Abstract：
:Nasal polyposis is the end result of a variety of pathologic processes. The aims of treatment are to relieve nasal blockage, restore olfaction, and improve sinus drainage. Treating any accompanying rhinitis is also an aim, which requires that medical treatment be given to all patients with an inflammatory problem. Most forms of nasal polyp recur after treatment, whether medical or surgical. There are few direct comparisons of medical and surgical treatment in the literature. Those that exist suggest that most patients should be treated medically, with surgery reserved for patients who respond poorly. Large prospective randomized trials of surgical versus medical therapy are needed in groups of well-characterized patients to determine the optimum approach for each and to decrease relapse rates. Topical corticosteroids are the mainstay of treatment. All patients with inflammatory polyps should receive topical corticosteroid treatment in the long-term, unless there is a compelling contraindication. Adverse effects of surgery are rare but can be devastating. The major side effects of medical therapy are those of oral corticosteroids, which need to be used carefully. The choice of topical corticosteroid is important because long-term use is necessary; the least absorbed should be used. No cost-benefit analysis has been undertaken in this area, although medical therapy is probably cheaper and involves less work/school absence than sinonasal surgery, even when the latter is performed with an endoscope.
journal_name
Curr Allergy Asthma Repjournal_title
Current allergy and asthma reportsauthors
Scadding GKdoi
10.1007/s11882-002-0090-2keywords:
subject
Has Abstractpub_date
2002-11-01 00:00:00pages
494-9issue
6eissn
1529-7322issn
1534-6315journal_volume
2pub_type
杂志文章,评审abstract：:The cutaneous microbiome has been investigated broadly in recent years and some traditional perspectives are beginning to change. A diverse microbiome exists on human skin and has a potential to influence pathogenic microbes and modulate the course of skin disorders, e.g. atopic dermatitis. In addition to the known dy...
journal_title：Current allergy and asthma reports
pub_type： 杂志文章,评审
doi：10.1007/s11882-016-0618-5
更新日期：2016-05-01 00:00:00
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journal_title：Current allergy and asthma reports
pub_type： 杂志文章
doi：10.1007/s11882-009-0017-2
更新日期：2009-03-01 00:00:00
abstract：:The role of the eosinophil in the pathophysiology of allergy and asthma has been the focus of intense interest during the last two decades. While the presence of eosinophils in humans with allergy and asthma is well established, the precise role of this cell in humans and in animal models is less clear. However, recen...
journal_title：Current allergy and asthma reports
pub_type： 杂志文章,评审
doi：10.1007/s11882-002-0005-2
更新日期：2002-03-01 00:00:00
abstract：:Over the past few decades, significant scientific progress has influenced clinical allergy practice. The biological standardization of extracts was followed by the massive identification and characterization of new allergens and their progressive use as diagnostic tools including allergen micro arrays that facilitate ...
journal_title：Current allergy and asthma reports
pub_type： 杂志文章,评审
doi：10.1007/s11882-014-0496-7
更新日期：2015-02-01 00:00:00
abstract：PURPOSE OF REVIEW:Chronic rhinosinusitis (CRS) is a multidimensional inflammatory disorder of the nose and paranasal sinuses. We reviewed the recent literature to identify improved methods to assess, control, and manage these difficult to control patients. RECENT FINDINGS:The role of endotyping in CRS has offered a be...
journal_title：Current allergy and asthma reports
pub_type： 杂志文章,评审
doi：10.1007/s11882-017-0728-8
更新日期：2017-09-01 00:00:00
abstract：PURPOSE OF REVIEW:COVID-19 (coronavirus viral disease 2019), due to the novel SARS-CoV-2, may present with different types of cutaneous manifestations of varying pathophysiology. During the ongoing pandemic, publications reporting dermatologic findings in COVID-19 continue to emerge. RECENT FINDINGS:Cutaneous vasculop...
journal_title：Current allergy and asthma reports
pub_type： 杂志文章,评审
doi：10.1007/s11882-020-00974-w
更新日期：2020-10-12 00:00:00
abstract：:Respiratory viruses appear to play a central role in asthma pathogenesis. In addition to a major role in triggering asthma exacerbations, viral infections early in life may play a role in disease development. Although defensins were initially identified as antimicrobial peptides, recent studies have demonstrated that ...
journal_title：Current allergy and asthma reports
pub_type： 杂志文章,评审
doi：10.1007/s11882-006-0015-6
更新日期：2006-02-01 00:00:00
abstract：:Subcutaneous allergen immunotherapy (SCIT) is beneficial for the treatment of allergic rhinitis, asthma, and in preventing stinging insect anaphylaxis, but is not without risks. Four retrospective surveillance surveys and one on-going national prospective study have attempted to characterize the incidence and risk fac...
