Abstract:
PURPOSE:High antibiotic and antifungal concentrations in wastewater from anti-infective drug production may exert selection pressure for multidrug-resistant (MDR) pathogens. We investigated the environmental presence of active pharmaceutical ingredients and their association with MDR Gram-negative bacteria in Hyderabad, South India, a major production area for the global bulk drug market. METHODS:From Nov 19 to 28, 2016, water samples were collected from the direct environment of bulk drug manufacturing facilities, the vicinity of two sewage treatment plants, the Musi River, and habitats in Hyderabad and nearby villages. Samples were analyzed for 25 anti-infective pharmaceuticals with liquid chromatography-tandem mass spectrometry and for MDR Gram-negative bacteria using chromogenic culture media. In addition, specimens were screened with PCR for bla VIM, bla KPC, bla NDM, bla IMP-1, and bla OXA-48 resistance genes. RESULTS:All environmental specimens from 28 different sampling sites were contaminated with antimicrobials. High concentrations of moxifloxacin, voriconazole, and fluconazole (up to 694.1, 2500, and 236,950 µg/L, respectively) as well as increased concentrations of eight other antibiotics were found in sewers in the Patancheru-Bollaram industrial area. Corresponding microbiological analyses revealed an extensive presence of extended-spectrum beta-lactamase and carbapenemase-producing Enterobacteriaceae and non-fermenters (carrying mainly bla OXA-48, bla NDM, and bla KPC) in more than 95% of the samples. CONCLUSIONS:Insufficient wastewater management by bulk drug manufacturing facilities leads to unprecedented contamination of water resources with antimicrobial pharmaceuticals, which seems to be associated with the selection and dissemination of carbapenemase-producing pathogens. The development and global spread of antimicrobial resistance present a major challenge for pharmaceutical producers and regulatory agencies.
journal_name
Infectionjournal_title
Infectionauthors
Lübbert C,Baars C,Dayakar A,Lippmann N,Rodloff AC,Kinzig M,Sörgel Fdoi
10.1007/s15010-017-1007-2subject
Has Abstractpub_date
2017-08-01 00:00:00pages
479-491issue
4eissn
0300-8126issn
1439-0973pii
10.1007/s15010-017-1007-2journal_volume
45pub_type
杂志文章相关文献
INFECTION文献大全abstract::Using 44 anti-O sera 789 Escherichia coli strains isolated from the urine of patients with urinary tract infections were typed. Of the 119 E. coli strains from the urine of children, 49.6% were O-typable; only 3.4% were rough strains. Of 357 strains from pregnant women, 47% were O-typable; 12.1% were rough strains. Th...
journal_title:Infection
pub_type: 杂志文章
doi:
更新日期:1980-01-01 00:00:00
abstract:BACKGROUND:There are conflicting results concerning an association between Chlamydia pneumoniae and MS (multiple sclerosis). In the present study, we investigated a possible therapeutic option with antibiotics. PATIENTS AND METHODS:In our randomized, placebo-controlled double-blind study, 28 patients with the confirme...
journal_title:Infection
pub_type: 杂志文章,随机对照试验
doi:10.1007/s15010-006-5114-8
更新日期:2006-12-01 00:00:00
abstract::The concentration of imipenem in organic bone, determined in 16 patients by bioassay after short infusion (15 min) of 1 g imipenem/cilastatin was 4.3 +/- 2.06 mg/kg (geometric mean +/- standard deviation, n = 13) after 45 minutes, and 2.8 +/- 1.86 mg/kg (n = 26) after 88 minutes. Imipenem penetrates into inorganic hyd...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF01647497
更新日期:1986-01-01 00:00:00
abstract::The MICs and MBCs of mecillinam, ticarcillin, mezlocillin, azlocillin and piperacillin were determined by the microdilution method in liquid medium using 700 strains of gram-negative bacilli and enterococci isolated from pathological sources and classified as a function of their sensitivity to ampicillin and carbenici...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF01640683
更新日期:1982-01-01 00:00:00
abstract::We describe a 66-year-old woman hospitalized with fever, fatigue and hepatopathy. In her medical history arterial hypertension (treated with propranolol and lisinopril), diabetes mellitus type 2 (no treatment before admission) and a gout arthropathy were noted wherefore a therapy with allopurinol 300 mg per day has be...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/s15010-007-6365-8
更新日期:2008-08-01 00:00:00
abstract::This report concerns a case of congenital rubella syndrome (CRS) with atypical immune response affecting an infant whose mother had repeated evidence of immunity before pregnancy. Laboratory diagnosis of CRS could only clearly be achieved by virus isolation after the second month of life despite typical clinical featu...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF01710747
更新日期:1993-03-01 00:00:00
abstract::A study on prevention of borreliosis in humans bitten by infected ticks was performed in 1992-1994 in the Perm' region of Russia. Adult Ixodes persulcatus ticks were removed from the study subjects, and live preparations made from the material obtained from the gut of each tick were microscopically analyzed (up to 250...
