The Effect of Inhalant Organic Dust on Bone Health.

Abstract:

PURPOSE OF REVIEW:Agriculture remains a major economic sector globally, and workers experience high rates of chronic inflammatory lung and musculoskeletal diseases. Whereas obstructive pulmonary diseases are known risk factors for bone loss, the underlying relationship between lung inflammation and bone health is not well known. RECENT FINDINGS:An agriculture organic dust extract inhalation animal model has recently linked lung injury-induced inflammation to systemic bone loss. This process is dependent upon lipopolysaccharide and the toll-like receptor 4 (TLR4) signaling pathway. Downstream systemic interleukin-6 is a key mediator that subsequently activates osteoclastogenesis. Age is a host factor that impacted bone disease with younger mice demonstrating increased susceptibility to bone loss following inhalant exposures as compared to older mice. Supplemental dietary vitamin D was shown to prevent organic dust-induced bone loss, but not lung disease, in animals. Recent animal studies provide new mechanistic insight into the lung-bone inflammatory axis. Host factors, diet, and lipopolysaccharide/TLR4 signaling pathways play a significant role in explaining how inhalant organic dust exposures impact bone health. These investigations might lead to specific targeted therapeutic approaches.

authors

Carrington JM,Poole JA

doi

10.1007/s11882-018-0773-y

subject

Has Abstract

pub_date

2018-02-22 00:00:00

pages

16

issue

3

eissn

1529-7322

issn

1534-6315

pii

10.1007/s11882-018-0773-y

journal_volume

18

pub_type

杂志文章,评审
  • Recent advances in the epidemiologic investigation of risk factors for asthma: a review of the 2011 literature.

    abstract::The present review aims to identify and summarize epidemiologic investigations published during 2011 on the environmental risk factors for asthma. Potentially eligible papers were identified by a MEDLINE search. In total, 1,130 items were retrieved. Based on a broad definition of environment, the following topics were...

    journal_title:Current allergy and asthma reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11882-012-0254-7

    authors: Antó JM

    更新日期:2012-06-01 00:00:00

  • Allergen immunotherapy extract treatment set preparation: making a safer and higher quality product for patients.

    abstract::The best possible allergen immunotherapy clinical outcomes require the provision of high quality and safe allergen immunotherapy extract preparations. Evolving national guidelines and regulatory bodies have devoted special attention to the safe compounding of sterile products, including allergen extracts. It is incumb...

    journal_title:Current allergy and asthma reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11882-013-0362-z

    authors: Nelson MR,Petersen MM,Wolverton WO,Mikita CP

    更新日期:2013-08-01 00:00:00

  • Sublingual immunotherapy in pediatric allergic rhinitis and asthma: efficacy, safety, and practical considerations.

    abstract::Specific allergen immunotherapy (SIT) is the only disease-modifying treatment for allergic rhinitis and asthma. Subcutaneous immunotherapy (SCIT) is the only method with a US Food and Drug Administration (FDA)-approved formulation, but safety concerns limit administration to medical facilities. Sublingual immunotherap...

    journal_title:Current allergy and asthma reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11882-007-0063-6

    authors: Cox L

    更新日期:2007-11-01 00:00:00

  • An update on stem cell transplantation in autoimmune rheumatologic disorders.

    abstract::Stem cell transplant (SCT) has long been the standard of care for several hematologic, immunodeficient, and oncologic disorders. Recently, SCT has become an increasingly utilized therapy for refractory autoimmune rheumatologic disorders (ARDs). The efficacy of SCT in ARDs has been attributed to resetting an aberrant i...

    journal_title:Current allergy and asthma reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11882-012-0298-8

    authors: Mascarenhas S,Avalos B,Ardoin SP

    更新日期:2012-12-01 00:00:00

  • Systematic Reviews and Meta-analysis in Rhinosinusitis: a Critical Review of the Reviews.

    abstract:PURPOSE OF REVIEW:There has been an explosion in the number of published systematic reviews on chronic rhinosinusitis in the last decade. RECENT FINDINGS:While the aim of these reviews in facilitating evidence-based practice is laudable, poor quality reviews may contain significant bias that can mislead a non-discerni...

    journal_title:Current allergy and asthma reports

    pub_type: 杂志文章,meta分析,评审

    doi:10.1007/s11882-018-0762-1

    authors: Walker A,Hopkins C

    更新日期:2018-02-16 00:00:00

  • Physical urticaria.

