Abstract:
:Since 1990, Pneumocystis carinii pneumonia (PCP) was diagnosed in 15 adult HIV-negative haematologic patients in our hospital. None of them had received PCP prophylaxis. All except one had been treated with prednisone. Symptoms usually started after stopping or tapering. In six patients the diagnosis of PCP was delayed because of confounding bacterial isolates from blood, sputum or urine leading to unsuccessful antibiotic treatment. PCP was diagnosed by demonstrating pneumocysts in bronchoalveolar lavage fluid. In four patients additional fungal or viral pathogens were identified. The infections were not clustered. The patients were treated with co-trimoxazole and, in case of a pO2 < 60 mmHg, with prednisone. Three patients died (20%); they all had a coinfection with cytomegalovirus and/or aspergillus. The others recovered completely. There were no relapses. Primary PCP prophylaxis should be considered in patients with lympho-proliferative disease and exposure to prednisone.
journal_name
Infectionjournal_title
Infectionauthors
van der Lelie J,Venema D,Kuijper EJ,van Steenwijk RP,van Oers MH,Thomas LL,von dem Borne AEdoi
10.1007/BF02113579subject
Has Abstractpub_date
1997-03-01 00:00:00pages
78-81issue
2eissn
0300-8126issn
1439-0973journal_volume
25pub_type
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