Biological and genetic markers in occupational asthma.

abstract：:Oral food challenges are the gold-standard diagnostic investigation for diagnosing food allergy. They allow a subject to consume an age-appropriate portion of allergenic food under surveillance to assess whether a reproducible immune-mediated adverse response is demonstrated. The specific design of food challenge must...

journal_title：Current allergy and asthma reports

authors： Feeney M,Marrs T,Lack G,Du Toit G

更新日期：2015-08-01 00:00:00

abstract：:Common variable immunodeficiency (CVID) is the most prevalent symptomatic primary immune deficiency. With widespread use of immunoglobulin replacement therapy, non-infectious complications, such as autoimmunity, chronic intestinal inflammation, and lung disease, have replaced infections as the major cause of morbidity...

journal_title：Current allergy and asthma reports

authors： Maglione PJ,Cols M,Cunningham-Rundles C

更新日期：2017-10-05 00:00:00

abstract：:Since rhinosinusitis is an inflammatory disease, cytokines as key regulators of inflammation play a central role in its pathophysiology. In acute rhinosinusitis, several proinflammatory cytokines of different types have been identified. Initial information about the involvement of the inflammasome in rhinosinusitis ha...

journal_title：Current allergy and asthma reports

authors： Scheckenbach K,Wagenmann M

更新日期：2016-01-01 00:00:00

abstract：:Asthma affects 5% to 10% of the population of the United States. In asthmatics, oxidative stress occurs not only as a result of inflammation but also from environmental exposure to air pollution. The specific localization of antioxidants in the lung and the adaptive changes during asthma underscore the importance of o...

journal_title：Current allergy and asthma reports

authors： Bowler RP

更新日期：2004-03-01 00:00:00

abstract：:The buildup of greenhouse gases in the atmosphere has resulted in global climate change that is having a significant effect on many allergenic plants through increases in plant productivity and pollen allergenicity and shifts in plant phenology. Based on experimental studies, increased atmospheric levels of carbon dio...

journal_title：Current allergy and asthma reports

authors： Levetin E,Van de Water P

更新日期：2008-09-01 00:00:00

abstract：:Glucocorticoid insensitivity presents a profound management problem in patients with asthma because conventional therapies are not effective. Glucocorticoids, acting through the glucocorticoid receptor (GR), are able to selectively repress inflammatory gene expression by utilizing several distinct mechanisms targeting...

journal_title：Current allergy and asthma reports

authors： Adcock IM,Ford PA,Bhavsar P,Ahmad T,Chung KF

更新日期：2008-04-01 00:00:00

abstract：:Nonspecific lipid transfer proteins (LTPs) are important allergens in fruits, vegetables, nuts, pollen, and latex. Despite their wide distribution throughout the plant kingdom, their clinical relevance is largely confined to the Mediterranean area. As they can sensitize via the gastrointestinal tract, LPTs are conside...

journal_title：Current allergy and asthma reports

authors： Egger M,Hauser M,Mari A,Ferreira F,Gadermaier G

更新日期：2010-09-01 00:00:00

abstract：:Although the smoking prevalence in the United States continues to decline since the Surgeon General's first report in 1964, certain vulnerable populations continue to be disproportionately affected by the adverse consequences of tobacco smoke exposure. Children are particularly vulnerable to exposure and are likely to...

journal_title：Current allergy and asthma reports

authors： Ciaccio CE,Gentile D

更新日期：2013-12-01 00:00:00

abstract：:Chronic rhinosinusitis (CRS) is a chronic inflammatory disease of the upper airways of which two major phenotypes exist, CRS without nasal polyps (CRSsNP) and CRS with nasal polyps (CRSwNP). Some patients with CRS have suboptimal response to current guideline treatments. These patients remain severe and uncontrolled b...

journal_title：Current allergy and asthma reports

authors： López-Chacón M,Mullol J,Pujols L

更新日期：2015-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Food allergy is increasing in prevalence, and management focuses on strict avoidance of known allergens and appropriately treating reactions. Any reaction has the potential to result in anaphylaxis, which can be fatal. Children spend a significant amount of time in the childcare or school setting, and...

