Abstract:
:Eosinophilic gastrointestinal disease (EGID) can be classified as eosinophilic esophagitis (EoE) when the eosinophilia is limited to the esophagus or as eosinophilic gastritis (EG) if it is limited to the gastric tract, eosinophilic colitis (EC) if it is limited to the colon, and eosinophilic gastroenteritis (EGE) if the eosinophilia involves one or more parts of the gastrointestinal tract. EoE is by far the most common EGID. It is a well-defined chronic atopic disease due to a T helper type 2 (Th2) inflammation triggered often by food allergens. EoE diagnosis is done if an esophageal biopsy shows at least 15 eosinophils per high power field (eos/hpf). Globally accepted long-term therapies for EoE are the use of swallowed inhaled steroids or food antigen avoidance. The treatment of EoE is done not only to control symptoms but also to prevent complications such as esophageal stricture and food impaction. EGE cause non-specific gastrointestinal (GI) symptoms and are diagnosed if esophagogastroduodenoscopy (EGD)/colonoscopy show eosinophilia in one or more parts of the GI tract. They are rare diseases with an unclear pathogenesis, and they are poorly defined in terms of diagnostic criteria and treatment. Before initiating treatment of any EGE, it is imperative to conduct a differential diagnosis to exclude other causes of hypereosinophilia with GI localization. EGE are often poorly responsive to therapy and there is no commonly accepted long-term treatment. EG has many characteristics similar to EoE, including the fact that it is often due to a food allergen-driven Th2 inflammation; transcriptome analysis however shows that it is more a systemic disease and has a different gene signature than EoE. EC is a benign form of delayed food allergy in infant and is instead a difficult-to-treat severe inflammatory condition in older children and adults. EC in the latter groups can be a manifestation of drug allergy or autoimmune disease. Overall EGE, EC, and EG are rare and are a diagnosis of exclusion until more common causes of eosinophilia have been excluded.
journal_name
Curr Allergy Asthma Repjournal_title
Current allergy and asthma reportsauthors
Cianferoni A,Spergel JMdoi
10.1007/s11882-015-0558-5subject
Has Abstractpub_date
2015-09-01 00:00:00pages
58issue
9eissn
1529-7322issn
1534-6315journal_volume
15pub_type
杂志文章,评审abstract::Natural oils include mineral oil with emollient, occlusive, and humectant properties and the plant-derived essential, coconut, and other vegetable oils, composed of triglycerides that microbiota lipases hydrolyze into glycerin, a potent humectant, and fatty acids (FAs) with varying physico-chemical properties. Unsatur...
journal_title:Current allergy and asthma reports
pub_type: 杂志文章,评审
doi:10.1007/s11882-016-0630-9
更新日期:2016-07-01 00:00:00
abstract::The physical urticarias are a heterogeneous subgroup of chronic urticarias in which wheals can be reproducibly induced by different specific physical stimuli such as cold, heat, pressure, vibration, or sunlight. Physical urticarias comprise up to 25 % of chronic urticarias and occur more frequently in young adults. Sy...
journal_title:Current allergy and asthma reports
pub_type: 杂志文章,评审
doi:10.1007/s11882-012-0269-0
更新日期:2012-08-01 00:00:00
abstract::Adverse reactions to contrast material are a concern because iodinated contrast materials are commonly used drugs. The risk for adverse reaction is 4% to 12% with ionic contrast materials and 1% to 3% with nonionic contrast materials. The risk for severe adverse reaction is 0.16% with ionic contrast materials and 0.03...
journal_title:Current allergy and asthma reports
pub_type: 杂志文章,评审
doi:10.1007/s11882-005-0051-7
更新日期:2005-01-01 00:00:00
abstract::The present review aims to identify and summarize epidemiologic investigations published during 2011 on the environmental risk factors for asthma. Potentially eligible papers were identified by a MEDLINE search. In total, 1,130 items were retrieved. Based on a broad definition of environment, the following topics were...
