Abstract：
:Allergic eye disease is associated with IgE-mediated conjunctival inflammation leading to signs of immediate hypersensitivity, including redness, itching, and tearing. Pathologic studies using conjunctival mast cells demonstrate that these cells, when sensitized with IgE antibody and exposed to environmental allergens, release mediators involved with allergic inflammation. The type, release kinetics, and concentration of these mediators in the conjunctiva have not been completely characterized. The ability to isolate and purify mast cells and epithelial cells from human conjunctival tissue has permitted the study of mediator release and cell-to-cell signaling in this tissue. Our laboratory has developed in vitro and in vivo models to better understand how inflammatory cells are recruited to and infiltrate conjunctival tissues. These models demonstrate that mast-cell activation may supply sufficient cytokine signaling to initiate and direct the well-orchestrated trafficking of eosinophils to the ocular surface, facilitate their adhesion, and cause release of potent mediators of ocular inflammation.
journal_name
Curr Allergy Asthma Repjournal_title
Current allergy and asthma reportsauthors
Stahl JL,Cook EB,Barney NP,Graziano FMdoi
10.1007/s11882-002-0062-6keywords:
subject
Has Abstractpub_date
2002-07-01 00:00:00pages
332-9issue
4eissn
1529-7322issn
1534-6315journal_volume
2pub_type
杂志文章,评审abstract：:Sublingual immunotherapy (SLIT) is a well-established allergen-specific immunotherapy and a safe and effective strategy to reorient inappropriate immune responses in allergic patients. SLIT takes advantage of the tolerogenic environment of the oral mucosa to promote tolerance to the allergen. Several clinical studies ...
journal_title：Current allergy and asthma reports
pub_type： 杂志文章,评审
doi：10.1007/s11882-014-0473-1
更新日期：2014-11-01 00:00:00
abstract：:Omalizumab is a recently developed monoclonal anti-IgE antibody. Clinical trials have demonstrated its efficacy in patients with moderate-to-severe and severe or poorly controlled allergic asthma, in patients with seasonal and perennial allergic disease, and in subjects with concomitant asthma and allergic rhinitis. P...
journal_title：Current allergy and asthma reports
pub_type： 杂志文章
doi：10.1007/s11882-005-0083-z
更新日期：2005-03-01 00:00:00
abstract：PURPOSE OF REVIEW:This review is focused on the existing evidence for circadian control of innate and adaptive immune responses to provide a framework for evaluating the contributions of diurnal rhythms to control of infections and pathogenesis of disease. RECENT FINDINGS:Circadian rhythms driven by cell-autonomous bi...
journal_title：Current allergy and asthma reports
pub_type： 杂志文章,评审
doi：10.1007/s11882-020-0896-9
更新日期：2020-01-10 00:00:00
abstract：:The cutaneous microbiome has been investigated broadly in recent years and some traditional perspectives are beginning to change. A diverse microbiome exists on human skin and has a potential to influence pathogenic microbes and modulate the course of skin disorders, e.g. atopic dermatitis. In addition to the known dy...
journal_title：Current allergy and asthma reports
pub_type： 杂志文章,评审
doi：10.1007/s11882-016-0618-5
更新日期：2016-05-01 00:00:00
abstract：PURPOSE OF REVIEW:The purpose of this review is to provide an overview of diagnostic testing in primary immunodeficiency and immune dysregulatory disorders (PIDDs), particularly focusing on flow cytometry and genetic techniques, utilizing specific examples of PIDDs. RECENT FINDINGS:Flow cytometry remains a vital tool ...
journal_title：Current allergy and asthma reports
pub_type： 杂志文章,评审
doi：10.1007/s11882-018-0770-1
更新日期：2018-02-22 00:00:00
abstract：:Respiratory viruses appear to play a central role in asthma pathogenesis. In addition to a major role in triggering asthma exacerbations, viral infections early in life may play a role in disease development. Although defensins were initially identified as antimicrobial peptides, recent studies have demonstrated that ...
journal_title：Current allergy and asthma reports
pub_type： 杂志文章,评审
doi：10.1007/s11882-006-0015-6
更新日期：2006-02-01 00:00:00
abstract：PURPOSE OF REVIEW:Chronic rhinosinusitis (CRS) is a multidimensional inflammatory disorder of the nose and paranasal sinuses. We reviewed the recent literature to identify improved methods to assess, control, and manage these difficult to control patients. RECENT FINDINGS:The role of endotyping in CRS has offered a be...
journal_title：Current allergy and asthma reports
pub_type： 杂志文章,评审
doi：10.1007/s11882-017-0728-8
更新日期：2017-09-01 00:00:00
abstract：:Allergic conjunctivitis (AC) can be divided into the primary form (caused by an allergic reaction occurring primarily in the conjunctivae) and the secondary form (induced by allergic reaction originating primarily in the nasal mucosa, where the released mediators can reach conjunctiva through the lacrimal system, the ...
