Abstract：
:Outbreaks of multidrug resistant bacteria including vancomycin-resistant enterococci (VRE) in healthcare institutions are increasing in Norway, despite a low level of resistance compared to other European countries. In this study, we describe epidemiological relatedness of vancomycin-resistant Enterococcus faecium isolated during an outbreak at a Norwegian hospital in 2012-2013. During the outbreak, 9454 fecal samples were screened for VRE by culture and/or PCR. Isolates from 86 patients carrying the vanA resistance gene were characterized using pulsed-field gel electrophoresis (PFGE), MALDI-TOF mass spectrometry and single nucleotide polymorphism typing. PFGE revealed two main clusters, the first comprised 56 isolates related to an initial outbreak strain, and the second comprised 21 isolates originating from a later introduced strain, together causing two partly overlapping outbreaks. Nine isolates, including the index case were not related to the two outbreak clusters. In conclusion, the epidemiological analyses show that the outbreak was discovered by coincidence, and that infection control measures were successful. All typing methods identified the two outbreak clusters, and the experiment congruence between the MALDI-TOF and the PFGE clustering was 63.2%, with a strong correlation (r = 72.4%). Despite lower resolution compared to PFGE, MALDI-TOF may provide an efficient mean for real-time monitoring spread of infection.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Rangberg A,Larsen AL,Kacelnik O,Sæther HS,Bjørland M,Ringstad J,Jonassen CMdoi
10.1038/s41598-019-48436-2subject
Has Abstractpub_date
2019-08-15 00:00:00pages
11917issue
1issn
2045-2322pii
10.1038/s41598-019-48436-2journal_volume
9pub_type
杂志文章abstract：:Gliomas are heterogeneous, primary brain tumours that originate from glial cells. The main type of gliomas is astrocytomas. There are four grades (I-IV) of astrocytoma malignancy. Astrocytoma grade IV known as glioblastoma multiforme (GBM) is the most common and aggressive type of astrocytic gliomas. Metallothioneins ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-41974-9
更新日期：2019-04-01 00:00:00
abstract：:We introduce a setup which realises a tunable engineered environment for experiments in circuit quantum electrodynamics. We illustrate this concept with the specific example of a quantum bit, qubit, in a high-quality-factor cavity which is capacitively coupled to another cavity including a resistor. The temperature of...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep01987
更新日期：2013-01-01 00:00:00
abstract：:The association between alcohol consumption and kidney function is intriguing, but study results are mixed and controversial. We examined the association of alcohol consumption with the overall change in kidney function over 12 years. We analyzed data from a population-based cohort that was part of the Korean Genome a...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-021-81777-5
更新日期：2021-01-27 00:00:00
abstract：:Case-control genetic association studies typically ignore possible later disease onset in currently healthy subjects and assume that subjects with diseases equally contribute to the likelihood for inference, regardless of their onset age. Therefore, we used an event-history with risk-free model to simultaneously chara...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-01791-4
更新日期：2017-05-16 00:00:00
abstract：:Rodent species like Myodes glareolus and Microtus spp. are natural reservoirs for many zoonotic pathogens causing human diseases and are gaining increasing interest in the field of eco-immunology as candidate animal models. Despite their importance the lack of immunological reagents has hampered research in these anim...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-21143-0
更新日期：2018-02-12 00:00:00
abstract：:Although N-acyl-L-homoserine lactone (AHL) based quorum sensing (QS) phenomenon has been observed in mature anaerobic granules, the biological role of AHL-based QS system in anaerobic granulation process remains unexplored. For the first time, a long-term anaerobic bioreactor was operated for 168 days to investigate t...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-34183-3
更新日期：2018-10-25 00:00:00
abstract：:There is a growing interest in developing microphysiological systems that can be used to model both normal and pathological human organs in vitro. This "organs-on-chips" approach aims to capture key structural and physiological characteristics of the target tissue. Here we describe in vitro vascularized microtumors (V...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep31589
更新日期：2016-08-23 00:00:00
