IFN-alpha: therapeutic options in HIV and HIV/HCV, HIV/HBV dual infection.

Abstract:

:The antiviral effects of interferon-alpha (IFN-alpha) are well documented for the treatment of hepatitis B or C infections, whereas antiretroviral effects for treatment of HIV-1 infection have been investigated up to now only in small-sized preclinical studies. New preclinical and clinical data on IFN-alpha for HIV, HCV, HBV and especially on co-infections of HIV with HCV or HBV were presented at a symposium of the ConVir conference 2002. This short paper summarizes the presented data on IFN-alpha treatment for HIV and/or HCV or HBV infections.

journal_name

Infection

journal_title

Infection

authors

Jablonowski H

keywords:

subject

Has Abstract

pub_date

2003-03-01 00:00:00

pages

131-3

issue

2

eissn

0300-8126

issn

1439-0973

journal_volume

31

pub_type

  • Soft-tissue infection secondary to cellulitis killed St. John of the Cross (1542-1591).

    abstract:PURPOSE:St. John of the Cross (1542-1591) died aged 49 years after 3 months of excruciating pain following a trivial lesion in his right foot. Erysipelas, a superficial bacterial infection of the skin, and subsequent sepsis were previously suggested as the cause of his death. Here, an alternative diagnosis is proposed....

    journal_title:Infection

    pub_type: 历史文章,杂志文章

    doi:10.1007/s15010-017-1089-x

    authors: Bianucci R,Appenzeller O,Evans P,Charlier P,Perciaccante A

    更新日期:2018-04-01 00:00:00

  • [A microbiological method for the rapid determination of antibiotic concentrations during therapy (author's transl)].

    abstract::The assay described is an agar diffusion test using Bacillus stearothermophilus as test organism. Incubation is at 62 degrees C; results can be obtained rapidly within 2 to 3 hours. The test was developed for the determination of gentamicin concentrations in serum and other body fluids. Because of its high sensitivity...

    journal_title:Infection

    pub_type: 杂志文章

    doi:

    authors: Wahlig H

    更新日期:1977-01-01 00:00:00

  • Management of superficial and deep-seated Staphylococcus aureus skin and soft tissue infections in sub-Saharan Africa: a post hoc analysis of the StaphNet cohort.

    abstract:PURPOSE:The incidence of Staphylococcus aureus skin and soft tissue infection (SSTI) is high in sub-Saharan Africa. This is fueled by a high prevalence of Panton-Valentine leukocidin (PVL), which can be associated with necrotizing disease. The aim was to describe the clinical presentation and the treatment of SSTI in t...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-018-1140-6

    authors: Alabi A,Kazimoto T,Lebughe M,Vubil D,Phaku P,Mandomando I,Kern WV,Abdulla S,Mellmann A,Peitzmann L,Bischoff M,Peters G,Herrmann M,Grobusch MP,Schaumburg F,Rieg S

    更新日期:2018-06-01 00:00:00

  • Efficacy and effects on pulmonary function tests of weekly 600 mg aerosol pentamidine as prophylaxis against Pneumocystis carinii pneumonia.

    abstract::A prospective study was designed to evaluate the efficacy and effects on pulmonary function tests of weekly 600 mg aerosolised pentamidine as prophylaxis against Pneumocystis carinii pneumonia (PCP) amongst two groups of patients infected with the human immunodeficiency virus. Group 1 (primary prophylaxis) consisted o...

    journal_title:Infection

    pub_type: 临床试验,杂志文章

    doi:10.1007/BF01704600

    authors: Ong EL,Dunbar EM,Mandal BK

    更新日期:1992-05-01 00:00:00

  • Serum levels of interleukin-18 (IL-18), interleukin-1beta (IL-1beta), its soluble receptor sIL-1RII and C-reactive protein (CRP) in patients with Lyme arthritis.

    abstract:BACKGROUND:In recent years, the role of pro- and antiinflammatory cytokines in the development of Lyme arthritis (LA) has been widely discussed. The purpose of the present study was to determine the concentration of interleukin-18 (IL-18), interleukin-1beta (IL-beta) and its soluble receptor sIL-1RII in serum of patien...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-006-5013-z

    authors: Pietruczuk A,Swierzbińska R,Pancewicz S,Pietruczuk M,Hermanowska-Szpakowicz T

    更新日期:2006-06-01 00:00:00

  • Low transmission rate of 2009 H1N1 Influenza during a long-distance bus trip.

