Abstract：
:The cutaneous microbiome has been investigated broadly in recent years and some traditional perspectives are beginning to change. A diverse microbiome exists on human skin and has a potential to influence pathogenic microbes and modulate the course of skin disorders, e.g. atopic dermatitis. In addition to the known dysfunctions in barrier function of the skin and immunologic disturbances, evidence is rising that frequent skin disorders, e.g. atopic dermatitis, might be connected to a dysbiosis of the microbial community and changes in the skin microbiome. As a future perspective, examining the skin microbiome could be seen as a potential new diagnostic and therapeutic target in inflammatory skin disorders.
journal_name
Curr Allergy Asthma Repjournal_title
Current allergy and asthma reportsauthors
Fyhrquist N,Salava A,Auvinen P,Lauerma Adoi
10.1007/s11882-016-0618-5subject
Has Abstractpub_date
2016-05-01 00:00:00pages
40issue
5eissn
1529-7322issn
1534-6315pii
10.1007/s11882-016-0618-5journal_volume
16pub_type
杂志文章,评审abstract：:Glucocorticoid insensitivity presents a profound management problem in patients with asthma because conventional therapies are not effective. Glucocorticoids, acting through the glucocorticoid receptor (GR), are able to selectively repress inflammatory gene expression by utilizing several distinct mechanisms targeting...
journal_title：Current allergy and asthma reports
pub_type： 杂志文章,评审
doi：10.1007/s11882-008-0028-4
更新日期：2008-04-01 00:00:00
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journal_title：Current allergy and asthma reports
pub_type： 杂志文章,评审
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更新日期：2013-02-01 00:00:00
abstract：:Aspirin-exacerbated respiratory disease (AERD) is an acquired disease characterized by chronic eosinophilic airway inflammation with underlying dysregulation of arachidonic acid metabolism. The purpose of this paper is to review the latest developments in our understanding of the underlying pathophysiology including t...
journal_title：Current allergy and asthma reports
pub_type： 杂志文章,评审
doi：10.1007/s11882-017-0673-6
更新日期：2017-01-01 00:00:00
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journal_title：Current allergy and asthma reports
pub_type： 杂志文章,评审
doi：10.1007/s11882-011-0190-y
更新日期：2011-06-01 00:00:00
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journal_title：Current allergy and asthma reports
pub_type： 杂志文章,评审
doi：10.1007/s11882-009-0078-2
更新日期：2010-01-01 00:00:00
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journal_title：Current allergy and asthma reports
pub_type： 杂志文章,评审
doi：10.1007/s11882-012-0254-7
更新日期：2012-06-01 00:00:00
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journal_title：Current allergy and asthma reports
pub_type： 杂志文章,评审
doi：10.1007/s11882-002-0090-2
更新日期：2002-11-01 00:00:00
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journal_title：Current allergy and asthma reports
pub_type： 杂志文章,评审
doi：10.1007/s11882-012-0269-0
更新日期：2012-08-01 00:00:00
abstract：:Multiple sclerosis (MS) is the most common cause of chronic neurologic disability in young people. Genetic susceptibility and unidentified environmental triggers appear to be necessary in order to result in disease. MS is an extraordinarily complex trait with evidence of heterogeneity at clinical, pathologic, and ther...
journal_title：Current allergy and asthma reports
pub_type： 杂志文章,评审
doi：10.1007/s11882-007-0042-y
更新日期：2007-07-01 00:00:00
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journal_title：Current allergy and asthma reports
pub_type： 杂志文章,评审
doi：10.1007/s11882-019-0860-8
更新日期：2019-03-26 00:00:00
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journal_title：Current allergy and asthma reports
pub_type： 杂志文章,评审
doi：10.1007/s11882-015-0512-6
更新日期：2015-04-01 00:00:00
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journal_title：Current allergy and asthma reports
pub_type： 杂志文章,评审
doi：10.1007/s11882-008-0091-x
更新日期：2008-11-01 00:00:00
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journal_title：Current allergy and asthma reports
pub_type： 杂志文章,评审
doi：10.1007/s11882-018-0812-8
更新日期：2018-09-15 00:00:00
abstract：:Common variable immunodeficiency (CVID) is the most prevalent symptomatic primary immune deficiency. With widespread use of immunoglobulin replacement therapy, non-infectious complications, such as autoimmunity, chronic intestinal inflammation, and lung disease, have replaced infections as the major cause of morbidity...
