Abstract:
:Glucocorticoid insensitivity presents a profound management problem in patients with asthma because conventional therapies are not effective. Glucocorticoids, acting through the glucocorticoid receptor (GR), are able to selectively repress inflammatory gene expression by utilizing several distinct mechanisms targeting nuclear factor-varphiB and activator protein-1 activation complexes and by effects on mitogen-activated protein kinases. Different model systems often activate distinct sets of signaling molecules and different glucocorticoid responsiveness may result from differences in concentrations and timing of steroid treatment of cells, GR expression levels, and the precise inflammatory stimulus used. Thus, abnormal activation of many signaling pathways may affect corticosteroid responsiveness in patients with corticosteroid-resistant asthma. Understanding the molecular mechanisms of GR action and inaction may lead to the development of new anti-inflammatory drugs or enable clinicians to reverse the relative steroid-insensitivity that is characteristic of some patients with severe asthma.
journal_name
Curr Allergy Asthma Repjournal_title
Current allergy and asthma reportsauthors
Adcock IM,Ford PA,Bhavsar P,Ahmad T,Chung KFdoi
10.1007/s11882-008-0028-4subject
Has Abstractpub_date
2008-04-01 00:00:00pages
171-8issue
2eissn
1529-7322issn
1534-6315journal_volume
8pub_type
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journal_title:Current allergy and asthma reports
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journal_title:Current allergy and asthma reports
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journal_title:Current allergy and asthma reports
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journal_title:Current allergy and asthma reports
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更新日期:2013-08-01 00:00:00
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更新日期:2013-10-01 00:00:00
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journal_title:Current allergy and asthma reports
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更新日期:2006-09-01 00:00:00
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