Abstract:
:A guinea pig model of experimental Pseudomonas aeruginosa pneumonia was used to evaluate factors affecting the efficacy of passive immune therapy with Psomaglobin N, a hyperimmune P. aeruginosa globulin. Animals treated 2 h after infection with a single intravenous infusion of Psomaglobin N, 500 mg/kg, demonstrated 33% survival. Lower dosages were less effective and no survivors occurred among albumin-treated controls. Treatment with Psomaglobin N was effective if given 2 h or 8 h after infection but not if delayed until 24 h after infection. Animals rendered neutropenic with cyclophosphamide did not survive if treated with Psomaglobin N alone. However, when Psomaglobin N was added to tobramycin treatment, a significant increase in survival occurred (86%) as compared to that observed with tobramycin alone (43%) (p less than 0.05). We conclude that Psomaglobin N may offer a useful therapeutic option in management of P. aeruginosa pneumonia.
journal_name
Infectionjournal_title
Infectionauthors
Pennington JE,Pier GBdoi
10.1007/BF01644192subject
Has Abstractpub_date
1987-01-01 00:00:00pages
S47-50eissn
0300-8126issn
1439-0973journal_volume
15 Suppl 2pub_type
杂志文章相关文献
INFECTION文献大全abstract::As highly active antiretroviral treatment (HAART) prolongs the life of HIV-infected individuals and reduces mortality associated with opportunistic infections, liver diseases have become a major challenge in the management of these patients. up to 45% of deaths of persons with HIV are related to endstage liver disease...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/s15010-004-6604-1
更新日期:2004-12-01 00:00:00
abstract:PURPOSE:Tuberculous pleural effusion (TPE) and parapneumonic effusion (PPE) are usually distinguished by cellular predominance and pleural fluid adenosine deaminase (ADA) levels. However, both diseases may occasionally show similar neutrophilic predominance and high ADA levels. In such cases, the differential diagnosis...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/s15010-016-0928-5
更新日期:2017-02-01 00:00:00
abstract::Three hundred and one patients with maxillary sinusitis participated in a double-blind, randomized study at 11 ENT-clinics in Europe. Sinusitis was diagnosed by the presence of at least two signs and symptoms and sinus X-ray showing more than 6 mm swelling of the maxillary mucosa. A microbiological specimen was obtain...
journal_title:Infection
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1007/BF01650753
更新日期:1988-07-01 00:00:00
abstract::The case of an HIV-infected patient with low CD4+ cell count and localized pulmonary infection associated with Mycobacterium tilburgii, a recently recognized atypical mycobacterial species, is reported. Diagnosis was confirmed by repeated detection of mycobacterial DNA in lung biopsy specimens. After surgical removal ...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/s15010-005-4118-0
更新日期:2005-08-01 00:00:00
abstract::Between 1 November 1993 and 31 October 1996, admissions to paediatric departments for Bordetella pertussis complications were reported to a nationwide, hospital-based active surveillance system. The case definition included pertussis complicated by pneumonia, apnoea requiring assisted ventilation, seizures, encephalop...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF02962368
更新日期:1998-07-01 00:00:00
abstract::Twenty-four homosexual adult patients suffering from LAS or AIDS were investigated for immunoglobulin class- and IgG subclass-specific antibodies to human immunodeficiency virus (HIV) by the indirect ELISA and Western blot using monoclonal tracer antibodies. All patients revealed HIV-specific serum antibodies of IgG s...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF01647729
更新日期:1987-01-01 00:00:00
abstract::Large outbreaks of diphtheria occurred recently in the former USSR. Between 1989 and 1994, a total of about 600,000 Soviet immigrants arrived in Israel. The immune status against diphtheria in a sample of 992 men aged 17-49 and 195 women aged 17-19, who arrived in Israel during 1990-91, was studied in order to evaluat...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF02767769
更新日期:1998-03-01 00:00:00
abstract::Efficacy of Oral Ofloxacin and Ciprofloxacin. Cross-over Study. The efficacy of the 4-quinolones ciprofloxacin (CPX) and ofloxacin (OFX) was studied in a cross-over study. Twenty out-patients with cystic fibrosis and chronic colonization of the respiratory tract with Pseudomonas aeruginosa were treated for ten days wi...