journal_title:Current allergy and asthma reports
pub_type: 杂志文章,评审
doi:10.1007/s11882-012-0254-7
更新日期:2012-06-01 00:00:00
abstract::The buildup of greenhouse gases in the atmosphere has resulted in global climate change that is having a significant effect on many allergenic plants through increases in plant productivity and pollen allergenicity and shifts in plant phenology. Based on experimental studies, increased atmospheric levels of carbon dio...
journal_title:Current allergy and asthma reports
pub_type: 杂志文章,评审
doi:10.1007/s11882-008-0081-z
更新日期:2008-09-01 00:00:00
abstract:PURPOSE OF REVIESW:Local respiratory allergy (LRA) is an eosinophilic phenotype of chronic airway disease. Three entities have been described within the LRA spectrum: local allergic rhinitis (LAR) and local allergic asthma (LAA) in non-atopic patients, and dual allergic rhinitis (DAR) in atopic patients (coexistence of...
journal_title:Current allergy and asthma reports
pub_type: 杂志文章,评审
doi:10.1007/s11882-020-00920-w
更新日期:2020-05-19 00:00:00
abstract::Many fungi are capable of causing IgE-mediated hypersensitivity in humans. However, the most predominant fungi implicated in allergy belong to the genera Aspergillus, Alternaria, Cladosporium, and Penicillium. Pure and relevant allergens are essential for diagnosis as well as for understanding the immunopathogenesis o...
journal_title:Current allergy and asthma reports
pub_type: 杂志文章,评审
doi:10.1007/s11882-003-0078-6
更新日期:2003-09-01 00:00:00
abstract::IgG4 is the least abundant subclass of IgG in normal human serum, but elevated IgG4 levels are triggered in response to a chronic antigenic stimulus and inflammation. Since the immune system is exposed to tumor-associated antigens over a relatively long period of time, and tumors notoriously promote inflammation, it i...
journal_title:Current allergy and asthma reports
pub_type: 杂志文章,评审
doi:10.1007/s11882-015-0580-7
更新日期:2016-01-01 00:00:00
abstract:PURPOSE OF REVIEW:Chronic rhinosinusitis (CRS) is a multidimensional inflammatory disorder of the nose and paranasal sinuses. We reviewed the recent literature to identify improved methods to assess, control, and manage these difficult to control patients. RECENT FINDINGS:The role of endotyping in CRS has offered a be...
journal_title:Current allergy and asthma reports
pub_type: 杂志文章,评审
doi:10.1007/s11882-017-0728-8
更新日期:2017-09-01 00:00:00
abstract::Concerns about cross-allergenicity between sulfonamide antibiotics and nonantibiotic sulfonamide-containing drugs continue to complicate pharmacotherapy. Several elegant investigations have demonstrated unequivocal lack of interaction between the sulfonamide group and either cellular or humoral immunity. The immunolog...
journal_title:Current allergy and asthma reports
pub_type: 杂志文章,评审
doi:10.1007/s11882-007-0029-8
更新日期:2007-04-01 00:00:00
abstract::Allergic conjunctivitis (AC) can be divided into the primary form (caused by an allergic reaction occurring primarily in the conjunctivae) and the secondary form (induced by allergic reaction originating primarily in the nasal mucosa, where the released mediators can reach conjunctiva through the lacrimal system, the ...
journal_title:Current allergy and asthma reports
pub_type: 杂志文章
doi:10.1007/s11882-010-0119-x
更新日期:2010-07-01 00:00:00
abstract::Atopic dermatitis is a chronic inflammatory skin disease that causes significant morbidity in affected individuals. It is characterized by dysregulated immune responses that consist of an increased systemic Th2 response and a combination of Th2 and Th1 responses in the skin lesions. In this article, we review factors ...
journal_title:Current allergy and asthma reports
pub_type: 杂志文章,评审
doi:10.1007/s11882-996-0008-5
更新日期:2006-09-01 00:00:00
abstract:PURPOSE OF REVIEW:Progestogen hypersensitivity (PH) is a rare disorder which usually occurs in women of childbearing age with symptoms ranging from urticaria with or without angioedema, multiple organ involvement consistent with allergic anaphylaxis, to a spectrum of other non-evanescent skin eruptions. In this review,...
