Abstract：
:There is a lack of evidence that either conventional observational rating scale or biomechanical system is a better tremor assessment tool. This work focuses on comparing a biomechanical system and the Movement Disorder Society-sponsored revision of the Unified Parkinson's Disease Rating Scale in terms of test-retest reliability. The Parkinson's disease tremors were quantified by biomechanical system in joint angular displacement and predicted rating, as well as assessed by three raters using observational ratings. Qualitative comparisons of the validity and function are made also. The observational rating captures the overall severity of body parts, whereas the biomechanical system provides motion- and joint-specific tremor severity. The tremor readings of the biomechanical system were previously validated against encoders' readings and doctors' ratings; the observational ratings were validated with previous ratings on assessing the disease and combined motor symptoms rather than on tremor specifically. Analyses show that the predicted rating is significantly more reliable than the average clinical ratings by three raters. The comparison work removes some of the inconsistent impressions of the tools and serves as guideline for selecting a tool that can improve tremor assessment. Nevertheless, further work is required to consider more variabilities that influence the overall judgement.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Chan PY,Mohd Ripin Z,Abdul Halim S,Kamarudin MI,Ng KS,Eow GB,Tan K,Cheah CF,Then L,Soong N,Hor JY,Yahya AS,Arifin WN,Tharakan J,Mustapha Mdoi
10.1038/s41598-019-44142-1subject
Has Abstractpub_date
2019-05-31 00:00:00pages
8117issue
1issn
2045-2322pii
10.1038/s41598-019-44142-1journal_volume
9pub_type
杂志文章abstract：:Tetrandrine (Tet) could enhance the antitumor effect of Paclitaxel (Ptx) by increasing intracellular Reactive Oxygen Species (ROS) levels, which leads to the possibility of co-delivery of both drugs for synergistic antitumor effect. In the current study, we reported an efficient, local therapeutic strategy employing e...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep26546
更新日期：2016-05-26 00:00:00
abstract：:Fast and nondestructive assessment of leaf nitrogen concentration (LNC) is critical for crop growth diagnosis and nitrogen management guidance. In the last decade, multispectral LiDAR (MSL) systems have promoted developments in the earth and ecological sciences with the additional spectral information. With more wavel...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep40362
更新日期：2017-01-16 00:00:00
abstract：:Asymmetric cell division is a ubiquitous feature during the development of higher organisms. Asymmetry is achieved by differential localization or activities of biological molecules such as proteins, and coding and non-coding RNAs. Here, we present subcellular transcriptomic and proteomic analyses along the animal-veg...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-26592-1
更新日期：2018-05-29 00:00:00
abstract：:Mal11 catalyzes proton-coupled maltose transport across the plasma membrane of Saccharomyces cerevisiae. We used structure-based design of mutants and a kinetic analysis of maltose transport to determine the energy coupling mechanism of transport. We find that wildtype Mal11 is extremely well coupled and allows yeast ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-14438-1
更新日期：2017-10-30 00:00:00
abstract：:Outbreaks of multidrug resistant bacteria including vancomycin-resistant enterococci (VRE) in healthcare institutions are increasing in Norway, despite a low level of resistance compared to other European countries. In this study, we describe epidemiological relatedness of vancomycin-resistant Enterococcus faecium iso...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-48436-2
更新日期：2019-08-15 00:00:00
abstract：:Three major white matter pathways connect the posterior temporal region and the adjacent inferior parietal lobule with the lateral frontal cortex: the arcuate fasciculus (AF), and the second and third branches of the superior longitudinal fasciculus (SLF II and SLF III). These pathways are found also in nonhuman prima...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-64124-y
更新日期：2020-05-18 00:00:00
abstract：:The hyaluronan synthase 2 (HAS2)-hyaluronic acid (HA)-CD44-Caspase-3 pathway is involved in ovarian granulosa cell (GC) functions in mammals. HAS2 is a key enzyme required for HA synthesis and is the key factor in this pathway. However, the regulation of HAS2 and the HAS2-mediated pathway by microRNAs in GCs is poorly...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep21197
