[Pseudomonas aeruginosa immunoglobulin in experimental pneumonia].

Abstract:

:A guinea pig model of experimental Pseudomonas aeruginosa pneumonia was used to evaluate factors affecting the efficacy of passive immune therapy with Psomaglobin N, a hyperimmune P. aeruginosa globulin. Animals treated 2 h after infection with a single intravenous infusion of Psomaglobin N, 500 mg/kg, demonstrated 33% survival. Lower dosages were less effective and no survivors occurred among albumin-treated controls. Treatment with Psomaglobin N was effective if given 2 h or 8 h after infection but not if delayed until 24 h after infection. Animals rendered neutropenic with cyclophosphamide did not survive if treated with Psomaglobin N alone. However, when Psomaglobin N was added to tobramycin treatment, a significant increase in survival occurred (86%) as compared to that observed with tobramycin alone (43%) (p less than 0.05). We conclude that Psomaglobin N may offer a useful therapeutic option in management of P. aeruginosa pneumonia.

journal_name

Infection

journal_title

Infection

authors

Pennington JE,Pier GB

doi

10.1007/BF01644192

subject

Has Abstract

pub_date

1987-01-01 00:00:00

pages

S47-50

eissn

0300-8126

issn

1439-0973

journal_volume

15 Suppl 2

pub_type

杂志文章
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    doi:10.1007/s15010-004-6604-1

    authors: Horster S,Goebel FD

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  • Pleural fluid adenosine deaminase/serum C-reactive protein ratio for the differentiation of tuberculous and parapneumonic effusions with neutrophilic predominance and high adenosine deaminase levels.

    abstract:PURPOSE:Tuberculous pleural effusion (TPE) and parapneumonic effusion (PPE) are usually distinguished by cellular predominance and pleural fluid adenosine deaminase (ADA) levels. However, both diseases may occasionally show similar neutrophilic predominance and high ADA levels. In such cases, the differential diagnosis...

    journal_title:Infection

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    doi:10.1007/s15010-016-0928-5

    authors: Lee J,Yoo SS,Lee SY,Cha SI,Park JY,Kim CH

    更新日期:2017-02-01 00:00:00

  • Efficacy of penicillin treatment in purulent maxillary sinusitis. A European multicenter trial.

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    journal_title:Infection

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1007/BF01650753

    authors: Nord CE

    更新日期:1988-07-01 00:00:00

  • Localized pulmonary infection associated with Mycobacterium tilburgii in an HIV-infected patient.

    abstract::The case of an HIV-infected patient with low CD4+ cell count and localized pulmonary infection associated with Mycobacterium tilburgii, a recently recognized atypical mycobacterial species, is reported. Diagnosis was confirmed by repeated detection of mycobacterial DNA in lung biopsy specimens. After surgical removal ...

    journal_title:Infection

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    doi:10.1007/s15010-005-4118-0

    authors: Kolditz M,Halank M,Spornraft-Ragaller P,Schmidt H,Höffken G

    更新日期:2005-08-01 00:00:00

  • Pertussis complications in Germany--3 years of hospital-based surveillance during the introduction of acellular vaccines.

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    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF02962368

    authors: Herzig P,Hartmann C,Fischer D,Weil J,von Kries R,Giani G,Schroten H,Wirsing von König CH

    更新日期:1998-07-01 00:00:00

  • Immunoglobulin class- and subclass-specific HIV antibody detection in serum and CSF specimens by ELISA and Western blot.

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    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01647729

    authors: Mergener K,Enzensberger W,Rübsamen-Waigmann H,von Briesen H,Doerr HW

    更新日期:1987-01-01 00:00:00

  • Immune status against diphtheria among immigrants from the former USSR who arrived in Israel during 1990-1991.

    abstract::Large outbreaks of diphtheria occurred recently in the former USSR. Between 1989 and 1994, a total of about 600,000 Soviet immigrants arrived in Israel. The immune status against diphtheria in a sample of 992 men aged 17-49 and 195 women aged 17-19, who arrived in Israel during 1990-91, was studied in order to evaluat...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF02767769

    authors: Low M,Almog R,Green MS,Ashkenazi S,Bercovier H,Katzenelson E,Ashkenazi I,Shemer J,Cohen D

