Oral tolerance of food.

Abstract:

:The gut-associated lymphoid tissue is the specialized arm of the immune system responsible for distinguishing innocuous dietary nutrients, self-proteins, and gut flora from pathogens. Oral tolerance is the active immunologic response to innocuous ingested antigens that leads to a systemic tolerance for that antigen. This process holds great promise for dealing with the host of immune disorders that occur when an inappropriate and destructive immune response is induced. Improved therapies for disorders such as autoimmune disease and allergy are being actively investigated.

authors

Stanley S

doi

10.1007/s11882-002-0043-9

keywords:

subject

Has Abstract

pub_date

2002-01-01 00:00:00

pages

73-7

issue

1

eissn

1529-7322

issn

1534-6315

journal_volume

2

pub_type

杂志文章,评审
  • Challenges for allergy diagnosis in regions with complex pollen exposures.

    abstract::Over the past few decades, significant scientific progress has influenced clinical allergy practice. The biological standardization of extracts was followed by the massive identification and characterization of new allergens and their progressive use as diagnostic tools including allergen micro arrays that facilitate ...

    journal_title:Current allergy and asthma reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11882-014-0496-7

    authors: Barber D,Díaz-Perales A,Villalba M,Chivato T

    更新日期:2015-02-01 00:00:00

  • Microbes and the Role of Antibiotic Treatment for Wheezy Lower Respiratory Tract Illnesses in Preschool Children.

    abstract:PURPOSE OF REVIEW:Antibiotics are commonly used to treat wheezy lower respiratory tract illnesses in preschoolers, although these infections have been traditionally thought to be predominantly of viral origin. Our purpose is to review recent research pertaining to the role of antibiotics in lower respiratory tract illn...

    journal_title:Current allergy and asthma reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11882-017-0701-6

    authors: Kwong CG,Bacharier LB

    更新日期:2017-05-01 00:00:00

  • Non-IgE-mediated Adverse Food Reactions.

    abstract:PURPOSE OF REVIEW:The purpose of this review is to update what is currently known about the major non-IgE-mediated food allergies: food protein-induced enterocolitis syndrome (FPIES), food protein-induced allergic proctocolitis (FPIAP), and food protein-induced enteropathy (FPE). These conditions are similar in that sy...

    journal_title:Current allergy and asthma reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11882-017-0744-8

    authors: Leonard SA

    更新日期:2017-11-14 00:00:00

  • New Developments in Non-allergen-specific Therapy for the Treatment of Food Allergy.

    abstract:PURPOSE OF REVIEW:The prevalence of food allergy is increasing. At the current time, there are no approved treatments for food allergy. Major limitations of immunotherapy are long treatment periods (months or years), frequent clinic visits, high costs, increased risk of adverse events during treatment, and lack of dura...

    journal_title:Current allergy and asthma reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11882-020-0897-8

    authors: Long A,Borro M,Sampath V,Chinthrajah RS

    更新日期:2020-01-16 00:00:00

  • Hypoallergenic Proteins for the Treatment of Food Allergy.

    abstract:PURPOSE OF REVIEW:Food allergy is a growing health problem worldwide that impacts millions of individuals. Current treatment options are limited and strict dietary avoidance remains the standard of care. Immunotherapy using whole, native allergens is under active clinical investigation but harbors the risk of severe si...

    journal_title:Current allergy and asthma reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11882-019-0846-6

    authors: Yang L,Kulis M

    更新日期:2019-02-22 00:00:00

  • Invited commentary: recommendation for a north american pediatric patch test series.

    abstract::Given the increased recognition of pediatric allergic contact dermatitis and lack of patch testing consensus in children, we present a minimum basic 20-allergen North American pediatric series, for screening children ages 6-12 with suspected contact allergy. ...

    journal_title:Current allergy and asthma reports

    pub_type: 杂志文章

    doi:10.1007/s11882-014-0444-6

    authors: Jacob SE,Admani S,Herro EM

    更新日期:2014-06-01 00:00:00

  • Sulfonamide allergy and cross-reactivity.

    abstract::Concerns about cross-allergenicity between sulfonamide antibiotics and nonantibiotic sulfonamide-containing drugs continue to complicate pharmacotherapy. Several elegant investigations have demonstrated unequivocal lack of interaction between the sulfonamide group and either cellular or humoral immunity. The immunolog...