    abstract::The physical urticarias are a heterogeneous subgroup of chronic urticarias in which wheals can be reproducibly induced by different specific physical stimuli such as cold, heat, pressure, vibration, or sunlight. Physical urticarias comprise up to 25 % of chronic urticarias and occur more frequently in young adults. Sy...

    journal_title:Current allergy and asthma reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11882-012-0269-0

    authors: Abajian M,Młynek A,Maurer M

    更新日期:2012-08-01 00:00:00

  • What Ancestry Can Tell Us About the Genetic Origins of Inter-Ethnic Differences in Asthma Expression.

    abstract::Differences in asthma prevalence have been described across different populations, suggesting that genetic ancestry can play an important role in this disease. In fact, several studies have demonstrated an association between African ancestry with increased asthma susceptibility and severity, higher immunoglobulin E l...

    journal_title:Current allergy and asthma reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11882-016-0635-4

    authors: Hernandez-Pacheco N,Flores C,Oh SS,Burchard EG,Pino-Yanes M

    更新日期:2016-07-01 00:00:00

  • The role of T cells in drug reaction.

    abstract::T cells are major protagonists of immune-mediated adverse drug eruptions. Immunohistochemical observation as well as isolation and functional characterization of T cells infiltrating the affected tissues provided new insights into the pathomechanisms of the diverse clinical manifestations of drug hypersensitivity, and...

    journal_title:Current allergy and asthma reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11882-006-0005-8

    authors: Cavani A,De Pità O

    更新日期:2006-02-01 00:00:00

  • Hymenoptera Allergy and Mast Cell Activation Syndromes.

    abstract::Mast cell activation syndrome (MCAS) can be diagnosed in patients with recurrent, severe symptoms from mast cell (MC)-derived mediators, which are transiently increased in serum and are attenuated by mediator-targeting drugs. When KIT-mutated, clonal MC are detected in these patients, a diagnosis of primary MCAS can b...

    journal_title:Current allergy and asthma reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11882-015-0582-5

    authors: Bonadonna P,Bonifacio M,Lombardo C,Zanotti R

    更新日期:2016-01-01 00:00:00

  • Olfactory Dysfunction in Traumatic Brain Injury: the Role of Neurogenesis.

    abstract:PURPOSE OF REVIEW:Olfactory functioning disturbances are common following traumatic brain injury (TBI) having a significant impact on quality of life. A spontaneous recovery of the olfactory function over time may occur in TBI patients. Although there is no standard treatment for patients with posttraumatic olfactory l...

    journal_title:Current allergy and asthma reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11882-020-00949-x

    authors: Marin C,Langdon C,Alobid I,Mullol J

    更新日期:2020-07-09 00:00:00

  • Autoimmune lymphoproliferative syndrome: an update and review of the literature.

    abstract::Autoimmune lymphoproliferative syndrome (ALPS) is characterized by immune dysregulation due to a defect in lymphocyte apoptosis. The clinical manifestations may be noted in multiple family members and include lymphadenopathy, splenomegaly, increased risk of lymphoma, and autoimmune disease, which typically involves he...

    journal_title:Current allergy and asthma reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11882-014-0462-4

    authors: Shah S,Wu E,Rao VK,Tarrant TK

    更新日期:2014-09-01 00:00:00

  • Immunotherapy safety: what have we learned from surveillance surveys?

    abstract::Subcutaneous allergen immunotherapy (SCIT) is beneficial for the treatment of allergic rhinitis, asthma, and in preventing stinging insect anaphylaxis, but is not without risks. Four retrospective surveillance surveys and one on-going national prospective study have attempted to characterize the incidence and risk fac...

    journal_title:Current allergy and asthma reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11882-013-0353-0

    authors: Kannan JA,Epstein TG

    更新日期:2013-08-01 00:00:00

  • Immunoglobulin G subclass deficiency: fact or fancy?

    abstract::Over the past four decades, many patients have been reported to have deficiencies of one or more subclasses of immunoglobulin G (IgG), despite normal total IgG serum concentrations. However, except for those with extremely low or absent IgG2 concentrations and an inability to produce antibodies to polysaccharide antig...

    journal_title:Current allergy and asthma reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11882-002-0067-1

    authors: Buckley RH

    更新日期:2002-09-01 00:00:00

  • Hypoallergenic Proteins for the Treatment of Food Allergy.

