Influence of cefodizime on the reagibility of human leukocytes.

Abstract:

:Cefodizime was evaluated for its effect on a number of parameters of leukocyte function in humans. Four healthy volunteers received 2 g i.v. b.i.d. for seven days. Leukocyte activity was measured before, during and after treatment. Using opsonized zymosan as a stimulant, no effect on the respiratory burst of granulocytes was observed. It was found, however, that the lymphocytes in three of the four subjects showed significantly more marked proliferation rates in the mixed lymphocyte reaction after administration of cefodizime than at baseline. The stimulation indices subsequently returned to normal. This pilot study therefore demonstrated that cefodizime has biological response modifying properties in healthy humans.

journal_name

Infection

journal_title

Infection

authors

Limbert M,Müllner H,Shah PM

doi

10.1007/BF01709952

keywords:

subject

Has Abstract

pub_date

1992-01-01 00:00:00

pages

S48-50

eissn

0300-8126

issn

1439-0973

journal_volume

20 Suppl 1

pub_type

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