Epinephrine autoinjector refill history in an HMO.

Abstract:

:Epinephrine can be lifesaving in episodes of anaphylaxis, yet it is underprescribed and underused. Tracking of epinephrine refills over time for patients with a diagnosis of anaphylaxis has not been reported. This study reports on the refill history of 14,677 patients in a large HMO who received an initial dispensing of EpiPen (Dey Pharma, Basking Ridge, NJ) or EpiPen Jr between 2000 and 2006. A total of 6,776 (46%) refilled at least once. Twenty-five percent of the patients who were in the cohort for 5 years or more refilled multiple times, and 11% refilled consistently at all expected refill times. Infants through children 12 years of age were more likely to receive a refill dispensing (63%) compared with teenagers and adults (40%). The most common ICD-9 codes that were linked to the initial epinephrine dispensing were allergic disorder (37%), miscellaneous anaphylaxis/angioedema (23%), hymenoptera/insect bite or sting (14%), and specific or nonspecific food allergy (11%). A total of 79% of patients with a food-related ICD-9 code and 59% of patients with an insect sting-related ICD-9 code refilled epinephrine at least once. An opportunity exists to identify system-based as well as personal barriers in an ongoing effort to provide patients at risk with the tools and empowerment that could reduce their risk during life-threatening anaphylactic reactions.

authors

Kaplan MS,Jung SY,Chiang ML

doi

10.1007/s11882-010-0155-6

subject

Has Abstract

pub_date

2011-02-01 00:00:00

pages

65-70

issue

1

eissn

1529-7322

issn

1534-6315

journal_volume

11

pub_type

杂志文章
  • Update on Aspirin-Exacerbated Respiratory Disease.

    abstract::Aspirin-exacerbated respiratory disease (AERD) is an acquired disease characterized by chronic eosinophilic airway inflammation with underlying dysregulation of arachidonic acid metabolism. The purpose of this paper is to review the latest developments in our understanding of the underlying pathophysiology including t...

    journal_title:Current allergy and asthma reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11882-017-0673-6

    authors: Woessner KM

    更新日期:2017-01-01 00:00:00

  • The role of innate immunity in the pathogenesis of chronic rhinosinusitis.

    abstract::Chronic rhinosinusitis (CRS) is a heterogeneous inflammatory condition with a multifactorial basis. Infectious triggers of CRS have been proposed, but demonstration remains elusive. Evolving research suggests that abnormal host mucosal immune responses, rather than specific pathogens themselves, may underlie the chron...

    journal_title:Current allergy and asthma reports

    pub_type: 杂志文章

    doi:10.1007/s11882-009-0030-5

    authors: Lane AP

    更新日期:2009-05-01 00:00:00

  • Hypersensitivity to Aspirin and other NSAIDs: Diagnostic Approach in Patients with Chronic Rhinosinusitis.

    abstract::Hypersensitivity to nonsteroidal anti-inflammatory drugs (NSAIDs) associated with chronic rhinosinusitis (CRS) and/or asthma comprises a distinct clinical syndrome referred to as NSAIDs exacerbated respiratory disease (NERD). Patients with NERD tend to have more severe course of both upper (CRS and nasal polyps) and l...

    journal_title:Current allergy and asthma reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11882-015-0552-y

    authors: Makowska J,Lewandowska-Polak A,Kowalski ML

    更新日期:2015-08-01 00:00:00

  • Hymenoptera Allergy and Mast Cell Activation Syndromes.

    abstract::Mast cell activation syndrome (MCAS) can be diagnosed in patients with recurrent, severe symptoms from mast cell (MC)-derived mediators, which are transiently increased in serum and are attenuated by mediator-targeting drugs. When KIT-mutated, clonal MC are detected in these patients, a diagnosis of primary MCAS can b...

    journal_title:Current allergy and asthma reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11882-015-0582-5

    authors: Bonadonna P,Bonifacio M,Lombardo C,Zanotti R

    更新日期:2016-01-01 00:00:00

  • Utility of next generation sequencing in clinical primary immunodeficiencies.

    abstract::Primary immunodeficiencies (PIDs) are a group of genetically heterogeneous disorders that present with very similar symptoms, complicating definitive diagnosis. More than 240 genes have hitherto been associated with PIDs, of which more than 30 have been identified in the last 3 years. Next generation sequencing (NGS) ...

