Abstract：
:Until recently, idiopathic pulmonary fibrosis (IPF) has been a devastating and generally fatal disease with no effective therapeutic. New developments in understanding the biology of the disease include a growing consensus that the lesions are mainly composed of cells that originated from resident fibroblasts. New developments in therapeutics include recommendations against several treatment regimes that have been previously used. On a positive note, the orally available drug pirfenidone has been approved for use in IPF in China, Japan, India, and the European Union, but not yet in the United States. Other possibilities for managing IPF include managing gastrointestinal reflux, and limiting excessive salt intake. A variety of potential therapeutics for IPF are in clinical trials; for instance, in a Phase 1b trial, intravenous injections of a recombinant version of the normal human serum protein Serum Amyloid P (SAP, also known as PTX2) improved lung function in IPF patients.
journal_name
Curr Allergy Asthma Repjournal_title
Current allergy and asthma reportsauthors
Gomer RHdoi
10.1007/s11882-013-0377-5subject
Has Abstractpub_date
2013-12-01 00:00:00pages
607-12issue
6eissn
1529-7322issn
1534-6315journal_volume
13pub_type
杂志文章,评审abstract：:T cells are major protagonists of immune-mediated adverse drug eruptions. Immunohistochemical observation as well as isolation and functional characterization of T cells infiltrating the affected tissues provided new insights into the pathomechanisms of the diverse clinical manifestations of drug hypersensitivity, and...
journal_title：Current allergy and asthma reports
pub_type： 杂志文章,评审
doi：10.1007/s11882-006-0005-8
更新日期：2006-02-01 00:00:00
abstract：:Omalizumab is a recently developed monoclonal anti-IgE antibody. Clinical trials have demonstrated its efficacy in patients with moderate-to-severe and severe or poorly controlled allergic asthma, in patients with seasonal and perennial allergic disease, and in subjects with concomitant asthma and allergic rhinitis. P...
journal_title：Current allergy and asthma reports
pub_type： 杂志文章
doi：10.1007/s11882-005-0083-z
更新日期：2005-03-01 00:00:00
abstract：:Specific allergen immunotherapy (SIT) is the only disease-modifying treatment for allergic rhinitis and asthma. Subcutaneous immunotherapy (SCIT) is the only method with a US Food and Drug Administration (FDA)-approved formulation, but safety concerns limit administration to medical facilities. Sublingual immunotherap...
journal_title：Current allergy and asthma reports
pub_type： 杂志文章,评审
doi：10.1007/s11882-007-0063-6
更新日期：2007-11-01 00:00:00
abstract：:Eosinophilic gastrointestinal disease (EGID) can be classified as eosinophilic esophagitis (EoE) when the eosinophilia is limited to the esophagus or as eosinophilic gastritis (EG) if it is limited to the gastric tract, eosinophilic colitis (EC) if it is limited to the colon, and eosinophilic gastroenteritis (EGE) if ...
journal_title：Current allergy and asthma reports
pub_type： 杂志文章,评审
doi：10.1007/s11882-015-0558-5
更新日期：2015-09-01 00:00:00
abstract：:Health-related quality of life (HRQL) has become an emerging focus of interest in food allergy. Food allergy is a disease characterized by low mortality and symptoms which only occur during an allergic reaction. However, food-allergic patients continuously need to be alert when eating in order to prevent potentially s...
journal_title：Current allergy and asthma reports
pub_type： 杂志文章,评审
doi：10.1007/s11882-013-0391-7
更新日期：2013-12-01 00:00:00
abstract：PURPOSE OF REVIEW:The purpose of this review is to describe the process of administering a telemedicine program including reviewing telemedicine guidelines; discussing licensing, credentialing, and privileging of providers; outlining scheduling and recruitment of patients; and measuring outcomes of a telemedicine progr...
journal_title：Current allergy and asthma reports
pub_type： 杂志文章,评审
doi：10.1007/s11882-018-0812-8
更新日期：2018-09-15 00:00:00
abstract：:Autoimmune lymphoproliferative syndrome (ALPS) is characterized by immune dysregulation due to a defect in lymphocyte apoptosis. The clinical manifestations may be noted in multiple family members and include lymphadenopathy, splenomegaly, increased risk of lymphoma, and autoimmune disease, which typically involves he...
journal_title：Current allergy and asthma reports
pub_type： 杂志文章,评审
doi：10.1007/s11882-014-0462-4
更新日期：2014-09-01 00:00:00
abstract：:The pathology of atopic dermatitis is orchestrated on the cellular level by several different cell types in the characteristic skin lesions. In such lesions, histamine as a mediator of many biological functions is also present in high concentrations. Most of the cells involved in the inflammatory responses express the...
journal_title：Current allergy and asthma reports
pub_type： 杂志文章,评审
doi：10.1007/s11882-010-0162-7
更新日期：2011-02-01 00:00:00
abstract：:Immune responses can be compartmentalized into innate versus adaptive components. This relatively recent dichotomy positioned the innate immune system at the interface between the host and the external environment and provided a new conceptual framework with which to view allergic diseases, including asthma. Airway ep...