    abstract:PURPOSE OF REVIEW:Food allergy is a growing health problem worldwide that impacts millions of individuals. Current treatment options are limited and strict dietary avoidance remains the standard of care. Immunotherapy using whole, native allergens is under active clinical investigation but harbors the risk of severe si...

    journal_title:Current allergy and asthma reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11882-019-0846-6

    authors: Yang L,Kulis M

    更新日期:2019-02-22 00:00:00

  • Consequences of a mutation in the UNC119 gene for T cell function in idiopathic CD4 lymphopenia.

    abstract::The activation of a T cell through T cell receptor (TCR) is fundamental to adaptive immune responses. The lymphocyte specific kinase (LCK) plays a central role in the initiation of signaling from the TCR. TCR activates LCK through the adaptor protein uncoordinated 119 (UNC119). A mutation of human UNC119 impairs LCK a...

    journal_title:Current allergy and asthma reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11882-012-0281-4

    authors: Gorska MM,Alam R

    更新日期:2012-10-01 00:00:00

  • The new biology of histamine receptors.

    abstract::The physiologic functions of histamine have been recognized for more than 100 years, yet new roles are still being uncovered. Most importantly, a newly discovered receptor of the amine has helped refine our understanding of histamine. This new receptor, the histamine H4 receptor (H4R), has a higher affinity for histam...

    journal_title:Current allergy and asthma reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11882-008-0005-y

    authors: Huang JF,Thurmond RL

    更新日期:2008-03-01 00:00:00

  • Viral rhinitis.

    abstract::Viral rhinitis is a common, morbid, and costly malady, often complicated by otitis media, sinusitis, and asthma. Current therapies are relatively ineffective and aimed at reducing symptoms rather than moderating underlying mechanisms. Nasal elevations of proinflammatory cytokines track symptom expression during viral ...

    journal_title:Current allergy and asthma reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11882-001-0009-3

    authors: Gentile DA,Skoner DP

    更新日期:2001-05-01 00:00:00

  • Review of Physical Urticarias and Testing Methods.

    abstract:PURPOSE OF REVIEW:This review aims to update the information available on the prevalence, clinical picture, diagnostic methods, and treatment of urticarias induced by external physical stimuli. RECENT FINDINGS:Physical urticarias are present in up to 5% of the general population, and in 10 to 50% of patients with chro...

    journal_title:Current allergy and asthma reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11882-017-0722-1

    authors: Sánchez-Borges M,González-Aveledo L,Caballero-Fonseca F,Capriles-Hulett A

    更新日期:2017-08-01 00:00:00

  • The relationship between HIV infection and atopic dermatitis.

    abstract::Patients with HIV infection exhibit a wide range of skin pathology, including bacterial, fungal, and viral infections, skin tumors, inflammatory and eczematous eruptions, and drug rashes. HIV-infected adults commonly develop a condition that strongly resembles atopic dermatitis and is sometimes called "atopic-like der...

    journal_title:Current allergy and asthma reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11882-002-0050-x

    authors: Rudikoff D

    更新日期:2002-07-01 00:00:00

  • The role of innate immunity in the pathogenesis of chronic rhinosinusitis.

    abstract::Chronic rhinosinusitis (CRS) is a heterogeneous inflammatory condition with a multifactorial basis. Infectious triggers of CRS have been proposed, but demonstration remains elusive. Evolving research suggests that abnormal host mucosal immune responses, rather than specific pathogens themselves, may underlie the chron...

    journal_title:Current allergy and asthma reports

    pub_type: 杂志文章

    doi:10.1007/s11882-009-0030-5

    authors: Lane AP

    更新日期:2009-05-01 00:00:00

  • How to Assess, Control, and Manage Uncontrolled CRS/Nasal Polyp Patients.

    abstract:PURPOSE OF REVIEW:Chronic rhinosinusitis (CRS) is a multidimensional inflammatory disorder of the nose and paranasal sinuses. We reviewed the recent literature to identify improved methods to assess, control, and manage these difficult to control patients. RECENT FINDINGS:The role of endotyping in CRS has offered a be...

    journal_title:Current allergy and asthma reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11882-017-0728-8

    authors: Sivasubramaniam R,Harvey RJ

    更新日期:2017-09-01 00:00:00

  • T cells in drug allergy.

