The role of T cells in drug reaction.

abstract：:Subcutaneous allergen immunotherapy (SCIT) is beneficial for the treatment of allergic rhinitis, asthma, and in preventing stinging insect anaphylaxis, but is not without risks. Four retrospective surveillance surveys and one on-going national prospective study have attempted to characterize the incidence and risk fac...

journal_title：Current allergy and asthma reports

authors： Kannan JA,Epstein TG

更新日期：2013-08-01 00:00:00

abstract：:Otitis media (OM) imposes significant morbidity on the pediatric age group and a large financial burden on the general population. Because standard medical treatments are not highly efficacious in resolving the accompanying middle ear (ME) inflammation, a goal of current research is OM prevention. Past studies show th...

journal_title：Current allergy and asthma reports

authors： Doyle WJ,Alper CM

更新日期：2003-07-01 00:00:00

abstract：:Hypersensitivity in the allergic setting refers to immune reactions, stimulated by soluble antigens that can be rapidly progressing and, in the case of anaphylaxis, are occasionally fatal. As the number of known exposures associated with anaphylaxis is limited, identification of novel causative agents is important in ...

journal_title：Current allergy and asthma reports

authors： Platts-Mills TA,Schuyler AJ,Hoyt AE,Commins SP

更新日期：2015-04-01 00:00:00

abstract：:The nasal mucosa is a complex tissue that interacts with its environment and effects local and systemic changes. Receptors in the nose receive signals from stimuli, and respond locally through afferent, nociceptive, type C neurons to elicit nasonasal reflex responses mediated via cholinergic neurons. This efferent lim...

journal_title：Current allergy and asthma reports

authors： Baraniuk JN,Kim D

更新日期：2007-05-01 00:00:00

abstract：PURPOSE OF REVIEW:There has been an explosion in the number of published systematic reviews on chronic rhinosinusitis in the last decade. RECENT FINDINGS:While the aim of these reviews in facilitating evidence-based practice is laudable, poor quality reviews may contain significant bias that can mislead a non-discerni...

journal_title：Current allergy and asthma reports

authors： Walker A,Hopkins C

更新日期：2018-02-16 00:00:00

abstract：:Common variable immunodeficiency (CVID) is the most prevalent symptomatic primary immune deficiency. With widespread use of immunoglobulin replacement therapy, non-infectious complications, such as autoimmunity, chronic intestinal inflammation, and lung disease, have replaced infections as the major cause of morbidity...

journal_title：Current allergy and asthma reports

authors： Maglione PJ,Cols M,Cunningham-Rundles C

更新日期：2017-10-05 00:00:00

abstract：PURPOSE OF REVIEW:Chronic rhinosinusitis (CRS) is a multidimensional inflammatory disorder of the nose and paranasal sinuses. We reviewed the recent literature to identify improved methods to assess, control, and manage these difficult to control patients. RECENT FINDINGS:The role of endotyping in CRS has offered a be...

journal_title：Current allergy and asthma reports

authors： Sivasubramaniam R,Harvey RJ

更新日期：2017-09-01 00:00:00

abstract：:The physiologic functions of histamine have been recognized for more than 100 years, yet new roles are still being uncovered. Most importantly, a newly discovered receptor of the amine has helped refine our understanding of histamine. This new receptor, the histamine H4 receptor (H4R), has a higher affinity for histam...

journal_title：Current allergy and asthma reports

authors： Huang JF,Thurmond RL

更新日期：2008-03-01 00:00:00

abstract：PURPOSES OF REVIEW:Th9 cells are recognized as a novel subset of effector T helper cells that preferentially produce IL-9. Here, we provide a current update on the reports related to the function of Th9 cells in allergic inflammatory diseases. RECENT FINDINGS:The effector Th9 cells differentiating from naïve T helper ...

journal_title：Current allergy and asthma reports

authors： Angkasekwinai P

更新日期：2019-03-26 00:00:00

abstract：:Perioperative anaphylaxis is a unique condition as a result of the additive cardiovascular effects of anesthetics on the cardiovascular disturbances of anaphylaxis. It occurs mainly in adulthood, primarily follows anesthetic induction, and for the most part, is an IgE-mediated pathomechanism. Neuromuscular blocking ag...

