Abstract：
PURPOSE OF REVIEW:Progestogen hypersensitivity (PH) is a rare disorder which usually occurs in women of childbearing age with symptoms ranging from urticaria with or without angioedema, multiple organ involvement consistent with allergic anaphylaxis, to a spectrum of other non-evanescent skin eruptions. In this review, we present a clinical vignette of PH and discuss the clinical presentation and proposed pathomechanisms, diagnosis, and treatment of PH. RECENT FINDINGS:The hypersensitivity symptoms are associated with exogenous progestin exposure (e.g., contraceptive medicines, in vitro fertilization therapy) or endogenous progesterone from progesterone surges during the luteal phase of the menstrual cycle and pregnancy. Recognition of this condition can be challenging to the clinician due to its heterogeneous clinical presentation. It has been recently proposed to use the new term "progestogen hypersensitivity" to replace "autoimmune progesterone dermatitis" due to the lack of evidence supporting an autoimmune mechanism for this disorder. In addition, diagnostic and treatment algorithms are now available that can lead to successful management of this condition. More new developments of Progesterone desensitization protocols are now available which appear to be the safest and most effective long-term treatment option for PH. With the extensive use of oral contraceptives and increased use of supra-physiologic doses of progesterone to support pregnancy in in vitro fertilization, there is likely to be a higher prevalence of PH in the future than currently recognized. Therefore, the allergist-immunologist will be required to collaborate with gynecologists and reproductive endocrinologists to diagnose and treat this condition.
journal_name
Curr Allergy Asthma Repjournal_title
Current allergy and asthma reportsauthors
Li RC,Buchheit KM,Bernstein JAdoi
10.1007/s11882-018-0758-xsubject
Has Abstractpub_date
2018-01-19 00:00:00pages
1issue
1eissn
1529-7322issn
1534-6315pii
10.1007/s11882-018-0758-xjournal_volume
18pub_type
杂志文章,评审abstract：:The environment is a major contributor to allergic disease, and great effort is being expended to identify the chemical pollutants and allergens that make a significant impact. Exposure to high levels of ozone, sulfur dioxide, nitrogen dioxide, and diesel exhaust particles is known to reduce lung function. Studies con...
journal_title：Current allergy and asthma reports
pub_type： 杂志文章,评审
doi：10.1007/s11882-001-0059-6
更新日期：2001-11-01 00:00:00
abstract：:In this review, we examine the critical periods of immune development and how these might be modified to prevent food allergy. The relevant dietary intervention studies, roles of microorganisms and their products, and other strategies are critically analyzed. Additionally, we highlight the potential importance of diff...
journal_title：Current allergy and asthma reports
pub_type： 杂志文章,评审
doi：10.1007/s11882-004-0041-1
更新日期：2004-01-01 00:00:00
abstract：:Cyclooxygenase (COX) enzymes catalyze the rate-limiting steps in prostaglandin synthesis. Prostaglandins have an important role in several physiological processes such as maintenance of gastrointestinal integrity and pathological processes such as inflammation and neoplasia. Several mechanisms have been proposed for t...
journal_title：Current allergy and asthma reports
pub_type： 杂志文章,评审
doi：10.1007/s11882-008-0037-3
更新日期：2008-05-01 00:00:00
abstract：:Mouse allergen has long been recognized as an important cause of occupational allergy and asthma, but only recently has it been implicated in asthma and allergic diseases in community settings. Recent studies have established that mouse allergen is detectable in most US homes, with strikingly high levels in some inner...
journal_title：Current allergy and asthma reports
pub_type： 杂志文章,评审
doi：10.1007/s11882-009-0054-x
更新日期：2009-09-01 00:00:00
abstract：PURPOSE OF REVIEW:An update on new therapies currently approved or potentially useful in the future for the management of patients suffering moderate-to-severe atopic dermatitis. RECENT FINDINGS:New pathogenic mechanisms involved in atopic dermatitis have permitted to propose novel therapeutic approaches devised to co...
