Which biomarkers are effective for identifying Th2-driven inflammation in asthma?

abstract：:Anaphylaxis is a potentially life-threatening allergic reaction characterized by a syndrome of dermatologic and systemic signs and symptoms, at times including cardiovascular collapse from distributive shock. Although it is recognized that the incidence of anaphylaxis is increasing, the extent of its prevalence, both ...

journal_title：Current allergy and asthma reports

authors： Matasar MJ,Neugut AI

更新日期：2003-01-01 00:00:00

abstract：:Allergic eye disease is associated with IgE-mediated conjunctival inflammation leading to signs of immediate hypersensitivity, including redness, itching, and tearing. Pathologic studies using conjunctival mast cells demonstrate that these cells, when sensitized with IgE antibody and exposed to environmental allergens...

journal_title：Current allergy and asthma reports

authors： Stahl JL,Cook EB,Barney NP,Graziano FM

更新日期：2002-07-01 00:00:00

abstract：:The incidence, morbidity, and mortality of asthma have been increasing at an alarming rate, making asthma the most common chronic illness of childhood. An asthma disease management program was developed to improve the care and management of patients with asthma--a comprehensive health care delivery model that was desi...

journal_title：Current allergy and asthma reports

authors： Miller K,Ward-Smith P,Cox K,Jones EM,Portnoy JM

更新日期：2003-11-01 00:00:00

abstract：:Chronic rhinosinusitis (CRS) is a chronic inflammatory disease of the upper airways of which two major phenotypes exist, CRS without nasal polyps (CRSsNP) and CRS with nasal polyps (CRSwNP). Some patients with CRS have suboptimal response to current guideline treatments. These patients remain severe and uncontrolled b...

journal_title：Current allergy and asthma reports

authors： López-Chacón M,Mullol J,Pujols L

更新日期：2015-05-01 00:00:00

abstract：:Viral rhinitis is a common, morbid, and costly malady, often complicated by otitis media, sinusitis, and asthma. Current therapies are relatively ineffective and aimed at reducing symptoms rather than moderating underlying mechanisms. Nasal elevations of proinflammatory cytokines track symptom expression during viral ...

journal_title：Current allergy and asthma reports

authors： Gentile DA,Skoner DP

更新日期：2001-05-01 00:00:00

abstract：:The best possible allergen immunotherapy clinical outcomes require the provision of high quality and safe allergen immunotherapy extract preparations. Evolving national guidelines and regulatory bodies have devoted special attention to the safe compounding of sterile products, including allergen extracts. It is incumb...

journal_title：Current allergy and asthma reports

authors： Nelson MR,Petersen MM,Wolverton WO,Mikita CP

更新日期：2013-08-01 00:00:00

abstract：:Differences in asthma prevalence have been described across different populations, suggesting that genetic ancestry can play an important role in this disease. In fact, several studies have demonstrated an association between African ancestry with increased asthma susceptibility and severity, higher immunoglobulin E l...

journal_title：Current allergy and asthma reports

authors： Hernandez-Pacheco N,Flores C,Oh SS,Burchard EG,Pino-Yanes M

更新日期：2016-07-01 00:00:00

abstract：:Although the smoking prevalence in the United States continues to decline since the Surgeon General's first report in 1964, certain vulnerable populations continue to be disproportionately affected by the adverse consequences of tobacco smoke exposure. Children are particularly vulnerable to exposure and are likely to...

journal_title：Current allergy and asthma reports

authors： Ciaccio CE,Gentile D

更新日期：2013-12-01 00:00:00

abstract：:The cutaneous microbiome has been investigated broadly in recent years and some traditional perspectives are beginning to change. A diverse microbiome exists on human skin and has a potential to influence pathogenic microbes and modulate the course of skin disorders, e.g. atopic dermatitis. In addition to the known dy...

journal_title：Current allergy and asthma reports

authors： Fyhrquist N,Salava A,Auvinen P,Lauerma A

更新日期：2016-05-01 00:00:00

abstract：PURPOSE OF REVIEW:This review is focused on the existing evidence for circadian control of innate and adaptive immune responses to provide a framework for evaluating the contributions of diurnal rhythms to control of infections and pathogenesis of disease. RECENT FINDINGS:Circadian rhythms driven by cell-autonomous bi...