    abstract:BACKGROUND:Current data on the risk of transmission of 2009 H1N1 Influenza in public transportation systems (e.g., public trains, busses, airplanes) are conflicting. The main transmission route of this virus is thought to be via droplets, but airborne transmission has not been completely ruled out. METHODS:This is a c...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-011-0084-x

    authors: Piso RJ,Albrecht Y,Handschin P,Bassetti S

    更新日期:2011-04-01 00:00:00

  • Ampicillin concentrations in middle ear effusions in acute otitis media after administration of bacampicillin.

    abstract::The penetration of ampicillin into middle ear effusions after oral administration of 800 mg bacampicillin to patients with acute otitis media was studied and compared with the serum levels. One hour after administration a mean (+/- SEM) concentration of 2.4 +/- 0.4 micrograms/ml ampicillin was found in the effusions a...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01659775

    authors: Virtanen S,Lahikainen EA

    更新日期:1979-01-01 00:00:00

  • Release of vancomycin and teicoplanin from a plasticized and resorbable gelatin sponge: in vitro investigation of a new antibiotic delivery system with glycopeptides.

    abstract:BACKGROUND:The aim of this study was to evaluate the efficacy of sustained release of vancomycin and teicoplanin from a resorbable gelatin glycerol sponge, in order to establish a new delivery system for local anti-infective therapy. MATERIALS AND METHODS:60 plasticized glycerol gelatin sponges containing either 10 or...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-006-1067-1

    authors: Drognitz O,Thorn D,Krüger T,Gatermann SG,Iven H,Bruch HP,Muhl E

    更新日期:2006-02-01 00:00:00

  • Prevalence rates of viral hepatitis infections in refugee Kurds from Iraq and Turkey.

    abstract:BACKGROUND:Since little is known about the burden of viral hepatitis in Kurds, the prevalence of infection with hepatitis A virus (HAV), hepatitis E virus (HEV), hepatitis B virus (HBV) and hepatitis C virus (HCV) was investigated in a sample of refugee Kurds from Iraq and Turkey. PATIENTS AND METHODS:A cross-sectiona...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-002-3100-3

    authors: Chironna M,Germinario C,Lopalco PL,Carrozzini F,Barbuti S,Quarto M

    更新日期:2003-03-01 00:00:00

  • Femoral osteomyelitis due to Cladophialophora arxii in a patient with chronic granulomatous disease.

    abstract::Fungal infections in patients with chronic granulomatous disease (CGD) are a poor prognostic factor. We describe the first case of CGD with femoral osteomyelitis due to Cladophialophora arxii, which is a member of the dematiaceous group. The causative fungus was identified on the basis of its morphological characteris...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-009-8238-9

    authors: Shigemura T,Agematsu K,Yamazaki T,Eriko K,Yasuda G,Nishimura K,Koike K

    更新日期:2009-10-01 00:00:00

  • SOFA and qSOFA usefulness for in-hospital death prediction of elderly patients admitted for suspected infection in internal medicine.

    abstract:PURPOSE:To reduce intensive care unit overcrowding and optimize resources, elderly patients affected by suspected infection with declining clinical conditions could be managed in internal medicine departments with stepdown beds. However, commonly used prognostic scores, as Sequential Organ Failure Assessment (SOFA) or ...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-020-01494-5

    authors: Falsetti L,Martino M,Zaccone V,Viticchi G,Raponi A,Moroncini G,Fioranelli A,di Pentima C,Martini A,Nitti C,Salvi A,Burattini M,Tarquinio N

    更新日期:2020-12-01 00:00:00

  • Low C-reactive protein values at admission predict mortality in patients with severe community-acquired pneumonia caused by Streptococcus pneumoniae that require intensive care management.

    abstract:PURPOSE:To identify risk factors associated with mortality in patients with severe community-acquired pneumonia (CAP) caused by S. pneumoniae who require intensive care unit (ICU) management, and to assess the prognostic values of these risk factors at the time of admission. METHODS:Retrospective analysis of all conse...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-015-0755-0

    authors: Que YA,Virgini V,Lozeron ED,Paratte G,Prod'hom G,Revelly JP,Pagani JL,Charbonney E,Eggimann P

    更新日期:2015-04-01 00:00:00

  • Environmental pollution with antimicrobial agents from bulk drug manufacturing industries in Hyderabad, South India, is associated with dissemination of extended-spectrum beta-lactamase and carbapenemase-producing pathogens.

    abstract:PURPOSE:High antibiotic and antifungal concentrations in wastewater from anti-infective drug production may exert selection pressure for multidrug-resistant (MDR) pathogens. We investigated the environmental presence of active pharmaceutical ingredients and their association with MDR Gram-negative bacteria in Hyderabad...

