Pathophysiology of ocular allergy: the roles of conjunctival mast cells and epithelial cells.

Abstract:

:Allergic eye disease is associated with IgE-mediated conjunctival inflammation leading to signs of immediate hypersensitivity, including redness, itching, and tearing. Pathologic studies using conjunctival mast cells demonstrate that these cells, when sensitized with IgE antibody and exposed to environmental allergens, release mediators involved with allergic inflammation. The type, release kinetics, and concentration of these mediators in the conjunctiva have not been completely characterized. The ability to isolate and purify mast cells and epithelial cells from human conjunctival tissue has permitted the study of mediator release and cell-to-cell signaling in this tissue. Our laboratory has developed in vitro and in vivo models to better understand how inflammatory cells are recruited to and infiltrate conjunctival tissues. These models demonstrate that mast-cell activation may supply sufficient cytokine signaling to initiate and direct the well-orchestrated trafficking of eosinophils to the ocular surface, facilitate their adhesion, and cause release of potent mediators of ocular inflammation.

authors

Stahl JL,Cook EB,Barney NP,Graziano FM

doi

10.1007/s11882-002-0062-6

keywords:

subject

Has Abstract

pub_date

2002-07-01 00:00:00

pages

332-9

issue

4

eissn

1529-7322

issn

1534-6315

journal_volume

2

pub_type

杂志文章,评审
  • What Ancestry Can Tell Us About the Genetic Origins of Inter-Ethnic Differences in Asthma Expression.

    abstract::Differences in asthma prevalence have been described across different populations, suggesting that genetic ancestry can play an important role in this disease. In fact, several studies have demonstrated an association between African ancestry with increased asthma susceptibility and severity, higher immunoglobulin E l...

    journal_title:Current allergy and asthma reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11882-016-0635-4

    authors: Hernandez-Pacheco N,Flores C,Oh SS,Burchard EG,Pino-Yanes M

    更新日期:2016-07-01 00:00:00

  • Fungal allergens.

    abstract::Many fungi are capable of causing IgE-mediated hypersensitivity in humans. However, the most predominant fungi implicated in allergy belong to the genera Aspergillus, Alternaria, Cladosporium, and Penicillium. Pure and relevant allergens are essential for diagnosis as well as for understanding the immunopathogenesis o...

    journal_title:Current allergy and asthma reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11882-003-0078-6

    authors: Kurup VP

    更新日期:2003-09-01 00:00:00

  • Epidemiology of anaphylaxis in the United States.

    abstract::Anaphylaxis is a potentially life-threatening allergic reaction characterized by a syndrome of dermatologic and systemic signs and symptoms, at times including cardiovascular collapse from distributive shock. Although it is recognized that the incidence of anaphylaxis is increasing, the extent of its prevalence, both ...

    journal_title:Current allergy and asthma reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11882-003-0007-8

    authors: Matasar MJ,Neugut AI

    更新日期:2003-01-01 00:00:00

  • Influenza Vaccination in Patients with Common Variable Immunodeficiency (CVID).

    abstract:PURPOSE OF REVIEW:Vaccination against influenza in patients with primary antibody deficiency is recommended. Common variable immunodeficiency (CVID) is the most frequent and clinically relevant antibody deficiency disease and is by definition characterized by an impaired vaccination response. The purpose of this review...

    journal_title:Current allergy and asthma reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11882-017-0749-3

    authors: Mieves JF,Wittke K,Freitag H,Volk HD,Scheibenbogen C,Hanitsch LG

    更新日期:2017-10-05 00:00:00

  • Viral rhinitis.

    abstract::Viral rhinitis is a common, morbid, and costly malady, often complicated by otitis media, sinusitis, and asthma. Current therapies are relatively ineffective and aimed at reducing symptoms rather than moderating underlying mechanisms. Nasal elevations of proinflammatory cytokines track symptom expression during viral ...

    journal_title:Current allergy and asthma reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11882-001-0009-3

    authors: Gentile DA,Skoner DP

    更新日期:2001-05-01 00:00:00

  • Lessons from murine models of atopic dermatitis.

    abstract::Atopic dermatitis (AD) is a complex disease that manifests immunologic abnormalities in the skin. The immunologic changes of AD are characterized by a T helper cell type 2 (Th2)-dominated immune response in its acute phase and a Th1/Th2 mixed immune response in its chronic phase. Although the clinical presentation and...