journal_title:Current allergy and asthma reports
pub_type: 杂志文章,评审
doi:10.1007/s11882-018-0758-x
更新日期:2018-01-19 00:00:00
abstract:PURPOSES OF REVIEW:Th9 cells are recognized as a novel subset of effector T helper cells that preferentially produce IL-9. Here, we provide a current update on the reports related to the function of Th9 cells in allergic inflammatory diseases. RECENT FINDINGS:The effector Th9 cells differentiating from naïve T helper ...
journal_title:Current allergy and asthma reports
pub_type: 杂志文章,评审
doi:10.1007/s11882-019-0860-8
更新日期:2019-03-26 00:00:00
abstract::Mast cell activation syndrome (MCAS) can be diagnosed in patients with recurrent, severe symptoms from mast cell (MC)-derived mediators, which are transiently increased in serum and are attenuated by mediator-targeting drugs. When KIT-mutated, clonal MC are detected in these patients, a diagnosis of primary MCAS can b...
journal_title:Current allergy and asthma reports
pub_type: 杂志文章,评审
doi:10.1007/s11882-015-0582-5
更新日期:2016-01-01 00:00:00
abstract:PURPOSE OF REVIEW:Told from the viewpoint of rheumatologists, this review tells the story of hydroxychloroquine and its swift ascent to become a household name as a therapeutic strategy against the novel SARS-CoV-2 virus. This review describes the history, mechanisms, pharmacokinetics, therapeutic applications, and saf...
journal_title:Current allergy and asthma reports
pub_type: 杂志文章,评审
doi:10.1007/s11882-020-00983-9
更新日期:2021-01-21 00:00:00
abstract::In recent years, greater attention has been given to the role of indoor allergens as a cause of sensitization and allergic respiratory diseases. Although indoor allergen control measures to reduce symptoms in individuals allergic to mites have produced controversial results, environmental allergen avoidance is today o...
journal_title:Current allergy and asthma reports
pub_type: 杂志文章,评审
doi:10.1007/s11882-002-0077-z
更新日期:2002-09-01 00:00:00
abstract:PURPOSE OF REVIEW:Antibiotics are commonly used to treat wheezy lower respiratory tract illnesses in preschoolers, although these infections have been traditionally thought to be predominantly of viral origin. Our purpose is to review recent research pertaining to the role of antibiotics in lower respiratory tract illn...
journal_title:Current allergy and asthma reports
pub_type: 杂志文章,评审
doi:10.1007/s11882-017-0701-6
更新日期:2017-05-01 00:00:00
abstract::Exposure to airborne pollen, fungal allergens, and dust mite allergens is associated with the development of allergic rhinitis. Biologic function of allergens is considered to be a key determinant for allergenicity, and many clinically important allergens have been shown to possess enzymatic activity. It is proposed t...
journal_title:Current allergy and asthma reports
pub_type: 杂志文章,评审
doi:10.1007/s11882-005-0041-9
更新日期:2005-05-01 00:00:00
abstract::Traditionally, symptoms are important patient-oriented outcomes in asthma treatment, and assessment of symptoms is an essential component of assessing asthma control. However, variable airways obstruction, airways hyperresponsiveness and chronic inflammation are key components of the asthma syndrome, and correlations ...
journal_title:Current allergy and asthma reports
pub_type: 杂志文章,评审
doi:10.1007/s11882-013-0364-x
更新日期:2013-10-01 00:00:00
abstract::Otitis media (OM) imposes significant morbidity on the pediatric age group and a large financial burden on the general population. Because standard medical treatments are not highly efficacious in resolving the accompanying middle ear (ME) inflammation, a goal of current research is OM prevention. Past studies show th...