journal_title：Current allergy and asthma reports
pub_type： 杂志文章,评审
doi：10.1007/s11882-019-0849-3
更新日期：2019-02-28 00:00:00
abstract：PURPOSE OF REVIEW:Food allergy is increasing in prevalence, and management focuses on strict avoidance of known allergens and appropriately treating reactions. Any reaction has the potential to result in anaphylaxis, which can be fatal. Children spend a significant amount of time in the childcare or school setting, and...
journal_title：Current allergy and asthma reports
pub_type： 杂志文章,评审
doi：10.1007/s11882-020-00933-5
更新日期：2020-06-06 00:00:00
abstract：:Weeds represent a heterogeneous group of plants, usually defined by no commercial or aesthetic value. Important allergenic weeds belong to the plant families Asteraceae, Amaranthaceae, Urticaceae, Euphorbiaceae, and Plantaginaceae. Major allergens from ragweed, mugwort, feverfew, pellitory, goosefoot, Russian thistle,...
journal_title：Current allergy and asthma reports
pub_type： 杂志文章,评审
doi：10.1007/s11882-004-0090-5
更新日期：2004-09-01 00:00:00
abstract：PURPOSE OF REVIEW:Vaccination against influenza in patients with primary antibody deficiency is recommended. Common variable immunodeficiency (CVID) is the most frequent and clinically relevant antibody deficiency disease and is by definition characterized by an impaired vaccination response. The purpose of this review...
journal_title：Current allergy and asthma reports
pub_type： 杂志文章,评审
doi：10.1007/s11882-017-0749-3
更新日期：2017-10-05 00:00:00
abstract：PURPOSE OF REVIEW:To describe inherited and acquired genetic variants and clinical entities associated with increased basal serum tryptase (BST), distinguish these levels from those which acutely rise due to mast cell activation, and finally to characterize the association between chronically elevated basal serum trypt...
journal_title：Current allergy and asthma reports
pub_type： 杂志文章,评审
doi：10.1007/s11882-019-0887-x
更新日期：2019-11-27 00:00:00
abstract：PURPOSE OF REVIEW:This study aimed to review important hidden causes of anaphylaxis in ingestants, non-ingestants, and uncommon settings. RECENT FINDINGS:Multiple new and elusive causes of anaphylaxis have been described over the past 35 years. Further research is required to identify the epidemiology, pathophysiology...
journal_title：Current allergy and asthma reports
pub_type： 杂志文章,评审
doi：10.1007/s11882-017-0713-2
更新日期：2017-07-01 00:00:00
abstract：:The increased prevalence of atopic diseases, atopic dermatitis, allergic rhinitis, and asthma has been described as an epidemic. New approaches in the fight against allergic diseases are called for, the target being the persistence of the atopic T helper 2-skewed immune responder pattern beyond infancy. Atopic dermati...
journal_title：Current allergy and asthma reports
pub_type： 杂志文章,评审
doi：10.1007/s11882-004-0070-9
更新日期：2004-07-01 00:00:00
abstract：:Atopic dermatitis is a chronic inflammatory skin disease that causes significant morbidity in affected individuals. It is characterized by dysregulated immune responses that consist of an increased systemic Th2 response and a combination of Th2 and Th1 responses in the skin lesions. In this article, we review factors ...
journal_title：Current allergy and asthma reports
pub_type： 杂志文章,评审
doi：10.1007/s11882-996-0008-5
更新日期：2006-09-01 00:00:00
abstract：:Asthma is an episodic respiratory syndrome caused by several pathogenic processes. This recurrent syndrome is associated with an accelerated decline in lung function and increase in airway obstruction over time. The reduced lung function is a consequence of tissue restructuring of all the components of the airway wall...
