Abstract：
:Sublingual immunotherapy (SLIT) is a well-established allergen-specific immunotherapy and a safe and effective strategy to reorient inappropriate immune responses in allergic patients. SLIT takes advantage of the tolerogenic environment of the oral mucosa to promote tolerance to the allergen. Several clinical studies have investigated the complex interplay of innate and adaptive immune responses that SLIT exploits. The oral immune system is composed of tolerogenic dendritic cells that, following uptake of allergen during SLIT, support the differentiation of T helper cell type 1 (Th1) and the induction of IL-10-producing regulatory T cells. Following SLIT, allergic disease-promoting T helper cell type 2 (Th2) responses shift to a Th1 inflammatory response, and IL-10 and transforming growth factor (TGF)-β production by regulatory T cells and tolerogenic dendritic cells suppress allergen-specific T cell responses. These immune changes occur both in the sublingual mucosa and in the periphery of a patient following SLIT. SLIT also promotes the synthesis of allergen-specific IgG and IgA antibodies that block allergen-IgE complex formation and binding to inflammatory cells, thus encouraging an anti-inflammatory environment. Several of these revealing findings have also paved the way for the identification of biomarkers of the clinical efficacy of SLIT. This review presents the emerging elucidation of the immune mechanisms mediated by SLIT.
journal_name
Curr Allergy Asthma Repjournal_title
Current allergy and asthma reportsauthors
Jay DC,Nadeau KCdoi
10.1007/s11882-014-0473-1subject
Has Abstractpub_date
2014-11-01 00:00:00pages
473issue
11eissn
1529-7322issn
1534-6315journal_volume
14pub_type
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journal_title：Current allergy and asthma reports
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journal_title：Current allergy and asthma reports
pub_type： 杂志文章
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journal_title：Current allergy and asthma reports
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journal_title：Current allergy and asthma reports
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pub_type： 杂志文章,评审
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更新日期：2005-01-01 00:00:00
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journal_title：Current allergy and asthma reports
pub_type： 杂志文章,评审
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更新日期：2002-03-01 00:00:00
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journal_title：Current allergy and asthma reports
pub_type： 杂志文章,评审
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pub_type： 杂志文章,评审
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pub_type： 杂志文章,评审
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journal_title：Current allergy and asthma reports
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journal_title：Current allergy and asthma reports
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更新日期：2009-09-01 00:00:00
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journal_title：Current allergy and asthma reports
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更新日期：2013-08-01 00:00:00
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journal_title：Current allergy and asthma reports
pub_type： 杂志文章,评审
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更新日期：2017-05-01 00:00:00
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更新日期：2006-07-01 00:00:00
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journal_title：Current allergy and asthma reports
pub_type： 杂志文章,评审
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更新日期：2020-03-06 00:00:00
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更新日期：2002-05-01 00:00:00