journal_title：Current allergy and asthma reports
pub_type： 杂志文章,评审
doi：10.1007/s11882-013-0353-0
更新日期：2013-08-01 00:00:00
abstract：:Atopic dermatitis is a chronic inflammatory skin disease that causes significant morbidity in affected individuals. It is characterized by dysregulated immune responses that consist of an increased systemic Th2 response and a combination of Th2 and Th1 responses in the skin lesions. In this article, we review factors ...
journal_title：Current allergy and asthma reports
pub_type： 杂志文章,评审
doi：10.1007/s11882-996-0008-5
更新日期：2006-09-01 00:00:00
abstract：:Mouse allergen has long been recognized as an important cause of occupational allergy and asthma, but only recently has it been implicated in asthma and allergic diseases in community settings. Recent studies have established that mouse allergen is detectable in most US homes, with strikingly high levels in some inner...
journal_title：Current allergy and asthma reports
pub_type： 杂志文章,评审
doi：10.1007/s11882-009-0054-x
更新日期：2009-09-01 00:00:00
abstract：:Cyclooxygenase (COX) enzymes catalyze the rate-limiting steps in prostaglandin synthesis. Prostaglandins have an important role in several physiological processes such as maintenance of gastrointestinal integrity and pathological processes such as inflammation and neoplasia. Several mechanisms have been proposed for t...
journal_title：Current allergy and asthma reports
pub_type： 杂志文章,评审
doi：10.1007/s11882-008-0037-3
更新日期：2008-05-01 00:00:00
abstract：:Expanding knowledge about an interaction of the bacterial colonization with pathogenic and non-pathogenic bacteria and the human immune system leads to speculation on potential effects on health and disease. Recent advances in sequencing technologies and new bioinformatic possibilities now allow investigating the micr...
journal_title：Current allergy and asthma reports
pub_type： 杂志文章,评审
doi：10.1007/s11882-013-0382-8
更新日期：2013-10-01 00:00:00
abstract：:Asthma and chronic obstructive pulmonary disease (COPD) have traditionally been viewed as distinct clinical entities. Recently, however, much attention has been focused on patients with overlapping features of both asthma and COPD: those with asthma COPD overlap syndrome (ACOS). Although no universal definition criter...
journal_title：Current allergy and asthma reports
pub_type： 杂志文章,评审
doi：10.1007/s11882-014-0509-6
更新日期：2015-03-01 00:00:00
abstract：:Exercise-induced bronchoconstriction (EIB) refers to acute airflow obstruction that is triggered by a period of physical exertion. EIB occurs mainly in individuals with other features of asthma but is especially prominent in a subset of asthmatics with pronounced indirect airway hyperresponsiveness. Leukotrienes (LTs)...
journal_title：Current allergy and asthma reports
pub_type： 杂志文章
doi：10.1007/s11882-009-0003-8
更新日期：2009-01-01 00:00:00
abstract：:Chronic rhinosinusitis (CRS) is a heterogeneous inflammatory condition with a multifactorial basis. Infectious triggers of CRS have been proposed, but demonstration remains elusive. Evolving research suggests that abnormal host mucosal immune responses, rather than specific pathogens themselves, may underlie the chron...
journal_title：Current allergy and asthma reports
pub_type： 杂志文章
doi：10.1007/s11882-009-0030-5
更新日期：2009-05-01 00:00:00
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journal_title：Current allergy and asthma reports
pub_type： 杂志文章,评审
doi：10.1007/s11882-015-0580-7
更新日期：2016-01-01 00:00:00
abstract：PURPOSE OF REVIEW:The purpose of this review is to provide an overview of diagnostic testing in primary immunodeficiency and immune dysregulatory disorders (PIDDs), particularly focusing on flow cytometry and genetic techniques, utilizing specific examples of PIDDs. RECENT FINDINGS:Flow cytometry remains a vital tool ...
journal_title：Current allergy and asthma reports
pub_type： 杂志文章,评审
doi：10.1007/s11882-018-0770-1
更新日期：2018-02-22 00:00:00
abstract：:Allergic eye disease is associated with IgE-mediated conjunctival inflammation leading to signs of immediate hypersensitivity, including redness, itching, and tearing. Pathologic studies using conjunctival mast cells demonstrate that these cells, when sensitized with IgE antibody and exposed to environmental allergens...
journal_title：Current allergy and asthma reports
pub_type： 杂志文章,评审
doi：10.1007/s11882-002-0062-6
更新日期：2002-07-01 00:00:00
abstract：:Pain and itch sensations are induced by depolarization of distinct populations of unmyelinated type C, and possibly other, neurons. Both sets of neurons and sensations serve critical protective mechanisms that maintain the integrity and patency of the upper airways. When noxious or pruritic stimuli are applied on the ...