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    pub_type: 杂志文章

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    authors: Lübbert C,Baars C,Dayakar A,Lippmann N,Rodloff AC,Kinzig M,Sörgel F

    更新日期:2017-08-01 00:00:00

  • Serological biomarkers of candidemia: a retrospective evaluation of three assays.

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    authors: Dichtl K,Seybold U,Wagener J

    更新日期:2019-04-01 00:00:00

  • Controversies in the therapeutic approach to congenital cytomegalovirus infection.

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    authors: Garrido-Barbero M,Arnaez J,Garcia-Alix A

    更新日期:2020-06-01 00:00:00

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    pub_type: 杂志文章

    doi:10.1007/BF01646885

    authors: Mackowiak PA,Goggans ML

    更新日期:1989-03-01 00:00:00

  • Acute disseminated encephalomyelitis (ADEM) due to Mycoplasma pneumoniae infection in an adolescent.

    abstract::A 17-year-old boy presented with a severe form of an acute disseminated encephalomyelitis (ADEM) with hemiparesis and coma after initial symptoms of a flu-like febrile infection 1 week previously. Titers against Mycoplasma pneumoniae were significantly increased in serum and cerebrospinal fluid (CSF). Detection of M. ...

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    authors: Riedel K,Kempf VA,Bechtold A,Klimmer M

    更新日期:2001-08-01 00:00:00

  • Onset of symptoms, diagnostic confirmation, and occurrence of multiple infective foci in patients with Staphylococcus aureus bloodstream infection: a look into the order of events and potential clinical implications.

    abstract:PURPOSE:Data on the systemic dissemination in Staphylococcus aureus bloodstream infection (SAB) remain sparse. We investigated the timing and the sequence of clinical symptoms, diagnostic confirmation, and occurrence of multiple infective foci in relation to three major infective foci. METHODS:From 2006 to 2011, all a...

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  • Infections in the differential diagnosis of Bell's palsy: a plea for performing CSF analysis.

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    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-016-0933-8

    authors: Henkel K,Lange P,Eiffert H,Nau R,Spreer A

    更新日期:2017-04-01 00:00:00

  • The optimal management of lower urinary tract infections.

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    journal_title:Infection

    pub_type: 杂志文章,评审

    doi:10.1007/BF01643426

    authors: Nicolle LE

    更新日期:1990-01-01 00:00:00

  • HIV transmission by needle stick and eczematous lesion--three cases from Germany.

    abstract::Two cases of documented HIV-1 transmission by needle stick and one case of probable transmission by eczematous lesion in three nurses in Germany are reported in the period 1988 to 1991. In two of the cases the nurse knew of the AIDS status of the index patient. A review of the three cases reiterates the importance of ...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01739310

    authors: Gürtler LG,Eberle J,Bader L

    更新日期:1993-01-01 00:00:00

  • Correlation between antibiotic consumption and resistance of bloodstream bacteria in a University Hospital in North Eastern Italy, 2008-2014.

    abstract:PURPOSE:The spread of multidrug-resistant bacteria is a worrisome problem worldwide. This study investigated the correlation between antibiotic consumption and antimicrobial resistance trends of the most important bacteria causing bacteremia at the University hospital of Trieste, Italy, from 2008 to 2014. METHODS:Anti...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-017-0998-z

    authors: Mascarello M,Simonetti O,Knezevich A,Carniel LI,Monticelli J,Busetti M,Schincariol P,Torelli L,Luzzati R

    更新日期:2017-08-01 00:00:00

  • Natural leukocyte interferon alpha (Alfaferone) combined with ribavirin in the treatment of patients with HCV-related cirrhosis: our experience.

    abstract:BACKGROUND:The aim of the study was to evaluate the efficacy and safety of combined treatment with natural leukocyte interferon alpha (Alfaferone) plus ribavirin in patients with HCV-related cirrhosis. PATIENTS AND METHODS:Twenty-three patients (15 women, 8 men) aged 17-68 years hospitalized in 2005-2008 were included...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-011-0135-3

    authors: Kozielewicz D,Dybowska D,Halota W,Dróżdż W

    更新日期:2011-10-01 00:00:00

  • Mortality after bloodstream infections in allogeneic haematopoietic stem cell transplant (HSCT) recipients.