journal_title：Current allergy and asthma reports

authors： Dewachter P,Mouton-Faivre C,Hepner DL

更新日期：2015-05-01 00:00:00

abstract：:Although eustachian tube dysfunction and bacterial infection have been shown to cause otitis media with effusion (OME), other etiologies are possible. One of the most common medical conditions in children is obesity, which can have effects throughout the body. Little is known, however, about the relationship between o...

journal_title：Current allergy and asthma reports

authors： Lee SK,Yeo SG

更新日期：2009-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Agriculture remains a major economic sector globally, and workers experience high rates of chronic inflammatory lung and musculoskeletal diseases. Whereas obstructive pulmonary diseases are known risk factors for bone loss, the underlying relationship between lung inflammation and bone health is not w...

journal_title：Current allergy and asthma reports

authors： Carrington JM,Poole JA

更新日期：2018-02-22 00:00:00

abstract：:In recent years, greater attention has been given to the role of indoor allergens as a cause of sensitization and allergic respiratory diseases. Although indoor allergen control measures to reduce symptoms in individuals allergic to mites have produced controversial results, environmental allergen avoidance is today o...

journal_title：Current allergy and asthma reports

authors： Fernández-Caldas E

更新日期：2002-09-01 00:00:00

abstract：:The activation of a T cell through T cell receptor (TCR) is fundamental to adaptive immune responses. The lymphocyte specific kinase (LCK) plays a central role in the initiation of signaling from the TCR. TCR activates LCK through the adaptor protein uncoordinated 119 (UNC119). A mutation of human UNC119 impairs LCK a...

journal_title：Current allergy and asthma reports

authors： Gorska MM,Alam R

更新日期：2012-10-01 00:00:00

abstract：:The buildup of greenhouse gases in the atmosphere has resulted in global climate change that is having a significant effect on many allergenic plants through increases in plant productivity and pollen allergenicity and shifts in plant phenology. Based on experimental studies, increased atmospheric levels of carbon dio...

journal_title：Current allergy and asthma reports

authors： Levetin E,Van de Water P

更新日期：2008-09-01 00:00:00

abstract：:Although the smoking prevalence in the United States continues to decline since the Surgeon General's first report in 1964, certain vulnerable populations continue to be disproportionately affected by the adverse consequences of tobacco smoke exposure. Children are particularly vulnerable to exposure and are likely to...

journal_title：Current allergy and asthma reports

authors： Ciaccio CE,Gentile D

更新日期：2013-12-01 00:00:00

abstract：PURPOSE OF REVIEW:This paper offers a comprehensive review of interactive mobile allergy and asthma smartphone applications available within the USA in 2018, with an emphasis on interactive asthma apps. RECENT FINDINGS:Primary care and specialty clinicians interested in introducing digital health apps into their pract...

journal_title：Current allergy and asthma reports

authors： Kagen S,Garland A

更新日期：2019-02-02 00:00:00

abstract：:Many fungi are capable of causing IgE-mediated hypersensitivity in humans. However, the most predominant fungi implicated in allergy belong to the genera Aspergillus, Alternaria, Cladosporium, and Penicillium. Pure and relevant allergens are essential for diagnosis as well as for understanding the immunopathogenesis o...

journal_title：Current allergy and asthma reports

authors： Kurup VP

更新日期：2003-09-01 00:00:00

abstract：:Differences in asthma prevalence have been described across different populations, suggesting that genetic ancestry can play an important role in this disease. In fact, several studies have demonstrated an association between African ancestry with increased asthma susceptibility and severity, higher immunoglobulin E l...

journal_title：Current allergy and asthma reports

authors： Hernandez-Pacheco N,Flores C,Oh SS,Burchard EG,Pino-Yanes M

更新日期：2016-07-01 00:00:00

abstract：:Genome-wide screens for asthma and atopy susceptibility loci have been completed in six population samples. Despite the extensive clinical heterogeneity associated with these phenotypes, 20 chromosomal regions show evidence of linkage (P < 0.01) in three or more population samples. Thus, this survey suggests that at l...

