Ageing with HIV: a multidisciplinary review.

Abstract:

INTRODUCTION:After the introduction of highly active antiretroviral treatment, the course of HIV infection turned into a chronic disease and most of HIV-positive patients will soon be over 50 years old. MATERIAL AND METHODS:This paper reviews the multiple aspects that physicians have to face while taking care of HIV-positive ageing patients including the definitions of frailty and the prevalence and risk factors of concomitant diseases. From a therapeutic point of view pharmacokinetic changes and antiretroviral-specific toxicities associated with ageing are discussed; finally therapeutic approaches to frailty are reviewed both in HIV-positive and negative patients. CONCLUSION AND DISCUSSION:We conclude by suggesting that the combined use of drugs with the least toxicity potential and the promotion of healthy behaviours (including appropriate nutrition and exercise) might be the best practice for ageing HIV-positive subjects.

journal_name

Infection

journal_title

Infection

authors

Calcagno A,Nozza S,Muss C,Celesia BM,Carli F,Piconi S,De Socio GV,Cattelan AM,Orofino G,Ripamonti D,Riva A,Di Perri G

doi

10.1007/s15010-015-0795-5

subject

Has Abstract

pub_date

2015-10-01 00:00:00

pages

509-22

issue

5

eissn

0300-8126

issn

1439-0973

pii

10.1007/s15010-015-0795-5

journal_volume

43

pub_type

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