    更新日期:1998-03-01 00:00:00

  • [A cross-over study on the effectiveness of ofloxacin and ciprofloxacin administered orally].

    abstract::Efficacy of Oral Ofloxacin and Ciprofloxacin. Cross-over Study. The efficacy of the 4-quinolones ciprofloxacin (CPX) and ofloxacin (OFX) was studied in a cross-over study. Twenty out-patients with cystic fibrosis and chronic colonization of the respiratory tract with Pseudomonas aeruginosa were treated for ten days wi...

    journal_title:Infection

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1007/BF01645207

    authors: Kurz CC,Marget W,Harms K,Bertele RM

    更新日期:1986-01-01 00:00:00

  • [Evaluation of the development of resistance as a factor for the limitation of therapeutic possibilities].

    abstract::From the microbiological point of view a variety of highly active compounds has contributed to improved efficacy of antibacterial chemotherapy during the last few decades. In some cases, however, resistance has increased due to different molecular mechanisms. Resistance to the new generation of broad-spectrum beta-lac...

    journal_title:Infection

    pub_type: 杂志文章,评审

    doi:10.1007/BF01644735

    authors: Heisig P,Wiedemann B

    更新日期:1991-01-01 00:00:00

  • TT virus infection and genotype distribution in blood donors and a group of patients from Turkey.

    abstract:BACKGROUND:TT virus (TTV) DNA has been found in a large proportion of patients with different forms of non-A-G hepatitis, however the clinical importance is unclear. We aimed to determine the genotypes of TTV isolates found in blood donors and different patient groups from the western part of Turkey. MATERIALS AND MET...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-002-2185-z

    authors: Erensoy S,Sayiner AA,Türkoğlu S,Canatan D,Akarca US,Sertöz R,Ozacar T,Batur Y,Badur S,Bilgiç A

    更新日期:2002-10-01 00:00:00

  • Recommendations for the management of acute hepatitis B: position paper of the Italian Society for the Study of Infectious and Tropical Diseases (SIMIT).

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    journal_title:Infection

    pub_type: 杂志文章,实务指引,评审

    doi:10.1007/s15010-014-0642-0

    authors: Bruno R,Carosi G,Coppola N,Gaeta GB,Puoti M,Santantonio T,Taliani G,Armignacco O,Sagnelli E,Andreoni M,Angarano G,Di Perri G,D'Offizi G,Galli M,Rizzardini G,Italian Society for the Study of Infectious and Tropical Diseases.

    更新日期:2014-10-01 00:00:00

  • Chlamydial antigen detection in urine samples by immunofluorescence tests.

    abstract::To investigate the diagnostic value of a direct immunofluorescence test (DIF-test), urethral samples and first catch urine (FCU) from 153 male patients attending an outpatient clinic for sexually transmitted diseases (STD) were studied. Of the male patients, 40 (26.1%) had a positive urethral culture, 39 (25.5%) had a...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01711077

    authors: Stary A,Genç M,Heller-Vitouch C,Mårdh PA

    更新日期:1992-03-01 00:00:00

  • Newly delineated periodontal pathogens with special reference to selenomonas species.

    abstract::Many new species have been isolated from subgingival periodontal pockets, for example Wolinella recta and Bacteroides forsythus, reflecting better basic microbiological techniques. Other species were created from existing species as a result of better characterization methods, i.e. Bacteroides buccae and Bacteroides o...

    journal_title:Infection

    pub_type: 杂志文章,评审

    doi:10.1007/BF01644027

    authors: Tanner A,Bouldin HD,Maiden MF

    更新日期:1989-05-01 00:00:00

  • Clinical experience of cefotaxime in infections caused by gram-positive pathogens.

    abstract::We studied the activity of cefotaxime both microbiologically and clinically. 138 blood cultures positive for gram-positive cocci were evaluated (90 strains of Staphylococcus aureus, 25 of Streptococcus faecalis, 13 of Streptococcus alpha and ten of Streptococcus mutans). Cefotaxime showed good activity against all str...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01644230

    authors: Bassetti D,Solbiati M,Fraizzoli G

    更新日期:1985-01-01 00:00:00

  • Urinary tract infection in renal transplant patients.

