Human nasal allergen provocation for determination of true allergic rhinitis: methods for clinicians.

abstract：:Diagnosing food allergies can be challenging to the practitioner. Our armamentarium includes standardized skin prick testing, radioallergoimmunosorbent (RAST) testing, and food challenges. These methods have certainly been helpful in the IgE-mediated disorders, including urticaria and anaphylaxis. However, diagnosing ...

journal_title：Current allergy and asthma reports

authors： Spergel JM,Brown-Whitehorn T

更新日期：2005-01-01 00:00:00

abstract：:Multiple sclerosis (MS) is the most common cause of chronic neurologic disability in young people. Genetic susceptibility and unidentified environmental triggers appear to be necessary in order to result in disease. MS is an extraordinarily complex trait with evidence of heterogeneity at clinical, pathologic, and ther...

journal_title：Current allergy and asthma reports

authors： Heard RN

更新日期：2007-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Rising costs and increasing morbidity makes the identification and treatment of high-risk asthma phenotypes important. In this review, we outline the complex relationship between obesity and asthma. RECENT FINDINGS:Studies have confirmed a bi-directional relationship between obesity and asthma. Patho...

journal_title：Current allergy and asthma reports

authors： Mohan A,Grace J,Wang BR,Lugogo N

更新日期：2019-09-10 00:00:00

abstract：:Monogenic autoinflammatory diseases encompass a distinct and growing clinical entity of multisystem inflammatory diseases with known genetic defects in the innate immune system. The diseases present clinically with episodes of seemingly unprovoked inflammation (fever, rashes, and elevation of acute phase reactants). U...

journal_title：Current allergy and asthma reports

authors： Glaser RL,Goldbach-Mansky R

更新日期：2008-07-01 00:00:00

abstract：:Otitis media is one of the most common childhood infections leading to doctor's visits and a leading cause of antibiotic prescriptions in children. Twin and family studies have confirmed that the predisposition of developing a bacterial middle ear infection is genetically determined. Several case-control studies have ...

journal_title：Current allergy and asthma reports

authors： Hafrén L,Kentala E,Einarsdottir E,Kere J,Mattila PS

更新日期：2012-12-01 00:00:00

abstract：:Traditionally, symptoms are important patient-oriented outcomes in asthma treatment, and assessment of symptoms is an essential component of assessing asthma control. However, variable airways obstruction, airways hyperresponsiveness and chronic inflammation are key components of the asthma syndrome, and correlations ...

journal_title：Current allergy and asthma reports

authors： Nuijsink M,De Jongste JC,Pijnenburg MW

更新日期：2013-10-01 00:00:00

abstract：:Mouse allergen has long been recognized as an important cause of occupational allergy and asthma, but only recently has it been implicated in asthma and allergic diseases in community settings. Recent studies have established that mouse allergen is detectable in most US homes, with strikingly high levels in some inner...

journal_title：Current allergy and asthma reports

authors： Matsui EC

更新日期：2009-09-01 00:00:00

abstract：:During the past decade, studies on facial pain have shown that there is a distinct group of patients who have a form of facial neuralgia that has all the characteristics of tension-type headache, except that it affects the midface; it is called midfacial segment pain. The pain is described as a feeling of pressure, al...

journal_title：Current allergy and asthma reports

authors： Jones NS

更新日期：2004-05-01 00:00:00

abstract：PURPOSES OF REVIEW:Th9 cells are recognized as a novel subset of effector T helper cells that preferentially produce IL-9. Here, we provide a current update on the reports related to the function of Th9 cells in allergic inflammatory diseases. RECENT FINDINGS:The effector Th9 cells differentiating from naïve T helper ...

journal_title：Current allergy and asthma reports

authors： Angkasekwinai P

更新日期：2019-03-26 00:00:00

abstract：:Omalizumab is a recently developed monoclonal anti-IgE antibody. Clinical trials have demonstrated its efficacy in patients with moderate-to-severe and severe or poorly controlled allergic asthma, in patients with seasonal and perennial allergic disease, and in subjects with concomitant asthma and allergic rhinitis. P...