journal_title：Current allergy and asthma reports
pub_type： 杂志文章,评审
doi：10.1007/s11882-010-0090-6
更新日期：2010-03-01 00:00:00
abstract：:Oral food challenges are the gold-standard diagnostic investigation for diagnosing food allergy. They allow a subject to consume an age-appropriate portion of allergenic food under surveillance to assess whether a reproducible immune-mediated adverse response is demonstrated. The specific design of food challenge must...
journal_title：Current allergy and asthma reports
pub_type： 杂志文章,评审
doi：10.1007/s11882-015-0549-6
更新日期：2015-08-01 00:00:00
abstract：:Otitis media (OM) imposes significant morbidity on the pediatric age group and a large financial burden on the general population. Because standard medical treatments are not highly efficacious in resolving the accompanying middle ear (ME) inflammation, a goal of current research is OM prevention. Past studies show th...
journal_title：Current allergy and asthma reports
pub_type： 杂志文章,评审
doi：10.1007/s11882-003-0093-7
更新日期：2003-07-01 00:00:00
abstract：:Hypersensitivity to nonsteroidal anti-inflammatory drugs (NSAIDs) associated with chronic rhinosinusitis (CRS) and/or asthma comprises a distinct clinical syndrome referred to as NSAIDs exacerbated respiratory disease (NERD). Patients with NERD tend to have more severe course of both upper (CRS and nasal polyps) and l...
journal_title：Current allergy and asthma reports
pub_type： 杂志文章,评审
doi：10.1007/s11882-015-0552-y
更新日期：2015-08-01 00:00:00
abstract：:Asthma and chronic obstructive pulmonary disease (COPD) have traditionally been viewed as distinct clinical entities. Recently, however, much attention has been focused on patients with overlapping features of both asthma and COPD: those with asthma COPD overlap syndrome (ACOS). Although no universal definition criter...
journal_title：Current allergy and asthma reports
pub_type： 杂志文章,评审
doi：10.1007/s11882-014-0509-6
更新日期：2015-03-01 00:00:00
abstract：:The cutaneous microbiome has been investigated broadly in recent years and some traditional perspectives are beginning to change. A diverse microbiome exists on human skin and has a potential to influence pathogenic microbes and modulate the course of skin disorders, e.g. atopic dermatitis. In addition to the known dy...
journal_title：Current allergy and asthma reports
pub_type： 杂志文章,评审
doi：10.1007/s11882-016-0618-5
更新日期：2016-05-01 00:00:00
abstract：:The gut-associated lymphoid tissue is the specialized arm of the immune system responsible for distinguishing innocuous dietary nutrients, self-proteins, and gut flora from pathogens. Oral tolerance is the active immunologic response to innocuous ingested antigens that leads to a systemic tolerance for that antigen. T...
journal_title：Current allergy and asthma reports
pub_type： 杂志文章,评审
doi：10.1007/s11882-002-0043-9
更新日期：2002-01-01 00:00:00
abstract：:Chronic rhinosinusitis (CRS) is a heterogeneous inflammatory condition with a multifactorial basis. Infectious triggers of CRS have been proposed, but demonstration remains elusive. Evolving research suggests that abnormal host mucosal immune responses, rather than specific pathogens themselves, may underlie the chron...
journal_title：Current allergy and asthma reports
pub_type： 杂志文章
doi：10.1007/s11882-009-0030-5
更新日期：2009-05-01 00:00:00
abstract：:Orbital myositis is an inflammatory process that primarily involves the extraocular muscles and most commonly affects young adults in the third decade of life, with a female predilection. Clinical characteristics of orbital myositis include orbital and periorbital pain, ocular movement impairment, diplopia, proptosis,...
journal_title：Current allergy and asthma reports
pub_type： 杂志文章,评审
doi：10.1007/s11882-009-0045-y
更新日期：2009-07-01 00:00:00
abstract：PURPOSE OF REVIEW:Chronic rhinosinusitis (CRS) is a multidimensional inflammatory disorder of the nose and paranasal sinuses. We reviewed the recent literature to identify improved methods to assess, control, and manage these difficult to control patients. RECENT FINDINGS:The role of endotyping in CRS has offered a be...
journal_title：Current allergy and asthma reports
pub_type： 杂志文章,评审
doi：10.1007/s11882-017-0728-8
更新日期：2017-09-01 00:00:00
abstract：:The incidence of immune disorders is growing parallel with practices associated with westernization, such as dietary changes, increased use of antibiotics, or elevated rates of Cesarean section. These practices can significantly impact the gut microbiota, the collection of bacteria residing in the human gastrointestin...