journal_title：Current allergy and asthma reports

authors： Ober C

更新日期：2001-03-01 00:00:00

abstract：PURPOSE OF REVIEW:This review is focused on the existing evidence for circadian control of innate and adaptive immune responses to provide a framework for evaluating the contributions of diurnal rhythms to control of infections and pathogenesis of disease. RECENT FINDINGS:Circadian rhythms driven by cell-autonomous bi...

journal_title：Current allergy and asthma reports

authors： Waggoner SN

更新日期：2020-01-10 00:00:00

abstract：:Hypersensitivity to nonsteroidal anti-inflammatory drugs (NSAIDs) associated with chronic rhinosinusitis (CRS) and/or asthma comprises a distinct clinical syndrome referred to as NSAIDs exacerbated respiratory disease (NERD). Patients with NERD tend to have more severe course of both upper (CRS and nasal polyps) and l...

journal_title：Current allergy and asthma reports

authors： Makowska J,Lewandowska-Polak A,Kowalski ML

更新日期：2015-08-01 00:00:00

abstract：:Allergic eye disease is associated with IgE-mediated conjunctival inflammation leading to signs of immediate hypersensitivity, including redness, itching, and tearing. Pathologic studies using conjunctival mast cells demonstrate that these cells, when sensitized with IgE antibody and exposed to environmental allergens...

journal_title：Current allergy and asthma reports

authors： Stahl JL,Cook EB,Barney NP,Graziano FM

更新日期：2002-07-01 00:00:00

abstract：:Anaphylaxis is a potentially life-threatening allergic reaction characterized by a syndrome of dermatologic and systemic signs and symptoms, at times including cardiovascular collapse from distributive shock. Although it is recognized that the incidence of anaphylaxis is increasing, the extent of its prevalence, both ...

journal_title：Current allergy and asthma reports

authors： Matasar MJ,Neugut AI

更新日期：2003-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Food allergy is increasing in prevalence, and management focuses on strict avoidance of known allergens and appropriately treating reactions. Any reaction has the potential to result in anaphylaxis, which can be fatal. Children spend a significant amount of time in the childcare or school setting, and...

journal_title：Current allergy and asthma reports

authors： Hui JW,Copeland M,Lanser BJ

更新日期：2020-06-06 00:00:00

abstract：:Epinephrine can be lifesaving in episodes of anaphylaxis, yet it is underprescribed and underused. Tracking of epinephrine refills over time for patients with a diagnosis of anaphylaxis has not been reported. This study reports on the refill history of 14,677 patients in a large HMO who received an initial dispensing ...

journal_title：Current allergy and asthma reports

authors： Kaplan MS,Jung SY,Chiang ML

更新日期：2011-02-01 00:00:00

abstract：:Exercise-induced bronchoconstriction (EIB) refers to acute airflow obstruction that is triggered by a period of physical exertion. EIB occurs mainly in individuals with other features of asthma but is especially prominent in a subset of asthmatics with pronounced indirect airway hyperresponsiveness. Leukotrienes (LTs)...

journal_title：Current allergy and asthma reports

authors： Hallstrand TS,Henderson WR Jr

更新日期：2009-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Rising costs and increasing morbidity makes the identification and treatment of high-risk asthma phenotypes important. In this review, we outline the complex relationship between obesity and asthma. RECENT FINDINGS:Studies have confirmed a bi-directional relationship between obesity and asthma. Patho...

journal_title：Current allergy and asthma reports

authors： Mohan A,Grace J,Wang BR,Lugogo N

更新日期：2019-09-10 00:00:00

abstract：:Vaccines have had a tremendous impact on public health by reducing morbidity and mortality from a variety of virulent pathogens. However, unintended side effects continue to pose a potential risk that may outweigh the vaccine's protective attributes. In this review, we discuss recent articles and controversies pertain...

journal_title：Current allergy and asthma reports

authors： Song BJ,Katial RK

更新日期：2004-11-01 00:00:00

abstract：:Specific allergen immunotherapy (SIT) is the only disease-modifying treatment for allergic rhinitis and asthma. Subcutaneous immunotherapy (SCIT) is the only method with a US Food and Drug Administration (FDA)-approved formulation, but safety concerns limit administration to medical facilities. Sublingual immunotherap...

journal_title：Current allergy and asthma reports

authors： Cox L

更新日期：2007-11-01 00:00:00