journal_title：Current allergy and asthma reports

authors： Hui JW,Copeland M,Lanser BJ

更新日期：2020-06-06 00:00:00

abstract：:IgG4 is the least abundant subclass of IgG in normal human serum, but elevated IgG4 levels are triggered in response to a chronic antigenic stimulus and inflammation. Since the immune system is exposed to tumor-associated antigens over a relatively long period of time, and tumors notoriously promote inflammation, it i...

journal_title：Current allergy and asthma reports

authors： Crescioli S,Correa I,Karagiannis P,Davies AM,Sutton BJ,Nestle FO,Karagiannis SN

更新日期：2016-01-01 00:00:00

abstract：PURPOSE OF REVIEW:This study aimed to review important hidden causes of anaphylaxis in ingestants, non-ingestants, and uncommon settings. RECENT FINDINGS:Multiple new and elusive causes of anaphylaxis have been described over the past 35 years. Further research is required to identify the epidemiology, pathophysiology...

journal_title：Current allergy and asthma reports

authors： Nanagas VC,Baldwin JL,Karamched KR

更新日期：2017-07-01 00:00:00

abstract：:Asthma is an increasingly prevalent disease, particularly in industrialized countries. With modern treatment, many patients can expect good asthma control; however, a significant minority continue to have excessive symptoms. Bronchial thermoplasty is a novel approach to treating asthma in which the hypertrophied airwa...

journal_title：Current allergy and asthma reports

authors： Martin N,Pavord ID

更新日期：2009-01-01 00:00:00

abstract：:Respiratory viruses appear to play a central role in asthma pathogenesis. In addition to a major role in triggering asthma exacerbations, viral infections early in life may play a role in disease development. Although defensins were initially identified as antimicrobial peptides, recent studies have demonstrated that ...

journal_title：Current allergy and asthma reports

authors： Proud D

更新日期：2006-02-01 00:00:00

abstract：:Asthma is an episodic respiratory syndrome caused by several pathogenic processes. This recurrent syndrome is associated with an accelerated decline in lung function and increase in airway obstruction over time. The reduced lung function is a consequence of tissue restructuring of all the components of the airway wall...

journal_title：Current allergy and asthma reports

authors： Bossé Y,Paré PD,Seow CY

更新日期：2008-07-01 00:00:00

abstract：:Research evidence supports a causative relationship between indoor allergen exposure and the development of asthma. Epidemiologic studies demonstrate that exposure to indoor allergens, particularly house-dust mites and cockroaches and, to a lesser extent, animal allergens and mold, is a risk factor for the development...

journal_title：Current allergy and asthma reports

authors： Arshad SH

更新日期：2003-03-01 00:00:00

abstract：:Differences in asthma prevalence have been described across different populations, suggesting that genetic ancestry can play an important role in this disease. In fact, several studies have demonstrated an association between African ancestry with increased asthma susceptibility and severity, higher immunoglobulin E l...

journal_title：Current allergy and asthma reports

authors： Hernandez-Pacheco N,Flores C,Oh SS,Burchard EG,Pino-Yanes M

更新日期：2016-07-01 00:00:00

abstract：:Hypersensitivity in the allergic setting refers to immune reactions, stimulated by soluble antigens that can be rapidly progressing and, in the case of anaphylaxis, are occasionally fatal. As the number of known exposures associated with anaphylaxis is limited, identification of novel causative agents is important in ...

journal_title：Current allergy and asthma reports

authors： Platts-Mills TA,Schuyler AJ,Hoyt AE,Commins SP

更新日期：2015-04-01 00:00:00

abstract：:Eosinophilic chronic rhinosinusitis (ECRS) encompasses a wide variety of etiologies. To date, a unifying pathophysiologic mechanism remains elusive. Eosinophilia is frequently, but not exclusively, caused by immunoglobulin (Ig)E-mediated hypersensitivity and is dominated by the associated cytokine milieu of Th2 inflam...

journal_title：Current allergy and asthma reports

authors： Sok JC,Ferguson BJ

更新日期：2006-05-01 00:00:00

abstract：:Pain and itch sensations are induced by depolarization of distinct populations of unmyelinated type C, and possibly other, neurons. Both sets of neurons and sensations serve critical protective mechanisms that maintain the integrity and patency of the upper airways. When noxious or pruritic stimuli are applied on the ...