journal_title:Current allergy and asthma reports
pub_type: 杂志文章,评审
doi:10.1007/s11882-003-0093-7
更新日期:2003-07-01 00:00:00
abstract::Atopic dermatitis (AD) is a complex disease that manifests immunologic abnormalities in the skin. The immunologic changes of AD are characterized by a T helper cell type 2 (Th2)-dominated immune response in its acute phase and a Th1/Th2 mixed immune response in its chronic phase. Although the clinical presentation and...
journal_title:Current allergy and asthma reports
pub_type: 杂志文章,评审
doi:10.1007/s11882-005-0069-x
更新日期:2005-07-01 00:00:00
abstract::The dynamic expression of various phenotypic markers during B cell development not only defines the particular stage in ontogeny but also provides the necessary growth, differentiation, maturation and survival signals. When a B cell at any given stage becomes cancerous, these cell surface molecules, intracellular sign...
journal_title:Current allergy and asthma reports
pub_type: 杂志文章,评审
doi:10.1007/s11882-012-0327-7
更新日期:2013-02-01 00:00:00
abstract:PURPOSE OF REVIEW:This study aimed to review important hidden causes of anaphylaxis in ingestants, non-ingestants, and uncommon settings. RECENT FINDINGS:Multiple new and elusive causes of anaphylaxis have been described over the past 35 years. Further research is required to identify the epidemiology, pathophysiology...
journal_title:Current allergy and asthma reports
pub_type: 杂志文章,评审
doi:10.1007/s11882-017-0713-2
更新日期:2017-07-01 00:00:00
abstract:PURPOSE OF REVIEW:Food allergy is a growing health problem worldwide that impacts millions of individuals. Current treatment options are limited and strict dietary avoidance remains the standard of care. Immunotherapy using whole, native allergens is under active clinical investigation but harbors the risk of severe si...
journal_title:Current allergy and asthma reports
pub_type: 杂志文章,评审
doi:10.1007/s11882-019-0846-6
更新日期:2019-02-22 00:00:00
abstract:PURPOSE OF REVIEW:There has been an explosion in the number of published systematic reviews on chronic rhinosinusitis in the last decade. RECENT FINDINGS:While the aim of these reviews in facilitating evidence-based practice is laudable, poor quality reviews may contain significant bias that can mislead a non-discerni...
journal_title:Current allergy and asthma reports
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s11882-018-0762-1
更新日期:2018-02-16 00:00:00
abstract::The role of the eosinophil in the pathophysiology of allergy and asthma has been the focus of intense interest during the last two decades. While the presence of eosinophils in humans with allergy and asthma is well established, the precise role of this cell in humans and in animal models is less clear. However, recen...
journal_title:Current allergy and asthma reports
pub_type: 杂志文章,评审
doi:10.1007/s11882-002-0005-2
更新日期:2002-03-01 00:00:00
abstract:PURPOSE OF REVIEW:Olfactory functioning disturbances are common following traumatic brain injury (TBI) having a significant impact on quality of life. A spontaneous recovery of the olfactory function over time may occur in TBI patients. Although there is no standard treatment for patients with posttraumatic olfactory l...
journal_title:Current allergy and asthma reports
pub_type: 杂志文章,评审
doi:10.1007/s11882-020-00949-x
更新日期:2020-07-09 00:00:00
abstract::In recent years, increasing evidence has indicated an important role for T cells in various drug-induced diseases. A detailed analysis of patients with various drug allergies revealed the existence of drug-specific T cells in the circulation or in eluate from skin infiltration in bullous, pustular, and maculopapular d...
journal_title:Current allergy and asthma reports
pub_type: 杂志文章,评审
doi:10.1007/s11882-002-0032-z
更新日期:2002-01-01 00:00:00
abstract::Chronic rhinosinusitis (CRS) is a chronic inflammatory disease of the upper airways of which two major phenotypes exist, CRS without nasal polyps (CRSsNP) and CRS with nasal polyps (CRSwNP). Some patients with CRS have suboptimal response to current guideline treatments. These patients remain severe and uncontrolled b...
journal_title:Current allergy and asthma reports
pub_type: 杂志文章,评审
doi:10.1007/s11882-015-0520-6
更新日期:2015-05-01 00:00:00