    journal_title:Current allergy and asthma reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11882-007-0029-8

    authors: Brackett CC

    更新日期:2007-04-01 00:00:00

  • Cutaneous Manifestations in Adult Patients with COVID-19 and Dermatologic Conditions Related to the COVID-19 Pandemic in Health Care Workers.

    abstract:PURPOSE OF REVIEW:COVID-19 (coronavirus viral disease 2019), due to the novel SARS-CoV-2, may present with different types of cutaneous manifestations of varying pathophysiology. During the ongoing pandemic, publications reporting dermatologic findings in COVID-19 continue to emerge. RECENT FINDINGS:Cutaneous vasculop...

    journal_title:Current allergy and asthma reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11882-020-00974-w

    authors: Mawhirt SL,Frankel D,Diaz AM

    更新日期:2020-10-12 00:00:00

  • Guillain-barré syndrome: modern theories of etiology.

    abstract::Guillain-Barré syndrome (GBS) is a classic failure of the immune system with a life-threatening attack upon a critical self-component. The active phase of the disease is short, concordant with the latency of a primary adaptive immune response. Triggers for GBS include infection and (rarely) vaccination; cross-reactivi...

    journal_title:Current allergy and asthma reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11882-011-0190-y

    authors: Hardy TA,Blum S,McCombe PA,Reddel SW

    更新日期:2011-06-01 00:00:00

  • The mold conundrum in chronic rhinosinusitis: where do we stand today?

    abstract::Chronic rhinosinusitis (CRS) is an inflammatory disorder affecting the nose and paranasal sinuses. Although bacteria have long been implicated as pathogens in most forms of CRS, fungi may be responsible for some forms. Several recent studies demonstrated that, under optimal conditions, fungi can be identified in the n...

    journal_title:Current allergy and asthma reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11882-008-0018-6

    authors: Ebbens FA,Fokkens WJ

    更新日期:2008-04-01 00:00:00

  • Immunotherapy safety: what have we learned from surveillance surveys?

    abstract::Subcutaneous allergen immunotherapy (SCIT) is beneficial for the treatment of allergic rhinitis, asthma, and in preventing stinging insect anaphylaxis, but is not without risks. Four retrospective surveillance surveys and one on-going national prospective study have attempted to characterize the incidence and risk fac...

    journal_title:Current allergy and asthma reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11882-013-0353-0

    authors: Kannan JA,Epstein TG

    更新日期:2013-08-01 00:00:00

  • Allergic Inflammation in Aspergillus fumigatus-Induced Fungal Asthma.

    abstract::Although fungi are pervasive in many environments, few cause disease in humans. Of these, Aspergillus fumigatus is particularly well suited to be a pathogen of the human lung. Its physical and biological characteristics combine to provide an organism that can cause tremendous morbidity and high mortality if left unche...

    journal_title:Current allergy and asthma reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11882-015-0561-x

    authors: Ghosh S,Hoselton SA,Schuh JM

    更新日期:2015-10-01 00:00:00

  • Prevention of otitis media caused by viral upper respiratory tract infection: vaccines, antivirals, and other approaches.

    abstract::Otitis media (OM) imposes significant morbidity on the pediatric age group and a large financial burden on the general population. Because standard medical treatments are not highly efficacious in resolving the accompanying middle ear (ME) inflammation, a goal of current research is OM prevention. Past studies show th...

    journal_title:Current allergy and asthma reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11882-003-0093-7

    authors: Doyle WJ,Alper CM

    更新日期:2003-07-01 00:00:00

  • Mechanisms of eosinophil recruitment and activation.

    abstract::The role of the eosinophil in the pathophysiology of allergy and asthma has been the focus of intense interest during the last two decades. While the presence of eosinophils in humans with allergy and asthma is well established, the precise role of this cell in humans and in animal models is less clear. However, recen...

    journal_title:Current allergy and asthma reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11882-002-0005-2

    authors: Adamko D,Lacy P,Moqbel R

    更新日期:2002-03-01 00:00:00

  • Susceptibility genes in asthma and allergy.

