Abstract:
:Chronic rhinosinusitis (CRS) is a chronic inflammatory disease of the upper airways of which two major phenotypes exist, CRS without nasal polyps (CRSsNP) and CRS with nasal polyps (CRSwNP). Some patients with CRS have suboptimal response to current guideline treatments. These patients remain severe and uncontrolled by treatment and have a poor quality of life. It is highly important to identify both clinical and biological markers, so-called biomarkers, in this subset of patients. The presence of nasal polyps and comorbidity with asthma and with aspirin-exacerbated respiratory disease (AERD) are the most common clinical traits that have been associated to difficult-to-treat severe CRS. In addition to clinical traits, numerous biological markers, with known etiopathogenic roles in CRS, have been associated to difficult-to-treat or recalcitrant CRS. This review summarizes the existing knowledge of the clinical and biological markers associated to difficult-to-treat or uncontrolled severe CRS.
journal_name
Curr Allergy Asthma Repjournal_title
Current allergy and asthma reportsauthors
López-Chacón M,Mullol J,Pujols Ldoi
10.1007/s11882-015-0520-6subject
Has Abstractpub_date
2015-05-01 00:00:00pages
19issue
5eissn
1529-7322issn
1534-6315journal_volume
15pub_type
杂志文章,评审abstract::The incidence of immune disorders is growing parallel with practices associated with westernization, such as dietary changes, increased use of antibiotics, or elevated rates of Cesarean section. These practices can significantly impact the gut microbiota, the collection of bacteria residing in the human gastrointestin...
journal_title:Current allergy and asthma reports
pub_type: 杂志文章,评审
doi:10.1007/s11882-015-0538-9
更新日期:2015-07-01 00:00:00
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journal_title:Current allergy and asthma reports
pub_type: 杂志文章,评审
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journal_title:Current allergy and asthma reports
pub_type: 杂志文章,评审
doi:10.1007/s11882-002-0067-1
更新日期:2002-09-01 00:00:00
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journal_title:Current allergy and asthma reports
pub_type: 杂志文章,评审
doi:10.1007/s11882-003-0042-5
更新日期:2003-05-01 00:00:00
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journal_title:Current allergy and asthma reports
pub_type: 杂志文章,评审
doi:10.1007/s11882-016-0601-1
更新日期:2016-03-01 00:00:00
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journal_title:Current allergy and asthma reports
pub_type: 杂志文章,评审
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更新日期:2002-07-01 00:00:00
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journal_title:Current allergy and asthma reports
pub_type: 杂志文章,评审
doi:10.1007/s11882-015-0512-6
更新日期:2015-04-01 00:00:00
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journal_title:Current allergy and asthma reports
pub_type: 杂志文章,评审
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更新日期:2002-07-01 00:00:00
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更新日期:2013-02-01 00:00:00
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journal_title:Current allergy and asthma reports
pub_type: 杂志文章,评审
doi:10.1007/s11882-016-0635-4
更新日期:2016-07-01 00:00:00
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journal_title:Current allergy and asthma reports
pub_type: 杂志文章,评审
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更新日期:2012-06-01 00:00:00
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journal_title:Current allergy and asthma reports
pub_type: 杂志文章,评审
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更新日期:2018-01-19 00:00:00
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journal_title:Current allergy and asthma reports
pub_type: 杂志文章,评审
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更新日期:2002-05-01 00:00:00
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journal_title:Current allergy and asthma reports
pub_type: 杂志文章,评审
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更新日期:2003-03-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2015-08-01 00:00:00
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journal_title:Current allergy and asthma reports
pub_type: 杂志文章,评审
doi:10.1007/s11882-017-0701-6
更新日期:2017-05-01 00:00:00
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journal_title:Current allergy and asthma reports
pub_type: 杂志文章,评审
doi:10.1007/s11882-007-0063-6
更新日期:2007-11-01 00:00:00
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journal_title:Current allergy and asthma reports
pub_type: 杂志文章
doi:10.1007/s11882-010-0103-5
更新日期:2010-05-01 00:00:00
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pub_type: 杂志文章,评审
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journal_title:Current allergy and asthma reports
pub_type: 杂志文章,评审
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更新日期:2016-05-01 00:00:00
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journal_title:Current allergy and asthma reports
pub_type: 杂志文章,评审
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更新日期:2013-10-01 00:00:00
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journal_title:Current allergy and asthma reports
pub_type: 杂志文章,评审
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更新日期:2013-04-01 00:00:00
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journal_title:Current allergy and asthma reports
pub_type: 杂志文章,meta分析,评审
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更新日期:2018-02-16 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2008-04-01 00:00:00
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journal_title:Current allergy and asthma reports
pub_type: 杂志文章,评审
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journal_title:Current allergy and asthma reports
pub_type: 杂志文章,评审
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journal_title:Current allergy and asthma reports
pub_type: 杂志文章,评审
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更新日期:2010-09-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2005-07-01 00:00:00