Abstract：
:The nasal mucosa is a complex tissue that interacts with its environment and effects local and systemic changes. Receptors in the nose receive signals from stimuli, and respond locally through afferent, nociceptive, type C neurons to elicit nasonasal reflex responses mediated via cholinergic neurons. This efferent limb leads to responses in the nose (eg, rhinorrhea, glandular hyperplasia, hypersecretion with mucosal swelling). Anticholinergic agents appear useful against this limb for symptomatic relief of a "runny nose." Chronic exposure to allergens can lead to hyperresponsiveness of the nasal mucosa. As a result, receptors upregulate specific ion channels to increase the sensitivity and potency of their reflex response. Nasal stimuli also affect distant parts of the body. Nerves in the sinus mucosa cause vasodilation; the lacrimal glands can be stimulated by nasal afferent triggers. Even the cardiopulmonary system can be affected via the trigeminal chemosensory system, where sensed irritants can lead to changes in tidal volume, respiratory rate, and blink frequency. The sneeze is an airway defense mechanism that removes irritants from the nasal epithelial surface. It is generally benign, but can lead to problems in certain circumstances. The afferent pathway involves histamine-mediated depolarization of H1 receptor-bearing type C trigeminal neurons and a complex coordination of reactions to effect a response.
journal_name
Curr Allergy Asthma Repjournal_title
Current allergy and asthma reportsauthors
Baraniuk JN,Kim Ddoi
10.1007/s11882-007-0007-1subject
Has Abstractpub_date
2007-05-01 00:00:00pages
105-11issue
2eissn
1529-7322issn
1534-6315journal_volume
7pub_type
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journal_title：Current allergy and asthma reports
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journal_title：Current allergy and asthma reports
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journal_title：Current allergy and asthma reports
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journal_title：Current allergy and asthma reports
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journal_title：Current allergy and asthma reports
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pub_type： 杂志文章,评审
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更新日期：2002-07-01 00:00:00
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journal_title：Current allergy and asthma reports
pub_type： 杂志文章,评审
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更新日期：2016-07-01 00:00:00
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更新日期：2003-01-01 00:00:00