journal_title:Infection
pub_type: 临床试验,杂志文章
doi:10.1007/BF01713337
更新日期:1996-03-01 00:00:00
abstract:PURPOSE:The main purpose of this study was to examine the overall distribution of chronic comorbidities in coronavirus disease-19 (COVID-19) infected populations and the risk of the underlying burden of disease in terms of the case fatality ratio (CFR). METHODS:We carried out a systematic review and meta-analysis of s...
journal_title:Infection
pub_type: 杂志文章,meta分析
doi:10.1007/s15010-020-01502-8
更新日期:2020-12-01 00:00:00
abstract:PURPOSE:Invasive Mycobacterium marinum disease (tenosynovitis and osteomyelitis) may be an increasingly common manifestation of M. marinum infection that presents unique diagnostic and therapeutic challenges. We conducted a retrospective case series and literature review of M. marinum infection to better understand the...
journal_title:Infection
pub_type: 杂志文章,评审
doi:10.1007/s15010-015-0776-8
更新日期:2015-12-01 00:00:00
abstract::The case of a 13-year-old girl with CVI is presented who required steroid treatment for myositis. After three weeks of treatment, the serum IgM level increased about ten-fold. Specific antibodies to vaccination antigens, which despite adequate vaccination were absent prior to any kind of treatment, could be synthesize...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF01643615
更新日期:1985-01-01 00:00:00
abstract:BACKGROUND:Reports on antibiotic use often lack complete definitions of the units of measurement, hampering the comparison of data between hospitals or hospital units. PATIENTS AND METHODS:To compare methods of measures of in-hospital antimicrobial use, we determined aggregate in-hospital consumption data at a tertiar...
journal_title:Infection
pub_type: 杂志文章,评审
doi:10.1007/s15010-008-7462-z
更新日期:2008-12-01 00:00:00
abstract::Nearly everyone agrees that violations in research occur. Nobody knows how often. But if Pediatrics is to progress children must be the subjects of research carried out in an acceptable way. The following guidelines should be followed in childhood experimentation: (1) Research should not be done on children if the sam...
journal_title:Infection
pub_type: 杂志文章,评审
doi:10.1007/BF01645562
更新日期:1989-11-01 00:00:00
abstract:BACKGROUND:In a study involving 200 patients, we previously found that 17.5% of patients developed viridans streptococcal (VS) bacteremia following autologous peripheral blood stem cell transplantation (aPBSCT) when ciprofloxacin or ciprofloxacin plus ampicillin was used for prophylaxis. PATIENTS AND METHODS:A retrosp...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/s15010-001-1028-7
更新日期:2001-08-01 00:00:00
abstract::Cefodizime was evaluated for its effect on a number of parameters of leukocyte function in humans. Four healthy volunteers received 2 g i.v. b.i.d. for seven days. Leukocyte activity was measured before, during and after treatment. Using opsonized zymosan as a stimulant, no effect on the respiratory burst of granulocy...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF01709952
更新日期:1992-01-01 00:00:00
abstract::Nosocomial infections (NIs) constitute a significant public health problem and contribute to prolonged hospitalization, additional healthcare costs and excess morbidity and mortality. NIs appear to be more common in patients with acquired immunodeficiency syndrome (AIDS) as a result of some degree of immunosuppression...
journal_title:Infection
pub_type: 杂志文章,评审
doi:
更新日期:2003-12-01 00:00:00
abstract::A time-dependent degree of immunosuppression or immunostimulation which may be correlated to pharmacokinetic variables was obtained by administering a single dose of ofloxacin, norfloxacin, pipemidic and piromidic acid to healthy volunteers. The plasma samples collected before drug administration and then at various t...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF01661284
更新日期:1986-01-01 00:00:00
abstract::The radiologic surveillance of smokers with low-dose CT scan has led to a significant surge of radiologic incidental findings, including the detection of early stages of pulmonary infections including nontuberculous mycobacteria (NTM). This causes a state of overdiagnosis and potential overtreatment of NTM lung diseas...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/s15010-018-1232-3
更新日期:2018-12-01 00:00:00
abstract::Between 1 November 1993 and 31 October 1996, admissions to paediatric departments for Bordetella pertussis complications were reported to a nationwide, hospital-based active surveillance system. The case definition included pertussis complicated by pneumonia, apnoea requiring assisted ventilation, seizures, encephalop...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF02962368
更新日期:1998-07-01 00:00:00
abstract::Assuming a local weakness in the defence system to be responsible for chronic, recurrent infection of the urinary tract in young girls, we made 86 determinations of the bacterial periurethral flora from 70 female patients aged between five and eleven years. Within three patient groups (urologically healthy, temporaril...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF01640729
更新日期:1981-01-01 00:00:00
abstract::The clinical tolrance of 350 mg pivampicillin tablets was evaluated in 470 hospitalized patients in Denmark, Norway and Iceland. The tablets were given to 229 fasting patients and to 241 non-fasting patients at mealtime. Side-effects were reported in 44 patients (9.4%). Upper gastro intestinal disturbances occurred in...