journal_title：Current allergy and asthma reports
pub_type： 杂志文章,评审
doi：10.1007/s11882-003-0042-5
更新日期：2003-05-01 00:00:00
abstract：:The environment is a major contributor to allergic disease, and great effort is being expended to identify the chemical pollutants and allergens that make a significant impact. Exposure to high levels of ozone, sulfur dioxide, nitrogen dioxide, and diesel exhaust particles is known to reduce lung function. Studies con...
journal_title：Current allergy and asthma reports
pub_type： 杂志文章,评审
doi：10.1007/s11882-001-0059-6
更新日期：2001-11-01 00:00:00
abstract：:T cells are major protagonists of immune-mediated adverse drug eruptions. Immunohistochemical observation as well as isolation and functional characterization of T cells infiltrating the affected tissues provided new insights into the pathomechanisms of the diverse clinical manifestations of drug hypersensitivity, and...
journal_title：Current allergy and asthma reports
pub_type： 杂志文章,评审
doi：10.1007/s11882-006-0005-8
更新日期：2006-02-01 00:00:00
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journal_title：Current allergy and asthma reports
pub_type： 杂志文章,评审
doi：10.1007/s11882-001-0085-4
更新日期：2001-03-01 00:00:00
abstract：:Many fungi are capable of causing IgE-mediated hypersensitivity in humans. However, the most predominant fungi implicated in allergy belong to the genera Aspergillus, Alternaria, Cladosporium, and Penicillium. Pure and relevant allergens are essential for diagnosis as well as for understanding the immunopathogenesis o...
journal_title：Current allergy and asthma reports
pub_type： 杂志文章,评审
doi：10.1007/s11882-003-0078-6
更新日期：2003-09-01 00:00:00
abstract：PURPOSE OF REVIEW:Food allergy is a growing health problem worldwide that impacts millions of individuals. Current treatment options are limited and strict dietary avoidance remains the standard of care. Immunotherapy using whole, native allergens is under active clinical investigation but harbors the risk of severe si...
journal_title：Current allergy and asthma reports
pub_type： 杂志文章,评审
doi：10.1007/s11882-019-0846-6
更新日期：2019-02-22 00:00:00
abstract：:The buildup of greenhouse gases in the atmosphere has resulted in global climate change that is having a significant effect on many allergenic plants through increases in plant productivity and pollen allergenicity and shifts in plant phenology. Based on experimental studies, increased atmospheric levels of carbon dio...
journal_title：Current allergy and asthma reports
pub_type： 杂志文章,评审
doi：10.1007/s11882-008-0081-z
更新日期：2008-09-01 00:00:00
abstract：:Recognition of asthma as a heterogeneous disease revealed different potential molecular targets and urged the development of targeted, customized treatment modalities. Evidence was provided for different inflammatory subsets of asthma and more recently, further refined to T helper (Th)2-high and Th2-low subphenotypes ...
journal_title：Current allergy and asthma reports
pub_type： 杂志文章,评审
doi：10.1007/s11882-013-0376-6
更新日期：2013-10-01 00:00:00
abstract：:Specific allergen immunotherapy (SIT) is the only disease-modifying treatment for allergic rhinitis and asthma. Subcutaneous immunotherapy (SCIT) is the only method with a US Food and Drug Administration (FDA)-approved formulation, but safety concerns limit administration to medical facilities. Sublingual immunotherap...
journal_title：Current allergy and asthma reports
pub_type： 杂志文章,评审
doi：10.1007/s11882-007-0063-6
更新日期：2007-11-01 00:00:00
abstract：:Multiple sclerosis (MS) is the most common cause of chronic neurologic disability in young people. Genetic susceptibility and unidentified environmental triggers appear to be necessary in order to result in disease. MS is an extraordinarily complex trait with evidence of heterogeneity at clinical, pathologic, and ther...
journal_title：Current allergy and asthma reports
pub_type： 杂志文章,评审
doi：10.1007/s11882-007-0042-y
更新日期：2007-07-01 00:00:00
abstract：:The nasal mucosa is a complex tissue that interacts with its environment and effects local and systemic changes. Receptors in the nose receive signals from stimuli, and respond locally through afferent, nociceptive, type C neurons to elicit nasonasal reflex responses mediated via cholinergic neurons. This efferent lim...
journal_title：Current allergy and asthma reports
pub_type： 杂志文章,评审
doi：10.1007/s11882-007-0007-1
更新日期：2007-05-01 00:00:00
abstract：:The incidence, morbidity, and mortality of asthma have been increasing at an alarming rate, making asthma the most common chronic illness of childhood. An asthma disease management program was developed to improve the care and management of patients with asthma--a comprehensive health care delivery model that was desi...
journal_title：Current allergy and asthma reports
pub_type： 杂志文章
doi：10.1007/s11882-003-0060-3
更新日期：2003-11-01 00:00:00
