Immune dysregulation in atopic dermatitis.

abstract：:In recent years, greater attention has been given to the role of indoor allergens as a cause of sensitization and allergic respiratory diseases. Although indoor allergen control measures to reduce symptoms in individuals allergic to mites have produced controversial results, environmental allergen avoidance is today o...

journal_title：Current allergy and asthma reports

authors： Fernández-Caldas E

更新日期：2002-09-01 00:00:00

abstract：:Eosinophilic chronic rhinosinusitis (ECRS) encompasses a wide variety of etiologies. To date, a unifying pathophysiologic mechanism remains elusive. Eosinophilia is frequently, but not exclusively, caused by immunoglobulin (Ig)E-mediated hypersensitivity and is dominated by the associated cytokine milieu of Th2 inflam...

journal_title：Current allergy and asthma reports

authors： Sok JC,Ferguson BJ

更新日期：2006-05-01 00:00:00

abstract：:Health-related quality of life (HRQL) has become an emerging focus of interest in food allergy. Food allergy is a disease characterized by low mortality and symptoms which only occur during an allergic reaction. However, food-allergic patients continuously need to be alert when eating in order to prevent potentially s...

journal_title：Current allergy and asthma reports

authors： van der Velde JL,Dubois AE,Flokstra-de Blok BM

更新日期：2013-12-01 00:00:00

abstract：:In this review, we examine the critical periods of immune development and how these might be modified to prevent food allergy. The relevant dietary intervention studies, roles of microorganisms and their products, and other strategies are critically analyzed. Additionally, we highlight the potential importance of diff...

journal_title：Current allergy and asthma reports

authors： Khakoo A,Lack G

更新日期：2004-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Rising costs and increasing morbidity makes the identification and treatment of high-risk asthma phenotypes important. In this review, we outline the complex relationship between obesity and asthma. RECENT FINDINGS:Studies have confirmed a bi-directional relationship between obesity and asthma. Patho...

journal_title：Current allergy and asthma reports

authors： Mohan A,Grace J,Wang BR,Lugogo N

更新日期：2019-09-10 00:00:00

abstract：:The physiologic functions of histamine have been recognized for more than 100 years, yet new roles are still being uncovered. Most importantly, a newly discovered receptor of the amine has helped refine our understanding of histamine. This new receptor, the histamine H4 receptor (H4R), has a higher affinity for histam...

journal_title：Current allergy and asthma reports

authors： Huang JF,Thurmond RL

更新日期：2008-03-01 00:00:00

abstract：:Chronic rhinosinusitis (CRS) is a heterogeneous inflammatory condition with a multifactorial basis. Infectious triggers of CRS have been proposed, but demonstration remains elusive. Evolving research suggests that abnormal host mucosal immune responses, rather than specific pathogens themselves, may underlie the chron...

journal_title：Current allergy and asthma reports

authors： Lane AP

更新日期：2009-05-01 00:00:00

abstract：:The role of fungi in chronic rhinosinusitis (CRS) is not clear. Fungi can be detected in the nose and paranasal sinuses of virtually all CRS patients; however, they also appear to be present in healthy controls. Various theories attempt to explain the mechanisms by which fungi can exert an effect on sinus mucosa in su...

journal_title：Current allergy and asthma reports

authors： Ebbens FA,Georgalas C,Fokkens WJ

更新日期：2009-03-01 00:00:00

abstract：:Hypersensitivity in the allergic setting refers to immune reactions, stimulated by soluble antigens that can be rapidly progressing and, in the case of anaphylaxis, are occasionally fatal. As the number of known exposures associated with anaphylaxis is limited, identification of novel causative agents is important in ...

journal_title：Current allergy and asthma reports

authors： Platts-Mills TA,Schuyler AJ,Hoyt AE,Commins SP

更新日期：2015-04-01 00:00:00

abstract：:The increased prevalence of atopic diseases, atopic dermatitis, allergic rhinitis, and asthma has been described as an epidemic. New approaches in the fight against allergic diseases are called for, the target being the persistence of the atopic T helper 2-skewed immune responder pattern beyond infancy. Atopic dermati...