    journal_title:Current allergy and asthma reports

    pub_type: 杂志文章

    doi:10.1007/s11882-014-0468-y

    authors: Raje N,Soden S,Swanson D,Ciaccio CE,Kingsmore SF,Dinwiddie DL

    更新日期:2014-10-01 00:00:00

  • Sublingual immunotherapy in pediatric allergic rhinitis and asthma: efficacy, safety, and practical considerations.

    abstract::Specific allergen immunotherapy (SIT) is the only disease-modifying treatment for allergic rhinitis and asthma. Subcutaneous immunotherapy (SCIT) is the only method with a US Food and Drug Administration (FDA)-approved formulation, but safety concerns limit administration to medical facilities. Sublingual immunotherap...

    journal_title:Current allergy and asthma reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11882-007-0063-6

    authors: Cox L

    更新日期:2007-11-01 00:00:00

  • Midfacial segment pain: implications for rhinitis and sinusitis.

    abstract::During the past decade, studies on facial pain have shown that there is a distinct group of patients who have a form of facial neuralgia that has all the characteristics of tension-type headache, except that it affects the midface; it is called midfacial segment pain. The pain is described as a feeling of pressure, al...

    journal_title:Current allergy and asthma reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11882-004-0025-1

    authors: Jones NS

    更新日期:2004-05-01 00:00:00

  • Mast cell activation in the context of elevated basal serum tryptase: genetics and presentations.

    abstract:PURPOSE OF REVIEW:To describe inherited and acquired genetic variants and clinical entities associated with increased basal serum tryptase (BST), distinguish these levels from those which acutely rise due to mast cell activation, and finally to characterize the association between chronically elevated basal serum trypt...

    journal_title:Current allergy and asthma reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11882-019-0887-x

    authors: Khoury P,Lyons JJ

    更新日期:2019-11-27 00:00:00

  • Pediatric athletic asthmatics.

    abstract::The main goals of this review are to help the reader to recognize the common symptoms and signs of exercise-induced asthma and the common objective tests used to confirm or rule out the diagnosis and to understand that different forms and intensities of exercise have different asthmagenicity. The review also aims to h...

    journal_title:Current allergy and asthma reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11882-008-0091-x

    authors: Carver TW Jr

    更新日期:2008-11-01 00:00:00

  • Influenza Vaccination in Patients with Common Variable Immunodeficiency (CVID).

    abstract:PURPOSE OF REVIEW:Vaccination against influenza in patients with primary antibody deficiency is recommended. Common variable immunodeficiency (CVID) is the most frequent and clinically relevant antibody deficiency disease and is by definition characterized by an impaired vaccination response. The purpose of this review...

    journal_title:Current allergy and asthma reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11882-017-0749-3

    authors: Mieves JF,Wittke K,Freitag H,Volk HD,Scheibenbogen C,Hanitsch LG

    更新日期:2017-10-05 00:00:00

  • Orbital myositis: diagnosis and management.

    abstract::Orbital myositis is an inflammatory process that primarily involves the extraocular muscles and most commonly affects young adults in the third decade of life, with a female predilection. Clinical characteristics of orbital myositis include orbital and periorbital pain, ocular movement impairment, diplopia, proptosis,...

    journal_title:Current allergy and asthma reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11882-009-0045-y

    authors: Costa RM,Dumitrascu OM,Gordon LK

    更新日期:2009-07-01 00:00:00

  • Immune dysregulation in atopic dermatitis.

    abstract::Atopic dermatitis is a chronic inflammatory skin disease that causes significant morbidity in affected individuals. It is characterized by dysregulated immune responses that consist of an increased systemic Th2 response and a combination of Th2 and Th1 responses in the skin lesions. In this article, we review factors ...

    journal_title:Current allergy and asthma reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11882-996-0008-5

    authors: Ong PY,Leung DY

    更新日期:2006-09-01 00:00:00

  • Olfactory Dysfunction in Traumatic Brain Injury: the Role of Neurogenesis.

    abstract:PURPOSE OF REVIEW:Olfactory functioning disturbances are common following traumatic brain injury (TBI) having a significant impact on quality of life. A spontaneous recovery of the olfactory function over time may occur in TBI patients. Although there is no standard treatment for patients with posttraumatic olfactory l...

    journal_title:Current allergy and asthma reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11882-020-00949-x

    authors: Marin C,Langdon C,Alobid I,Mullol J

    更新日期:2020-07-09 00:00:00

  • Invited commentary: recommendation for a north american pediatric patch test series.