journal_title：Current allergy and asthma reports
pub_type： 杂志文章,评审
doi：10.1007/s11882-008-0056-0
更新日期：2008-07-01 00:00:00
abstract：:Experimental autoimmune encephalomyelitis (EAE) is widely depicted as the prototypical CD4+ Th1-mediated autoimmune disease. Microglia and perivascular macrophages are believed to act as antigen-presenting cells during the effector phase of EAE. In this article, recent data that challenge these conceptions are reviewe...
journal_title：Current allergy and asthma reports
pub_type： 杂志文章,评审
doi：10.1007/s11882-003-0017-6
更新日期：2003-01-01 00:00:00
abstract：:Diagnosing food allergies can be challenging to the practitioner. Our armamentarium includes standardized skin prick testing, radioallergoimmunosorbent (RAST) testing, and food challenges. These methods have certainly been helpful in the IgE-mediated disorders, including urticaria and anaphylaxis. However, diagnosing ...
journal_title：Current allergy and asthma reports
pub_type： 杂志文章,评审
doi：10.1007/s11882-005-0061-5
更新日期：2005-01-01 00:00:00
abstract：:Vaccines have had a tremendous impact on public health by reducing morbidity and mortality from a variety of virulent pathogens. However, unintended side effects continue to pose a potential risk that may outweigh the vaccine's protective attributes. In this review, we discuss recent articles and controversies pertain...
journal_title：Current allergy and asthma reports
pub_type： 杂志文章,评审
doi：10.1007/s11882-004-0010-8
更新日期：2004-11-01 00:00:00
abstract：:Although the smoking prevalence in the United States continues to decline since the Surgeon General's first report in 1964, certain vulnerable populations continue to be disproportionately affected by the adverse consequences of tobacco smoke exposure. Children are particularly vulnerable to exposure and are likely to...
journal_title：Current allergy and asthma reports
pub_type： 杂志文章,评审
doi：10.1007/s11882-013-0389-1
更新日期：2013-12-01 00:00:00
abstract：:Given the increased recognition of pediatric allergic contact dermatitis and lack of patch testing consensus in children, we present a minimum basic 20-allergen North American pediatric series, for screening children ages 6-12 with suspected contact allergy. ...
journal_title：Current allergy and asthma reports
pub_type： 杂志文章
doi：10.1007/s11882-014-0444-6
更新日期：2014-06-01 00:00:00
abstract：:The role of the eosinophil in the pathophysiology of allergy and asthma has been the focus of intense interest during the last two decades. While the presence of eosinophils in humans with allergy and asthma is well established, the precise role of this cell in humans and in animal models is less clear. However, recen...
journal_title：Current allergy and asthma reports
pub_type： 杂志文章,评审
doi：10.1007/s11882-002-0005-2
更新日期：2002-03-01 00:00:00
abstract：:Over the past few decades, significant scientific progress has influenced clinical allergy practice. The biological standardization of extracts was followed by the massive identification and characterization of new allergens and their progressive use as diagnostic tools including allergen micro arrays that facilitate ...
journal_title：Current allergy and asthma reports
pub_type： 杂志文章,评审
doi：10.1007/s11882-014-0496-7
更新日期：2015-02-01 00:00:00
abstract：:The nasal mucosa is a complex tissue that interacts with its environment and effects local and systemic changes. Receptors in the nose receive signals from stimuli, and respond locally through afferent, nociceptive, type C neurons to elicit nasonasal reflex responses mediated via cholinergic neurons. This efferent lim...
journal_title：Current allergy and asthma reports
pub_type： 杂志文章,评审
doi：10.1007/s11882-007-0007-1
更新日期：2007-05-01 00:00:00
abstract：:The nasal provocation test (NPT) could be more extensively used in the diagnosis of allergic rhinitis by practicing physicians. However, the procedure has not been standardized, and has mainly been utilized for scientific purposes in the US. This review illustrates a wide variety of techniques and approaches to dosing...