journal_title：Current allergy and asthma reports

authors： Waggoner SN

更新日期：2020-01-10 00:00:00

abstract：:In this review, we examine the critical periods of immune development and how these might be modified to prevent food allergy. The relevant dietary intervention studies, roles of microorganisms and their products, and other strategies are critically analyzed. Additionally, we highlight the potential importance of diff...

journal_title：Current allergy and asthma reports

authors： Khakoo A,Lack G

更新日期：2004-01-01 00:00:00

abstract：PURPOSE OF REVIEW:The purpose of this review is to provide an overview of diagnostic testing in primary immunodeficiency and immune dysregulatory disorders (PIDDs), particularly focusing on flow cytometry and genetic techniques, utilizing specific examples of PIDDs. RECENT FINDINGS:Flow cytometry remains a vital tool ...

journal_title：Current allergy and asthma reports

authors： Richardson AM,Moyer AM,Hasadsri L,Abraham RS

更新日期：2018-02-22 00:00:00

abstract：PURPOSE OF REVIEW:This review aims to provide an update of recent advances in the epidemiology, clinical features and diagnosis, and management of food-induced anaphylaxis (FIA). RECENT FINDINGS:Food allergy prevalence and FIA rates continue to rise, but FIA fatalities are stable. Basophil and mast cell activation tes...

journal_title：Current allergy and asthma reports

authors： Parrish CP,Kim H

更新日期：2018-06-14 00:00:00

abstract：:Otitis media is currently the most common diagnosis made by clinicians, which has a major impact on managed care. The emergence of resistant bacterial pathogens has caused controversy over the use of antibiotics when acute otitis media (AOM) is diagnosed. All infants with AOM and all older children with severe AOM sho...

journal_title：Current allergy and asthma reports

authors： Gungor A,Bluestone CD

更新日期：2001-07-01 00:00:00

abstract：:Multiple sclerosis (MS) is the most common cause of chronic neurologic disability in young people. Genetic susceptibility and unidentified environmental triggers appear to be necessary in order to result in disease. MS is an extraordinarily complex trait with evidence of heterogeneity at clinical, pathologic, and ther...

journal_title：Current allergy and asthma reports

authors： Heard RN

更新日期：2007-07-01 00:00:00

abstract：:Hypersensitivity in the allergic setting refers to immune reactions, stimulated by soluble antigens that can be rapidly progressing and, in the case of anaphylaxis, are occasionally fatal. As the number of known exposures associated with anaphylaxis is limited, identification of novel causative agents is important in ...

journal_title：Current allergy and asthma reports

authors： Platts-Mills TA,Schuyler AJ,Hoyt AE,Commins SP

更新日期：2015-04-01 00:00:00

abstract：:The use of saline nasal irrigation (SNI) in the treatment of nasal and sinus disorders has its roots in the yoga tradition and homeopathic medicine. In recent years, SNI has been increasingly observed as concomitant therapy for acute (ARS) and chronic rhinosinusitis (CRS). Various devices are employed, such as nasal d...

journal_title：Current allergy and asthma reports

authors： Achilles N,Mösges R

更新日期：2013-04-01 00:00:00

abstract：:Patients with HIV infection exhibit a wide range of skin pathology, including bacterial, fungal, and viral infections, skin tumors, inflammatory and eczematous eruptions, and drug rashes. HIV-infected adults commonly develop a condition that strongly resembles atopic dermatitis and is sometimes called "atopic-like der...

journal_title：Current allergy and asthma reports

authors： Rudikoff D

更新日期：2002-07-01 00:00:00

abstract：:Health-related quality of life (HRQL) has become an emerging focus of interest in food allergy. Food allergy is a disease characterized by low mortality and symptoms which only occur during an allergic reaction. However, food-allergic patients continuously need to be alert when eating in order to prevent potentially s...

journal_title：Current allergy and asthma reports

authors： van der Velde JL,Dubois AE,Flokstra-de Blok BM

更新日期：2013-12-01 00:00:00

abstract：:Nasal polyposis is the end result of a variety of pathologic processes. The aims of treatment are to relieve nasal blockage, restore olfaction, and improve sinus drainage. Treating any accompanying rhinitis is also an aim, which requires that medical treatment be given to all patients with an inflammatory problem. Mos...