journal_title：Current allergy and asthma reports

authors： Sandström T

更新日期：2005-03-01 00:00:00

abstract：:The increased prevalence of atopic diseases, atopic dermatitis, allergic rhinitis, and asthma has been described as an epidemic. New approaches in the fight against allergic diseases are called for, the target being the persistence of the atopic T helper 2-skewed immune responder pattern beyond infancy. Atopic dermati...

journal_title：Current allergy and asthma reports

authors： Isolauri E

更新日期：2004-07-01 00:00:00

abstract：:Nonspecific lipid transfer proteins (LTPs) are important allergens in fruits, vegetables, nuts, pollen, and latex. Despite their wide distribution throughout the plant kingdom, their clinical relevance is largely confined to the Mediterranean area. As they can sensitize via the gastrointestinal tract, LPTs are conside...

journal_title：Current allergy and asthma reports

authors： Egger M,Hauser M,Mari A,Ferreira F,Gadermaier G

更新日期：2010-09-01 00:00:00

abstract：PURPOSE OF REVIEW:B cell disorders result in decreased levels or function of immunoglobulins in an individual. Genetic mutations have been reported in a variety of B cell disorders. This review, in follow-up to a previous review, describes some rare B cell disorders as well as their known underlying genetic etiologies....

journal_title：Current allergy and asthma reports

authors： Griffin DD,Dolen WK

更新日期：2020-08-21 00:00:00

abstract：:Respiratory viruses appear to play a central role in asthma pathogenesis. In addition to a major role in triggering asthma exacerbations, viral infections early in life may play a role in disease development. Although defensins were initially identified as antimicrobial peptides, recent studies have demonstrated that ...

journal_title：Current allergy and asthma reports

authors： Proud D

更新日期：2006-02-01 00:00:00

abstract：:The incidence, morbidity, and mortality of asthma have been increasing at an alarming rate, making asthma the most common chronic illness of childhood. An asthma disease management program was developed to improve the care and management of patients with asthma--a comprehensive health care delivery model that was desi...

journal_title：Current allergy and asthma reports

authors： Miller K,Ward-Smith P,Cox K,Jones EM,Portnoy JM

更新日期：2003-11-01 00:00:00

abstract：:Chronic rhinosinusitis (CRS) is a heterogeneous inflammatory condition with a multifactorial basis. Infectious triggers of CRS have been proposed, but demonstration remains elusive. Evolving research suggests that abnormal host mucosal immune responses, rather than specific pathogens themselves, may underlie the chron...

journal_title：Current allergy and asthma reports

authors： Lane AP

更新日期：2009-05-01 00:00:00

abstract：:The cutaneous microbiome has been investigated broadly in recent years and some traditional perspectives are beginning to change. A diverse microbiome exists on human skin and has a potential to influence pathogenic microbes and modulate the course of skin disorders, e.g. atopic dermatitis. In addition to the known dy...

journal_title：Current allergy and asthma reports

authors： Fyhrquist N,Salava A,Auvinen P,Lauerma A

更新日期：2016-05-01 00:00:00

abstract：:T cells are major protagonists of immune-mediated adverse drug eruptions. Immunohistochemical observation as well as isolation and functional characterization of T cells infiltrating the affected tissues provided new insights into the pathomechanisms of the diverse clinical manifestations of drug hypersensitivity, and...

journal_title：Current allergy and asthma reports

authors： Cavani A,De Pità O

更新日期：2006-02-01 00:00:00

abstract：PURPOSE OF REVIEW:Told from the viewpoint of rheumatologists, this review tells the story of hydroxychloroquine and its swift ascent to become a household name as a therapeutic strategy against the novel SARS-CoV-2 virus. This review describes the history, mechanisms, pharmacokinetics, therapeutic applications, and saf...

journal_title：Current allergy and asthma reports

authors： Udupa A,Leverenz D,Balevic SJ,Sadun RE,Tarrant TK,Rogers JL

更新日期：2021-01-21 00:00:00

abstract：:Immune responses can be compartmentalized into innate versus adaptive components. This relatively recent dichotomy positioned the innate immune system at the interface between the host and the external environment and provided a new conceptual framework with which to view allergic diseases, including asthma. Airway ep...