    abstract::In recent years, increasing evidence has indicated an important role for T cells in various drug-induced diseases. A detailed analysis of patients with various drug allergies revealed the existence of drug-specific T cells in the circulation or in eluate from skin infiltration in bullous, pustular, and maculopapular d...

    journal_title:Current allergy and asthma reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11882-002-0032-z

    authors: Pichler WJ

    更新日期:2002-01-01 00:00:00

  • The role of lipid transfer proteins in allergic diseases.

    abstract::Nonspecific lipid transfer proteins (LTPs) are important allergens in fruits, vegetables, nuts, pollen, and latex. Despite their wide distribution throughout the plant kingdom, their clinical relevance is largely confined to the Mediterranean area. As they can sensitize via the gastrointestinal tract, LPTs are conside...

    journal_title:Current allergy and asthma reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11882-010-0128-9

    authors: Egger M,Hauser M,Mari A,Ferreira F,Gadermaier G

    更新日期:2010-09-01 00:00:00

  • Hidden Causes of Anaphylaxis.

    abstract:PURPOSE OF REVIEW:This study aimed to review important hidden causes of anaphylaxis in ingestants, non-ingestants, and uncommon settings. RECENT FINDINGS:Multiple new and elusive causes of anaphylaxis have been described over the past 35 years. Further research is required to identify the epidemiology, pathophysiology...

    journal_title:Current allergy and asthma reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11882-017-0713-2

    authors: Nanagas VC,Baldwin JL,Karamched KR

    更新日期:2017-07-01 00:00:00

  • Asthma and Allergy Mobile Apps in 2018.

    abstract:PURPOSE OF REVIEW:This paper offers a comprehensive review of interactive mobile allergy and asthma smartphone applications available within the USA in 2018, with an emphasis on interactive asthma apps. RECENT FINDINGS:Primary care and specialty clinicians interested in introducing digital health apps into their pract...

    journal_title:Current allergy and asthma reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11882-019-0840-z

    authors: Kagen S,Garland A

    更新日期:2019-02-02 00:00:00

  • The role of novel genes in modifying airway responses in asthma.

    abstract::Major progress has been made during the past few years in developing a better understanding of the genetic basis of asthma, which has led to the identification of several chromosomal regions and loci showing linkage to and association with asthma and asthma-related phenotypes. Recent positional cloning approaches have...

    journal_title:Current allergy and asthma reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11882-006-0048-x

    authors: Park HS,Kim SH,Park CS

    更新日期:2006-03-01 00:00:00

  • Nasonasal reflexes, the nasal cycle, and sneeze.

    abstract::The nasal mucosa is a complex tissue that interacts with its environment and effects local and systemic changes. Receptors in the nose receive signals from stimuli, and respond locally through afferent, nociceptive, type C neurons to elicit nasonasal reflex responses mediated via cholinergic neurons. This efferent lim...

    journal_title:Current allergy and asthma reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11882-007-0007-1

    authors: Baraniuk JN,Kim D

    更新日期:2007-05-01 00:00:00

  • Engineering the Microbiome: a Novel Approach to Immunotherapy for Allergic and Immune Diseases.

    abstract::The incidence of immune disorders is growing parallel with practices associated with westernization, such as dietary changes, increased use of antibiotics, or elevated rates of Cesarean section. These practices can significantly impact the gut microbiota, the collection of bacteria residing in the human gastrointestin...

    journal_title:Current allergy and asthma reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11882-015-0538-9

    authors: Shen N,Clemente JC

    更新日期:2015-07-01 00:00:00

  • Anaphylactoid reactions to radiocontrast media.

    abstract::Adverse reactions to contrast material are a concern because iodinated contrast materials are commonly used drugs. The risk for adverse reaction is 4% to 12% with ionic contrast materials and 1% to 3% with nonionic contrast materials. The risk for severe adverse reaction is 0.16% with ionic contrast materials and 0.03...

    journal_title:Current allergy and asthma reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11882-005-0051-7

    authors: Cochran ST

    更新日期:2005-01-01 00:00:00

  • Immune dysregulation in atopic dermatitis.

    abstract::Atopic dermatitis is a chronic inflammatory skin disease that causes significant morbidity in affected individuals. It is characterized by dysregulated immune responses that consist of an increased systemic Th2 response and a combination of Th2 and Th1 responses in the skin lesions. In this article, we review factors ...

    journal_title:Current allergy and asthma reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11882-996-0008-5

    authors: Ong PY,Leung DY

    更新日期:2006-09-01 00:00:00