journal_title：Current allergy and asthma reports

authors： Scadding GK

更新日期：2002-11-01 00:00:00

abstract：:Research evidence supports a causative relationship between indoor allergen exposure and the development of asthma. Epidemiologic studies demonstrate that exposure to indoor allergens, particularly house-dust mites and cockroaches and, to a lesser extent, animal allergens and mold, is a risk factor for the development...

journal_title：Current allergy and asthma reports

authors： Arshad SH

更新日期：2003-03-01 00:00:00

abstract：PURPOSES OF REVIEW:Th9 cells are recognized as a novel subset of effector T helper cells that preferentially produce IL-9. Here, we provide a current update on the reports related to the function of Th9 cells in allergic inflammatory diseases. RECENT FINDINGS:The effector Th9 cells differentiating from naïve T helper ...

journal_title：Current allergy and asthma reports

authors： Angkasekwinai P

更新日期：2019-03-26 00:00:00

abstract：:The physiologic functions of histamine have been recognized for more than 100 years, yet new roles are still being uncovered. Most importantly, a newly discovered receptor of the amine has helped refine our understanding of histamine. This new receptor, the histamine H4 receptor (H4R), has a higher affinity for histam...

journal_title：Current allergy and asthma reports

authors： Huang JF,Thurmond RL

更新日期：2008-03-01 00:00:00

abstract：:Since rhinosinusitis is an inflammatory disease, cytokines as key regulators of inflammation play a central role in its pathophysiology. In acute rhinosinusitis, several proinflammatory cytokines of different types have been identified. Initial information about the involvement of the inflammasome in rhinosinusitis ha...

journal_title：Current allergy and asthma reports

authors： Scheckenbach K,Wagenmann M

更新日期：2016-01-01 00:00:00

abstract：:Glucocorticoid insensitivity presents a profound management problem in patients with asthma because conventional therapies are not effective. Glucocorticoids, acting through the glucocorticoid receptor (GR), are able to selectively repress inflammatory gene expression by utilizing several distinct mechanisms targeting...

journal_title：Current allergy and asthma reports

authors： Adcock IM,Ford PA,Bhavsar P,Ahmad T,Chung KF

更新日期：2008-04-01 00:00:00

abstract：PURPOSE OF REVIEW:Food allergy is a growing health problem worldwide that impacts millions of individuals. Current treatment options are limited and strict dietary avoidance remains the standard of care. Immunotherapy using whole, native allergens is under active clinical investigation but harbors the risk of severe si...

journal_title：Current allergy and asthma reports

authors： Yang L,Kulis M

更新日期：2019-02-22 00:00:00

abstract：:The present review aims to identify and summarize epidemiologic investigations published during 2011 on the environmental risk factors for asthma. Potentially eligible papers were identified by a MEDLINE search. In total, 1,130 items were retrieved. Based on a broad definition of environment, the following topics were...

journal_title：Current allergy and asthma reports

authors： Antó JM

更新日期：2012-06-01 00:00:00

abstract：PURPOSE OF REVIEW:This paper offers a comprehensive review of interactive mobile allergy and asthma smartphone applications available within the USA in 2018, with an emphasis on interactive asthma apps. RECENT FINDINGS:Primary care and specialty clinicians interested in introducing digital health apps into their pract...

journal_title：Current allergy and asthma reports

authors： Kagen S,Garland A

更新日期：2019-02-02 00:00:00

abstract：:Primary immunodeficiencies (PIDs) are a group of genetically heterogeneous disorders that present with very similar symptoms, complicating definitive diagnosis. More than 240 genes have hitherto been associated with PIDs, of which more than 30 have been identified in the last 3 years. Next generation sequencing (NGS) ...

journal_title：Current allergy and asthma reports

authors： Raje N,Soden S,Swanson D,Ciaccio CE,Kingsmore SF,Dinwiddie DL

更新日期：2014-10-01 00:00:00

abstract：:Asthma is a chronic inflammatory disease of the airways characterized by structural airway changes, which are known as airway remodeling, including smooth muscle hypertrophy, goblet cell hyperplasia, subepithelial fibrosis, and angiogenesis. Vascular remodeling in asthmatic lungs results from increased angiogenesis, w...

journal_title：Current allergy and asthma reports

authors： Meyer N,Akdis CA

更新日期：2013-02-01 00:00:00