Abstract:
:Cefodizime was evaluated for its effect on a number of parameters of leukocyte function in humans. Four healthy volunteers received 2 g i.v. b.i.d. for seven days. Leukocyte activity was measured before, during and after treatment. Using opsonized zymosan as a stimulant, no effect on the respiratory burst of granulocytes was observed. It was found, however, that the lymphocytes in three of the four subjects showed significantly more marked proliferation rates in the mixed lymphocyte reaction after administration of cefodizime than at baseline. The stimulation indices subsequently returned to normal. This pilot study therefore demonstrated that cefodizime has biological response modifying properties in healthy humans.
journal_name
Infectionjournal_title
Infectionauthors
Limbert M,Müllner H,Shah PMdoi
10.1007/BF01709952keywords:
subject
Has Abstractpub_date
1992-01-01 00:00:00pages
S48-50eissn
0300-8126issn
1439-0973journal_volume
20 Suppl 1pub_type
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