Role of Type 2 Innate Lymphoid Cells in Allergic Diseases.

Abstract:

PURPOSE OF REVIEW:The adaptive immune response orchestrated by type 2 T helper (Th2) lymphocytes, strictly cooperates with the innate response of group 2 innate lymphoid cells (ILC2), in the protection from helminths infection, as well as in the pathogenesis of allergic disease. The aim of this review is to explore the pathogenic role of ILC2 in different type 2-mediated disorders. RECENT FINDINGS:Recent studies have shown that epithelial cell-derived cytokines and their responding cells, ILC2, play a pathogenic role in bronchial asthma, chronic rhinosinusitis, and atopic dermatitis. The growing evidences of the contribution of ILC2 in the induction and maintenance of allergic inflammation in such disease suggest the possibility to target them in therapy. Biological therapies blocking ILC2 activation or neutralizing their effector cytokines are currently under evaluation to be used in patients with type 2-dominated diseases.

authors

Cosmi L,Liotta F,Maggi L,Annunziato F

doi

10.1007/s11882-017-0735-9

subject

Has Abstract

pub_date

2017-09-11 00:00:00

pages

66

issue

10

eissn

1529-7322

issn

1534-6315

pii

10.1007/s11882-017-0735-9

journal_volume

17

pub_type

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