journal_title：Current allergy and asthma reports

authors： Isolauri E

更新日期：2004-07-01 00:00:00

abstract：:T cells are major protagonists of immune-mediated adverse drug eruptions. Immunohistochemical observation as well as isolation and functional characterization of T cells infiltrating the affected tissues provided new insights into the pathomechanisms of the diverse clinical manifestations of drug hypersensitivity, and...

journal_title：Current allergy and asthma reports

authors： Cavani A,De Pità O

更新日期：2006-02-01 00:00:00

abstract：:Asthma is an increasingly prevalent disease, particularly in industrialized countries. With modern treatment, many patients can expect good asthma control; however, a significant minority continue to have excessive symptoms. Bronchial thermoplasty is a novel approach to treating asthma in which the hypertrophied airwa...

journal_title：Current allergy and asthma reports

authors： Martin N,Pavord ID

更新日期：2009-01-01 00:00:00

abstract：:Orbital myositis is an inflammatory process that primarily involves the extraocular muscles and most commonly affects young adults in the third decade of life, with a female predilection. Clinical characteristics of orbital myositis include orbital and periorbital pain, ocular movement impairment, diplopia, proptosis,...

journal_title：Current allergy and asthma reports

authors： Costa RM,Dumitrascu OM,Gordon LK

更新日期：2009-07-01 00:00:00

abstract：:Genome-wide screens for asthma and atopy susceptibility loci have been completed in six population samples. Despite the extensive clinical heterogeneity associated with these phenotypes, 20 chromosomal regions show evidence of linkage (P < 0.01) in three or more population samples. Thus, this survey suggests that at l...

journal_title：Current allergy and asthma reports

authors： Ober C

更新日期：2001-03-01 00:00:00

abstract：PURPOSE OF REVIEW:This paper offers a comprehensive review of interactive mobile allergy and asthma smartphone applications available within the USA in 2018, with an emphasis on interactive asthma apps. RECENT FINDINGS:Primary care and specialty clinicians interested in introducing digital health apps into their pract...

journal_title：Current allergy and asthma reports

authors： Kagen S,Garland A

更新日期：2019-02-02 00:00:00

abstract：:Specific allergen immunotherapy (SIT) is the only disease-modifying treatment for allergic rhinitis and asthma. Subcutaneous immunotherapy (SCIT) is the only method with a US Food and Drug Administration (FDA)-approved formulation, but safety concerns limit administration to medical facilities. Sublingual immunotherap...

journal_title：Current allergy and asthma reports

authors： Cox L

更新日期：2007-11-01 00:00:00

abstract：:The role of the eosinophil in the pathophysiology of allergy and asthma has been the focus of intense interest during the last two decades. While the presence of eosinophils in humans with allergy and asthma is well established, the precise role of this cell in humans and in animal models is less clear. However, recen...

journal_title：Current allergy and asthma reports

authors： Adamko D,Lacy P,Moqbel R

更新日期：2002-03-01 00:00:00

abstract：:Although eustachian tube dysfunction and bacterial infection have been shown to cause otitis media with effusion (OME), other etiologies are possible. One of the most common medical conditions in children is obesity, which can have effects throughout the body. Little is known, however, about the relationship between o...

journal_title：Current allergy and asthma reports

authors： Lee SK,Yeo SG

更新日期：2009-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Chronic rhinosinusitis (CRS) is a multidimensional inflammatory disorder of the nose and paranasal sinuses. We reviewed the recent literature to identify improved methods to assess, control, and manage these difficult to control patients. RECENT FINDINGS:The role of endotyping in CRS has offered a be...

journal_title：Current allergy and asthma reports

authors： Sivasubramaniam R,Harvey RJ

更新日期：2017-09-01 00:00:00

abstract：PURPOSE OF REVIEW:To describe inherited and acquired genetic variants and clinical entities associated with increased basal serum tryptase (BST), distinguish these levels from those which acutely rise due to mast cell activation, and finally to characterize the association between chronically elevated basal serum trypt...

journal_title：Current allergy and asthma reports

authors： Khoury P,Lyons JJ

更新日期：2019-11-27 00:00:00

abstract：PURPOSE OF REVIEW:The prevalence of food allergy is increasing. At the current time, there are no approved treatments for food allergy. Major limitations of immunotherapy are long treatment periods (months or years), frequent clinic visits, high costs, increased risk of adverse events during treatment, and lack of dura...