    journal_title:Current allergy and asthma reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11882-005-0069-x

    authors: Zheng T,Zhu Z

    更新日期:2005-07-01 00:00:00

  • Olfactory Dysfunction in Traumatic Brain Injury: the Role of Neurogenesis.

    abstract:PURPOSE OF REVIEW:Olfactory functioning disturbances are common following traumatic brain injury (TBI) having a significant impact on quality of life. A spontaneous recovery of the olfactory function over time may occur in TBI patients. Although there is no standard treatment for patients with posttraumatic olfactory l...

    journal_title:Current allergy and asthma reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11882-020-00949-x

    authors: Marin C,Langdon C,Alobid I,Mullol J

    更新日期:2020-07-09 00:00:00

  • Nasal saline irrigations for the symptoms of acute and chronic rhinosinusitis.

    abstract::The use of saline nasal irrigation (SNI) in the treatment of nasal and sinus disorders has its roots in the yoga tradition and homeopathic medicine. In recent years, SNI has been increasingly observed as concomitant therapy for acute (ARS) and chronic rhinosinusitis (CRS). Various devices are employed, such as nasal d...

    journal_title:Current allergy and asthma reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11882-013-0339-y

    authors: Achilles N,Mösges R

    更新日期:2013-04-01 00:00:00

  • Systematic Reviews and Meta-analysis in Rhinosinusitis: a Critical Review of the Reviews.

    abstract:PURPOSE OF REVIEW:There has been an explosion in the number of published systematic reviews on chronic rhinosinusitis in the last decade. RECENT FINDINGS:While the aim of these reviews in facilitating evidence-based practice is laudable, poor quality reviews may contain significant bias that can mislead a non-discerni...

    journal_title:Current allergy and asthma reports

    pub_type: 杂志文章,meta分析,评审

    doi:10.1007/s11882-018-0762-1

    authors: Walker A,Hopkins C

    更新日期:2018-02-16 00:00:00

  • The asthma COPD overlap syndrome (ACOS).

    abstract::Asthma and chronic obstructive pulmonary disease (COPD) have traditionally been viewed as distinct clinical entities. Recently, however, much attention has been focused on patients with overlapping features of both asthma and COPD: those with asthma COPD overlap syndrome (ACOS). Although no universal definition criter...

    journal_title:Current allergy and asthma reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11882-014-0509-6

    authors: Bujarski S,Parulekar AD,Sharafkhaneh A,Hanania NA

    更新日期:2015-03-01 00:00:00

  • The mold conundrum in chronic hyperplastic sinusitis.

    abstract::The role of fungi in chronic rhinosinusitis (CRS) is not clear. Fungi can be detected in the nose and paranasal sinuses of virtually all CRS patients; however, they also appear to be present in healthy controls. Various theories attempt to explain the mechanisms by which fungi can exert an effect on sinus mucosa in su...

    journal_title:Current allergy and asthma reports

    pub_type: 杂志文章

    doi:10.1007/s11882-009-0017-2

    authors: Ebbens FA,Georgalas C,Fokkens WJ

    更新日期:2009-03-01 00:00:00

  • Hypersensitivity to Aspirin and other NSAIDs: Diagnostic Approach in Patients with Chronic Rhinosinusitis.

    abstract::Hypersensitivity to nonsteroidal anti-inflammatory drugs (NSAIDs) associated with chronic rhinosinusitis (CRS) and/or asthma comprises a distinct clinical syndrome referred to as NSAIDs exacerbated respiratory disease (NERD). Patients with NERD tend to have more severe course of both upper (CRS and nasal polyps) and l...

    journal_title:Current allergy and asthma reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11882-015-0552-y

    authors: Makowska J,Lewandowska-Polak A,Kowalski ML

    更新日期:2015-08-01 00:00:00

  • Sublingual immunotherapy in pediatric allergic rhinitis and asthma: efficacy, safety, and practical considerations.

    abstract::Specific allergen immunotherapy (SIT) is the only disease-modifying treatment for allergic rhinitis and asthma. Subcutaneous immunotherapy (SCIT) is the only method with a US Food and Drug Administration (FDA)-approved formulation, but safety concerns limit administration to medical facilities. Sublingual immunotherap...

    journal_title:Current allergy and asthma reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11882-007-0063-6

    authors: Cox L

    更新日期:2007-11-01 00:00:00

  • Microbes and the Role of Antibiotic Treatment for Wheezy Lower Respiratory Tract Illnesses in Preschool Children.