journal_title：Current allergy and asthma reports

authors： Georas SN,Rezaee F,Lerner L,Beck L

更新日期：2010-03-01 00:00:00

abstract：PURPOSE OF REVIEW:This review aims to update the information available on the prevalence, clinical picture, diagnostic methods, and treatment of urticarias induced by external physical stimuli. RECENT FINDINGS:Physical urticarias are present in up to 5% of the general population, and in 10 to 50% of patients with chro...

journal_title：Current allergy and asthma reports

authors： Sánchez-Borges M,González-Aveledo L,Caballero-Fonseca F,Capriles-Hulett A

更新日期：2017-08-01 00:00:00

abstract：:Major progress has been made during the past few years in developing a better understanding of the genetic basis of asthma, which has led to the identification of several chromosomal regions and loci showing linkage to and association with asthma and asthma-related phenotypes. Recent positional cloning approaches have...

journal_title：Current allergy and asthma reports

authors： Park HS,Kim SH,Park CS

更新日期：2006-03-01 00:00:00

abstract：:Glucocorticoid insensitivity presents a profound management problem in patients with asthma because conventional therapies are not effective. Glucocorticoids, acting through the glucocorticoid receptor (GR), are able to selectively repress inflammatory gene expression by utilizing several distinct mechanisms targeting...

journal_title：Current allergy and asthma reports

authors： Adcock IM,Ford PA,Bhavsar P,Ahmad T,Chung KF

更新日期：2008-04-01 00:00:00

abstract：:Health-related quality of life (HRQL) has become an emerging focus of interest in food allergy. Food allergy is a disease characterized by low mortality and symptoms which only occur during an allergic reaction. However, food-allergic patients continuously need to be alert when eating in order to prevent potentially s...

journal_title：Current allergy and asthma reports

authors： van der Velde JL,Dubois AE,Flokstra-de Blok BM

更新日期：2013-12-01 00:00:00

abstract：:The physiologic functions of histamine have been recognized for more than 100 years, yet new roles are still being uncovered. Most importantly, a newly discovered receptor of the amine has helped refine our understanding of histamine. This new receptor, the histamine H4 receptor (H4R), has a higher affinity for histam...

journal_title：Current allergy and asthma reports

authors： Huang JF,Thurmond RL

更新日期：2008-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Food allergy is a growing health problem worldwide that impacts millions of individuals. Current treatment options are limited and strict dietary avoidance remains the standard of care. Immunotherapy using whole, native allergens is under active clinical investigation but harbors the risk of severe si...

journal_title：Current allergy and asthma reports

authors： Yang L,Kulis M

更新日期：2019-02-22 00:00:00

abstract：:Specific allergen immunotherapy (SIT) is the only disease-modifying treatment for allergic rhinitis and asthma. Subcutaneous immunotherapy (SCIT) is the only method with a US Food and Drug Administration (FDA)-approved formulation, but safety concerns limit administration to medical facilities. Sublingual immunotherap...

journal_title：Current allergy and asthma reports

authors： Cox L

更新日期：2007-11-01 00:00:00

abstract：:Allergic conjunctivitis (AC) can be divided into the primary form (caused by an allergic reaction occurring primarily in the conjunctivae) and the secondary form (induced by allergic reaction originating primarily in the nasal mucosa, where the released mediators can reach conjunctiva through the lacrimal system, the ...

journal_title：Current allergy and asthma reports

authors： Pelikan Z

更新日期：2010-07-01 00:00:00

abstract：:Atopic dermatitis is a chronic inflammatory skin disease that causes significant morbidity in affected individuals. It is characterized by dysregulated immune responses that consist of an increased systemic Th2 response and a combination of Th2 and Th1 responses in the skin lesions. In this article, we review factors ...

journal_title：Current allergy and asthma reports

authors： Ong PY,Leung DY

更新日期：2006-09-01 00:00:00

abstract：:Common variable immunodeficiency (CVID) is the most prevalent symptomatic primary immune deficiency. With widespread use of immunoglobulin replacement therapy, non-infectious complications, such as autoimmunity, chronic intestinal inflammation, and lung disease, have replaced infections as the major cause of morbidity...

journal_title：Current allergy and asthma reports

authors： Maglione PJ,Cols M,Cunningham-Rundles C

更新日期：2017-10-05 00:00:00