journal_title：Current allergy and asthma reports

authors： Long A,Borro M,Sampath V,Chinthrajah RS

更新日期：2020-01-16 00:00:00

abstract：:Weeds represent a heterogeneous group of plants, usually defined by no commercial or aesthetic value. Important allergenic weeds belong to the plant families Asteraceae, Amaranthaceae, Urticaceae, Euphorbiaceae, and Plantaginaceae. Major allergens from ragweed, mugwort, feverfew, pellitory, goosefoot, Russian thistle,...

journal_title：Current allergy and asthma reports

authors： Gadermaier G,Dedic A,Obermeyer G,Frank S,Himly M,Ferreira F

更新日期：2004-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Food allergy is increasing in prevalence, and management focuses on strict avoidance of known allergens and appropriately treating reactions. Any reaction has the potential to result in anaphylaxis, which can be fatal. Children spend a significant amount of time in the childcare or school setting, and...

journal_title：Current allergy and asthma reports

authors： Hui JW,Copeland M,Lanser BJ

更新日期：2020-06-06 00:00:00

abstract：PURPOSE OF REVIEW:Focusing on the strict relationship between house dust mites and crustaceans from the allergenic point of view. RECENT FINDINGS:The well-known tropomyosin was considered for years as the cross-reacting allergen between shrimp and house dust mites. In the last few years, several allergens not only in ...

journal_title：Current allergy and asthma reports

authors： Asero R,Pravettoni V,Scala E,Villalta D

更新日期：2020-03-06 00:00:00

abstract：:Otitis media is currently the most common diagnosis made by clinicians, which has a major impact on managed care. The emergence of resistant bacterial pathogens has caused controversy over the use of antibiotics when acute otitis media (AOM) is diagnosed. All infants with AOM and all older children with severe AOM sho...

journal_title：Current allergy and asthma reports

authors： Gungor A,Bluestone CD

更新日期：2001-07-01 00:00:00

abstract：:Allergic eye disease is associated with IgE-mediated conjunctival inflammation leading to signs of immediate hypersensitivity, including redness, itching, and tearing. Pathologic studies using conjunctival mast cells demonstrate that these cells, when sensitized with IgE antibody and exposed to environmental allergens...

journal_title：Current allergy and asthma reports

authors： Stahl JL,Cook EB,Barney NP,Graziano FM

更新日期：2002-07-01 00:00:00

abstract：:The activation of a T cell through T cell receptor (TCR) is fundamental to adaptive immune responses. The lymphocyte specific kinase (LCK) plays a central role in the initiation of signaling from the TCR. TCR activates LCK through the adaptor protein uncoordinated 119 (UNC119). A mutation of human UNC119 impairs LCK a...

journal_title：Current allergy and asthma reports

authors： Gorska MM,Alam R

更新日期：2012-10-01 00:00:00

abstract：:Viral rhinitis is a common, morbid, and costly malady, often complicated by otitis media, sinusitis, and asthma. Current therapies are relatively ineffective and aimed at reducing symptoms rather than moderating underlying mechanisms. Nasal elevations of proinflammatory cytokines track symptom expression during viral ...

journal_title：Current allergy and asthma reports

authors： Gentile DA,Skoner DP

更新日期：2001-05-01 00:00:00

abstract：:Glucocorticoid insensitivity presents a profound management problem in patients with asthma because conventional therapies are not effective. Glucocorticoids, acting through the glucocorticoid receptor (GR), are able to selectively repress inflammatory gene expression by utilizing several distinct mechanisms targeting...

journal_title：Current allergy and asthma reports

authors： Adcock IM,Ford PA,Bhavsar P,Ahmad T,Chung KF

更新日期：2008-04-01 00:00:00

abstract：:Atopic dermatitis (AD) is a complex disease that manifests immunologic abnormalities in the skin. The immunologic changes of AD are characterized by a T helper cell type 2 (Th2)-dominated immune response in its acute phase and a Th1/Th2 mixed immune response in its chronic phase. Although the clinical presentation and...

journal_title：Current allergy and asthma reports

authors： Zheng T,Zhu Z

更新日期：2005-07-01 00:00:00