journal_title：Current allergy and asthma reports
pub_type： 杂志文章
doi：10.1007/s11882-010-0119-x
更新日期：2010-07-01 00:00:00
abstract：PURPOSE OF REVIESW:Local respiratory allergy (LRA) is an eosinophilic phenotype of chronic airway disease. Three entities have been described within the LRA spectrum: local allergic rhinitis (LAR) and local allergic asthma (LAA) in non-atopic patients, and dual allergic rhinitis (DAR) in atopic patients (coexistence of...
journal_title：Current allergy and asthma reports
pub_type： 杂志文章,评审
doi：10.1007/s11882-020-00920-w
更新日期：2020-05-19 00:00:00
abstract：:Eosinophilic chronic rhinosinusitis (ECRS) encompasses a wide variety of etiologies. To date, a unifying pathophysiologic mechanism remains elusive. Eosinophilia is frequently, but not exclusively, caused by immunoglobulin (Ig)E-mediated hypersensitivity and is dominated by the associated cytokine milieu of Th2 inflam...
journal_title：Current allergy and asthma reports
pub_type： 杂志文章,评审
doi：10.1007/s11882-006-0036-1
更新日期：2006-05-01 00:00:00
abstract：:Asthma affects 5% to 10% of the population of the United States. In asthmatics, oxidative stress occurs not only as a result of inflammation but also from environmental exposure to air pollution. The specific localization of antioxidants in the lung and the adaptive changes during asthma underscore the importance of o...
journal_title：Current allergy and asthma reports
pub_type： 杂志文章,评审
doi：10.1007/s11882-004-0056-7
更新日期：2004-03-01 00:00:00
abstract：:The pathology of atopic dermatitis is orchestrated on the cellular level by several different cell types in the characteristic skin lesions. In such lesions, histamine as a mediator of many biological functions is also present in high concentrations. Most of the cells involved in the inflammatory responses express the...
journal_title：Current allergy and asthma reports
pub_type： 杂志文章,评审
doi：10.1007/s11882-010-0162-7
更新日期：2011-02-01 00:00:00
abstract：:Differences in asthma prevalence have been described across different populations, suggesting that genetic ancestry can play an important role in this disease. In fact, several studies have demonstrated an association between African ancestry with increased asthma susceptibility and severity, higher immunoglobulin E l...
journal_title：Current allergy and asthma reports
pub_type： 杂志文章,评审
doi：10.1007/s11882-016-0635-4
更新日期：2016-07-01 00:00:00
abstract：:Exercise-induced bronchoconstriction (EIB) refers to acute airflow obstruction that is triggered by a period of physical exertion. EIB occurs mainly in individuals with other features of asthma but is especially prominent in a subset of asthmatics with pronounced indirect airway hyperresponsiveness. Leukotrienes (LTs)...
journal_title：Current allergy and asthma reports
pub_type： 杂志文章
doi：10.1007/s11882-009-0003-8
更新日期：2009-01-01 00:00:00
abstract：:The dynamic expression of various phenotypic markers during B cell development not only defines the particular stage in ontogeny but also provides the necessary growth, differentiation, maturation and survival signals. When a B cell at any given stage becomes cancerous, these cell surface molecules, intracellular sign...
journal_title：Current allergy and asthma reports
pub_type： 杂志文章,评审
doi：10.1007/s11882-012-0327-7
更新日期：2013-02-01 00:00:00
abstract：:Multiple sclerosis (MS) is the most common cause of chronic neurologic disability in young people. Genetic susceptibility and unidentified environmental triggers appear to be necessary in order to result in disease. MS is an extraordinarily complex trait with evidence of heterogeneity at clinical, pathologic, and ther...
journal_title：Current allergy and asthma reports
pub_type： 杂志文章,评审
doi：10.1007/s11882-007-0042-y
更新日期：2007-07-01 00:00:00
abstract：:Recent advances in our understanding of mast cell biology and disease resulted in identification of important differences in expression of mast cell surface antigens in normal and neoplastic mast cells. Most notably, detection of aberrant expression of CD25 and CD2 on the surface of neoplastic mast cells but not on th...
journal_title：Current allergy and asthma reports
pub_type： 杂志文章,评审
doi：10.1007/s11882-006-0061-0
更新日期：2006-07-01 00:00:00
abstract：PURPOSE OF REVIEW:This paper offers a comprehensive review of interactive mobile allergy and asthma smartphone applications available within the USA in 2018, with an emphasis on interactive asthma apps. RECENT FINDINGS:Primary care and specialty clinicians interested in introducing digital health apps into their pract...
journal_title：Current allergy and asthma reports
pub_type： 杂志文章,评审
doi：10.1007/s11882-019-0840-z
更新日期：2019-02-02 00:00:00
abstract：:Hypersensitivity in the allergic setting refers to immune reactions, stimulated by soluble antigens that can be rapidly progressing and, in the case of anaphylaxis, are occasionally fatal. As the number of known exposures associated with anaphylaxis is limited, identification of novel causative agents is important in ...