journal_title:Infection
pub_type: 临床试验,杂志文章
doi:10.1007/BF01639105
更新日期:1977-01-01 00:00:00
abstract:PURPOSE:Investigation of the injecting drug users (IDUs) population is becoming extremely critical and timely in light of the recent evidence that IDUs now act as the core of hepatitis C virus (HCV) epidemics in developed countries. The purpose of this article, therefore, is not only to review the epidemiology of HCV i...
journal_title:Infection
pub_type: 杂志文章,评审
doi:10.1007/s15010-011-0236-z
更新日期:2012-02-01 00:00:00
abstract::Staphylococcus lugdunensis is a coagulase-negative Staphylococcus that causes skin and soft tissue infections and occasionally life threatening endocarditis of native valves. Prosthetic valve infection due to this pathogen is very rare and has not been described in HIV infected individuals. We report on the first case...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/s15010-007-6029-8
更新日期:2007-02-01 00:00:00
abstract:PURPOSE:To describe the influence of cardiac conduction tissue infection by Influenza A virus. METHODS AND RESULTS:A 54-year-old man with non-sustained ventricular tachycardia underwent noninvasive and invasive cardiac studies including left ventricular endomyocardial biopsy (LVEMB). Non-invasive studies showed normal...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/s15010-016-0892-0
更新日期:2016-06-01 00:00:00
abstract:INTRODUCTION:After the introduction of highly active antiretroviral treatment, the course of HIV infection turned into a chronic disease and most of HIV-positive patients will soon be over 50 years old. MATERIAL AND METHODS:This paper reviews the multiple aspects that physicians have to face while taking care of HIV-p...
journal_title:Infection
pub_type: 杂志文章,评审
doi:10.1007/s15010-015-0795-5
更新日期:2015-10-01 00:00:00
abstract::Recently, important advances have been made in the immunodiagnosis of tuberculosis. New T cell interferon-gamma release assays (TIGRA) are more specific and more sensitive than the tuberculin skin test (TST) for the diagnosis of Mycobacterium tuberculosis (MTB) infection. However, like the TST, TIGRA are unable to dis...
journal_title:Infection
pub_type: 杂志文章,评审
doi:10.1007/s15010-008-8089-9
更新日期:2008-12-01 00:00:00
abstract::Twenty-eight patients who underwent open-heart surgery were divided into three groups, each of which received a different antibiotic from the cephalosporin series (cephalotin, cefazolin or cefamandole) in order to prevent infection. All antibiotics were given via intravenous infusion in a dosage of 2 g prior to surger...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF01641087
更新日期:1978-01-01 00:00:00
abstract:PURPOSE:The purpose of this study was to evaluate the diagnostic value of 18F-fluorodeoxyglucose (FDG) positron emission tomography and computed tomography (PET/CT scan) and magnetic resonance imaging (MRI) in diagnosing spondylodiscitis and its complications, such as epidural and paraspinal abscesses. METHODS:From Ja...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/s15010-016-0914-y
更新日期:2017-02-01 00:00:00
abstract:PURPOSE:Shoulder arthroplasties are increasingly performed, but data on periprosthetic joint infections (PJI) in this anatomical position are limited. We retrospectively investigated the characteristics and outcome of shoulder PJI after primary arthroplasty from 1998 to 2010 in a single centre. METHODS:Periprosthetic ...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/s15010-012-0360-4
更新日期:2013-06-01 00:00:00
abstract::A 97-year-old lady was hospitalized for left leg cellulitis. Comorbidity included hypertension and congestive heart failure. While in hospital, she developed a painless vesicular rash localized to the territory of the left trigeminal nerve (third branch), which evolved to pustules and crusts (Figure 1). A chickenpox-l...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/s15010-008-8287-5
更新日期:2009-04-01 00:00:00
abstract:OBJECTIVE:"Choosing Wisely" is a growing international campaign aiming at practice changes to improve patient health and safety by both, conduct of essential and avoidance of unnecessary diagnostic, preventive and therapeutic procedures. The goal is to create an easily recognizable and distributable list ("Choosing Wis...
journal_title:Infection
pub_type: 杂志文章,评审
doi:10.1007/s15010-017-0997-0
更新日期:2017-06-01 00:00:00