    abstract::Given the increased recognition of pediatric allergic contact dermatitis and lack of patch testing consensus in children, we present a minimum basic 20-allergen North American pediatric series, for screening children ages 6-12 with suspected contact allergy. ...

    journal_title:Current allergy and asthma reports

    pub_type: 杂志文章

    doi:10.1007/s11882-014-0444-6

    authors: Jacob SE,Admani S,Herro EM

    更新日期:2014-06-01 00:00:00

  • Non-IgE-mediated Adverse Food Reactions.

    abstract:PURPOSE OF REVIEW:The purpose of this review is to update what is currently known about the major non-IgE-mediated food allergies: food protein-induced enterocolitis syndrome (FPIES), food protein-induced allergic proctocolitis (FPIAP), and food protein-induced enteropathy (FPE). These conditions are similar in that sy...

    journal_title:Current allergy and asthma reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11882-017-0744-8

    authors: Leonard SA

    更新日期:2017-11-14 00:00:00

  • Challenges for allergy diagnosis in regions with complex pollen exposures.

    abstract::Over the past few decades, significant scientific progress has influenced clinical allergy practice. The biological standardization of extracts was followed by the massive identification and characterization of new allergens and their progressive use as diagnostic tools including allergen micro arrays that facilitate ...

    journal_title:Current allergy and asthma reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11882-014-0496-7

    authors: Barber D,Díaz-Perales A,Villalba M,Chivato T

    更新日期:2015-02-01 00:00:00

  • Fungal allergens.

    abstract::Many fungi are capable of causing IgE-mediated hypersensitivity in humans. However, the most predominant fungi implicated in allergy belong to the genera Aspergillus, Alternaria, Cladosporium, and Penicillium. Pure and relevant allergens are essential for diagnosis as well as for understanding the immunopathogenesis o...

    journal_title:Current allergy and asthma reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11882-003-0078-6

    authors: Kurup VP

    更新日期:2003-09-01 00:00:00

  • Sulfonamide allergy and cross-reactivity.

    abstract::Concerns about cross-allergenicity between sulfonamide antibiotics and nonantibiotic sulfonamide-containing drugs continue to complicate pharmacotherapy. Several elegant investigations have demonstrated unequivocal lack of interaction between the sulfonamide group and either cellular or humoral immunity. The immunolog...

    journal_title:Current allergy and asthma reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11882-007-0029-8

    authors: Brackett CC

    更新日期:2007-04-01 00:00:00

  • Role of leukotrienes in exercise-induced bronchoconstriction.

    abstract::Exercise-induced bronchoconstriction (EIB) refers to acute airflow obstruction that is triggered by a period of physical exertion. EIB occurs mainly in individuals with other features of asthma but is especially prominent in a subset of asthmatics with pronounced indirect airway hyperresponsiveness. Leukotrienes (LTs)...

    journal_title:Current allergy and asthma reports

    pub_type: 杂志文章

    doi:10.1007/s11882-009-0003-8

    authors: Hallstrand TS,Henderson WR Jr

    更新日期:2009-01-01 00:00:00

  • Consequences of a mutation in the UNC119 gene for T cell function in idiopathic CD4 lymphopenia.

    abstract::The activation of a T cell through T cell receptor (TCR) is fundamental to adaptive immune responses. The lymphocyte specific kinase (LCK) plays a central role in the initiation of signaling from the TCR. TCR activates LCK through the adaptor protein uncoordinated 119 (UNC119). A mutation of human UNC119 impairs LCK a...

    journal_title:Current allergy and asthma reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11882-012-0281-4

    authors: Gorska MM,Alam R

    更新日期:2012-10-01 00:00:00

  • Oxidative stress in the pathogenesis of asthma.

    abstract::Asthma affects 5% to 10% of the population of the United States. In asthmatics, oxidative stress occurs not only as a result of inflammation but also from environmental exposure to air pollution. The specific localization of antioxidants in the lung and the adaptive changes during asthma underscore the importance of o...

    journal_title:Current allergy and asthma reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11882-004-0056-7

    authors: Bowler RP

    更新日期:2004-03-01 00:00:00

  • The role of CT and MRI in the diagnosis of chronic rhinosinusitis.

    abstract::Chronic rhinosinusitis (CRS) is one of the most common chronic disease conditions in the United States. Currently, diagnosis is based initially on clinical symptomatology and signs, but the final diagnosis of CRS should be confirmed by objective measures. CT of the paranasal sinuses is the most commonly obtained test ...