journal_title：Current allergy and asthma reports

authors： Tai CF,Baraniuk JN

更新日期：2003-05-01 00:00:00

abstract：:Monogenic autoinflammatory diseases encompass a distinct and growing clinical entity of multisystem inflammatory diseases with known genetic defects in the innate immune system. The diseases present clinically with episodes of seemingly unprovoked inflammation (fever, rashes, and elevation of acute phase reactants). U...

journal_title：Current allergy and asthma reports

authors： Glaser RL,Goldbach-Mansky R

更新日期：2008-07-01 00:00:00

abstract：PURPOSE OF REVIESW:Local respiratory allergy (LRA) is an eosinophilic phenotype of chronic airway disease. Three entities have been described within the LRA spectrum: local allergic rhinitis (LAR) and local allergic asthma (LAA) in non-atopic patients, and dual allergic rhinitis (DAR) in atopic patients (coexistence of...

journal_title：Current allergy and asthma reports

authors： Eguiluz-Gracia I,Ariza A,Testera-Montes A,Rondón C,Campo P

更新日期：2020-05-19 00:00:00

abstract：:Although fungi are pervasive in many environments, few cause disease in humans. Of these, Aspergillus fumigatus is particularly well suited to be a pathogen of the human lung. Its physical and biological characteristics combine to provide an organism that can cause tremendous morbidity and high mortality if left unche...

journal_title：Current allergy and asthma reports

authors： Ghosh S,Hoselton SA,Schuh JM

更新日期：2015-10-01 00:00:00

abstract：:Many fungi are capable of causing IgE-mediated hypersensitivity in humans. However, the most predominant fungi implicated in allergy belong to the genera Aspergillus, Alternaria, Cladosporium, and Penicillium. Pure and relevant allergens are essential for diagnosis as well as for understanding the immunopathogenesis o...

journal_title：Current allergy and asthma reports

authors： Kurup VP

更新日期：2003-09-01 00:00:00

abstract：:In this review, we examine the critical periods of immune development and how these might be modified to prevent food allergy. The relevant dietary intervention studies, roles of microorganisms and their products, and other strategies are critically analyzed. Additionally, we highlight the potential importance of diff...

journal_title：Current allergy and asthma reports

authors： Khakoo A,Lack G

更新日期：2004-01-01 00:00:00

abstract：:In recent years, greater attention has been given to the role of indoor allergens as a cause of sensitization and allergic respiratory diseases. Although indoor allergen control measures to reduce symptoms in individuals allergic to mites have produced controversial results, environmental allergen avoidance is today o...

journal_title：Current allergy and asthma reports

authors： Fernández-Caldas E

更新日期：2002-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Told from the viewpoint of rheumatologists, this review tells the story of hydroxychloroquine and its swift ascent to become a household name as a therapeutic strategy against the novel SARS-CoV-2 virus. This review describes the history, mechanisms, pharmacokinetics, therapeutic applications, and saf...

journal_title：Current allergy and asthma reports

authors： Udupa A,Leverenz D,Balevic SJ,Sadun RE,Tarrant TK,Rogers JL

更新日期：2021-01-21 00:00:00

abstract：:The physical urticarias are a heterogeneous subgroup of chronic urticarias in which wheals can be reproducibly induced by different specific physical stimuli such as cold, heat, pressure, vibration, or sunlight. Physical urticarias comprise up to 25 % of chronic urticarias and occur more frequently in young adults. Sy...

journal_title：Current allergy and asthma reports

authors： Abajian M,Młynek A,Maurer M

更新日期：2012-08-01 00:00:00

abstract：:Over the past few decades, significant scientific progress has influenced clinical allergy practice. The biological standardization of extracts was followed by the massive identification and characterization of new allergens and their progressive use as diagnostic tools including allergen micro arrays that facilitate ...

journal_title：Current allergy and asthma reports

authors： Barber D,Díaz-Perales A,Villalba M,Chivato T

更新日期：2015-02-01 00:00:00

abstract：:Although eustachian tube dysfunction and bacterial infection have been shown to cause otitis media with effusion (OME), other etiologies are possible. One of the most common medical conditions in children is obesity, which can have effects throughout the body. Little is known, however, about the relationship between o...

journal_title：Current allergy and asthma reports

authors： Lee SK,Yeo SG

更新日期：2009-11-01 00:00:00