journal_title:Infection
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF01645207
更新日期:1986-01-01 00:00:00
abstract::From the microbiological point of view a variety of highly active compounds has contributed to improved efficacy of antibacterial chemotherapy during the last few decades. In some cases, however, resistance has increased due to different molecular mechanisms. Resistance to the new generation of broad-spectrum beta-lac...
journal_title:Infection
pub_type: 杂志文章,评审
doi:10.1007/BF01644735
更新日期:1991-01-01 00:00:00
abstract:BACKGROUND:TT virus (TTV) DNA has been found in a large proportion of patients with different forms of non-A-G hepatitis, however the clinical importance is unclear. We aimed to determine the genotypes of TTV isolates found in blood donors and different patient groups from the western part of Turkey. MATERIALS AND MET...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/s15010-002-2185-z
更新日期:2002-10-01 00:00:00
abstract:PURPOSE:To develop recommendations for the management of acute hepatitis B by the Italian Society for the Study of Infectious and Tropical Diseases. METHODS:Development of the recommendations divided into three levels of evidence according to the GRADE system: A (high), B (medium) and C (low experts opinion), together...
journal_title:Infection
pub_type: 杂志文章,实务指引,评审
doi:10.1007/s15010-014-0642-0
更新日期:2014-10-01 00:00:00
abstract::To investigate the diagnostic value of a direct immunofluorescence test (DIF-test), urethral samples and first catch urine (FCU) from 153 male patients attending an outpatient clinic for sexually transmitted diseases (STD) were studied. Of the male patients, 40 (26.1%) had a positive urethral culture, 39 (25.5%) had a...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF01711077
更新日期:1992-03-01 00:00:00
abstract::Many new species have been isolated from subgingival periodontal pockets, for example Wolinella recta and Bacteroides forsythus, reflecting better basic microbiological techniques. Other species were created from existing species as a result of better characterization methods, i.e. Bacteroides buccae and Bacteroides o...
journal_title:Infection
pub_type: 杂志文章,评审
doi:10.1007/BF01644027
更新日期:1989-05-01 00:00:00
abstract::We studied the activity of cefotaxime both microbiologically and clinically. 138 blood cultures positive for gram-positive cocci were evaluated (90 strains of Staphylococcus aureus, 25 of Streptococcus faecalis, 13 of Streptococcus alpha and ten of Streptococcus mutans). Cefotaxime showed good activity against all str...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF01644230
更新日期:1985-01-01 00:00:00
abstract::The incidence of urinary tract infections (UTI) in 299 renal graft transplantations (281 patients) was analyzed. UTI episodes were demonstrated in 185 grafts (62%), most frequently in the first month after transplantation. The infectious episodes were mostly recurrent. Persistent infection, detected in 11% of grafts, ...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF01667212
更新日期:1985-09-01 00:00:00
abstract::To detect microorganisms in the blood it is necessary not only that the microbiologist uses reliable methods, but also that the clinician takes a sufficient number of blood samples at the right point in time using a correct method for drawing the blood. The best results are obtained if the blood sample is transferred ...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF01639113
更新日期:1977-03-01 00:00:00
abstract::After the cytology and the chemistry of the CSF had returned to normal, the concentration of ceftizoxime was determined in the CSF and in the serum of 27 patients who had suffered from purulent or serous meningitis. The patients were divided into four groups. The concentration in the CSF was mean = 0.87 mg/l two hours...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF01816728
更新日期:1982-01-01 00:00:00
abstract::Susceptibility to HIV-1 infections is, beside other factors, determined by individual host genetic variants like HLA class I alleles, CCR5 and CCR2 variants and levels of CCR5 binding chemokines. A new approach to determine the individual risk of acquiring an HIV infection or to estimate the disease progression could ...