    abstract:PURPOSE OF REVIEW:Antibiotics are commonly used to treat wheezy lower respiratory tract illnesses in preschoolers, although these infections have been traditionally thought to be predominantly of viral origin. Our purpose is to review recent research pertaining to the role of antibiotics in lower respiratory tract illn...

    journal_title:Current allergy and asthma reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11882-017-0701-6

    authors: Kwong CG,Bacharier LB

    更新日期:2017-05-01 00:00:00

  • Review of Physical Urticarias and Testing Methods.

    abstract:PURPOSE OF REVIEW:This review aims to update the information available on the prevalence, clinical picture, diagnostic methods, and treatment of urticarias induced by external physical stimuli. RECENT FINDINGS:Physical urticarias are present in up to 5% of the general population, and in 10 to 50% of patients with chro...

    journal_title:Current allergy and asthma reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11882-017-0722-1

    authors: Sánchez-Borges M,González-Aveledo L,Caballero-Fonseca F,Capriles-Hulett A

    更新日期:2017-08-01 00:00:00

  • Human nasal allergen provocation for determination of true allergic rhinitis: methods for clinicians.

    abstract::The nasal provocation test (NPT) could be more extensively used in the diagnosis of allergic rhinitis by practicing physicians. However, the procedure has not been standardized, and has mainly been utilized for scientific purposes in the US. This review illustrates a wide variety of techniques and approaches to dosing...

    journal_title:Current allergy and asthma reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11882-002-0019-9

    authors: Litvyakova LI,Baraniuk JN

    更新日期:2002-05-01 00:00:00

  • Dust mite allergens: mitigation and control.

    abstract::In recent years, greater attention has been given to the role of indoor allergens as a cause of sensitization and allergic respiratory diseases. Although indoor allergen control measures to reduce symptoms in individuals allergic to mites have produced controversial results, environmental allergen avoidance is today o...

    journal_title:Current allergy and asthma reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11882-002-0077-z

    authors: Fernández-Caldas E

    更新日期:2002-09-01 00:00:00

  • Midfacial segment pain: implications for rhinitis and sinusitis.

    abstract::During the past decade, studies on facial pain have shown that there is a distinct group of patients who have a form of facial neuralgia that has all the characteristics of tension-type headache, except that it affects the midface; it is called midfacial segment pain. The pain is described as a feeling of pressure, al...

    journal_title:Current allergy and asthma reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11882-004-0025-1

    authors: Jones NS

    更新日期:2004-05-01 00:00:00

  • Antibody-based therapeutics for the treatment of human B cell malignancies.

    abstract::The dynamic expression of various phenotypic markers during B cell development not only defines the particular stage in ontogeny but also provides the necessary growth, differentiation, maturation and survival signals. When a B cell at any given stage becomes cancerous, these cell surface molecules, intracellular sign...

    journal_title:Current allergy and asthma reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11882-012-0327-7

    authors: Baskar S,Muthusamy N

    更新日期:2013-02-01 00:00:00

  • The relationship between advances in understanding the microbiome and the maturing hygiene hypothesis.

    abstract::Expanding knowledge about an interaction of the bacterial colonization with pathogenic and non-pathogenic bacteria and the human immune system leads to speculation on potential effects on health and disease. Recent advances in sequencing technologies and new bioinformatic possibilities now allow investigating the micr...

    journal_title:Current allergy and asthma reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11882-013-0382-8

    authors: Bendiks M,Kopp MV

    更新日期:2013-10-01 00:00:00

  • Role of Type 2 Innate Lymphoid Cells in Allergic Diseases.

    abstract:PURPOSE OF REVIEW:The adaptive immune response orchestrated by type 2 T helper (Th2) lymphocytes, strictly cooperates with the innate response of group 2 innate lymphoid cells (ILC2), in the protection from helminths infection, as well as in the pathogenesis of allergic disease. The aim of this review is to explore the...

    journal_title:Current allergy and asthma reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11882-017-0735-9

    authors: Cosmi L,Liotta F,Maggi L,Annunziato F

    更新日期:2017-09-11 00:00:00

  • Cutaneous Manifestations in Adult Patients with COVID-19 and Dermatologic Conditions Related to the COVID-19 Pandemic in Health Care Workers.

    abstract:PURPOSE OF REVIEW:COVID-19 (coronavirus viral disease 2019), due to the novel SARS-CoV-2, may present with different types of cutaneous manifestations of varying pathophysiology. During the ongoing pandemic, publications reporting dermatologic findings in COVID-19 continue to emerge. RECENT FINDINGS:Cutaneous vasculop...