    abstract::Genome-wide screens for asthma and atopy susceptibility loci have been completed in six population samples. Despite the extensive clinical heterogeneity associated with these phenotypes, 20 chromosomal regions show evidence of linkage (P < 0.01) in three or more population samples. Thus, this survey suggests that at l...

    journal_title:Current allergy and asthma reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11882-001-0085-4

    authors: Ober C

    更新日期:2001-03-01 00:00:00

  • Development of an asthma disease management program in a children's hospital.

    abstract::The incidence, morbidity, and mortality of asthma have been increasing at an alarming rate, making asthma the most common chronic illness of childhood. An asthma disease management program was developed to improve the care and management of patients with asthma--a comprehensive health care delivery model that was desi...

    journal_title:Current allergy and asthma reports

    pub_type: 杂志文章

    doi:10.1007/s11882-003-0060-3

    authors: Miller K,Ward-Smith P,Cox K,Jones EM,Portnoy JM

    更新日期:2003-11-01 00:00:00

  • Delayed Anaphylaxis Involving IgE to Galactose-alpha-1,3-galactose.

    abstract::Hypersensitivity in the allergic setting refers to immune reactions, stimulated by soluble antigens that can be rapidly progressing and, in the case of anaphylaxis, are occasionally fatal. As the number of known exposures associated with anaphylaxis is limited, identification of novel causative agents is important in ...

    journal_title:Current allergy and asthma reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11882-015-0512-6

    authors: Platts-Mills TA,Schuyler AJ,Hoyt AE,Commins SP

    更新日期:2015-04-01 00:00:00

  • Vascular endothelial growth factor as a key inducer of angiogenesis in the asthmatic airways.

    abstract::Asthma is a chronic inflammatory disease of the airways characterized by structural airway changes, which are known as airway remodeling, including smooth muscle hypertrophy, goblet cell hyperplasia, subepithelial fibrosis, and angiogenesis. Vascular remodeling in asthmatic lungs results from increased angiogenesis, w...

    journal_title:Current allergy and asthma reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11882-012-0317-9

    authors: Meyer N,Akdis CA

    更新日期:2013-02-01 00:00:00

  • Skin Biomes.

    abstract::The cutaneous microbiome has been investigated broadly in recent years and some traditional perspectives are beginning to change. A diverse microbiome exists on human skin and has a potential to influence pathogenic microbes and modulate the course of skin disorders, e.g. atopic dermatitis. In addition to the known dy...

    journal_title:Current allergy and asthma reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11882-016-0618-5

    authors: Fyhrquist N,Salava A,Auvinen P,Lauerma A

    更新日期:2016-05-01 00:00:00

  • Dysregulation of Innate Lymphoid Cells in Common Variable Immunodeficiency.

    abstract::Common variable immunodeficiency (CVID) is the most prevalent symptomatic primary immune deficiency. With widespread use of immunoglobulin replacement therapy, non-infectious complications, such as autoimmunity, chronic intestinal inflammation, and lung disease, have replaced infections as the major cause of morbidity...

    journal_title:Current allergy and asthma reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11882-017-0746-6

    authors: Maglione PJ,Cols M,Cunningham-Rundles C

    更新日期:2017-10-05 00:00:00

  • Hidden Causes of Anaphylaxis.

    abstract:PURPOSE OF REVIEW:This study aimed to review important hidden causes of anaphylaxis in ingestants, non-ingestants, and uncommon settings. RECENT FINDINGS:Multiple new and elusive causes of anaphylaxis have been described over the past 35 years. Further research is required to identify the epidemiology, pathophysiology...

    journal_title:Current allergy and asthma reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11882-017-0713-2

    authors: Nanagas VC,Baldwin JL,Karamched KR

    更新日期:2017-07-01 00:00:00

  • Targeting immunoglobulin E as a novel treatment for asthma.

    abstract::Omalizumab is a recently developed monoclonal anti-IgE antibody. Clinical trials have demonstrated its efficacy in patients with moderate-to-severe and severe or poorly controlled allergic asthma, in patients with seasonal and perennial allergic disease, and in subjects with concomitant asthma and allergic rhinitis. P...