    abstract::The incidence of urinary tract infections (UTI) in 299 renal graft transplantations (281 patients) was analyzed. UTI episodes were demonstrated in 185 grafts (62%), most frequently in the first month after transplantation. The infectious episodes were mostly recurrent. Persistent infection, detected in 11% of grafts, ...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01667212

    authors: Prát V,Horcicková M,Matousovic K,Hatala M,Liska M

    更新日期:1985-09-01 00:00:00

  • [Microbiological diagnosis of septicemia].

    abstract::To detect microorganisms in the blood it is necessary not only that the microbiologist uses reliable methods, but also that the clinician takes a sufficient number of blood samples at the right point in time using a correct method for drawing the blood. The best results are obtained if the blood sample is transferred ...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01639113

    authors: Rotter M

    更新日期:1977-03-01 00:00:00

  • [Penetration of ceftizoxime (FK 749) into the cerebrospinal fluid (author's transl)].

    abstract::After the cytology and the chemistry of the CSF had returned to normal, the concentration of ceftizoxime was determined in the CSF and in the serum of 27 patients who had suffered from purulent or serous meningitis. The patients were divided into four groups. The concentration in the CSF was mean = 0.87 mg/l two hours...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01816728

    authors: Ruf B

    更新日期:1982-01-01 00:00:00

  • Susceptibility to HIV/AIDS: an individual characteristic we can measure?

    abstract::Susceptibility to HIV-1 infections is, beside other factors, determined by individual host genetic variants like HLA class I alleles, CCR5 and CCR2 variants and levels of CCR5 binding chemokines. A new approach to determine the individual risk of acquiring an HIV infection or to estimate the disease progression could ...

    journal_title:Infection

    pub_type: 杂志文章,评审

    doi:10.1007/s15010-005-6305-4

    authors: Jülg B,Goebel FD

    更新日期:2005-06-01 00:00:00

  • Temporofacial zygomycosis in a pregnant woman.

    abstract::A 38-year-old Omani woman, seven months pregnant, developed extensive zygomycosis involving maxillary and temporal bones. No evidence of any underlying immune deficiency was detected except that which may be attributed to pregnancy. After delivery the patient was treated with repeated courses of amphotericin B, which ...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF02033066

    authors: Buhl MR,Joseph TP,Snelling BE,Buhl L

    更新日期:1992-07-01 00:00:00

  • A Thr72Ala polymorphism in the NKG2D gene is associated with early symptomatic congenital cytomegalovirus disease.

    abstract::The potential risk factors for congenital cytomegalovirus (cCMV) infection or development of disease remain unclear. Here, we investigated the genetic polymorphisms in natural killer (NK) group 2, member D (NKG2D), an activating receptor expressed on NK cells, and in MHC class I-related chains A, the ligand of NKG2D, ...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-015-0774-x

    authors: Taniguchi R,Koyano S,Suzutani T,Goishi K,Ito Y,Morioka I,Nakamura H,Yamada H,Oka A,Inoue N

    更新日期:2015-06-01 00:00:00

  • Influence of cefodizime on the reagibility of human leukocytes.

    abstract::Cefodizime was evaluated for its effect on a number of parameters of leukocyte function in humans. Four healthy volunteers received 2 g i.v. b.i.d. for seven days. Leukocyte activity was measured before, during and after treatment. Using opsonized zymosan as a stimulant, no effect on the respiratory burst of granulocy...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01709952

    authors: Limbert M,Müllner H,Shah PM

    更新日期:1992-01-01 00:00:00

  • New fluoroquinolones in lower respiratory tract infections and emerging patterns of pneumococcal resistance.

    abstract::The increasing resistance of Streptococcus pneumoniae, the most important community respiratory pathogen, to beta-lactams and other first-line antimicrobial agents usually employed for the empirical treatment of lower respiratory tract infections has led to the inclusion, in several current guidelines, of a fluoroquin...

    journal_title:Infection

    pub_type: 杂志文章,评审

    doi:10.1007/s15010-005-4102-8

    authors: Ferrara AM

    更新日期:2005-06-01 00:00:00

  • Serum levels of interleukin-18 (IL-18), interleukin-1beta (IL-1beta), its soluble receptor sIL-1RII and C-reactive protein (CRP) in patients with Lyme arthritis.