    abstract:PURPOSE:Bloodstream infections (BSIs) are frequent after allogeneic haematopoietic stem cell transplantation (HSCT). The aim of this study was to identify predictors of mortality after BSI in patients who undergo HSCT. METHODS:Patients who underwent HSCT between 1 January 2004 and 31 January 2008 and developed BSI dur...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-011-0229-y

    authors: Mikulska M,Del Bono V,Bruzzi P,Raiola AM,Gualandi F,Van Lint MT,Bacigalupo A,Viscoli C

    更新日期:2012-06-01 00:00:00

  • Investigation of Rickettsia conorii antibodies in the Antalya area.

    abstract::Mediterranean spotted fever, caused by Rickettsia conorii, is a tick-borne infection. Serum samples for screening R. conorii antibodies of professionally exposed persons in the Antalya region, on the Mediterranean coast of Turkey, were analyzed. R. conorii IgG antibodies were detected in 13 of 98 (13.3%) serum samples...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF02771845

    authors: Vural T,Ergin C,Sayin F

    更新日期:1998-05-01 00:00:00

  • Antibacterial activity and kill kinetics of amoxicillin-clavulanic acid combinations against Escherichia coli and Klebsiella aerogenes.

    abstract::Combinations of amoxicillin and clavulanic acid were tested against 11 Escherichia coli strains and five Klebsiella aerogenes strains. Apart from one E. coli, the strains were highly resistant to amoxicillin due to beta-lactamase production. Synergy was demonstrated in all strains by agar dilution. Synergy was detecte...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01641359

    authors: Fuglesang JE,Bergan T

    更新日期:1983-11-01 00:00:00

  • Epidemiology of SARS-CoV-2.

    abstract:PURPOSE:SARS-CoV-2 is a recently emerged ß-coronavirus. Here we present the current knowledge on its epidemiologic features. METHODS:Non-systematic review. RESULTS:SARS-CoV-2 replicates in the upper and lower respiratory tract. It is mainly transmitted by droplets and aerosols from asymptomatic and symptomatic infect...

    journal_title:Infection

    pub_type: 杂志文章,评审

    doi:10.1007/s15010-020-01531-3

    authors: Salzberger B,Buder F,Lampl B,Ehrenstein B,Hitzenbichler F,Holzmann T,Schmidt B,Hanses F

    更新日期:2020-10-08 00:00:00

  • Clinical characteristics of Raoultella ornithinolytica bacteremia.

    abstract:PURPOSE:Raoultella ornithinolytica is not well known as a clinical pathogen. We performed a retrospective review of R. ornithinolytica bacteremia to investigate its clinical features, antimicrobial susceptibility, and overall patient outcomes. METHODS:R. ornithinolytica bacteremia cases were collected from an electron...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-014-0696-z

    authors: Chun S,Yun JW,Huh HJ,Lee NY

    更新日期:2015-02-01 00:00:00

  • Hospital at home for the management of COVID-19: preliminary experience with 63 patients.

    abstract::Alternatives to conventional hospitalization are needed to increase health systems resilience in the face of COVID-19 pandemic. Herein, we describe the characteristics and outcomes of 63 patients admitted to a single HaH during the peak of COVID-19 in Barcelona. Our results suggest that HaH seems to be a safe and effi...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-020-01527-z

    authors: Pericàs JM,Cucchiari D,Torrallardona-Murphy O,Calvo J,Serralabós J,Alvés E,Agelet A,Hidalgo J,Alves E,Castells E,Seijas N,Hernández C,Bodro M,Cardozo C,Coloma E,Nicolás D,Hospital Clínic 4H Team (Hospital at Home-Health H

    更新日期:2020-09-29 00:00:00

  • The epidemiological burden and overall distribution of chronic comorbidities in coronavirus disease-2019 among 202,005 infected patients: evidence from a systematic review and meta-analysis.

    abstract:PURPOSE:The main purpose of this study was to examine the overall distribution of chronic comorbidities in coronavirus disease-19 (COVID-19) infected populations and the risk of the underlying burden of disease in terms of the case fatality ratio (CFR). METHODS:We carried out a systematic review and meta-analysis of s...

    journal_title:Infection

    pub_type: 杂志文章,meta分析

    doi:10.1007/s15010-020-01502-8

    authors: Mahumud RA,Kamara JK,Renzaho AMN

    更新日期:2020-12-01 00:00:00