    journal_title:Current allergy and asthma reports

    pub_type: 杂志文章

    doi:10.1007/s11882-005-0083-z

    authors: Sandström T

    更新日期:2005-03-01 00:00:00

  • Biological and genetic markers in occupational asthma.

    abstract::Occupational asthma (OA) is a complex disease that is often hard to diagnose due to difficulties in detecting relevant exposure, along with inherent differences in disease susceptibility. Numerous studies have attempted to identify relevant biological and genetic markers for OA and to devise tools capable of detecting...

    journal_title:Current allergy and asthma reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11882-014-0488-7

    authors: Hur GY,Park HS

    更新日期:2015-01-01 00:00:00

  • Autoimmune lymphoproliferative syndrome: an update and review of the literature.

    abstract::Autoimmune lymphoproliferative syndrome (ALPS) is characterized by immune dysregulation due to a defect in lymphocyte apoptosis. The clinical manifestations may be noted in multiple family members and include lymphadenopathy, splenomegaly, increased risk of lymphoma, and autoimmune disease, which typically involves he...

    journal_title:Current allergy and asthma reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11882-014-0462-4

    authors: Shah S,Wu E,Rao VK,Tarrant TK

    更新日期:2014-09-01 00:00:00

  • The use of patch testing in the diagnosis of food allergy.

    abstract::Diagnosing food allergies can be challenging to the practitioner. Our armamentarium includes standardized skin prick testing, radioallergoimmunosorbent (RAST) testing, and food challenges. These methods have certainly been helpful in the IgE-mediated disorders, including urticaria and anaphylaxis. However, diagnosing ...

    journal_title:Current allergy and asthma reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11882-005-0061-5

    authors: Spergel JM,Brown-Whitehorn T

    更新日期:2005-01-01 00:00:00

  • Dangerous allergens: why some allergens are bad actors.

    abstract::Immune responses can be compartmentalized into innate versus adaptive components. This relatively recent dichotomy positioned the innate immune system at the interface between the host and the external environment and provided a new conceptual framework with which to view allergic diseases, including asthma. Airway ep...

    journal_title:Current allergy and asthma reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11882-010-0090-6

    authors: Georas SN,Rezaee F,Lerner L,Beck L

    更新日期:2010-03-01 00:00:00

  • Differential diagnosis of eosinophilic chronic rhinosinusitis.

    abstract::Eosinophilic chronic rhinosinusitis (ECRS) encompasses a wide variety of etiologies. To date, a unifying pathophysiologic mechanism remains elusive. Eosinophilia is frequently, but not exclusively, caused by immunoglobulin (Ig)E-mediated hypersensitivity and is dominated by the associated cytokine milieu of Th2 inflam...

    journal_title:Current allergy and asthma reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11882-006-0036-1

    authors: Sok JC,Ferguson BJ

    更新日期:2006-05-01 00:00:00

  • Food Allergy Management at School in the Era of Immunotherapy.

    abstract:PURPOSE OF REVIEW:Food allergy is increasing in prevalence, and management focuses on strict avoidance of known allergens and appropriately treating reactions. Any reaction has the potential to result in anaphylaxis, which can be fatal. Children spend a significant amount of time in the childcare or school setting, and...

    journal_title:Current allergy and asthma reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11882-020-00933-5

    authors: Hui JW,Copeland M,Lanser BJ

    更新日期:2020-06-06 00:00:00

  • The relationship between HIV infection and atopic dermatitis.

    abstract::Patients with HIV infection exhibit a wide range of skin pathology, including bacterial, fungal, and viral infections, skin tumors, inflammatory and eczematous eruptions, and drug rashes. HIV-infected adults commonly develop a condition that strongly resembles atopic dermatitis and is sometimes called "atopic-like der...

    journal_title:Current allergy and asthma reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11882-002-0050-x

    authors: Rudikoff D

    更新日期:2002-07-01 00:00:00

  • Pediatric athletic asthmatics.

    abstract::The main goals of this review are to help the reader to recognize the common symptoms and signs of exercise-induced asthma and the common objective tests used to confirm or rule out the diagnosis and to understand that different forms and intensities of exercise have different asthmagenicity. The review also aims to h...

    journal_title:Current allergy and asthma reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11882-008-0091-x

    authors: Carver TW Jr

    更新日期:2008-11-01 00:00:00