journal_title：Current allergy and asthma reports
pub_type： 杂志文章,评审
doi：10.1007/s11882-017-0746-6
更新日期：2017-10-05 00:00:00
abstract：PURPOSE OF REVIEW:Told from the viewpoint of rheumatologists, this review tells the story of hydroxychloroquine and its swift ascent to become a household name as a therapeutic strategy against the novel SARS-CoV-2 virus. This review describes the history, mechanisms, pharmacokinetics, therapeutic applications, and saf...
journal_title：Current allergy and asthma reports
pub_type： 杂志文章,评审
doi：10.1007/s11882-020-00983-9
更新日期：2021-01-21 00:00:00
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journal_title：Current allergy and asthma reports
pub_type： 杂志文章,评审
doi：10.1007/s11882-009-0069-3
更新日期：2009-11-01 00:00:00
abstract：:Otitis media is currently the most common diagnosis made by clinicians, which has a major impact on managed care. The emergence of resistant bacterial pathogens has caused controversy over the use of antibiotics when acute otitis media (AOM) is diagnosed. All infants with AOM and all older children with severe AOM sho...
journal_title：Current allergy and asthma reports
pub_type： 杂志文章,评审
doi：10.1007/s11882-001-0050-2
更新日期：2001-07-01 00:00:00
abstract：:Patients with specific food allergies are commonly sensitized to related foods, for example, shrimp with other shellfish and peanut with other legumes. In some instances, this represents a true allergy to the related food, defined as cross-reactivity, while in other instances, it represents a positive skin or IgE test...
journal_title：Current allergy and asthma reports
pub_type： 杂志文章,评审
doi：10.1007/s11882-016-0601-1
更新日期：2016-03-01 00:00:00
abstract：PURPOSE OF REVIEW:There has been an explosion in the number of published systematic reviews on chronic rhinosinusitis in the last decade. RECENT FINDINGS:While the aim of these reviews in facilitating evidence-based practice is laudable, poor quality reviews may contain significant bias that can mislead a non-discerni...
journal_title：Current allergy and asthma reports
pub_type： 杂志文章,meta分析,评审
doi：10.1007/s11882-018-0762-1
更新日期：2018-02-16 00:00:00
abstract：:The buildup of greenhouse gases in the atmosphere has resulted in global climate change that is having a significant effect on many allergenic plants through increases in plant productivity and pollen allergenicity and shifts in plant phenology. Based on experimental studies, increased atmospheric levels of carbon dio...
journal_title：Current allergy and asthma reports
pub_type： 杂志文章,评审
doi：10.1007/s11882-008-0081-z
更新日期：2008-09-01 00:00:00
abstract：:Eosinophilic chronic rhinosinusitis (ECRS) encompasses a wide variety of etiologies. To date, a unifying pathophysiologic mechanism remains elusive. Eosinophilia is frequently, but not exclusively, caused by immunoglobulin (Ig)E-mediated hypersensitivity and is dominated by the associated cytokine milieu of Th2 inflam...
journal_title：Current allergy and asthma reports
pub_type： 杂志文章,评审
doi：10.1007/s11882-006-0036-1
更新日期：2006-05-01 00:00:00
abstract：:The role of the eosinophil in the pathophysiology of allergy and asthma has been the focus of intense interest during the last two decades. While the presence of eosinophils in humans with allergy and asthma is well established, the precise role of this cell in humans and in animal models is less clear. However, recen...