journal_title：Current allergy and asthma reports
pub_type： 杂志文章,评审
doi：10.1007/s11882-015-0512-6
更新日期：2015-04-01 00:00:00
abstract：:Chronic rhinosinusitis (CRS) is a heterogeneous inflammatory condition with a multifactorial basis. Infectious triggers of CRS have been proposed, but demonstration remains elusive. Evolving research suggests that abnormal host mucosal immune responses, rather than specific pathogens themselves, may underlie the chron...
journal_title：Current allergy and asthma reports
pub_type： 杂志文章
doi：10.1007/s11882-009-0030-5
更新日期：2009-05-01 00:00:00
abstract：:Urticaria can present acutely and be self-limiting or become chronic and persist for weeks, months, or years. In either case, the condition may have a significant impact on the patient's quality of life. Two major consensus groups, the EAACI/WAO and the AAAAI/ACAAI Joint Task Force, have written guidelines on the diag...
journal_title：Current allergy and asthma reports
pub_type： 杂志文章,评审
doi：10.1007/s11882-015-0535-z
更新日期：2015-06-01 00:00:00
abstract：:Although eustachian tube dysfunction and bacterial infection have been shown to cause otitis media with effusion (OME), other etiologies are possible. One of the most common medical conditions in children is obesity, which can have effects throughout the body. Little is known, however, about the relationship between o...
journal_title：Current allergy and asthma reports
pub_type： 杂志文章,评审
doi：10.1007/s11882-009-0069-3
更新日期：2009-11-01 00:00:00
abstract：:Otitis media is one of the most common childhood infections leading to doctor's visits and a leading cause of antibiotic prescriptions in children. Twin and family studies have confirmed that the predisposition of developing a bacterial middle ear infection is genetically determined. Several case-control studies have ...
journal_title：Current allergy and asthma reports
pub_type： 杂志文章,评审
doi：10.1007/s11882-012-0292-1
更新日期：2012-12-01 00:00:00
abstract：:Although fungi are pervasive in many environments, few cause disease in humans. Of these, Aspergillus fumigatus is particularly well suited to be a pathogen of the human lung. Its physical and biological characteristics combine to provide an organism that can cause tremendous morbidity and high mortality if left unche...
journal_title：Current allergy and asthma reports
pub_type： 杂志文章,评审
doi：10.1007/s11882-015-0561-x
更新日期：2015-10-01 00:00:00
abstract：:Otitis media (OM) imposes significant morbidity on the pediatric age group and a large financial burden on the general population. Because standard medical treatments are not highly efficacious in resolving the accompanying middle ear (ME) inflammation, a goal of current research is OM prevention. Past studies show th...
journal_title：Current allergy and asthma reports
pub_type： 杂志文章,评审
doi：10.1007/s11882-003-0093-7
更新日期：2003-07-01 00:00:00
abstract：:Genome-wide screens for asthma and atopy susceptibility loci have been completed in six population samples. Despite the extensive clinical heterogeneity associated with these phenotypes, 20 chromosomal regions show evidence of linkage (P < 0.01) in three or more population samples. Thus, this survey suggests that at l...
journal_title：Current allergy and asthma reports
pub_type： 杂志文章,评审
doi：10.1007/s11882-001-0085-4
更新日期：2001-03-01 00:00:00
abstract：:Stem cell transplant (SCT) has long been the standard of care for several hematologic, immunodeficient, and oncologic disorders. Recently, SCT has become an increasingly utilized therapy for refractory autoimmune rheumatologic disorders (ARDs). The efficacy of SCT in ARDs has been attributed to resetting an aberrant i...
journal_title：Current allergy and asthma reports
pub_type： 杂志文章,评审
doi：10.1007/s11882-012-0298-8
更新日期：2012-12-01 00:00:00
abstract：:Otitis media is currently the most common diagnosis made by clinicians, which has a major impact on managed care. The emergence of resistant bacterial pathogens has caused controversy over the use of antibiotics when acute otitis media (AOM) is diagnosed. All infants with AOM and all older children with severe AOM sho...
journal_title：Current allergy and asthma reports
pub_type： 杂志文章,评审
doi：10.1007/s11882-001-0050-2
更新日期：2001-07-01 00:00:00
abstract：:Natural oils include mineral oil with emollient, occlusive, and humectant properties and the plant-derived essential, coconut, and other vegetable oils, composed of triglycerides that microbiota lipases hydrolyze into glycerin, a potent humectant, and fatty acids (FAs) with varying physico-chemical properties. Unsatur...
journal_title：Current allergy and asthma reports
pub_type： 杂志文章,评审
doi：10.1007/s11882-016-0630-9
更新日期：2016-07-01 00:00:00
abstract：:Epinephrine can be lifesaving in episodes of anaphylaxis, yet it is underprescribed and underused. Tracking of epinephrine refills over time for patients with a diagnosis of anaphylaxis has not been reported. This study reports on the refill history of 14,677 patients in a large HMO who received an initial dispensing ...
journal_title：Current allergy and asthma reports
pub_type： 杂志文章
doi：10.1007/s11882-010-0155-6
更新日期：2011-02-01 00:00:00