    journal_title:Current allergy and asthma reports

    pub_type: 杂志文章

    doi:10.1007/s11882-010-0103-5

    authors: Bhattacharyya N

    更新日期:2010-05-01 00:00:00

  • The new biology of histamine receptors.

    abstract::The physiologic functions of histamine have been recognized for more than 100 years, yet new roles are still being uncovered. Most importantly, a newly discovered receptor of the amine has helped refine our understanding of histamine. This new receptor, the histamine H4 receptor (H4R), has a higher affinity for histam...

    journal_title:Current allergy and asthma reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11882-008-0005-y

    authors: Huang JF,Thurmond RL

    更新日期:2008-03-01 00:00:00

  • Recent advances in the epidemiologic investigation of risk factors for asthma: a review of the 2011 literature.

    abstract::The present review aims to identify and summarize epidemiologic investigations published during 2011 on the environmental risk factors for asthma. Potentially eligible papers were identified by a MEDLINE search. In total, 1,130 items were retrieved. Based on a broad definition of environment, the following topics were...

    journal_title:Current allergy and asthma reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11882-012-0254-7

    authors: Antó JM

    更新日期:2012-06-01 00:00:00

  • Skin Biomes.

    abstract::The cutaneous microbiome has been investigated broadly in recent years and some traditional perspectives are beginning to change. A diverse microbiome exists on human skin and has a potential to influence pathogenic microbes and modulate the course of skin disorders, e.g. atopic dermatitis. In addition to the known dy...

    journal_title:Current allergy and asthma reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11882-016-0618-5

    authors: Fyhrquist N,Salava A,Auvinen P,Lauerma A

    更新日期:2016-05-01 00:00:00

  • Immune mechanisms of sublingual immunotherapy.

    abstract::Sublingual immunotherapy (SLIT) is a well-established allergen-specific immunotherapy and a safe and effective strategy to reorient inappropriate immune responses in allergic patients. SLIT takes advantage of the tolerogenic environment of the oral mucosa to promote tolerance to the allergen. Several clinical studies ...

    journal_title:Current allergy and asthma reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11882-014-0473-1

    authors: Jay DC,Nadeau KC

    更新日期:2014-11-01 00:00:00

  • A tale of two neurons in the upper airways: pain versus itch.

    abstract::Pain and itch sensations are induced by depolarization of distinct populations of unmyelinated type C, and possibly other, neurons. Both sets of neurons and sensations serve critical protective mechanisms that maintain the integrity and patency of the upper airways. When noxious or pruritic stimuli are applied on the ...

    journal_title:Current allergy and asthma reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11882-003-0042-5

    authors: Tai CF,Baraniuk JN

    更新日期:2003-05-01 00:00:00

  • Mechanisms of eosinophil recruitment and activation.

    abstract::The role of the eosinophil in the pathophysiology of allergy and asthma has been the focus of intense interest during the last two decades. While the presence of eosinophils in humans with allergy and asthma is well established, the precise role of this cell in humans and in animal models is less clear. However, recen...

    journal_title:Current allergy and asthma reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11882-002-0005-2

    authors: Adamko D,Lacy P,Moqbel R

    更新日期:2002-03-01 00:00:00

  • Airway wall remodeling in asthma: from the epithelial layer to the adventitia.

    abstract::Asthma is an episodic respiratory syndrome caused by several pathogenic processes. This recurrent syndrome is associated with an accelerated decline in lung function and increase in airway obstruction over time. The reduced lung function is a consequence of tissue restructuring of all the components of the airway wall...

    journal_title:Current allergy and asthma reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11882-008-0056-0

    authors: Bossé Y,Paré PD,Seow CY

    更新日期:2008-07-01 00:00:00

  • New and Potential Treatments for Atopic Dermatitis: Biologicals and Small Molecules.

    abstract:PURPOSE OF REVIEW:An update on new therapies currently approved or potentially useful in the future for the management of patients suffering moderate-to-severe atopic dermatitis. RECENT FINDINGS:New pathogenic mechanisms involved in atopic dermatitis have permitted to propose novel therapeutic approaches devised to co...

    journal_title:Current allergy and asthma reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11882-019-0849-3

    authors: Sánchez-Borges M,Capriles-Hulett A,Ortega-Martell JA,Zubeldia IA

    更新日期:2019-02-28 00:00:00