Abstract:
:Hypersensitivity in the allergic setting refers to immune reactions, stimulated by soluble antigens that can be rapidly progressing and, in the case of anaphylaxis, are occasionally fatal. As the number of known exposures associated with anaphylaxis is limited, identification of novel causative agents is important in facilitating both education and other allergen-specific approaches that are crucial to long-term risk management. Within the last 10 years, several seemingly separate observations were recognized to be related, all of which resulted from the development of antibodies to a carbohydrate moiety on proteins where exposure differed from airborne allergens but which were nevertheless capable of producing anaphylactic and hypersensitivity reactions. Our recent work has identified these responses as being due to a novel IgE antibody directed against a mammalian oligosaccharide epitope, galactose-alpha-1,3-galactose (alpha-gal). This review will present the history and biology of alpha-gal and discuss our current approach to management of the mammalian meat allergy and delayed anaphylaxis.
journal_name
Curr Allergy Asthma Repjournal_title
Current allergy and asthma reportsauthors
Platts-Mills TA,Schuyler AJ,Hoyt AE,Commins SPdoi
10.1007/s11882-015-0512-6subject
Has Abstractpub_date
2015-04-01 00:00:00pages
12issue
4eissn
1529-7322issn
1534-6315journal_volume
15pub_type
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