abstract：:The alveolar echinococcosis of human is a severe helminthic disease caused by the larva of Echinococcus multilocularis tapeworms. Novel compounds or therapy strategies for the treatment of alveolar echinococcosis are urgently needed due to the limitation of the widely used albendazole. Magnetic microspheres as drug ca...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-69484-z
更新日期：2020-07-28 00:00:00
abstract：:MicroRNAs (miRNAs) play an important role in guiding development and maintaining function of the human heart. Dysregulation of miRNAs has been linked to various congenital heart diseases including Tetralogy of Fallot (TOF), which represents the most common cyanotic heart malformation in humans. Several studies have id...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-55570-4
更新日期：2019-12-13 00:00:00
abstract：:Fragmentation of thin layers of materials is mediated by a network of cracks on its surface. It is commonly seen in dehydrated paintings or asphalt pavements and even in graphene or other two-dimensional materials, but is also observed in the characteristic polygonal pattern on a crocodile's head. Here, we build a sim...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep04966
更新日期：2014-05-27 00:00:00
abstract：:When making choices between smaller, sooner rewards and larger, later ones, people tend to discount future outcomes. Individual differences in temporal discounting in older adults have been associated with episodic memory abilities and entorhinal cortical thickness. The cause of this association between better memory ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-63373-1
更新日期：2020-04-14 00:00:00
abstract：:The key to arthritis management is early diagnosis and treatment to prevent further joint destruction and maximize functional ability. Osteoarthritis (OA) and rheumatoid arthritis (RA) are two common types of arthritis that the primary care provider must differentiate, in terms of diagnosis and treatment. Effective an...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-35473-6
更新日期：2018-11-20 00:00:00
abstract：:The use of engineered viral strains such as gene therapy vectors and oncolytic viruses (OV) to selectively destroy cancer cells is poised to make a major impact in the clinic and revolutionize cancer therapy. In particular, several studies have shown that OV therapy is safe and well tolerated in humans and can infect ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep26786
更新日期：2016-05-26 00:00:00
abstract：:Disseminated tumor cells (DTCs) in the bone marrow (BM) and circulating tumor cells (CTCs) in blood of breast cancer patients (pts) are known to correlate with worse outcome. Here we demonstrate a different prognostic value of DTCs and CTCs and explain these findings by early clodronate intake. CTCs (n = 376 pts) were...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep26355
更新日期：2016-05-23 00:00:00
abstract：:Deferiprone (DFP) is a hydroxypyridinone-derived iron chelator currently in clinical use for iron chelation therapy. DFP has also been known to elicit antiproliferative activities, yet the mechanism of this effect has remained elusive. We herein report that DFP chelates the Fe2+ ion at the active sites of selected iro...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-39214-1
更新日期：2019-03-18 00:00:00
abstract：:A discrete optical system can broaden the spatial distribution of the input light through optical coupling in array waveguides, just like diffraction in continuous media. Here, we theoretically demonstrate several kinds of control methods of optical field propagation in a discrete optical system, which is composed of ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-05414-w
更新日期：2017-07-12 00:00:00
abstract：:Network structure has often proven to be important in understanding the decision behavior of individuals or agents in different interdependent situations. Computational studies predict that network structure has a crucial influence on behavior in iterated 2 by 2 asymmetric 'battle of the sexes' games. We test such beh...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-43260-0
更新日期：2019-05-02 00:00:00
abstract：:The polychaetous annelid Neanthes acuminata complex has a widespread distribution, with the California population referred to as N. arenaceodentata. The reproductive pattern in this complex is unique, in that the female reproduces once and then dies, whereas the male can reproduce up to nine times. The male incubates ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep13561
更新日期：2015-09-04 00:00:00
abstract：:Hemodialysis patients are a special group of patients with higher mortality rates. Hemodialysis patients with vitamin D deficiency {plasma levels of 25-hydroxyvitamin D [25(OH)D] below 20 ng/mL} are associated with even higher mortality rates. The prognostic importance of vitamin D deficiency in hemodialysis patients ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-64359-9
