00:00
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更新日期：2013-02-01 00:00:00
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更新日期：2001-07-01 00:00:00
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更新日期：2005-03-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2003-05-01 00:00:00
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journal_title：Current allergy and asthma reports
pub_type： 杂志文章,评审
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更新日期：2015-01-01 00:00:00
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journal_title：Current allergy and asthma reports
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pub_type： 杂志文章,评审
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更新日期：2012-10-01 00:00:00
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journal_title：Current allergy and asthma reports
pub_type： 杂志文章,评审
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更新日期：2009-01-01 00:00:00
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pub_type： 杂志文章
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更新日期：2010-07-01 00:00:00
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pub_type： 杂志文章,评审
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journal_title：Current allergy and asthma reports
pub_type： 杂志文章,评审
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更新日期：2001-11-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2002-09-01 00:00:00
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journal_title：Current allergy and asthma reports
pub_type： 杂志文章,评审
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更新日期：2005-07-01 00:00:00
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journal_title：Current allergy and asthma reports
pub_type： 杂志文章,评审
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更新日期：2009-11-01 00:00:00
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journal_title：Current allergy and asthma reports
pub_type： 杂志文章,评审
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更新日期：2008-04-01 00:00:00