    journal_title:Current allergy and asthma reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11882-020-00974-w

    authors: Mawhirt SL,Frankel D,Diaz AM

    更新日期:2020-10-12 00:00:00

  • The role of regulatory T cells in respiratory infections and allergy and asthma.

    abstract::The role of distinct CD4(+) T-cell populations in regulating the nature and strength of immune responses is well documented and in the past has principally focused on the cross-regulation of T-helper type 1 (Th1) and Th2 cells, which secrete interferon-gamma and interleukin-4, respectively. However, the identification...

    journal_title:Current allergy and asthma reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11882-009-0078-2

    authors: McGuirk P,Higgins SC,Mills KH

    更新日期:2010-01-01 00:00:00

  • New approaches to modulating idiopathic pulmonary fibrosis.

    abstract::Until recently, idiopathic pulmonary fibrosis (IPF) has been a devastating and generally fatal disease with no effective therapeutic. New developments in understanding the biology of the disease include a growing consensus that the lesions are mainly composed of cells that originated from resident fibroblasts. New dev...

    journal_title:Current allergy and asthma reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11882-013-0377-5

    authors: Gomer RH

    更新日期:2013-12-01 00:00:00

  • Oxidative stress in the pathogenesis of asthma.

    abstract::Asthma affects 5% to 10% of the population of the United States. In asthmatics, oxidative stress occurs not only as a result of inflammation but also from environmental exposure to air pollution. The specific localization of antioxidants in the lung and the adaptive changes during asthma underscore the importance of o...

    journal_title:Current allergy and asthma reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11882-004-0056-7

    authors: Bowler RP

    更新日期:2004-03-01 00:00:00

  • Dietary modification of atopic disease: Use of probiotics in the prevention of atopic dermatitis.

    abstract::The increased prevalence of atopic diseases, atopic dermatitis, allergic rhinitis, and asthma has been described as an epidemic. New approaches in the fight against allergic diseases are called for, the target being the persistence of the atopic T helper 2-skewed immune responder pattern beyond infancy. Atopic dermati...

    journal_title:Current allergy and asthma reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11882-004-0070-9

    authors: Isolauri E

    更新日期:2004-07-01 00:00:00

  • Eosinophilic Esophagitis and Gastroenteritis.

    abstract::Eosinophilic gastrointestinal disease (EGID) can be classified as eosinophilic esophagitis (EoE) when the eosinophilia is limited to the esophagus or as eosinophilic gastritis (EG) if it is limited to the gastric tract, eosinophilic colitis (EC) if it is limited to the colon, and eosinophilic gastroenteritis (EGE) if ...

    journal_title:Current allergy and asthma reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11882-015-0558-5

    authors: Cianferoni A,Spergel JM

    更新日期:2015-09-01 00:00:00

  • Food Allergy Management at School in the Era of Immunotherapy.

    abstract:PURPOSE OF REVIEW:Food allergy is increasing in prevalence, and management focuses on strict avoidance of known allergens and appropriately treating reactions. Any reaction has the potential to result in anaphylaxis, which can be fatal. Children spend a significant amount of time in the childcare or school setting, and...

    journal_title:Current allergy and asthma reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11882-020-00933-5

    authors: Hui JW,Copeland M,Lanser BJ

    更新日期:2020-06-06 00:00:00

  • Steroid resistance in asthma: mechanisms and treatment options.

    abstract::Glucocorticoid insensitivity presents a profound management problem in patients with asthma because conventional therapies are not effective. Glucocorticoids, acting through the glucocorticoid receptor (GR), are able to selectively repress inflammatory gene expression by utilizing several distinct mechanisms targeting...

    journal_title:Current allergy and asthma reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11882-008-0028-4

    authors: Adcock IM,Ford PA,Bhavsar P,Ahmad T,Chung KF

    更新日期:2008-04-01 00:00:00

  • Economics of Chronic Rhinosinusitis.

    abstract:PURPOSE OF REVIEW:The objective of this article is to provide an updated review of the economic burden of chronic rhinosinusitis (CRS) and discuss how both medical and surgical interventions impact direct and indirect costs related to CRS. By understanding the economics of CRS, clinicians may improve the patient-center...

    journal_title:Current allergy and asthma reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11882-017-0690-5

    authors: Rudmik L

    更新日期:2017-04-01 00:00:00