更新日期：2020-05-05 00:00:00
abstract：:Recent studies have elucidated the crucial role for microRNAs in peripheral nerve myelination by ablating components of the microRNA synthesis machinery. Few studies have focused on the role of individual microRNAs. To fill this gap, we focused this study on miR-138, which was shown to be drastically reduced in Dicer1...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-22010-8
更新日期：2018-02-28 00:00:00
abstract：:Particulate matter (PM) induces oxidative stress in vivo, leading to adverse health effects. Oxidative potential (OP) of PM is increasingly studied as a relevant metric for health impact (instead of PM mass concentration) as much of the ambient particle mass do not contribute to PM toxicity. Several assays have been d...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-11979-3
更新日期：2017-09-14 00:00:00
abstract：:Hypertension is a public health issue in Iran. The study aimed to estimate the prevalence, awareness, treatment, and control of hypertension, and to explore their determinants among 10,040 Kurdish adults from Ravansar Non-Communicable Disease (RaNCD) cohort study in Iran. Univariate, and multivariate analyses were use...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-48232-y
更新日期：2019-08-27 00:00:00
abstract：:The study of organic/inorganic molecules with activity against intracellular fungi of the phylum Microsporidia is of critical importance. Here, for the first time, the inactivation of these parasitic fungi by porphyrins is reported. The biological effects of porphyrins (10 µM and 100 µM) on the microsporidian Nosema c...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-23678-8
更新日期：2018-04-03 00:00:00
abstract：:In this paper, the composition, structure, morphology and kinetics of evolution during isothermal oxidation of Fe48Cr15Mo14Y2C15B6 metallic glass powder in the supercooled region are investigated by an integrated ex-situ and in-situ characterization and modelling approach. Raman and X-ray diffraction spectra establish...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-43317-0
更新日期：2019-05-02 00:00:00
abstract：:Most of the current studies on myocardial strain are mainly applied in patients with sinus rhythm because the image quality of arrhythmias obtained with conventional scanning sequences does not meet diagnostic needs. Here, we intend to assess left ventricular (LV) global myocardial strain in patients with arrhythmias ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-66315-z
更新日期：2020-06-09 00:00:00
abstract：:Highly efficient and specific biomolecular recognition requires both affinity and specificity. Previous quantitative descriptions of biomolecular recognition were mostly driven by improving the affinity prediction, but lack of quantification of specificity. We developed a novel method SPA (SPecificity and Affinity) ba...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep00309
更新日期：2012-01-01 00:00:00
abstract：:Odors elicit complex patterns of activated olfactory sensory neurons. Knowing the complete olfactome, i.e. the responses in all sensory neurons for all relevant odorants, is desirable to understand olfactory coding. The DoOR project combines all available Drosophila odorant response data into a single consensus respon...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep21841
更新日期：2016-02-25 00:00:00
abstract：:Psoriatic skin differs distinctly from normal skin by its thickened epidermis. Most gene expression comparisons utilize full-thickness biopsies, with substantial amount of dermis. We assayed the transcriptomes of normal, lesional, and non-lesional psoriatic epidermis, sampled as split-thickness skin grafts, with 5'-en...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep22745
更新日期：2016-03-15 00:00:00
abstract：:We report a modified two-dimensional Cherenkov radiation, which occurs on a high-index dielectric nano-film driven by uniformly moving electron-beam. It is essentially different from the ordinary Cherenkov radiation in that, in the nondispersive medium, it shows unique dispersion characteristics-the waves with higher ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-06176-1
更新日期：2017-07-19 00:00:00
abstract：:We aimed to investigate the association of smoking and physical exercise on ventricular function and structure, determined by cardiac magnetic resonance imaging (CMR), in subjects without known cardiovascular diseases. A total of 381 participants (median age 57 years) of the Cooperative Health Research in the Region o...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-54956-8
更新日期：2019-12-09 00:00:00
