Abstract:
PURPOSE OF REVIESW:Local respiratory allergy (LRA) is an eosinophilic phenotype of chronic airway disease. Three entities have been described within the LRA spectrum: local allergic rhinitis (LAR) and local allergic asthma (LAA) in non-atopic patients, and dual allergic rhinitis (DAR) in atopic patients (coexistence of LAR and allergic rhinitis). In this article, we aim to review the current evidence on the therapeutic options for LRA. RECENT FINDINGS:No controlled study has assessed the effect of standard therapy (oral antihistamines, intranasal or inhaled corticosteroids, bronchodilators) in LRA subjects. Three randomized clinical trials and one observational study demonstrated that allergen immunotherapy (AIT) is able to control nasal and ocular symptoms, decrease the need for rescue medication, and improve quality of life in LAR individuals. Nasal or inhaled steroids can be expected to improve eosinophilic inflammation in LRA patients but cannot change the natural course of the disease. Moreover, the long-term and disease-modifying effects of AIT in LRA subjects need to be investigated.
journal_name
Curr Allergy Asthma Repjournal_title
Current allergy and asthma reportsauthors
Eguiluz-Gracia I,Ariza A,Testera-Montes A,Rondón C,Campo Pdoi
10.1007/s11882-020-00920-wsubject
Has Abstractpub_date
2020-05-19 00:00:00pages
23issue
7eissn
1529-7322issn
1534-6315pii
10.1007/s11882-020-00920-wjournal_volume
20pub_type
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