journal_title:Infection
pub_type: 杂志文章,评审
doi:10.1007/s15010-005-6305-4
更新日期:2005-06-01 00:00:00
abstract::A 38-year-old Omani woman, seven months pregnant, developed extensive zygomycosis involving maxillary and temporal bones. No evidence of any underlying immune deficiency was detected except that which may be attributed to pregnancy. After delivery the patient was treated with repeated courses of amphotericin B, which ...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF02033066
更新日期:1992-07-01 00:00:00
abstract::The potential risk factors for congenital cytomegalovirus (cCMV) infection or development of disease remain unclear. Here, we investigated the genetic polymorphisms in natural killer (NK) group 2, member D (NKG2D), an activating receptor expressed on NK cells, and in MHC class I-related chains A, the ligand of NKG2D, ...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/s15010-015-0774-x
更新日期:2015-06-01 00:00:00
abstract::Cefodizime was evaluated for its effect on a number of parameters of leukocyte function in humans. Four healthy volunteers received 2 g i.v. b.i.d. for seven days. Leukocyte activity was measured before, during and after treatment. Using opsonized zymosan as a stimulant, no effect on the respiratory burst of granulocy...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF01709952
更新日期:1992-01-01 00:00:00
abstract::The increasing resistance of Streptococcus pneumoniae, the most important community respiratory pathogen, to beta-lactams and other first-line antimicrobial agents usually employed for the empirical treatment of lower respiratory tract infections has led to the inclusion, in several current guidelines, of a fluoroquin...
journal_title:Infection
pub_type: 杂志文章,评审
doi:10.1007/s15010-005-4102-8
更新日期:2005-06-01 00:00:00
abstract:BACKGROUND:In recent years, the role of pro- and antiinflammatory cytokines in the development of Lyme arthritis (LA) has been widely discussed. The purpose of the present study was to determine the concentration of interleukin-18 (IL-18), interleukin-1beta (IL-beta) and its soluble receptor sIL-1RII in serum of patien...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/s15010-006-5013-z
更新日期:2006-06-01 00:00:00
abstract::A guinea pig model of experimental Pseudomonas aeruginosa pneumonia was used to evaluate factors affecting the efficacy of passive immune therapy with Psomaglobin N, a hyperimmune P. aeruginosa globulin. Animals treated 2 h after infection with a single intravenous infusion of Psomaglobin N, 500 mg/kg, demonstrated 33...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF01646124
更新日期:1987-01-01 00:00:00
abstract::The aminoglycosides play a central role in the treatment of infectious diseases caused by gram-negative bacteria. During the period of January to June 1984, 45 clinical specimens collected in our neonatal intensive care unit grew Enterobacter cloacae; 41 of them were gentamicin resistant. One neonate developed septice...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF01646115
更新日期:1987-01-01 00:00:00
abstract:PURPOSE:Data on the systemic dissemination in Staphylococcus aureus bloodstream infection (SAB) remain sparse. We investigated the timing and the sequence of clinical symptoms, diagnostic confirmation, and occurrence of multiple infective foci in relation to three major infective foci. METHODS:From 2006 to 2011, all a...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/s15010-018-1165-x
更新日期:2018-10-01 00:00:00
abstract:PURPOSE:Chlamydophila pneumoniae has been implicated in atherosclerosis/restenosis; however, clear evidence is missing. Therefore, the aim of our study was to examine the influence of intimal infection and systemic inflammation on cardiovascular complications after coronary intervention. METHODS:45 atheroma specimens ...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/s15010-014-0694-1
更新日期:2015-02-01 00:00:00
abstract::Infection is an important cause of death in patients receiving cytostatic drugs or with any other impairment of host resistance. Such infections are frequently due to opportunist micro-organisms usually belonging to the endogenous flora of the patient. It is often difficult to obtain an exact diagnosis of the cause an...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF01642766
更新日期:1975-01-01 00:00:00
abstract::In this study the presence of Mycoplasma species in patients suffering from infertility was examined. 41 women and 37 men were examined, including 31 couples, and ten single women and six single men. Samples of vaginal and cervical mucus were taken from each woman, and samples of seminal fluid from each man. Identific...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF01642082
更新日期:1977-01-01 00:00:00
abstract::The penetration of ampicillin into middle ear effusions after oral administration of 800 mg bacampicillin to patients with acute otitis media was studied and compared with the serum levels. One hour after administration a mean (+/- SEM) concentration of 2.4 +/- 0.4 micrograms/ml ampicillin was found in the effusions a...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF01659775
更新日期:1979-01-01 00:00:00