journal_title：Current allergy and asthma reports
pub_type： 杂志文章,评审
doi：10.1007/s11882-015-0538-9
更新日期：2015-07-01 00:00:00
abstract：:Vaccines have had a tremendous impact on public health by reducing morbidity and mortality from a variety of virulent pathogens. However, unintended side effects continue to pose a potential risk that may outweigh the vaccine's protective attributes. In this review, we discuss recent articles and controversies pertain...
journal_title：Current allergy and asthma reports
pub_type： 杂志文章,评审
doi：10.1007/s11882-004-0010-8
更新日期：2004-11-01 00:00:00
abstract：:The main goals of this review are to help the reader to recognize the common symptoms and signs of exercise-induced asthma and the common objective tests used to confirm or rule out the diagnosis and to understand that different forms and intensities of exercise have different asthmagenicity. The review also aims to h...
journal_title：Current allergy and asthma reports
pub_type： 杂志文章,评审
doi：10.1007/s11882-008-0091-x
更新日期：2008-11-01 00:00:00
abstract：PURPOSE OF REVIEW:The adaptive immune response orchestrated by type 2 T helper (Th2) lymphocytes, strictly cooperates with the innate response of group 2 innate lymphoid cells (ILC2), in the protection from helminths infection, as well as in the pathogenesis of allergic disease. The aim of this review is to explore the...
journal_title：Current allergy and asthma reports
pub_type： 杂志文章,评审
doi：10.1007/s11882-017-0735-9
更新日期：2017-09-11 00:00:00
abstract：:Atopic dermatitis (AD) is a complex disease that manifests immunologic abnormalities in the skin. The immunologic changes of AD are characterized by a T helper cell type 2 (Th2)-dominated immune response in its acute phase and a Th1/Th2 mixed immune response in its chronic phase. Although the clinical presentation and...
journal_title：Current allergy and asthma reports
pub_type： 杂志文章,评审
doi：10.1007/s11882-005-0069-x
更新日期：2005-07-01 00:00:00
abstract：:In this review, we examine the critical periods of immune development and how these might be modified to prevent food allergy. The relevant dietary intervention studies, roles of microorganisms and their products, and other strategies are critically analyzed. Additionally, we highlight the potential importance of diff...
journal_title：Current allergy and asthma reports
pub_type： 杂志文章,评审
doi：10.1007/s11882-004-0041-1
更新日期：2004-01-01 00:00:00
abstract：PURPOSE OF REVIEW:This review aims to update the information available on the prevalence, clinical picture, diagnostic methods, and treatment of urticarias induced by external physical stimuli. RECENT FINDINGS:Physical urticarias are present in up to 5% of the general population, and in 10 to 50% of patients with chro...
journal_title：Current allergy and asthma reports
pub_type： 杂志文章,评审
doi：10.1007/s11882-017-0722-1
更新日期：2017-08-01 00:00:00
abstract：:The buildup of greenhouse gases in the atmosphere has resulted in global climate change that is having a significant effect on many allergenic plants through increases in plant productivity and pollen allergenicity and shifts in plant phenology. Based on experimental studies, increased atmospheric levels of carbon dio...
journal_title：Current allergy and asthma reports
pub_type： 杂志文章,评审
doi：10.1007/s11882-008-0081-z
更新日期：2008-09-01 00:00:00
abstract：:Multiple sclerosis (MS) is the most common cause of chronic neurologic disability in young people. Genetic susceptibility and unidentified environmental triggers appear to be necessary in order to result in disease. MS is an extraordinarily complex trait with evidence of heterogeneity at clinical, pathologic, and ther...
journal_title：Current allergy and asthma reports
pub_type： 杂志文章,评审
doi：10.1007/s11882-007-0042-y
更新日期：2007-07-01 00:00:00
abstract：:Exercise-induced bronchoconstriction (EIB) refers to acute airflow obstruction that is triggered by a period of physical exertion. EIB occurs mainly in individuals with other features of asthma but is especially prominent in a subset of asthmatics with pronounced indirect airway hyperresponsiveness. Leukotrienes (LTs)...
journal_title：Current allergy and asthma reports
pub_type： 杂志文章
doi：10.1007/s11882-009-0003-8
更新日期：2009-01-01 00:00:00
abstract：:The dynamic expression of various phenotypic markers during B cell development not only defines the particular stage in ontogeny but also provides the necessary growth, differentiation, maturation and survival signals. When a B cell at any given stage becomes cancerous, these cell surface molecules, intracellular sign...
journal_title：Current allergy and asthma reports
pub_type： 杂志文章,评审
doi：10.1007/s11882-012-0327-7
更新日期：2013-02-01 00:00:00
abstract：:IgG4 is the least abundant subclass of IgG in normal human serum, but elevated IgG4 levels are triggered in response to a chronic antigenic stimulus and inflammation. Since the immune system is exposed to tumor-associated antigens over a relatively long period of time, and tumors notoriously promote inflammation, it i...
journal_title：Current allergy and asthma reports
pub_type： 杂志文章,评审
doi：10.1007/s11882-015-0580-7
更新日期：2016-01-01 00:00:00
