A Thr72Ala polymorphism in the NKG2D gene is associated with early symptomatic congenital cytomegalovirus disease.

Abstract:

:The potential risk factors for congenital cytomegalovirus (cCMV) infection or development of disease remain unclear. Here, we investigated the genetic polymorphisms in natural killer (NK) group 2, member D (NKG2D), an activating receptor expressed on NK cells, and in MHC class I-related chains A, the ligand of NKG2D, in 87 cCMV cases, and found that there was a significant association between cCMV disease and a single nucleotide polymorphism, Thr72Ala, in NKG2D.

journal_name

Infection

journal_title

Infection

authors

Taniguchi R,Koyano S,Suzutani T,Goishi K,Ito Y,Morioka I,Nakamura H,Yamada H,Oka A,Inoue N

doi

10.1007/s15010-015-0774-x

subject

Has Abstract

pub_date

2015-06-01 00:00:00

pages

353-9

issue

3

eissn

0300-8126

issn

1439-0973

journal_volume

43

pub_type

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