更新日期：2016-02-18 00:00:00
abstract：:The p53 protein is a key mediator of the cellular response to various stress signals. In response to DNA damage, the concentration of p53 can temporally oscillate with fluctuations in both the amplitude and period. The underlying mechanism for p53 variability is not fully understood. Here, we construct a core regulato...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-41904-9
更新日期：2019-04-10 00:00:00
abstract：:The use of fire played an important role in the social and technological development of the genus Homo. Most archaeologists agree that this was a multi-stage process, beginning with the exploitation of natural fires and ending with the ability to create fire from scratch. Some have argued that in the Middle Palaeolith...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-51433-0
更新日期：2019-10-25 00:00:00
abstract：:Miscanthus is a promising lignocellulosic bioenergy crop for bioethanol production. To identify candidate genes and regulation networks involved in secondary cell wall (SCW) development in Miscanthus, we performed de novo transcriptome analysis of a developing internode. According to the histological and in-situ histo...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-08690-8
更新日期：2017-08-22 00:00:00
abstract：:The aim of this study was to fabricate a novel polymer-free everolimus-eluting stent with nanostructure using a femtosecond laser (FSL). The stent were coated with everolimus (EVL) using FSL and electrospinning processes. The surface was rendered hydrophobic, which negatively affected both platelet adhesion (82.1%) an...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-25629-9
更新日期：2018-05-09 00:00:00
abstract：:Contest behaviour, and in particular the propensity to attack an unfamiliar conspecific, is influenced by an individual's aggressiveness, as well as by experience of winning and losing (so called 'winner-loser effects'). Individuals vary in aggressiveness and susceptibility to winner-loser effects but the relationship...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-69664-x
更新日期：2020-08-07 00:00:00
abstract：:Savant syndrome is a phenomenon whereby individuals with cognitive impairments have one or more outstanding abilities, inconsistent with their general intellectual functioning. Approximately 50% of savant individuals have autism spectrum disorder (ASD), and 10-30% of people with ASD have savant skills. To shed additio...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-59209-7
更新日期：2020-02-10 00:00:00
abstract：:Free living nematodes (FLN) are microscopic worms found in all soils. While many FLN species are beneficial to crops, some species cause significant damage by feeding on roots and vectoring viruses. With the planned legislative removal of traditionally used chemical treatments, identification of new ways to manage FLN...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-18797-7
更新日期：2018-01-23 00:00:00
abstract：:Technical advances including liquid chromatography-tandem mass spectrometry and its data analysis enable detailed proteomic analysis of the nasal mucus. Alterations of the nasal mucus proteome may provoke substantial changes of the nasal physiology and have already been associated with rhinologic diseases such as alle...
journal_title：Scientific reports
pub_type： 临床试验,杂志文章
doi：10.1038/s41598-018-35776-8
更新日期：2018-12-03 00:00:00
abstract：:Obese individuals can be categorized as "healthy obese" (MHO) and "unhealthy obese" (MUO) based on the presence or absence of metabolic abnormality. This study sets out to assess potential genetic causes behind persistence of healthy metabolic status in individuals categorized as "healthy obese". This study was conduc...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-70627-5
更新日期：2020-08-12 00:00:00
abstract：:New clinical trials for diabetic macular oedema (DMO) are being designed to prove superiority over aflibercept when this agent is already very effective in improving visual acuity (VA) and DMO. The aim of this study was to determine the optimal inclusion-exclusion criteria for trials to aim for superiority in visual o...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-73571-6
更新日期：2020-10-05 00:00:00
abstract：:BEST1 is a Ca2+-activated Cl- channel predominantly expressed in retinal pigment epithelium (RPE), and over 250 genetic mutations in the BEST1 gene have been identified to cause retinal degenerative disorders generally known as bestrophinopathies. As most BEST1 mutations are autosomal dominant, it is of great biomedic...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-54892-7
更新日期：2019-12-13 00:00:00
