Abstract：
:The pathology of atopic dermatitis is orchestrated on the cellular level by several different cell types in the characteristic skin lesions. In such lesions, histamine as a mediator of many biological functions is also present in high concentrations. Most of the cells involved in the inflammatory responses express the histamine H1 and H2 receptors, but drugs targeting these receptors are not clinically effective. The discovery of the fourth histamine receptor, which is differentially expressed on immune and nonimmune cells, has shed new light on the actions of histamine in the complexity of atopic dermatitis. In this review, we describe a possible genetic impact on the expression level of the histamine H4 receptor and summarize the current data regarding the activity of the histamine H4 receptor on the key effector cells in atopic dermatitis. We do so in the context of whether the histamine H4 receptor offers a novel target for effective treatments of inflammatory skin diseases.
journal_name
Curr Allergy Asthma Repjournal_title
Current allergy and asthma reportsauthors
Mommert S,Gschwandtner M,Gutzmer R,Werfel Tdoi
10.1007/s11882-010-0162-7subject
Has Abstractpub_date
2011-02-01 00:00:00pages
21-8issue
1eissn
1529-7322issn
1534-6315journal_volume
11pub_type
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更新日期：2009-03-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2007-05-01 00:00:00
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更新日期：2010-09-01 00:00:00
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更新日期：2020-07-09 00:00:00
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更新日期：2004-03-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2010-01-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2002-11-01 00:00:00
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