journal_title：Current allergy and asthma reports
pub_type： 杂志文章,评审
doi：10.1007/s11882-002-0019-9
更新日期：2002-05-01 00:00:00
abstract：PURPOSE OF REVIEW:Focusing on the strict relationship between house dust mites and crustaceans from the allergenic point of view. RECENT FINDINGS:The well-known tropomyosin was considered for years as the cross-reacting allergen between shrimp and house dust mites. In the last few years, several allergens not only in ...
journal_title：Current allergy and asthma reports
pub_type： 杂志文章,评审
doi：10.1007/s11882-020-0902-2
更新日期：2020-03-06 00:00:00
abstract：PURPOSE OF REVIEW:Chronic rhinosinusitis (CRS) is a multidimensional inflammatory disorder of the nose and paranasal sinuses. We reviewed the recent literature to identify improved methods to assess, control, and manage these difficult to control patients. RECENT FINDINGS:The role of endotyping in CRS has offered a be...
journal_title：Current allergy and asthma reports
pub_type： 杂志文章,评审
doi：10.1007/s11882-017-0728-8
更新日期：2017-09-01 00:00:00
abstract：:Hypersensitivity to nonsteroidal anti-inflammatory drugs (NSAIDs) associated with chronic rhinosinusitis (CRS) and/or asthma comprises a distinct clinical syndrome referred to as NSAIDs exacerbated respiratory disease (NERD). Patients with NERD tend to have more severe course of both upper (CRS and nasal polyps) and l...
journal_title：Current allergy and asthma reports
pub_type： 杂志文章,评审
doi：10.1007/s11882-015-0552-y
更新日期：2015-08-01 00:00:00
abstract：:Mast cell activation syndrome (MCAS) can be diagnosed in patients with recurrent, severe symptoms from mast cell (MC)-derived mediators, which are transiently increased in serum and are attenuated by mediator-targeting drugs. When KIT-mutated, clonal MC are detected in these patients, a diagnosis of primary MCAS can b...
journal_title：Current allergy and asthma reports
pub_type： 杂志文章,评审
doi：10.1007/s11882-015-0582-5
更新日期：2016-01-01 00:00:00
abstract：:Allergic conjunctivitis (AC) can be divided into the primary form (caused by an allergic reaction occurring primarily in the conjunctivae) and the secondary form (induced by allergic reaction originating primarily in the nasal mucosa, where the released mediators can reach conjunctiva through the lacrimal system, the ...
journal_title：Current allergy and asthma reports
pub_type： 杂志文章
doi：10.1007/s11882-010-0119-x
更新日期：2010-07-01 00:00:00
abstract：:Until recently, idiopathic pulmonary fibrosis (IPF) has been a devastating and generally fatal disease with no effective therapeutic. New developments in understanding the biology of the disease include a growing consensus that the lesions are mainly composed of cells that originated from resident fibroblasts. New dev...
journal_title：Current allergy and asthma reports
pub_type： 杂志文章,评审
doi：10.1007/s11882-013-0377-5
更新日期：2013-12-01 00:00:00
abstract：:Monogenic autoinflammatory diseases encompass a distinct and growing clinical entity of multisystem inflammatory diseases with known genetic defects in the innate immune system. The diseases present clinically with episodes of seemingly unprovoked inflammation (fever, rashes, and elevation of acute phase reactants). U...
journal_title：Current allergy and asthma reports
pub_type： 杂志文章,评审
doi：10.1007/s11882-008-0047-1
更新日期：2008-07-01 00:00:00
abstract：:Exercise-induced bronchoconstriction (EIB) refers to acute airflow obstruction that is triggered by a period of physical exertion. EIB occurs mainly in individuals with other features of asthma but is especially prominent in a subset of asthmatics with pronounced indirect airway hyperresponsiveness. Leukotrienes (LTs)...
journal_title：Current allergy and asthma reports
pub_type： 杂志文章
doi：10.1007/s11882-009-0003-8
更新日期：2009-01-01 00:00:00