    abstract:BACKGROUND:In recent years, the role of pro- and antiinflammatory cytokines in the development of Lyme arthritis (LA) has been widely discussed. The purpose of the present study was to determine the concentration of interleukin-18 (IL-18), interleukin-1beta (IL-beta) and its soluble receptor sIL-1RII in serum of patien...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-006-5013-z

    authors: Pietruczuk A,Swierzbińska R,Pancewicz S,Pietruczuk M,Hermanowska-Szpakowicz T

    更新日期:2006-06-01 00:00:00

  • [Pseudomonas aeruginosa immunoglobulin in experimental pneumonia].

    abstract::A guinea pig model of experimental Pseudomonas aeruginosa pneumonia was used to evaluate factors affecting the efficacy of passive immune therapy with Psomaglobin N, a hyperimmune P. aeruginosa globulin. Animals treated 2 h after infection with a single intravenous infusion of Psomaglobin N, 500 mg/kg, demonstrated 33...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01646124

    authors: Pennington JE,Pier GB

    更新日期:1987-01-01 00:00:00

  • The elimination of gentamicin-resistant gram-negative bacteria in a newborn intensive care unit.

    abstract::The aminoglycosides play a central role in the treatment of infectious diseases caused by gram-negative bacteria. During the period of January to June 1984, 45 clinical specimens collected in our neonatal intensive care unit grew Enterobacter cloacae; 41 of them were gentamicin resistant. One neonate developed septice...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01646115

    authors: Raz R,Sharir R,Shmilowitz L,Kenes I,Ephros M

    更新日期:1987-01-01 00:00:00

  • Onset of symptoms, diagnostic confirmation, and occurrence of multiple infective foci in patients with Staphylococcus aureus bloodstream infection: a look into the order of events and potential clinical implications.

    abstract:PURPOSE:Data on the systemic dissemination in Staphylococcus aureus bloodstream infection (SAB) remain sparse. We investigated the timing and the sequence of clinical symptoms, diagnostic confirmation, and occurrence of multiple infective foci in relation to three major infective foci. METHODS:From 2006 to 2011, all a...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-018-1165-x

    authors: Smit J,Rieg SR,Wendel AF,Kern WV,Seifert H,Schønheyder HC,Kaasch AJ

    更新日期:2018-10-01 00:00:00

  • Influence of intimal Chlamydophila pneumoniae persistence on cardiovascular complications after coronary intervention.

    abstract:PURPOSE:Chlamydophila pneumoniae has been implicated in atherosclerosis/restenosis; however, clear evidence is missing. Therefore, the aim of our study was to examine the influence of intimal infection and systemic inflammation on cardiovascular complications after coronary intervention. METHODS:45 atheroma specimens ...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-014-0694-1

    authors: Tuleta I,Reek D,Braun P,Bauriedel G,Nickenig G,Skowasch D,Andrié R

    更新日期:2015-02-01 00:00:00

  • Infection in immunodepressed patients. The approach to diagnosis and treatment.

    abstract::Infection is an important cause of death in patients receiving cytostatic drugs or with any other impairment of host resistance. Such infections are frequently due to opportunist micro-organisms usually belonging to the endogenous flora of the patient. It is often difficult to obtain an exact diagnosis of the cause an...

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    pub_type: 杂志文章

    doi:10.1007/BF01642766

    authors: Nauta EH,van Furth R

    更新日期:1975-01-01 00:00:00

  • Isolation of mycoplasma species from infertile patients: an epidemiological contribution.

    abstract::In this study the presence of Mycoplasma species in patients suffering from infertility was examined. 41 women and 37 men were examined, including 31 couples, and ten single women and six single men. Samples of vaginal and cervical mucus were taken from each woman, and samples of seminal fluid from each man. Identific...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01642082

    authors: Brenciaglia MI,Cipriani P,Lilli D,Lorino G,Mancini C,Sangnier C

    更新日期:1977-01-01 00:00:00

  • Ampicillin concentrations in middle ear effusions in acute otitis media after administration of bacampicillin.

    abstract::The penetration of ampicillin into middle ear effusions after oral administration of 800 mg bacampicillin to patients with acute otitis media was studied and compared with the serum levels. One hour after administration a mean (+/- SEM) concentration of 2.4 +/- 0.4 micrograms/ml ampicillin was found in the effusions a...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01659775

    authors: Virtanen S,Lahikainen EA

    更新日期:1979-01-01 00:00:00