journal_title：Current allergy and asthma reports
pub_type： 杂志文章,评审
doi：10.1007/s11882-002-0005-2
更新日期：2002-03-01 00:00:00
abstract：:The gut-associated lymphoid tissue is the specialized arm of the immune system responsible for distinguishing innocuous dietary nutrients, self-proteins, and gut flora from pathogens. Oral tolerance is the active immunologic response to innocuous ingested antigens that leads to a systemic tolerance for that antigen. T...
journal_title：Current allergy and asthma reports
pub_type： 杂志文章,评审
doi：10.1007/s11882-002-0043-9
更新日期：2002-01-01 00:00:00
abstract：PURPOSE OF REVIEW:An update on new therapies currently approved or potentially useful in the future for the management of patients suffering moderate-to-severe atopic dermatitis. RECENT FINDINGS:New pathogenic mechanisms involved in atopic dermatitis have permitted to propose novel therapeutic approaches devised to co...
journal_title：Current allergy and asthma reports
pub_type： 杂志文章,评审
doi：10.1007/s11882-019-0849-3
更新日期：2019-02-28 00:00:00
abstract：:Anaphylaxis is a potentially life-threatening allergic reaction characterized by a syndrome of dermatologic and systemic signs and symptoms, at times including cardiovascular collapse from distributive shock. Although it is recognized that the incidence of anaphylaxis is increasing, the extent of its prevalence, both ...
journal_title：Current allergy and asthma reports
pub_type： 杂志文章,评审
doi：10.1007/s11882-003-0007-8
更新日期：2003-01-01 00:00:00
abstract：PURPOSE OF REVIEW:The objective of this article is to provide an updated review of the economic burden of chronic rhinosinusitis (CRS) and discuss how both medical and surgical interventions impact direct and indirect costs related to CRS. By understanding the economics of CRS, clinicians may improve the patient-center...
journal_title：Current allergy and asthma reports
pub_type： 杂志文章,评审
doi：10.1007/s11882-017-0690-5
更新日期：2017-04-01 00:00:00
abstract：:Otitis media (OM) imposes significant morbidity on the pediatric age group and a large financial burden on the general population. Because standard medical treatments are not highly efficacious in resolving the accompanying middle ear (ME) inflammation, a goal of current research is OM prevention. Past studies show th...
journal_title：Current allergy and asthma reports
pub_type： 杂志文章,评审
doi：10.1007/s11882-003-0093-7
更新日期：2003-07-01 00:00:00
abstract：:Over the past four decades, many patients have been reported to have deficiencies of one or more subclasses of immunoglobulin G (IgG), despite normal total IgG serum concentrations. However, except for those with extremely low or absent IgG2 concentrations and an inability to produce antibodies to polysaccharide antig...
journal_title：Current allergy and asthma reports
pub_type： 杂志文章,评审
doi：10.1007/s11882-002-0067-1
更新日期：2002-09-01 00:00:00
abstract：:Atopic dermatitis is a chronic inflammatory skin disease that causes significant morbidity in affected individuals. It is characterized by dysregulated immune responses that consist of an increased systemic Th2 response and a combination of Th2 and Th1 responses in the skin lesions. In this article, we review factors ...
journal_title：Current allergy and asthma reports
pub_type： 杂志文章,评审
doi：10.1007/s11882-996-0008-5
更新日期：2006-09-01 00:00:00
abstract：:Asthma is a chronic inflammatory disease of the airways characterized by structural airway changes, which are known as airway remodeling, including smooth muscle hypertrophy, goblet cell hyperplasia, subepithelial fibrosis, and angiogenesis. Vascular remodeling in asthmatic lungs results from increased angiogenesis, w...
journal_title：Current allergy and asthma reports
pub_type： 杂志文章,评审
doi：10.1007/s11882-012-0317-9
更新日期：2013-02-01 00:00:00