abstract：:The 2,5-Diketopiperazines (DKPs) constitute a large family of natural products with important biological activities. Bicyclomycin is a clinically-relevant DKP antibiotic that is the first and only member in a class known to target the bacterial transcription termination factor Rho. It derives from cyclo-(L-isoleucyl-L...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-56747-7
更新日期：2019-12-27 00:00:00
abstract：:Doxorubicin (Dox) is a highly effective anticancer drug but cause acute ventricular dysfunction, and also induce late-onset cardiomyopathy and heart failure. Despite extensive studies, the pathogenic sequelae leading to the progression of Dox-associated cardiomyopathy remains unknown. We assessed temporal changes in a...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-37862-3
更新日期：2019-02-14 00:00:00
abstract：:The domain wall-related change in the anisotropic magnetoresistance in L-shaped permalloy nanowires is measured as a function of the magnitude and orientation of the applied magnetic field. The magnetoresistance curves, compiled into so-called domain wall magnetoresistance state space maps, are used to identify highly...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep06045
更新日期：2014-08-13 00:00:00
abstract：:We propose a method for dual-channel near-field manipulations by designing isotropic but inhomogeneous metasurfaces. As example, we present a dual-channel near-field focusing metasurface device. When the device is driven by surface waves from different channels on the metasurface, the near fields will be focused at th...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep15853
更新日期：2015-11-03 00:00:00
abstract：:Oxidative stress and mitochondrial dysfunction are implicated in aging-related neurodegenerative disorders. 8-Oxoguanine (8-oxoG), a common oxidised base lesion, is often highly accumulated in brains from patients with neurodegenerative disorders. MTH1 hydrolyses 8-oxo-2'-deoxyguanosine triphosphate (8-oxo-dGTP) to 8-...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep22086
更新日期：2016-02-25 00:00:00
abstract：:The strong electronegativity of O dictates that the ground state of singlet CO has positively charged C and negatively charged O, in agreement with ab initio charge analysis, but in disagreement with the dipole direction. Though this unusual phenomenon has been fairly studied, the study of electrostatic potential (EP)...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep16307
更新日期：2015-11-06 00:00:00
abstract：:Here we present a set of measurements using Differential Scanning Fluorimetry (DSF) as an inexpensive, high throughput screening method to investigate the folding of silk protein molecules as they abandon their first native melt conformation, dehydrate and denature into their final solid filament conformation. Our fir...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep05625
更新日期：2014-07-09 00:00:00
abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-018-34742-8
更新日期：2018-11-01 00:00:00
abstract：:MicroRNA-200 (miR-200) family is highly expressed in ovarian cancer. We evaluated the levels of family members relative to the internal control miR-103a in ovarian cancer and control blood specimens collected from American and Hong Kong Chinese institutions, as well as from a laying hen spontaneous ovarian cancer mode...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-77068-0
更新日期：2020-11-18 00:00:00
abstract：:Previous studies have suggested that microRNA-107 (miR-107) regulates cell migration in tumor and promotes Hypoxia Inducible Factor 1α (HIF1α) regulated angiogenesis under hypoxia. We found that miR-107 was strongly expressed in ischemic boundary zone (IBZ) after permanent middle cerebral artery occlusion (pMCAO) in r...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep13316
更新日期：2015-08-21 00:00:00
abstract：:The epithelial-mesenchymal plasticity, in tight association with stemness, contributes to the mammary gland homeostasis, evolution of early neoplastic lesions and cancer dissemination. Focused on cell surfaceome, we used mouse models of pre-neoplastic mammary epithelial and cancer stem cells to reveal the connection b...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-67827-4
更新日期：2020-07-09 00:00:00
abstract：:Proteasome inhibition represents an important anticancer strategy. Here, we studied the mechanisms at the basis of the pro-apoptotic activity of the standardized decoction of Hemidesmus indicus, a plant evoking a complex anticancer activity, and explored its inhibition of proteasome activity in human leukemia cells. A...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-43609-5
更新日期：2019-05-10 00:00:00
